Zonke izinsuku, abantu abanesifo sikashukela sohlobo lokuqala baphoqelelwa ukuthi bangenele imijovo ye-insulin ebuhlungu futhi ebuhlungu noma basebenzise amaphampu. Osokhemisi sekuyisikhathi eside belwa nezindlela ezinobumnene zokuletha i-hormone edingekayo egazini, futhi kubonakala sengathi enye yazo igcina itholakele.
Kuze kube namuhla, ngisho nabantu abesaba imijovo babengekho enye indlela. Isixazululo esizedlula zonke kungaba ukuthatha i-insulin ngomlomo, kepha ubunzima obukhulu ukuthi i-insulin idiliza ngokushesha okukhulu ngaphansi kwethonya lejusi yesisu nama-enzyme wokugaya ukudla. Isikhathi eside, ososayensi behluleka ukuthuthukisa igobolondo lapho i-insulin izonqoba khona yonke “imigoqo” yendlela yokugaya bese ingena egazini ingashintshiwe.
Futhi ekugcineni, ososayensi baseHarvard ngaphansi kobuholi bukaSamir Mitragotri bakwazile ukuxazulula le nkinga. Imiphumela yomsebenzi wabo yashicilelwa ephephabhukwini le-US Academy of Sciences - PNAS.
Izazi zebhayoloji zikwazile ukudala iphilisi, zona uqobo ziqhathanisa nokusebenza okuningi namakhono ngommese wamasosha waseSwitzerland.
I-insulin ifakwa esakhiweni osomakhemisi abakubiza ngokuthi "uketshezi lwe-ionic." Ngokuvamile ayinawo amanzi, kodwa ngenxa yendawo encibilikisa kakhulu, iziphatha futhi ibukeka njengamanzi. Uketshezi lwe-ionic luqukethe usawoti ohlukahlukene, i-organic compound choline (uvithamini B4) ne-geranium acid. Ngokubambisana ne-insulin, afakwe ngaphakathi kwe-membrane engamelana ne-gastric acid, kepha encibilika emathunjini amancane. Ngemuva kokungena emathunjini amancane ngaphandle kwegobolondo, uketshezi lwe-ionic lusebenza njengesikhali se-insulin, luwuvikele kuma-enzymes wokugaya ukudla, futhi, ngasikhathi sinye, uyisize ingene ekulweni kwegazi ngokusebenzisa izindonga zeseli le-mucous and obukhulu besisu uqobo. Enye inzuzo esobala yamakhompiyutha ane-insulin ku-ionic kezi ukuthi zingagcinwa emazingeni okushisa asekamelweni izinyanga ezimbili, okwenza kalula izimpilo zabantu abanesifo sikashukela.
Ososayensi bayaphawula ukuthi amaphilisi anjalo alula futhi awabizi ukukhiqiza. Ngaphandle kokuthi abantu abanesifo sikashukela bangenza ngaphandle kwemijovo eyisicefe, mhlawumbe le ndlela yokuhambisa i-insulin emzimbeni izosebenza kakhulu futhi ilawulwe. Iqiniso ukuthi indlela eyehlisa ushukela ingena ngayo egazini ngoketshezi lwe-ionic ifana kakhulu nezinqubo zemvelo zokufakwa kwe-insulin ezikhiqizwe ngamanyikwe kunemijovo.
Izifundo ezengeziwe ezilwaneni futhi kulapho kuphela lapho abantu bezodingeka khona ukufakazela ukuphepha komuthi, noma kunjalo, abathuthukisi bagcwele ithemba. I-Choline ne-geranic acid isivele isetshenziswa kwizengezo zokudla, okusho ukuthi zinakwa njengezingekho ubuthi, okungukuthi, isigamu somsebenzi senziwa. Onjiniyela banethemba lokuthi amaphilisi we-insulin azothengiswa eminyakeni embalwa.
