Ucwaningo lwamuva nje luveze indlela entsha yokuvikela amaseli we-pancreatic beta futhi ngaleyo ndlela kwehlise ukukhula kwesifo sikashukela. Futhi uvithamini D usetshenziswa kule ndlela.
Vitamin D nesifo sikashukela
Le vithamini ivame ukubizwa ngokuthi yilanga ngoba ikhiqizwa esikhunjeni sethu ngaphansi kwethonya lokukhanya kwelanga okuqondile. Phambilini ososayensi sebetholile ubudlelwane phakathi kokushoda kwe-Vitamin D kanye nengozi yesifo sikashukelakepha kusebenza kanjani - bekumele bathole.
IVithamini D inenqwaba yezenzo eziningi: ibandakanyeka ekukhuleni kwamaseli, isekela impilo yamathambo, amasosha omzimba kanye namasosha omzimba. Ngaphezu kwalokho, futhi okubaluleke kakhulu, uvithamini D usiza umzimba ukulwa nokuvuvukala.
"Siyazi ukuthi isifo sikashukela yisifo esidala ukuvuvukala. Manje sesithole ukuthi i-vitamin D receptor (iprotheni ebhekele ukukhiqizwa kanye nokungenisa i-vitamin D) ibaluleke kakhulu ekulweni nokulimazeka nokusinda kwamaseli we-beta pancreatic," kusho omunye wabaholi ocwaningweni uRonald Evans.
Ungawukhulisa kanjani umphumela wevithamini D
Ososayensi bathole ukuthi inhlanganisela ekhethekile yamakhemikhali ebizwa nge- iBRD9 ingakhulisa umsebenzi wama-vitamin D receptors. Ngenxa yalokhu Izici zokulwa nokuvuvukala zevithamini ngokwazo ziphinyiselwa ngokwengeziwe, futhi lokhu kusiza ukuvikela amaseli we-pancreatic beta, lawo ngesifo sikashukela asebenza ngaphansi kwezimo ezicindezelayo ngokwawo. Ekuhlolweni okwenziwe kumagundane, ukusetshenziswa kwe-iBRD9 kufake isandla ekujwayelweni kwamazinga kashukela egazini.
Phambilini ososayensi bazamile ukufeza umphumela ofanayo ngokwandisa izinga le-Vitamin D kuphela egazini leziguli ezinesifo sikashukela. Manje sekucacile ukuthi kuyadingeka futhi ukukhuthaza ama-vithamini receptor ka-V. Ngenhlanhla, izindlela ezivumela lokhu ukuthi ziqedwe.
Ukusetshenziswa kwesivuseleli se-iBRD9 kuvula imibono emisha kosokhemisi abebesazama amashumi eminyaka ukwakha umuthi omusha kashukela. Lokhu kutholwa kuyavumela qinisa zonke izakhiwo ezinhle ze-vitamin D, futhi ingaba yisisekelo sokudalwa kokwelashwa okusebenzayo kwezinye izifo, njengomdlavuza we-pancreatic.
Ososayensi banomsebenzi omningi okufanele bawenze. Ngaphambi kokuthi umuthi udalwe futhi uhlolwe kubantu, izifundo eziningi kudingeka zenziwe. Kodwa-ke, kuze kube manje akukho miphumela emibi yokuhlolwa eye yabonwa emgundweni wokuhlolwa, okunikeza ithemba elithile lokuthi kulokhu osokhemisi bazophumelela. Ekuqaleni kwalo nyaka, kwaziwa ukuthi odokotela basekhaya baphinde bathengisa uhlobo lomuthi wesifo sikashukela sohlobo 1, kodwa kuze kube manje azikho izindaba ngalesi sihloko. Ngenkathi silindele ukwehla emakethe yezokwelapha, ungathola ukuthi yiziphi izindlela nezidakamizwa zesifo sikashukela ezibhekwa njengezithuthuke kakhulu manje.
