I-Tricorrhine isidakamizwa esinciphisa i-lipid esetshenziselwa i-dyslipidemia, futhi sisetshenziselwa i-mellitus yesifo sikashukela, uma ukwelashwa kokudla nokudla okwenziwe ngokomzimba kungasebenzi.
Umuthi wehlisa izinga le-fibrinogen nokuqukethwe kwezingxenyana ze-atherogenic ze-cholesterol egazini (i-VLDL, LDL), okwandisa ukuphuma kwe-uric acid.
Khipha ifomu nokwakheka
I-Tricor ithengiswa ngohlobo lwamacwecwe ambozwe ngefilimu ephaketheni lamaphilisi angama-30. Ithebhulethi ngayinye ifaka i-fenofibrate engama-micronized angu-145 mg, nezinto ezilandelayo:
- lactose monohydrate,
- sodium lauryl sulfate,
- sucrose
- i-hypromellose,
- i-silicon dioxide
- crospovidone
- isodomende sodium.
Umphumela wokwelapha
I-Fenofibrate isuselwa ku-fibric acid. Inamandla okushintsha amazinga ezingxenyeni ezahlukahlukene ze-lipid esegazini. Umuthi unezibonakaliso ezilandelayo:
- Kwenyuka imvume
- Yehlisa inani le-atherogenic lipoproteins (LDL ne-VLDL) ezigulini ezinobungozi obukhulu besifo senhliziyo,
- Iphakamisa izinga le-cholesterol "enhle" (HDL),
- Kakhulu kunciphisa kakhulu okuqukethwe kwama-cholesterol deposits,
- I-Lowers fibrinogen okuhlushwa,
- Yehlisa izinga le-uric acid egazini ne-C-reactive protein.
Izinga eliphezulu le-fenofibrate egazini lomuntu liyavela emahoreni ambalwa ngemuva kokusetshenziswa okukodwa. Ngaphansi kwesimo sokusetshenziswa isikhathi eside, awukho umphumela wokuqongelelwayo.
Ukusetshenziswa kwesidakamizwa Tricor ngesikhathi sokukhulelwa
Imininingwane encane ibikiwe ngokusetshenziswa kwe-fenofibrate ngesikhathi sokukhulelwa. Ekuhlolweni kwezilwane, umphumela we-teratogenic we-fenofibrate awuzange uvezwe.
I-embryotoxicity yenzeka njengengxenye yokuhlolwa kwangaphambi kokudalwa kokuthathwa komthamo onobuthi emzimbeni wowesifazane okhulelwe. Okwamanje, abukho bungozi ebantwini obukhonjwayo. Noma kunjalo, umuthi ngesikhathi sokukhulelwa ungasetshenziswa kuphela ngesisekelo sokuhlolwa ngokucophelela kwesilinganiso sezinzuzo nezingozi.
Njengoba kungekho datha eqondile ngokuphepha kweTricor yezidakamizwa ngesikhathi sokuncelisa ibele, khona-ke ngalesi sikhathi asinqunyelwe.
Ukuphambana okulandelayo kokuthatha isidakamizwa Tricor yile:
- Izinga eliphakeme lokuzwela ku-fenofibrate noma ezinye izinto zomuthi;
- Ukwehluleka okukhulu kwe-renal, ngokwesibonelo, i-cirrhosis yesibindi;
- Iminyaka yobudala eyi-18;
- Umlando we-photosensitization noma i-Phototoxicity ekwelapheni i-ketoprofen noma i-ketoprofen;
- Izifo ezahlukahlukene ze-gallbladder;
- Ukuncelisa;
- I-galactosemia ye-endo native, amazinga angenele we-lactase, ukungasebenzi kahle kwe-galactose ne-glucose (umuthi uqukethe i-lactose);
- I-Endo native fructosemia, ukusilela kwe-sucrose-isomaltase (umuthi uqukethe i-sucrose) - uTricor 145;
- Ukusabela okungahambisani nebhotela lamantongomane, amantongomane, i-soya lecithin, noma umlando ofanayo wokudla (ngoba kunobungozi be-hypersensitivity).
Kuyadingeka ukusebenzisa umkhiqizo ngokuqapha, uma kukhona:
- Ukwehluleka kanye / noma kwesibindi;
- Ukusetshenziswa kabi kotshwala;
- I-Hypothyroidism;
- Isiguli sikhulile;
- Isiguli sinomlando osindayo maqondana nezifo zemisipha yefa.
Imithamo umuthi kanye nendlela yokusebenzisa
Umkhiqizo kumele uthathwe ngomlomo, ugwinye lonke futhi uphuze amanzi amaningi. Ithebhulethi isetshenziswa nganoma yisiphi isikhathi sosuku, ayincikile ekudleni kokudla (kweTricor 145), futhi ngasikhathi sinye ngokudla (kukaTricor 160).
Abantu abadala baphuza ithebhulethi elilodwa kanye ngosuku. Iziguli ezithatha i-1 capsule ye-Lipantil 200 M noma i-1 i-Tricor 160 ngosuku ingaqala ukuthatha ithebhulethi engu-1 yeTricor 145 ngaphandle koshintsho olwengeziwe lomthamo.
Iziguli ezithatha i-1 capsule yeLipantil 200 M ngosuku zinethuba lokushintshela kwithebhulethi le-1 leTricor 160 ngaphandle kokushintshwa komthamo owengeziwe.
Iziguli esezikhulile kufanele zisebenzise umthamo ojwayelekile wabantu abadala: Ithebhulethi elilodwa leTricor kanye ngosuku.
Iziguli ezihluleka ukwehluleka kwezinso kufanele zinciphise umthamo ngokubonana nodokotela.
Uyacelwa uqaphele: ukusetshenziswa kwesidakamizwa Tricor ezigulini ezinesifo sesibindi asifundwanga. Ukubuyekezwa akunikeli isithombe esicacile.
Umuthi kumele uphuzwe isikhathi eside, ngenkathi ubheka imiyalo yokudla umuntu owalandele ngaphambi kokuqala ukusebenzisa umuthi. Ukusebenza kwomuthi kufanele kuhlolwe ngudokotela ohambelayo.
Ukwelashwa kuhlolwa ngamazinga we-serum lipid. Sikhuluma nge-cholesterol ye-LDL, i-cholesterol ephelele ne-triglycerides. Uma umphumela wokwelapha ubengenzekanga ezinyangeni ezimbalwa, khona-ke ukuqokwa kokunye ukwelashwa kufanele kuxoxwe.
Ukweqisa izidakamizwa
Akukho ncazelo yamacala okweqa ngokweqile. Kepha uma usola lesi simo, ungakuthola ukwelashwa okubonakalayo nokwesekelayo. I-Hemodialysis ayisebenzi lapha.
Ukuthi umuthi uxhumana kanjani nezinye izidakamizwa
- Ngama-anticoagulants omlomo: i-fenofibrate ithuthukisa ukusebenza kwama-anticoagulants omlomo futhi ikhulisa ingozi yokopha. Lokhu kungenxa yokufuduswa kwe-anticoagulant kusuka kumasayithi okubopha amaprotheni e-plasma.
Ezigabeni zokuqala zokwelashwa kwe-fenofibrate, kuyadingeka ukwehlisa umthamo wama-anticoagulants ngowesithathu, bese ukhetha kancane kancane umthamo. Umthamo kufanele ukhethwe ngaphansi kokulawulwa kweleveli ye-INR.
- Nge-cyclosporine: kukhona izincazelo zamacala ambalwa abucayi bokusebenza kwesibindi okunciphisiwe ngesikhathi sokwelashwa nge-cyclosporine ne-fenofibrate. Kuyadingeka ukuthi kuqashwe njalo ukusebenza kwesibindi ezigulini futhi kususwe i-fenofibrate uma kunezinguquko ezinkulu emingceleni yeelebhu.
- Ngama-HMG-CoA reductase inhibitors namanye ama-fibrate: lapho uthatha i-fenofibrate nge-HMG-CoA reductase inhibitors noma amanye ama-fibrate, ubungozi bokudakwa kumisipha yemisipha kukhuphuka.
- Ngama-enzymes we-cytochrome P450: ucwaningo lwama-microsomes wesibindi womuntu libonisa ukuthi i-fenofibroic acid ne-fenofibrate azisebenzi njengama-inhibitors we-cytochrome P450 isoenzymes:
- CYP2D6,
- CYP3A4,
- CYP2E1 noma CYP1A2.
Emithanjeni yokwelapha, lezi zihlanganisi zingamakhompiyutha abuthakathaka we-CYP2C19 ne-CYP2A6 isoenzymes, kanye nama-inhibitors ama-CYP2C9 amnene noma alinganiselayo.
Imiyalo embalwa ekhethekile lapho uphuza umuthi
Ngaphambi kokuthi uqale usebenzise umuthi, udinga ukwenza ukwelashwa okuhlose ukuqeda izimbangela ze-hypercholesterolemia yesibili, esikhuluma ngakho:
- uhlobo lwesifo sikashukela esingalawulwa esingu-2,
- i-hypothyroidism
- nephrotic syndrome
- dysproteinemia,
- izifo zesibindi ezivimbayo
- imiphumela yokwelashwa kwezidakamizwa,
- utshwala.
Ukusebenza kokwelashwa kuhlolwa ngokuya ngokuqukethwe kwe-lipids:
- i-cholesterol ephelele
- I-LDL
- i-serum triglycerides.
Uma umphumela wezokwelapha ungazange uvele izinyanga ezingaphezu kwezintathu, kuyadingeka ukuqala enye indlela yokwelapha noma yokuhlangana.
Iziguli ezine-hyperlipidemia ezithatha ama-hormone okuvimbela inzalo noma ama-estrogens kufanele zithole uhlobo lwe-hyperlipidemia, kungaba eyokuqala noma yesekondari. Kulezi zimo, ukukhuphuka kwenani lama-lipid kungabangelwa ukudonsa kwe-estrogen, okuqinisekiswa ukubuyekezwa kweziguli.
Uma usebenzisa i-Tricor noma ezinye izidakamizwa ezinciphisa ukuqoqwa kwama-lipids, ezinye iziguli zingathola ukwanda kwenani lama-hepatic transaminases.
Ezimweni eziningi, ukwanda kuncane futhi kungokwesikhashana, kudlula ngaphandle kwezimpawu ezibonakalayo. Ezinyangeni zokuqala eziyi-12 zokwelashwa, kuyadingeka ukuqapha ngokucophelela izinga lama-transaminases (AST, ALT), njalo ezinyangeni ezintathu.
Iziguli okuthi, phakathi nokwelashwa, zibe nenqwaba yokukhuphuka kwama-transaminases, zidinga ukunakwa okukhethekile uma ukuqoqwa kwe-ALT ne-AST kuphindaphindwe izikhathi ezintathu noma ngaphezulu kunomkhawulo ophezulu. Ezimweni ezinjalo, umuthi kufanele umiswe masinyane.
I-pancreatitis
Kunezincazelo zamacala okuthuthukiswa kwe-pancreatitis ngesikhathi sokusetshenziswa kweTraicor. Izimbangela ze-pancreatitis:
- Ukuntuleka kokusebenza kahle kwalesi sidakamizwa kubantu abane-hypertriglyceridemia enkulu,
- Ukuchayeka ngqo kulo muthi,
- Ukubonakaliswa kwesibili okuhambisana namatshe noma ukwakheka kokudonswa phansi gallbladder, okuhambisana nokuphazamiseka kwe-bile duct ejwayelekile.
Imisipha
Lapho usebenzisa i-Tricor nezinye izidakamizwa ezokwehlisa ukugcwala kwama-lipid, kuye kwabikwa amacala emiphumela enobuthi kwezicubu zemisipha. Ngaphezu kwalokho, amacala angavamile we-rhabdomyolysis ayaqoshwa.
Ukuphazamiseka okunjalo kuba kaningi uma kunezimo zokuhluleka kwe-renal noma umlando we-hypoalbuminemia.
Imiphumela enobuthi kwezicubu zemisipha ingasolwa uma isiguli sikhononda:
- Ukuhlanzeka kwemisipha kanye namaqhubu
- Ubuthakathaka obujwayelekile
- Diffuse myalgia,
- I-Myositis
- Ukwanda okumakiwe emsebenzini we-creatine phosphokinase (izikhathi ezi-5 noma ngaphezulu kuqhathaniswa nomkhawulo ophezulu wesimo esijwayelekile).
Kubalulekile ukwazi ukuthi kuzo zonke lezi zimo, ukwelashwa ngeTricor kufanele kuyekwe.
Ezigulini ezimiselwe i-myopathy, kubantu abadala kuneminyaka engama-70, nasezigulini ezinomlando osindayo, i-rhabdomyolysis ingahle ivele. Ngaphezu kwalokho, lesi simo siyaxaka:
- Izifo zemisipha ebanjiwe
- Umsebenzi wezinso ongasebenzi kahle,
- I-Hypothyroidism,
- Ukusebenzisa kabi utshwala.
Umuthi unqunyelwe lezi ziguli kuphela lapho inzuzo elindelekile yokwelashwa idlula kakhulu ubungozi obukhona be-rhabdomyolysis.
Uma usebenzisa iTraicor ngokuhlangana nama-HMG-CoA reductase inhibitors noma amanye ama-fibrate, ubungozi bemiphumela emibi ebuthaka emisipha yemisipha uyanda. Lokhu kuyiqiniso ikakhulukazi lapho isiguli sinezifo zemisipha ngaphambi kokuqala ukwelashwa.
Ukwelashwa okuhlanganyelwe neTesticor ne-statin kungaba kuphela uma isiguli sine-dyslipidemia enkulu nengxubevange kanye nengozi enkulu yenhliziyo. Akufanele kube nomlando wezifo zemisipha. Ukukhonjwa okuqinile kwezimpawu zemiphumela enobuthi kwezicubu zomzimba kuyadingeka.
Umsebenzi weRenal
Uma ukunyuka kokuqalwa kwe-creatinine kwe-50% noma ngaphezulu kuqoshwa, khona-ke ukwelashwa kwezidakamizwa kufanele kumiswe. Ezinyangeni zokuqala ezintathu zokwelashwa kukaTreicor, ukugxila kwe-creatinine kufanele kunqunywe.
Ukubuyekezwa mayelana nomuthi akuqukethe imininingwane mayelana nanoma yiziphi izinguquko empilweni lapho ushayela imoto nokulawula imishini.
