Isixazululo seMilgma somjovo we-intramuscular siqukethe izinto eziningana ezisebenzayo. Okuqukethwe ama-ampoules kufaka:
- i-lidocaine hydrochloride;
- i-cyanocobalamin;
- i-thiamine hydrochloride;
- i-pyridoxine hydrochloride.
Ngaphezu kwalokho, imijovo yesidakamizwa inezingxenye ezingeziwe:
- amanzi wokujova;
- i-sodium polyphosphate;
- i-sodium hydroxide;
- potasium hexacyanoferrate;
- utshwala be-benzyl.
Uhlobo lwethebhulethi yeMilgamma liqukethe:
- glycerides okuyingxenye ende;
- i-povidone K30;
- i-talc;
- i-microcrystalline cellulose;
- i-croscarmellose sodium;
- i-colloidal silicon dioxide i-anhydrous;
- i-pyridoxine hydrochloride;
- benfotiamine.
I-Milgamma compositum - ifomu lokukhulula
Umuthi uyatholakala ngesimo samathebulethi, ama-dragees kanye nesisombululo esikhonjelwa ngaphakathi kwe-intramuscularly. Isixazululo se-vitamin sifakwe ku-2 ml ampoules. Ekwenzeni ama-ampoules, umenzi usebenzisa ingilazi e-brown hydrolytic.
I-ampoule ngayinye ifakwe ilebuli futhi inechashaza elimhlophe. Amaphakeji angama-5 nama-10 ampoule.
Ifomu lethebhulethi lifakiwe futhi lahlanganiswa ngezingcezu ezingama-30 nezingama-60.
Kukhona enye indlela yokukhishwa - ama-dragees, angama-biconvex, amaphilisi amhlophe ayindilinga. Ithebhulele amaphakethe ezinhlakeni zamaselula zezingcezu eziyi-15. Ukufakwa kwekhadibhodi kungaqukatha amabhulashi amabili noma amane.
Izici ze-Pharmacological
Umuthi obizwa ngeMilgma compositum, njengama-analogue awo, uqukethe amavithamini we-neurotropic okuyiqembu B. Lesi sidakamizwa sisetshenziswa kumthamo wokwelapha wezifo zezinzwa nezicubu zezinzwa, lapho isiguli sinegalelo lokulimala nokuqina noma i-nerve conduction.
I-Milgamma iboniswa kubantu abanezifo zohlelo lwe-musculoskeletal.
Ngenxa yeMilgamma, equkethe inani elikhulu lamavithamini B, kwenzeka ukuthi ikhulule ukubonakaliswa kobuhlungu obukhali, ukuthuthukisa ukusebenza kohlelo lwezinzwa nohlelo lokwakheka kwegazi, kanye nokwenza kusebenze izinqubo ze-microcirculation.
Kanye emzimbeni womuntu, iVitamin B1 (thiamine) iguqulwa yi-phosphorylation ibe yi-thiamine diphosphate ne-cocarboxylase. I-Cocarboxylase, nayo ibamba iqhaza ezinhlelweni ze-carbohydrate metabolism, ithuthukise ukuhanjiswa kwezinzwa futhi ibuye ibuyele emisebenzini yezinzwa nezicubu zezinzwa.
Uma umzimba ungasebenzi ku-Vitamin B1, imikhiqizo engaphansi kwe-oxidized ye-carbohydrate metabolism inganqwabelana kwezicubu, ngaleyo ndlela ibangele zonke izinhlobo zezimo ze-pathological.
Lapho uthatha isinqumo sokuthi yikuphi okungcono kunezibhebhe noma imijovo yeMilgamma, kufanele kukhunjulwe ukuthi amaphilisi aqukethe i-benfotiamine hhayi i-thiamine chloride. I-Benfotiamine itholakala ku-fat-soluble thiamine.
Lapho udakiwe, uvithamini B6 (pyridoxine) uphosphorylated. Imikhiqizo ye-cleavage yayo ibandakanyeka ku-decarboxylation yama-amino acid, ngenxa yokuthi abalamuli abasebenza ngokomzimba bakhiqizwa emzimbeni - i-serotonin, i-dopamine, i-tyramine, i-histamine, i-adrenaline. Ngaphezu kwalokho, uvithamini B6 uthinta i-metabolism ye-tryptophan.
Womabili la mavithamini kanye ne-B1, ne-B6 anikezela ngamandla wethonya lomunye nomunye. Yingakho amaphilisi we-compactum we-Milkamma, imijovo nokufana kwayo kuba nomphumela ocacile wenzuzo enhlalakahleni kanye nesimo sempilo seziguli ezinezifo zemishini yezinhlelo zemoto nohlelo lwezinzwa.
ICyanocobalamin - Vitamin B12:
- inomphumela we-antianemic;
- isebenzisa ukwakheka kwe-methionine, i-creatinine, i-choline, i-nucleic acid;
- kusebenze i-metabolic acid metabolism;
- kunciphisa izinhlungu ezibangelwa ukulimala kohlelo lwezinzwa oluyingozi;
- Ibandakanya izinqubo ze-metabolic zamaseli.
I-Lidocaine iyindlela yokubulala izinzwa yendawo futhi inokubuyekezwa okuhle.
I-Pharmacodynamics ne-pharmacokinetics
Imiyalo esetshenzisiwe, kanye nokubuyekezwa kukhombisa ukuthi i-thiamine ngemuva kokujova intramuscular idonswa ngokushesha futhi ingene egazini. Emzimbeni, into isatshalaliswa ngokungalingani. Njengoba umzimba ungenazo izinqolobane ezibalulekile ze-thiamine, into leyo kufanele idakwe nsuku zonke.
I-Thiamine iyakwazi ukungena ekuvinjelweni kwe-placental and brain-brain, ekhishwe emzimbeni yizinso. Uma kuqhathaniswa namanye amavithamini, i-thiamine iqongelela izicubu namaseli ngamanani amancane.
Ngemuva kokujova okungaphakathi kwe-pyridoxine, isisombululo singena ngokushesha egazini elijwayelekile bese sisakazeka emzimbeni wonke. Cishe ama-80% amavithamini abopha amaprotheni e-plasma.
Umuthi ungawela ku-placenta bese udlulela obisini lukamama okhulisayo. Kamuva, iyagcwala, iphenduke i-4-dioxic acid, ethi ngemuva kwamahora ama-2-5 ikhishwe emzimbeni yizinso.
ICyanocobalamin, engena egazini lomuntu, ibopha amaprotheni, okuholela ekwakhekeni kohlelo lokuhamba. Lapho-ke umuthi udonswa izicubu zesibindi bese unqwabelana kumnkantsha wethambo. Kakade ngemuva kokuthi i-cyanocobalamin ikhishwe emathunjini nge-bile, ingaphinde idakwe.
I-Milgamma compositum - izinkomba zokusetshenziswa
Amacwecwe nemijovo kubhekwa njengengxenye yokwelashwa okuyinkimbinkimbi kwama-syndromes nezifo zesistimu yezinzwa, ezinama-etiologies ahlukile. Kunezinkomba ezinjalo zokusetshenziswa kweMilgamma:
- i-plexopathy;
- i-neuropathy;
- i-polyneuropathy yotshwala ne-diabetes;
- ganglionitis herpes zoster;
- i-paresis yezinzwa yobuso;
- i-retrobulbar neuritis;
- i-neuralgia;
- i-neuritis.
Ngaphezu kwalokho, imijovo ibekelwe abantu abaphethwe yizimpawu zemizwa ye-speo osteochondrosis, yokugoba ebusuku. Ukuthi uMilgma nezimpawu zayo baziphatha kanjani njengengxenye yokwelashwa okuphelele, nokuthi kungani imijovo yakhe isadingeka, ungakuthola lokhu nokunye okuningi kudokotela wakho.
Contraindication Milgamma
Njenganoma yisiphi esinye isidakamizwa, iMilgamma ine-contraindication yayo ukuthi isetshenziswe:
- ukwehluleka kwenhliziyo okubolile;
- umkhawulo ophakeme wokuzwela kwezakhi zomuthi;
- iminyaka yezingane;
- ukukhulelwa
- inkathi yokuqunjelwa.
Njengomthetho, imiphumela emibi yesidakamizwa ivela ezimweni ezingavamile:
- Uhlelo lwezinzwa: isiyezi, ukungazi kahle.
- Uhlelo lomzimba: ukusabela komzimba.
- Uhlelo lokugaya: ukugabha.
- Izicubu ezixhunyiwe nezesisu:
- Isikhumba: ukulunywa, ukujuluka okunzima, umqubuko.
- Isistimu yenhliziyo: i-arrhythmia, i-tachycardia, i-bradycardia.
Kubalulekile! Kwesinye isikhathi ngemuva kokuphathwa ngokungena kwe-Milgamma, isiguli singathola ukuthukuthela endaweni yomjovo. Ukubonakaliswa kokuphendula okuhlelekile kubonwa kuphela uma ngabe kunokweqisa noma ngesingeniso esisheshayo. Lokhu kufakazelwa ukubuyekeza kwezidakamizwa.
Uma eminye imiphumela emibi ivele kungazelelwe noma leyo echazwe ngenhla iyaqina, kufanele wazise udokotela ozongena omunye umuthi ngomunye noma anikeze izincomo eziphathelene nokuphathwa okufanele.
Imiyalo yokusebenzisa - indlela nethamo
Imiyalo yokusebenzisa umuthi i-Milgama compositum kufanele ibonwe ngokucacile yisiguli. Okokuqala, imijovo yenziwa ekujuleni kwezicubu zomzimba 1 isikhathi ngosuku, 2 ml izinsuku ezingama-5-10. Uma umuthi noma i-analogues yakhelwe ukwelashwa kokulungiswa, kufanele uwuphathe ngendlela yamaphilisi, ucezu olu-1 nsuku zonke.
Imiyalo yokusetshenziswa komuthi nokubuyekezwa ngakho kukhombisa ukuthi kungcono ukusebenzisa imijovo ukuze ususe ngokushesha i-pain syndrome. Amaphilisi namadonsa aqala ukusebenza ngokuhamba kwesikhathi.
Inkambo yokwelashwa noMilgma ingahlala inyanga eyi-1. Kulokhu, isimo sempilo sesiguli kufanele siqashelwe udokotela oholayo masonto onke.
Inkambo yokwelashwa ngomjovo inganwetshwa uma udokotela ekubona kufanelekile. Ngaphezu kwalokho, uzokutshela ukuthi iyiphi indlela yokukhulula okufanele ikhethwe esimweni esithile nokuthi umuthi kufanele uphathiswe kangaki.
Uma ngasizathu simbe ukuvunyelwa okweqisayo komuthi, isiguli singathola lezo zimpawu ezifakiwe ohlwini lwemiphumela emibi, ngakho-ke ukwelashwa okubonakalayo nakho kuyasetshenziswa kulesi simo.
Indlela iMilgamma nezimpawu zayo ezixhumana ngayo nezinye izidakamizwa
Lapho uxuba i-vithamini B1 nezixazululo ze-sulfate, kuphuka ngokuphelele.
Ukulahleka komsebenzi we-thiamine kubonwa ngesikhathi sokusebenzisana:
- nge-metabisulfite;
- nge-penicillin;
- nge-ammonium citrate;
- nge-tannic acid;
- nge-riboflavin;
- ngama-carbonate;
- nge-mercury chloride;
- ngama-acetates.
Kwimithamo yokwelapha, i-pyridoxine inganciphisa umphumela we-levodopa, ngakho-ke, i-pyridoxine ayisetshenziswa nayo kanye namalungiselelo ayo okuyingxenye. Ukuxhumana ne-isoniazid, i-penicillamine, i-cycloserine nakho kuyaphawulwa.
ICyanocobalamin lapho kukhona usawoti wezinsimbi ezisindayo ilahlekelwa umsebenzi wayo. I-Riboflavin inethonya elimazayo entweni ethile (ikakhulukazi lapho ivezwa ukukhanya).
Amathebulegi kanye nesisombululo seMilgma kungathengwa kumthengisi wasekhemisi ngomuthi kadokotela.
IMilgammia nama-analogues ayo kufanele agcinwe endaweni emnyama engafinyeleleki ezinganeni ngamazinga okushisa angeqi ku-15.
Imiyalo ekhethekile yokusebenzisa
Umyalo uthi umuthi uphathwa kuphela nge-intramuscularly. Uma, ngokunganaki, iMilgamma iphathwe ngokuhlinzwa, isiguli kufanele sinikezwe ukwelashwa okubonakalayo kwemiphumela emibi nokubhekwa kwezokwelashwa.
Akukho okubukwayo ngomphumela wesidakamizwa ekhonweni lokushayela imoto nokusebenza ngamasu ayingozi, futhi umyalo uthule ngalokhu. Uma utadisha i-Wikipedia, ungathola ulwazi kuyo ukuthi umuthi usetshenziselwa umuthi wezilwane ukwelapha izilwane ezifuywayo.
Ukuze ubuyisele umzimba, umuthi unqunywa ngemuva kokudakwa ngokweqile. Kepha ukusetshenziswa kwayo kanyekanye ngotshwala akuvunyelwe ngokuphelele. Naphezu kweqiniso lokuthi akukho ukubukezwa kokusebenzisana okunjalo, ngokuqinisekile kusula wonke amandla ashukumisayo ekwelashweni nomuthi.
Inhlanganisela yotshwala ne-lidocaine nayo kungakhipha imiphumela emibi eminingana: ukukhathazeka, ukozela, ikhanda.
Ukukhulelwa nokukhulelwa
Umuthi awubekelwe abesifazane ngesikhathi sokukhulelwa nokuqunjelwa. Lokhu kungenxa yokuthi alukabikho ulwazi olwanele ngemiphumela yezakhi zalo ku-fetus nobisi lwebele.
Ngaphambi kokuqala ukwelashwa, udinga ukuvakashela umtholampilo, funda imiyalo nokubuyekezwa kweziguli.
