I-Diabetes Beta Cell Therapy Center neViaCyte, Inc. imemezele ukuthi ngokokuqala ngqa, kwafakwa umkhiqizo wokuhlola ezigulini ezinesifo sikashukela sohlobo loku-1 esikwelashini elingaphansi ukuze zibuyise amaseli e-beta alahlekile.
Ngasekupheleni kukaJanuwari, imininingwane yavela kwiWebhu mayelana nokuqala kokufakwa kokufakwa kokunye okwenza umsebenzi we-thyroid. Ngokwesitatimende esivela eBeta Cell Therapy Center yesifo sikashukela, okuyindawo okugxilwe kuyo ekucwaningweni nasekuvinjelweni kwesifo sikashukela 1, neViaCyte, Inc., okuyinkampani egxile ekwakheni amaseli amasha wokubuyiselwa kwesifo sikashukela, prototype iqukethe amaseli we-pancreatic cell afakiwe buyisela amaseli we-beta alahlekile (kubantu abanempilo enhle bakhiqiza i-insulin) futhi babuyisele ukulawula kwamazinga kashukela egazini ezigulini ezinesifo sikashukela sohlobo 1.
Kumamodeli e-preclinical, i-PEC-Direct implants (eyaziwa nangokuthi i-VC-02) iyakwazi ukwenza isisindo esisebenzayo se-beta-cell elawula amazinga kashukela wegazi. Amandla abo njengamanje ayafundwa esifundweni sokuqala semitholampilo saseYurophu. Phakathi kwabahlanganyeli kukhona iziguli ezinomhlobo 1 wesifo sikashukela, ezilungele ukwelashwa esikhundleni se-beta-cell.
Ngokuzayo, ukwelashwa kokubuyiselwa kweseli kwe-beta kunganikeza ukwelashwa okusebenzayo kwaleli qembu leziguli.
Esigabeni sokuqala sesifundo saseYurophu, izimila zizofakwa ekuhlolweni kwazo ukwakha amaseli we-beta; Esinyathelweni sesibili, kuzofundwa amandla abo wokukhiqiza amazinga e-insulin ehlelekile asungula ukulawula ushukela.
Ukufakwa ngaphakathi kwe-PEC-Direct, ngokusho kwabakhiqizi, isinyathelo esibalulekile ekwakhiweni kwezindlela zokwelapha iseli sikashukela sohlobo 1.
Ukufakwa kokuqala kwenziwa esibhedlela iVrieux University Hospital eBrussels, lapho isiguli sathola umfuziselo wePEC-Direct ovela eViaCyte.
Njengoba wazi, isifo sikashukela sohlobo loku-1 singenzeka kunoma iyiphi iminyaka, kepha sivame ukutholakala ngaphambi kweminyaka yobudala engama-40. Ezigulini ezinesifo sikashukela sohlobo 1, amanyikwe awasakwazi ukukhiqiza i-insulin, ngakho-ke kudingeka anikezwe le hormone njalo. Kodwa-ke, imijovo ye-exo native (i.e., evela ngaphandle) i-insulin ayibukhiphi ubungozi bezinkinga, kufaka phakathi eziyingozi.
Ukufakwa kwe-beta-cell okwenziwe kuma-pancreas omnikeli womuntu kungabuyisela ukukhiqizwa kwe-insulin nokulawulwa kweglucose ngezizathu ezisobala, kepha ngenxa yezizathu ezisobala le ndlela yokwelapha amaseli inemikhawulo enkulu. Amaseli we-stem cell wabantu (ahlukile kwabanye emandleni abo okuhlukanisa phakathi kwazo zonke izinhlobo zamaseli, ngaphandle kwamaseli angaphezulu kwamagciwane) angakunqoba lokhu kulinganiselwa, ngoba amelela umthombo omkhulu wamaseli futhi angakhula abe amaseli we-pancreatic elabhoratri ngaphansi kwezimo ezinzima kakhulu.
