Ungasisebenzisa kanjani isidakamizwa uJanumet 1000?

I-Yanumet 1000 is umuthi osebenzayo onomphumela we-hypoglycemic. Kusetshenziselwa ukwelapha izinhlobo ezingafani ne-insulin ezinoshukela.

Igama Lezwe elingafanele

I-Metformin + Sitagliptin

I-Yanumet 1000 is umuthi osebenzayo onomphumela we-hypoglycemic.

I-ATX

A10BD07. Kubhekiselwa kuzidakamizwa zomlomo ze-hypoglycemic.

Khipha amafomu nokwakheka

Kutholakala ngesimo samathebulethi ehlanganisiwe. Ithebhulethi ngayinye iqukethe ama-64.25 mg we-sitagliptin ne-metformin (1000 mg). Ithebhulethi iqukethe amanani amancane izinto ezisimisayo ezenza lula ukutholwa kwezinto ezisebenzayo. Ukwakheka kwe-metformin ezinhlobonhlobo zezimali kungahluka kusuka ku-50 mg kuya ku-1000 mg.

I-membrane yefilimu iqukethe i-macrogol, udayi.

Isenzo se-Pharmacological

Kubhekwa njengesidakamizwa esihlanganisiwe esifaka inhlanganisela yezidakamizwa ezimbili ezisela ushukela ezihambisana. Lokhu kuyadingeka ukwenza ngcono ukulawulwa kweziguli emazingeni e-insulin egazini.

I-Sitagliptin iyi-inhibitor ye-DPP 4. Le nto isetshenziswa kabanzi ekwelapheni abantu abane-Type II sikashukela mellitus. Umphumela ubangelwa ukuthi into isebenza nge-incretins. Umuthi ukhulisa ukugcwala kwe-plasma kwe-glucagon-peptide-1 ne-glucose-insulinotropic polypeptide. Lezi zinto ziyingxenye yohlelo lokulawula ushukela.

I-Metformin ikhulisa ukumelana kwesiguli ne-glucose futhi inciphise ukuhanjiswa kwento esegazini.

Ngaphansi kwethonya le-sitagliptin, ubukhulu bokwakhiwa kwe-glucagon kwezicubu zamanyikwe kuncipha. Indlela yokuvimbela ihlukile kumalungiselelo we-sulfonylurea, yingakho iziguli mancane kakhulu amathuba okukhombisa ukubonakaliswa kwe-hypoglycemia.

Ekugxiliseni okwelashwa, i-sitagliptin ayinciphisi ukwakheka kwamanye ama-peptides afana neglucagon.

I-Metformin ingumphumela we-hypoglycemic. Kwandisa ukumelana kwesiguli glucose futhi kunciphisa ukuhlangana kwaleli gazi egazini. Kwandisa ukuzwela komzimba womuntu kuyi-insulin. Njengo-sitagliptin, le nto ayibangeli i-hypoglycemia uma usebenzisa imithamo yokwelapha.

Ukusetshenziswa kwe-metformin kuhamba phambili futhi kuphephile uma kuqhathaniswa nezinye izidakamizwa zokwelapha ushukela kanye ne-placebo. Umuthi awubangeli ukwanda kwe-insulin egazini.

I-Pharmacokinetics

I-bioavailability ye-sitagliptin ingama-87%, kanti ukudla ukudla okunamafutha akunakho noshintsho kuma-pharmacokinetics.

I-bioavailability ye-metformin lapho ithathwa ngaphambi kokudla ifinyelela ku-60%. Uma umuthi uthathwa ngokudla, khona-ke ukutholakala kwawo kuncishiswa. Leli qiniso kumele libhekwe lapho kuthuthukiswa uhlobo lokudla olunconyiwe.

Uma umuthi uthathwa ngokudla, khona-ke ukutholakala kwawo kuncishiswa.

Ukubopha kwe-sitagliptin kumaphrotheni ku-plasma cishe kungama-38%. I-Metformin, ngokwezinga elincane, ihlangana namaprotheni e-plasma. Ngokwengxenye futhi isikhashana, igxiliswa emangqamuzaneni abomvu egazi.

Iningi le-sitagliptin likhishwe emchameni lingashintshiwe, futhi i-metformin icishe ikhishwe emzimbeni ngendlela efanayo naleyo eyatholwa lapho uthathwa ngomlomo.

Izinkomba zokusetshenziswa

Kuboniswa njengokwengezwa ekwelashweni okuyinhloko kwesifo sikashukela sohlobo 2 kubantu abangakwazi ukuthola i-glycemia efanelekile kanye nesisindo somzimba ngokwelashwa kokudla kanye nokubuyiselwa kwemithwalo ejwayelekile. Ingahlanganiswa ne:

• amalungiselelo e-sulfonylurea;
• I-PPAR-γ ejenti yokuphikisana nabo (njengesengezo sokudla kanye nohlobo);

Ingasetshenziselwa isifo sikashukela sohlobo 2 ngokuhambisana nokwelashwa kwe-insulin.

Contraindication

Contraindication kokuthatha i-Yanumet yile:

• ukuzwela komzimba ku-sitagliptin, i-metformin hydrochloride nezinye izinto zomuthi;
• iziguli ezinesifo sikashukela sohlobo lwe-I;
• noma yisiphi isimo esibuhlungu esingathinta kabi umsebenzi ojwayelekile wezinso;
• ukomisa;
• isimo sokushaqeka;
• ukuhluleka kwenhliziyo nokuphefumula, ukumamatheka okulimazayo kwe-myocardial;
• ubuthi obunobuthi notshwala;
• inkathi yokondla ingane;
• metabolic acidosis, kufaka phakathi isifo sikashukela;
• Ukuhlolwa komzimba ngokungenisa kuwo isidakamizwa i-radiopaque.

Contraindication to taking Yanumet are iziguli ezinesifo sikashukela sohlobo I.

Ukudilizwa kokuthathwa kokuthatha iJanumet kungukufakelwa kwe-myocardial acute.

Ukwephula umthetho wokuthatha iJanumet yisimo sokuthuthumela.

Ngokunakekela

Ngokuqapha, udinga ukunquma le khambi uma kwenzeka ukungasebenzi kahle kwezinso nesibindi (ukuncishiswa komthamo kuyenziwa).

Ungayithatha kanjani iJanumet 1000

Lo muthi kufanele uphuzwe izikhathi ezi-2 ngosuku. Isibhebhe kufanele siphuzwe nokudla. Kwenqatshelwe ukuchoboza noma ukugaya umuthi.

Ngoshukela

Umthamo wokuqala onconyiwe unqunywa udokotela ngemuva kokuhlaziywa ngokuphelele kwesimo sesiguli. Uma okususelwa ku-sulfonylurea kusathathwa, khona-ke udinga ukunciphisa umthamo weYanumet ukuze i-hypoglycemia ingakhuli.

Imiphumela emibi

Umuthi ungadala ukwephulwa kokufakwa kwe-vitamin B12, ushintsho ekwakhekeni kwegazi. Kwesinye isikhathi kukhula i-anemiablastic anemia.

UJanumet angadala ushintsho ekwakhekeni kwegazi.

Amapheshana wesisu

Ngesikhathi sokulashwa, isifo sohudo, ukulahleka kwesifiso, ukuphendukezela ukunambitheka, ukuqhakaza kungenzeka. Ukungajabuli esiswini kwesinye isikhathi kuba khona. Akuvamile ukuthi iziguli zibone ukunambitheka kwensimbi emgodini womlomo.

Le mizwa idlula kancane kancane. Ukuze unciphise ukuqina kwabo, udinga ukuthatha izidakamizwa ze-analgesic, antispasmodics. Akuvamile ukuthi uphuze izidakamizwa ezingezona ze-steroidal ezilwa nokuvuvukala.

Ngasohlangothini lwe-metabolism

I-Hypoglycemia yenzeka esikhathini esingatheni futhi ingumphumela wokuphathwa okungafanele komuthi kanye nama-angues we-sulfonylurea. Izimpawu ze-hypoglycemia zivela kakhulu futhi zanda ngokushesha. Kuvele izithukuthuku ezibandayo esigulini, ubuso bakhe buphaphathekile, kuqubuke imizwa yokuzwa yindlala. Ubudlova nokulinganiselwa kokuziphatha kuyaphawulwa. Ezimweni ezinzima, ulahlekelwa ukwazi.

Ukunciphisa izimpawu ze-hypoglycemia engenayo, udinga ukunika isiguli uswidi oluncane. Amacala amakhulukazi amiswa kuphela esibhedlela.

Engxenyeni yesikhumba

Akuvamile ukudala ubomvu nokuvuvukala.

Kusuka ohlelweni lwezinhliziyo

Ukuqandula kwengcindezi yegazi akuvamile ukuba kwenzeke.

Ukusuka kokungezwani komzimba, ukuqubuka esikhunjeni kungenzeka.

Allergies

Ukusuka kokungezwani komzimba, ukuqubuka esikhunjeni kungenzeka. Amathuba okusabela okunjalo anda kowesifazane osekhulile.

Umthelela ekhonweni lokulawula izindlela

Ngoba Njengoba umuthi okwazi ukubangela i-hypoglycemia, esikhathini sokwelashwa kungcono ukwenqaba ukushayela imoto nokusebenza ngamasu wokuphamba.

Imiyalo ekhethekile

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Ngesikhathi sokukhulelwa, ukwelashwa kuvunyelwe kuphela uma kungekho okunye ukusongela enganeni. Ngesikhathi sokwelashwa, ingane esanda kuzalwa kufanele idluliselwe kwindlela yokufakelwa yokondla.

Ukuqokwa kweYanumet ezinganeni eziyi-1000

Akukho datha ekusetshenzisweni kwesidakamizwa ezenzweni zezingane.

Ngesikhathi sokwelashwa, ingane esanda kuzalwa kufanele idluliselwe kwindlela yokufakelwa yokondla.

Sebenzisa ebudaleni

Kuyadingeka ukunciphisa umthamo womuthi ngenxa yezinguquko kumetabolism yayo.

Isicelo sokusebenza kokulimala kwezinso

Ezindabeni ezibulalayo zokungasebenzi kahle kwezinso, lo muthi awunqunyelwe, ngoba iningi lazo lichazwa emchanjeni. Ama-pathologies ashubile futhi angamahlalakhona adinga imikhawulo yedosi ukuvimbela ukudakwa.

Sebenzisa umsebenzi wesibindi okhubazekile

Umuthi awemukelekile kubantu abanenkinga yokuqina kwesibindi.

Ukweqisa

I-lactic acidosis iyakhula. Ngokushesha ngaphambi kokuqala kwe-lactic acidosis, kukhona i-aura. Liziveza ngokuphefumula okunomsindo nokuvama ukuphefumula.

Ingozi yokukhula kwe-lactic acidosis iyanda kubantu abanezinhlobo ezahlukahlukene zokuhluleka kwenhliziyo.

Ingozi yokukhula kwe-lactic acidosis iyakhula kubantu abanezinhlobo ezahlukahlukene zenhliziyo, izinso, kanye nokwehluleka kwesibindi. Ngokukhula komzimba, ukubulawa yindlala komoya-mpilo, kufanele ukhansele umuthi ngokushesha.

I-overdose iphathwa nge-hemodialysis.

Ukuxhumana nezinye izidakamizwa

Izidakamizwa ezilandelayo zehlisa umphumela wesidakamizwa:

• diuretic thiazide;
• ama-hormone egilo;
• izindlela zokuvimbela inzalo ngomlomo;
• i-sympathomimetic;
• Isoniazid.

Ukuhambisana notshwala

Utshwala obunamandla bukhulisa imiphumela ye-metformin kanye nokwephuka kwe-lactic acid. Ngisho nemithamo emincane yotshwala ikhulisa kakhulu ingozi ye-lactic acidosis.

Ama-Analog

Izidakamizwa ezingezansi ezinezakhiwo ezifanayo zifaka:

• Avandamet;
• IVokanamet;
• I-Glibomet;
• Ama-Glucovans;
• Gentadueto;
• I-Dianorm;
• I-Dibizide;
• I-Yanumet Long;
• Sinjardi.

Izidakamizwa ezingezansi ezinezakhiwo ezifanayo zifaka phakathi i-Avandamet.

I-Glybomet ingeyezidakamizwa ezithatha indawo yezindawo ezinendawo efanayo.

IGentadueto isidakamizwa esidingayo esinezindawo ezifanayo.

Izimo zeholide Yanumeta 1000 kusuka ekhemisi

Ingathengwa kuphela ngokunikeza incwadi kadokotela.

Ngingakwazi ukuthenga ngaphandle kadokotela

Kukhishwe.

Intengo yeYanumet 1000

Amacwecwe angama-56 - cishe ama-ruble angama-2200.

Izimo zokugcina zomuthi

Gcina endaweni emnyama kude nezingane.

Isikhathi sokuphelelwa yisikhathi

Akudluli iminyaka engu-2.

Umkhiqizi uYanumet 1000

"UPateon wasePuerto Rico, Inc.", ePuerto Rico.

Ukubuyekezwa kodokotela ngeYanumet 1000

U-Irina, oneminyaka engama-55, i-endocrinologist, uNizhny Novgorod: "Lesi sidakamizwa sehlisa i-glucose ngempumelelo kubantu abanesifo sikashukela 2. Ngesikhathi sokwelashwa, angizange ngikuqaphele ukubukeka kwemiphumela emibi, ngoba zonke iziguli zaziphuza umthamo ophakanyisiwe kuphela. glycemia elungile futhi ivikele ukukhula kwezinkinga zesifo sikashukela. "

U-Oksana, oneminyaka engama-34 ubudala, udokotela wesifo sikashukela, eMoscow: "Lokhu kungenye indlela efanelekile yokusebenzisa izidakamizwa ze-hypoglycemic nge-sulfonylurea. Lesi sidakamizwa silawula kangcono ushukela futhi sivimbela ukukhula kwezimo ezisongela impilo. Angibonanga ukukhula kwe-hypoglycemia ngesikhathi salo mkhuba. Iziguli ziyathuthuka."

Ukubuyekezwa kweziguli

U-Alexander, oneminyaka engama-55, eMoscow: "Ngosizo lweYanumet, ngikwazi ukugcina ukubalwa kwezinga lami likashukela isikhathi eside. Ngokungafani neminye imithi, angizange ngibe ne-hypoglycemia. Isimo sami sempilo sihle, ngaba namandla, ngiphelelwe umuzwa wokuhlala ngilamba."

U-Olga, oneminyaka engama-49, eSt. Petersburg: "Lo muthi wathuthukisa impilo yami, ngaba nezinhlungu emaphethelweni ami, ngaqala ukuya endlini yangasese kaningi ebusuku. Manje ngibonile ukuthi amehlo ami abona ngcono kancane ngemuva kweYanumet. Ushukela wami wegazi usesimweni esijwayelekile, akukho ukweqa ngezindlela ezihlukile, bekungekho i-hypoglycemia ngemuva kokuqala kokwelashwa. "

U-Oleg, oneminyaka engama-60, uStavropol: "Lapho ngisebenzisa lo muthi, ngibona ukuthuthuka empilweni yami. Ngicishe ngayeka ukuya endlini yangasese ebusuku, amandla ami ayathuthuka. Nginezela ekwelashweni kwami ​​ngokudla okulungile futhi ngikhohlwe ngokuphelele ngokuxhuma ushukela wegazi. Ukulala kwami ​​bekujwayelekile futhi bekuqubuka ulaka. Ngibheka ukuhambisana nokusebenza ngokomzimba. "