I-Diabeteson MV isidakamizwa esenzelwe ukwelapha isifo sikashukela sohlobo 2.
Into esebenzayo yesidakamizwa yi-gliclazide, ekhuthaza amaseli we-beta we-pancreas ukuze akhiqize i-insulin eningi, lokhu kubangela ukwehla kushukela wegazi. Ukuqokwa kwe-MV yamathebulethi wokukhishwa modified. I-Glyclazide itholakala sulfonylurea. IGliclazide ikhishwa emacwecweni amahora angama-24 ngokulingana, okuyi-plus ekwelapheni isifo sikashukela.
Isifo sikashukela singathathwa kuphela ngemuva kwenkambo efanelekile ye-metformin. Umuthi unqunyelwe uhlobo lwe-2 yesifo sikashukela, uma ukuzivocavoca umzimba nokudla kungalethi imiphumela ebilindelekile.
Imiyalo nomthamo
Umthamo wokuqala womuthi kubantu abadala nasebekhulile ngu-30 mg emahoreni angama-24, lokhu kuyingxenye yepilisi. Umthamo ukhuphuka isikhathi esingekho ngaphezulu kwe-1 ezinsukwini eziyi-15-30, inqobo nje uma kungancishiswa ushukela.Udokotela ukhetha umthamo kuleso naleso simo, kususelwa emazingeni kashukela egazini, kanye ne-glycated hemoglobin HbA1C. Umthamo omkhulu yi-120 mg ngosuku.
Umuthi ungahlanganiswa nezinye izidakamizwa zesifo sikashukela.
Imithi
Umuthi wenziwa ezibhebheni, kunqunywa ukuthi kuthayiphe abantu abe-2 sikashukela, lapho ukudla okuqinile nokuzivocavoca kungasizi ngesifo sikashukela. Ithuluzi linciphisa kakhulu ukuhlangana koshukela.
Ukuvezwa okuyinhloko kwesidakamizwa:
- ithuthukisa isigaba soku secretion se-insulin, futhi ibuye iphinde iphinde iphakamise ukuphakama kwayo njengempendulo kokufaka kweglucose,
- kunciphisa ubungozi be-vascular thrombosis,
- Abantu besifo sikashukela babonisa izici ze-antioxidant.
Izinzuzo
Ngamafuphi, ukusetshenziswa komuthi ekwelapheni isifo sikashukela sohlobo 2 kunikeza imiphumela elandelayo:
- iziguli zehle kakhulu kushukela wegazi,
- ubungozi bokukhula nge-hypoglycemia bufika kuma-7%, okuyinto ephansi kunaleyo etholakala kwezinye izinto zokuphuma kwe-sulfonylurea;
- umuthi udinga ukuthatha kanye kuphela ngosuku, ukutholakala kalula kwenza ukuthi abantu abaningi bangayeki ukwelashwa,
- ngenxa yokusetshenziswa kwe-gliclazide kumathebhulethi wokukhishwa okuqhubekayo, isisindo somzimba seziguli sengezwe emikhawulweni ephansi.
Kulula kakhulu ukuthi ama-endocrinologists anqume ngenhloso yalesi sidakamizwa kunokuncenga abantu abanesifo sikashukela ukuthi balandele indlela yokudla nokuzivocavoca. Ithuluzi ngesikhathi esifushane linciphisa ushukela wegazi futhi, ezimeni eziningi, liyabekezelelwa ngaphandle kokuzitika ngokweqile. I-1% kuphela labanesifo sikashukela eliqaphela imiphumela emibi, ama-99% asele athi lo muthi ubalandela.
Ukushiyeka kwezidakamizwa
Umuthi unezinkinga ezithile:
- Umuthi uphuthumisa ukuqedwa kwamaseli we-beta we-pancreas, ngakho-ke lesi sifo singangena ohlotsheni olunesifo sikashukela sohlobo olu-1. Imvamisa lokhu kwenzeka phakathi kweminyaka emibili nengu-8.
- Abantu abanomthetho-sisekelo onomzimba omncane futhi onobunzima bangakha uhlobo olunzima lwesifo sikashukela esincike ku-insulin. Njengomthetho, lokhu kwenzeka ngaphambi kweminyaka engu-3.
- Umuthi awuqedi imbangela yohlobo 2 lwesifo sikashukela - ukuncipha kokuzwela kwawo wonke amaseli ku-insulin. Ukuphazamiseka okufanayo kwe-metabolic kunegama - ukumelana ne-insulin. Ukuthatha umuthi kungaqhakambisa lesi simo.
- Ithuluzi lenza ushukela wegazi uphansi, kepha ukufa okujwayelekile kweziguli akubeki phansi. Leli qiniso selivele liqinisekisiwe ngocwaningo lwamazwe omhlaba olukhulu olwenziwe yi-ADVANCE.
- Umuthi ungavusa i-hypoglycemia. Kodwa-ke, amathuba okuba khona kwawo angaphansi uma kwenzeka kusetshenziswa ezinye izinto eziphuma ku-sulfonylurea. Kodwa-ke, manje isifo sikashukela sohlobo 2 singalawulwa ngempumelelo ngaphandle kwengozi ye-hypoglycemia.
Akungatshazwa ukuthi umuthi unomphumela owonakalisayo kumaseli we-beta kumaseli we-pancreatic beta. Kepha lokhu akuvame ukushiwo. Iqiniso ngukuthi iningi labantu abanesifo sikashukela sohlobo lwe-2 abasindiswa nje kuze kube ukuthi banesifo sikashukela esincike ku-insulin. Uhlelo lwezinhliziyo zabantu abanjalo luthambile kune-pancreas. Ngakho-ke, abantu babulawa yisifo sohlangothi, isifo senhliziyo noma ubunzima babo. Ukwelashwa okuphelele okuphumelelayo kwesifo sikashukela sohlobo 2 ngokudla okuphansi kwe-carb kuhlanganisa nokunciphisa umfutho wegazi, onomphumela omuhle enhliziyweni nasemithanjeni yegazi.
Izici zamathebulethi wokukhishwa modified
Ithuluzi, njengoba kushiwo ngenhla, linezimfanelo zokukhishwa okuguquliwe. Ithebhulethi yomuthi iyancibilika esiswini sesiguli ngemuva kwamahora angama-2-3. Lonke ivolumu le-gliclazide mb elivela kwithebhulethi lingena ngokushesha egazini. Umuthi wehlisela ushukela egazini kahle futhi kancane. Amaphilisi ajwayelekile enza lokhu futhi ngokungazelelwe, ngaphezu kwalokho, isenzo sawo siyaphela ngokushesha.
Umuthi wakamuva okhululwe kabusha osisizukulwane sakamuva unezinzuzo ezinkulu ngaphezu kwezandulelayo. Umehluko omkhulu ukuthi umuthi omusha uphephile, futhi imiyalo yawo yokusebenzisa isetshenziswa kalula.
Umuthi wanamuhla awunamathuba amaningi okuvusa i-hypoglycemia, okungukuthi, isimo sikashukela wegazi, ngokungafani nezinye izinto ezisuselwa ku-sulfonylurea.
Ukuhlolwa kwamuva nje kwezokwelapha kusikisela ukuthi lapho uthatha lesi sizukulwane esisha somuthi, i-hypoglycemia ebukhali ayivamisile ukuvela, ihambisana nokuqwashiswa okungenamandla.
Ngokuvamile, isidakamizwa sanamuhla sibekezelelwa ngokwenele ngohlobo 2 sikashukela. Ukuvama okumaphakathi kwemiphumela emibi kuzo zonke iziguli akukho ngaphezulu kwe-1% yamacala.
Emisebenzini yezokwelapha, kuyaphawuleka ukuthi i-molecule ye-Diabeteson mb entsha inesakhiwo esiyingqayizivele futhi, empeleni, yi-antioxidant. Kodwa-ke, lokhu akunanzuzo engokoqobo ebonakalayo, futhi akukuthinti ukuphumelela ngokuphelele kokwelashwa.
I-Diabeteson ethuthukisiwe sekufakazelwe ukuthi inciphisa ukwakheka kwegazi, okunciphisa kakhulu ingozi yokushaywa unhlangothi. Kodwa-ke, akukho mininingwane yokuthi umuthi ubangela umphumela ofanayo.
Kuyaqapheleka ukuthi umuthi unezinto ezimbalwa ezikhathazayo kunezidakamizwa ezindala. Uhlobo olusha lunomphumela wokulondolozwa kumaseli we-beta wamanyikwe. Ngakho-ke, uhlobo lwe-1 yesifo sikashukela esincike ku-insulin lukhula kancane.
Ungawuthatha kanjani umuthi, izincomo zokusetshenziswa
Amaphilisi kufanele asetshenziswe njengesengezo ekudleni nasekusebenzeni komzimba, kepha akunakushiwo hhayi esikhundleni sawo.
Kuyaqapheleka ukuthi iningi labantu abanesifo sikashukela alilandeli izincomo zezokwelashwa maqondana nenguquko eya empilweni enempilo. Udokotela unquma umthamo wansuku zonke wezidakamizwa, kuya ngokuthi likhulu kangakanani ushukela wegazi lesiguli. Akunakusho ukuthi uma umthamo osunguliwe ungakhula ngokuzimela noma unciphise. Uma usebenzisa umthamo omkhulu we-Diabeteson, khona-ke i-hypoglycemia ingaqala - isimo sikashukela wegazi eliphakeme kakhulu. Izimpawu zesimo:
- ukungaphatheki kahle
- ukuxhawula isandla
- ukujuluka
- indlala.
Kunezimo ezinzima lapho kwenzeka ukulahleka okukhulu kwengqondo, ngemuva kwalokho umphumela obulalayo.
I-Diabeteson MV ithathwa ngesidlo sasekuseni, isikhathi esingu-1 ngosuku. Ithebhulethi ye-notched engama-60 mg kwesinye isikhathi ihlukaniswe izingxenye ezimbili ukuthola umthamo we-30 mg. Kodwa-ke, odokotela abancomi ukuchoboza noma ukuhlafuna ithebhulethi. Lapho uthatha umuthi, kungcono ukuwuphuza ngamanzi.
Ngaphezu komuthi, kunezinye izindlela eziningi zokwelapha isifo sikashukela sohlobo 2. Kepha uma isiguli sisenqume ukuphuza amaphilisi, lapho-ke udinga ukuwenza nsuku zonke, noma yikuphi ukushiya kungathandeki kakhulu. Ngaphandle kwalokho, ushukela wegazi uzokhuphuka ngokushesha okukhulu kakhulu.
Isifo sikashukela singanciphisa ukubekezelela utshwala. Izimpawu ezingaba khona:
- ikhanda
- ubunzima bokuphefumula
- Ubuhlungu besisu
- ukuhlanza
- ukuhlanza kwenhliziyo njalo.
Ukutholwa kweSulfonylurea, kufaka phakathi iDiabeteson MV, akubonwa njengezidakamizwa ezikhetha kuqala uma kunesifo sikashukela sohlobo 2. Umuthi osemthethweni uncoma ukuthatha amaphilisi e-metformin nalolu hlobo lwesifo sikashukela: iSiofor, iGlucofage.
Ngokuhamba kwesikhathi, umthamo wezidakamizwa ezinjalo ukhuphuka uye phezulu, ekugcineni ungama-2000-3000 mg ngosuku. Futhi kuphela uma lokhu kungenele, kwenziwa isinqumo ngokusetshenziswa kwesifo sikashukela.
Odokotela ababeka lesi sidakamizwa esikhundleni se-metformin benza okungalungile ngokuphelele. Zombili lezi zidakamizwa zingahlanganiswa, ezinikeza imiphumela ehlala njalo. Kepha inketho engcono kakhulu: shintshela ohlelweni olukhethekile lwesifo sikashukela sohlobo 2, ekugcineni ulahle amaphilisi.
I-Diabeteson MV ivunyelwe ukuhlangana nezinye izidakamizwa ekwelapheni isifo sikashukela, kepha lokhu akusebenzi kokutholakala kwe-sulfonylurea and glinides (meglitinides).
Uma umuthi unganciphisi izinga likashukela egazini lomuntu, khona-ke akufanele ungabaze futhi udlulisele isiguli kumijovo ye-insulin.
Kulesi simo, lena ukuphela kwendlela yokuphuma, ngoba amaphilisi ngeke asasiza. Imijovo ye-insulin izonga isikhathi esibalulekile, okusho ukuthi izinkinga ezinkulu ngeke zenzeke.
Ngokuthabisako, okuphuma esulfonylurea kukhulisa ukuzwela kwesikhumba emisebeni ye-ultraviolet. Lokhu kusho ukuthi izingozi zokushiswa yilanga zikhuphuka kakhulu. Sebenzisa ama-sunscreens njalo. Kepha kungcono ukungashisi ilanga, nokuba elangeni kancane ngangokunokwenzeka.
Kubalulekile ukucabanga ngengozi ye-hypoglycemia, engadala ukusetshenziswa kwe-Diabeteson. Lapho ushayela imoto noma wenza imisebenzi eyingozi, kubaluleke kakhulu ukubheka ushukela wegazi lakho njalo ngehora ngemitha yeglucose legazi.
Contraindication ekusebenziseni isidakamizwa
I-Diabeteson MV ayinakuthathwa nakancane, ngoba izindlela zokwelapha ezinesifo sikashukela sohlobo 2 zisebenza kahle impela futhi azinayo imiphumela emibi. Lesi sidakamizwa sikwamukele ngokusemthethweni ukwephulwa komthetho.
Ngezansi kunolwazi ngezigaba zeziguli okufanele zelashwe ngalo muthi, ezinesisindo sakho konke okuhle nokubi.
- Kuyenqatshelwe ngokuphelele ukuthatha umuthi ngesikhathi sokuncelisa kanye nokukhulelwa.
- I-Diabeteson MV ayinqunyelwe izingane kanye nentsha, ngoba ukuphepha kanye nokusebenza kahle komuthi walolu hlobo lweziguli akukasungulwa.
- Akunconyelwe ukusebenzisa umkhiqizo kubantu abangayihlanganisi nawo noma ezinye izinto ezisuselwa ku-sulfonylurea.
- Umuthi lo ubekwa ngemibandela ethile yesifo sikashukela sohlobo 1 noma isifundo esingazinzile sohlobo 2 sikashukela esinesiqephu esivela njalo se-hypoglycemia.
- Ukutholwa kweSulfonylurea akwamukelwa ngabantu abalimele kakhulu izinso nesibindi. Lapho kukhona i-nephropathy yesifo sikashukela, ukuphuza umuthi kufanele kuxoxwe nodokotela wakho. Njengomthetho, udokotela weluleka ukuthi ungene esikhundleni somuthi ngemijovo ye-insulin.
- I-Diabeteson MV ivunyelwe ngokusemthethweni asebekhulile, uma benezinso ezinempilo nesibindi. Kodwa-ke, ezimweni eziningi, umuthi uvusa ukuguqulwa kwesifo sikashukela sohlobo 2 kusifo sikashukela esincike ku-1. Ngakho-ke, uma sizibekela umsebenzi wokuphila isikhathi eside futhi ngaphandle kwezinkinga ezingenasidingo, ke kungcono ukungathathi i-MV Diabeteson.
I-Diabeteson MV kufanele ichazwe ngokucophelela ngaphansi kwale mibandela elandelayo:
- I-Hypothyroidism - ukwenziwa buthaka kwamanyikwe, ukushoda kwama-hormone ayo egazini,
- Ukushoda kwama-hormone akhiqizwa i-adrenal gland kanye ne-pituitary gland,
- Ukudla okungenamsoco
- I-Alcoholism ngendlela engapheli.
Izindleko zezidakamizwa
Njengamanje, noma yiluphi uhlobo lwesidakamizwa lungabhalwa ku-inthanethi noma luthengwe ekhemisi. Intengo ejwayelekile yesidakamizwa ama-ruble angama-350, noma ngabe nguhlobo luni lomuthi. Kumakhemikhali akwi-inthanethi kukhona amasampula ashibhile kakhulu omuthi, intengo yawo cishe ama-ruble angama-282.
