Ukusebenza kahle komuthi i-Victoza kushukela kanye nokunciphisa umzimba

I-Victoza iyi-analogue yokuqala futhi okuwukuphela kwayo ye-glucagon-peptide. Le nto icishe ibe yi-100% evumelana ne-GLP yomuntu. Njengomuthi wemvelaphi yemvelo, umuthi i-Victoza uvusa ukukhishwa kwe-insulin ngezindlela ezikhethekile zamaselula uma izinga likashukela lidlula okujwayelekile.

Namuhla iViktoza yokunciphisa isisindo futhi, njengenye yemithi yabanesifo sikashukela, isetshenziswa emazweni angaphezu kwama-35 emhlabeni wonke, kufaka phakathi amazwe aseMelika naseYurophu. Abaphenyi bafunda ngokungakhathali izakhiwo ze-GLP ukuze bakwazi ukuqeda ngempumelelo izimo zezifo ezigulini zamaqembu ahlukahlukene.

Ifomu lomthamo nokwakheka kwalo

I-Victoza yezidakamizwa yethulwe njengesixazululo sokuphatha ngokungahambi kahle. Into esebenzayo yi-liraglutide. Uketshezi lomuthi lufakwa esibayeni esikhethekile sesirinji esinevolumu engu-3 ml.

Isixazululo sekhwalithi asin umbala, akufanele siqukethe ukungcola. Umbala we-turbidity noma we-heterogeneous kufanele uxwayise - mhlawumbe umuthi sewonakalisiwe. Izithombe eziningi zepeni yesirinji yeVictoza zingatholakala kwimithombo ehlukahlukene ye-Intanethi ukuze uzijwayeze ukuthi umuthi kufanele ubukeke kanjani kusengaphambili.

Izici ze-Pharmacotherapeutic

Imijovo yeVictoza ingumenzeli onamandla we-hypoglycemic. Imiphumela emqoka yezidakamizwa ebangela intshisakalo yangempela evela kwabelaphi kanye nama-endocrinologists:

1. Ukugqugquzela ukukhiqizwa kwe-insulin okuncike egazini;
2. Ukucindezelwa kokukhiqizwa kwe-glucagon ngohlobo oluncike kushukela;
3. Ukuvikelwa ezimeni ezibucayi ze-hypoglycemic;
4. Ukulungiswa kwesisu ngenxa yokwehla okuncane kwe-motility (ukumunca ushukela ngemuva kokudla kuncishisiwe kancane);
5. Ukwehla okukhulu kokumelana ne-insulin kwezitho zomzimba ezizungeze i-periphery;
6. Ukwehla ukukhiqizwa koshukela ngokwezinhlaka ze-hepatic;
7. Ukuxhumana ne-nuclei ye-hypothalamus ukuze wakhe umuzwa wokudinwa futhi wehlise umuzwa wendlala;
8. Ukwenza ngcono ukusebenza kwezicubu nezitho zohlelo lwenhliziyo;
9. Umfutho wegazi;
10. Ukwenza ngcono ukugeleza kwegazi kwe-coronary.

Imininingwane YezeMithi

Umuthi i-Victoza, ngokuya ngemiyalo esetshenziswayo, uphathwa kanye ngosuku. Umphumela wesikhathi eside wezinto ezisebenzayo liraglutide unikezwa izindlela ezintathu:

1. Inqubo yokunciphisa ijubane yokufakwa kwezidakamizwa ngenxa yemigomo yokuzihlanganisa;
2. I-Ligament ene-albhamuin;
3. Izinga eliphakeme lokuqina kwenani lama-enzyme, okuvumela ukukhipha imikhiqizo esele yele yezidakamizwa, isikhathi eside ngangokunokwenzeka.

Isixazululo seVictoza sithinta kahle isakhiwo se-pancreatic, sithuthukisa amandla okusebenza kwamaseli we-beta. Futhi, kukhona ukwehla kokusitheka kwe-glucagon. Uhlelo lokuxhumanisa umsebenzi wama-enzyme kanye nokusebenza kwama-pancreas uqobo luphelele.

Izakhiwo Ezincane

IVictoza isetshenziselwa kakhulu ukunciphisa isisindo, uma kungekho isifo sikashukela kanye nokunye ukungahambi kahle kwe-endocrine.

Lokhu kungenxa yokuthi, ngokumelene nesizinda sokwehla kwezinga le-glycemia, ukuphuma kwe-gastric kwehlisa ijubane.

Into esebenzayo isiza ukunciphisa isisindo somzimba. Ungqimba lwamafutha luncishiswa ngokwemvelo, futhi zonke izindlela ezihilelekile kule nqubo azikwazi ukulimaza umzimba. Umphumela wokushisa amafutha usekwe ekunciphiseni indlala nasekunciphiseni ukusetshenziswa kwamandla.

Umuthi i-Victoza noma i-Saksenda (elinye igama lesidakamizwa okuhloswe ngalo ukulwa nokukhuluphisa ezigulini ngaphandle kwe-pathologies yesifo sikashukela) sinqunyelwe ezigulini ukuqinisa isisindo bese zilungisa inkomba ye-glycemic. Ukubonisana nomuthi akusifanele - ngaphambi kokuwusebenzisa kuyadingeka kakhulu ukuthola ukwesekwa kokubonisana nodokotela noma nodokotela onempilo.

Mayelana nezimo zangaphambi kwesifo sikashukela

Ucwaningo ezilwaneni ezine-prediabetes ithi kukhombisa ukuthi i-liraglutide inciphisa kakhulu ukwakheka kwesifo sikashukela. Ezimweni eziningi, umphumela omuhle utholakala ngenxa yokwanda kwamaseli we-beta wamanyikwe. Kalula nje, isitho silulama ngokushesha, futhi izinqubo zokuvuselela kabusha zinqoba izinqubo zokubhujiswa.

Indima ebalulekile idlalwa ukuvikela izakhiwo ze-glandular ezintweni eziningi eziphikisayo:

• Ukuba khona kwama-cytotoxins;
• Ukuba khona kwamafutha acid yamahhala ebangela ukufa kwamaseli e-beta asebenzayo we-gland.
• Amaseli amancane wesisindo se-glandular cell, okuholela ekungasebenzi kahle kwesitho.

Izici ze-Pharmacokinetic

Ukufakwa kwento esebenzayo kuhamba kancane, okuqinisekisa umphumela wesikhathi eside emzimbeni.

Ukuhlungwa kwe-plasma ephezulu kakhulu kwenzeka emahoreni angama-8 kuye kwayi-10 emva kokuphathwa kwomuthi.

I-Liraglutide ikhombisa ukusebenza kahle kweziguli zayo yonke iminyaka nezigaba. Ucwaningo lapho amavolontiya asukela eminyakeni eyi-18 kuye kwengama-80 abamba iqhaza athola imiphumela ekuqinisekisa lokhu.

Izinkomba zokuthatha umuthi

IVictoza, njenge-analogues yayo, ikhonjiswa kuzo zonke iziguli ezinesifo sikashukela sohlobo 2. Ngokuphikisana nesizinda sokudla okufanele nokuvivinya umzimba okujwayelekile, lesi sidakamizwa sikhombisa ukusebenza kahle. Ngokuya kwezibuyekezo zeziguli, i-Victoza ikuvumela ukuthi ulawule inkomba ye-glycemic, kungakhathalekile ukuthi unamuphi umlando nezimpawu eziqondene nomuntu ngamunye.

Kunezimo eziningana zokuqokwa kweVictoza. Ukubuyekezwa kodokotela kulungile maqondana nenye nenye yazo:

1. I-Monotherapy (Victoza eyodwa kuphela esibayeni sesirinji Kubekelwe ukulawula isimo sikashukela nokuqinisa isisindo ezigulini ezine-carbohydrate metabolism ephazamisekile ngemuva kwesifiso sokudla).
2. Ukwelapha okuhlanganayo nomuthi owodwa noma ngaphezulu we-hypoglycemic ophuzwa ngomlomo. Kaningi sikhuluma nge-metformin ne-urea sulfinyl derivatives. Le ndlela yokwelapha ibalulekile ezigulini ezingazange zikwazi ukuphatha ukufinyeleleka kahle kokuqondisa izinkomba ze-glucose kuma-regimens yangaphambi kokwelashwa.
3. Ukwelapha okuhlanganisiwe okususelwa ku-insal insulin ezigulini ezingazwazanga umphumela oyifunayo lapho zidla izidakamizwa ngokohlelo oluboniswe ngenhla.

Mayelana ne-contraindication

Intengo enengqondo i-Victoza nokubuyekezwa okuhle kwenza lo mkhiqizo we-pharmacological uthandwe kakhulu. Kodwa-ke, ngisho nokuphepha okuhlobene, ifomula ephelele yamakhemikhali kanye nokusetshenziswa kwendawo yonke ekwelashweni kwazo zonke iziguli akusona isizathu sokukhohlwa mayelana nokuphikisana:

1. I-Hypersensitivity kuzakhi ze-Victoza, kungakhathalekile ukuthi umenzi (lokhu kungukuphikisana okujwayelekile, okufanele kunoma yimuphi umkhiqizo we-pharmacological);
2. Umlando womdlavuza we-yegilo wohlobo lwe-medullary (ngisho nomlando womndeni);
3. I-Neoplasia yemvelaphi ye-endocrine (amaningi);
4. Ukwehluleka okukhulu kwe-renal;
5. Ukwehluleka kwesibindi okukhulu kakhulu;
6. Ukwehluleka kwenhliziyo I-II isigaba sokusebenza.

Izigaba ezikhethekile

IVictoza, ngokusho kwezibuyekezo, ibekwe njengesidakamizwa esiphephile futhi esisebenza kakhulu. Noma kunjalo, kunezimo ezithile lapho kungenakwenzeka ukunquma umuthi, ngoba ngaphansi kwemibandela ethile into esebenzayo ayisebenzi.

Sikhuluma nge-pathologies elandelayo nemibandela ethile:

• Uhlobo lwoshukela lohlobo lokuqala;
• I-Ketoacidosis yemvelaphi yesifo sikashukela;
• Ukukhulelwa
• Isikhathi sokuzala;
• Ukuvuvukala kwe-mucosa yesisu esincane noma esikhulu;
• Iminyaka engaphansi kweminyaka eyi-18 (akukho datha ekusebenzeni kokungenisa, ngoba izifundo ezigulini ezingaphansi kweminyaka yobudala eziningi azenziwanga);
• I-Gastroparesis yohlobo lwesifo sikashukela.

Imiphumela emibi

Izifundo zokwelashwa zomuthi zenziwe kaninginingi. Ochwepheshe bakwazile ukutadisha yonke imiphumela emibi ye-Viktoza. Njenganoma yisiphi esinye isidakamizwa, umuthi osuselwa ku-liraglutide ungadala imiphumela emibi. Ungafunda kabanzi ngokuphendula okungathandeki komzimba ngokufunda idatha esetafuleni.

Mayelana nokuhlanganiswa okwelapha

Isisulu sinciphisa ukusebenza kwe-digoxin lapho sithatha lezi zidakamizwa zombili ngasikhathi sinye. Umphumela ofanayo ubonwa ngokuhlanganiswa ne-lisinopril.

Umuthi ungahlanganiswa ngokuphephile nezidakamizwa ze-antihypertensive, amaphilisi okulawula ukuzalwa kwe-hormonal.

Ngokusho kokuhlolwa kodokotela, i-Viktoza yokunciphisa umzimba kufanele ithathwe ngokuqapha ngokweqile futhi ingafakwa neletinye izidakamizwa ezingathinta izinga le-glucose emzimbeni.

Izindlela zokuthatha iVictoza

Umuthi lo uphathwa njengomjovo ongama-subcutaneous kanye ngosuku. Ukwethulwa kwalesi sidakamizwa akuboshelwanga ekudleni kokudla. Uma kunzima ukujova, thola ukuthi ungayisebenzisa kanjani ipeni yesirinji neViktoza, kungenzeka kudokotela ohambelayo.

Ithuluzi lihlala lithengiswa kumthamo oqinile nakwisirinji, elungele ukusetshenziswa kunoma yisiphi isimo. IVictoza ingafakwa "amaphuzu" alandelayo:

• Belly
• Hips
• Ihlombe.

Uma kunesidingo, izindawo lapho lo muthi uphathwa khona kanye nesikhathi somjovo, ungashintshwa ngokubona kwesiguli. Umphumela wokwelapha uwonke uzohlala ungashintshiwe. Umuthi awemukelekile neze ukusisebenzisa ukuphathwa kwe-intravenous.

Umthamo wokuqala akufanele udlule ku-0,6 mg wento esebenzayo ngosuku. Ngesonto lokuqala, umthamo omncane ungakhuphuka kancane kancane ufike ku-1,2 mg. Inani eliphakeme elivunyelwe ezimweni ezihlukile yi-1.8 mg ngokungqongqozwa ngakunye.

Ungayiphatha kanjani isirinji

Umuthi uvezwa ngendlela yesisombululo (i-6 mg ku-3 ml koketshezi), ubekwe esibayeni esivumelana nesirinji. I-algorithm yokusebenzisa umkhiqizo we-pharmacological imi ngale ndlela elandelayo:

1. I-cap yokuvikela isuswa ngokucophelela ku-syringe.
2. Isembozo sephepha sikhishwa ngenaliti enokulahlwa.
3. Inaliti ilimele kwisirinji.
4. Susa isicoco esivikela ngenalithi, kodwa ungayilahli.
5. Ngemuva kwalokho kuyadingeka ukukhipha inaliti ye-cap yangaphakathi (ngaphansi kwayo inaliti).
6. Ihlola impilo yesirinji.
7. Isibambo sijikelezwe ngobumnene, kukhethwa umthamo. Isikhombi somthamo kumele sibe sezingeni elifanayo nophawu lokuhlola.
8. Isirinji sigoqiwe ngenaliti phezulu, ngokuthepha ngokuthepha ku-cartridge ngomunwe index. Ukukhwabanisa kuyadingeka ngoba kukuvumela ukuthi ukhiphe ngokushesha ama-bubble womoya anqunyelwe kusisombululo.
9. Isirinji kufanele sigcinwe endaweni “yenalthi” bese sicindezelwa “ukuqala” kaningana. Ukukhwabanisa kwenziwa kuze kube yilapho kuvela u- “zero” kwisibonakaliso, kanti nethonsi uketshezi libonakala ekugcineni kwenalithi.

Masinyane ngaphambi komjovo uqobo, kuzodingeka ukuthi uqinisekise ukuthi umthamo ofanele ukhethiwe. Ukuphatha umuthi, i-syringe iyaphendulwa bese kufakwa inaliti ngaphansi kwesikhumba. Cindezela inkinobho yokuqala ngokunensa futhi kancane. Isixazululo kufanele singene kahle esikhunjeni imizuzwana emi-5 kuya kwengama-7.

Lapho-ke inalithi idonswa kancane. I-cap yangaphandle ibekwa. Kwenqatshelwe ngokuqinile ukuthinta inaliti ngeminwe yakho. Ngemuva kwalokho isakhi asisuswa futhi siyalahlwa. Ipeni lesirinji ngokwalo livaliwe nge-cap ekhethekile.

ILycumia neVictoza

Imvamisa kuphakama umbuzo, uyini umehluko phakathi kweLixumia neViktoza, isidakamizwa osikhethayo ukulwa nokukhuluphala nokubonakaliswa kwesifo sikashukela. I-Viktoza ngenani libhekisa ezidakamizweni ezibizayo okunzima ukuzithenga ukuze zisetshenziswe nsuku zonke. Lesi ngesinye sezizathu ezenza bazame ukubuyisela umuthi osebenza ngempumelelo futhi ophephe ngokuphelele ngezinye izindlela.

I-Lixumia isidakamizwa esibekelwe ukwelashwa kohlobo lwe-2 yesifo sikashukela sihlanganiswe ne-metformin. Uma uVictoza elawula izinga le-glucose ne-glucagon, khona-ke uLixumia uyakwazi ukusebenza endaweni eyodwa kuphela - ngokulungisa izinga le-glucose.

Omunye umehluko obalulekile, ongathi kwezinye izimo ubhekwe njengedonsela ebalulekile ukunamathiselwa kokudla. Umuthi uphathwa ihora ngaphambi kokudla ekuseni noma kusihlwa, okungahlali kuhlale kunjalo. Esimweni seVictoza, umjovo ungenziwa nganoma yisiphi isikhathi esikahle.

Ngokuvamile, izinkomba, ama-contraindication, isitoreji nokusetshenziswa kwezimo zamalungiselelo ziyefana. Ikhophi elenziwe le-GLP lisetshenziselwa ukunciphisa umzimba kuma-mono-Therapeutic regimens. Sekukonke, i-Liksumia ingathathelwa indawo yiVictoza, kepha ukufakwa esikhundleni kungalingani. Kumapharamitha amaningi, umuthi wokugcina ukhange kakhulu ukuxazulula izinkinga zokwelapha.

I-Baeta noma iVictoza: okufanele ukhethe

Omunye umbuzo onesihloko wokuthi yikuphi okungcono kuneBayet noma iViktoza. I-Baeta yi-amino acid aminopeptide. Ihluka kakhulu emvelweni yamakhemikhali kwinto esebenzayo iVictoza, kodwa iphindaphindwe ngokuphelele izimfanelo zalo muthi. Ekusesheni kwe "Victoza yamahhala," i-aminopeptide ayikwazi ukubizwa ngokuthi inketho enhle kakhulu. Kubiza kakhulu kunomuthi osuselwa ku-liraglutide.

Kodwa-ke, kukhona umehluko lapho kufanelekile ukunaka ngokukhethekile. Umuthi i-Baeta udinga ukuphathwa kabili ngosuku.

Kungakapheli ihora, umuntu kufanele alale phansi, futhi umuthi ufakwa ngaphansi kwesikhumba kancane kakhulu.

Le yingqondo ebalulekile okufanele icatshangelwe lapho ukhetha isakhi sokwelapha esiyisiguli ezinesifo sikashukela sohlobo 2.

IVictoza ishibhile kuneBaeta, futhi nayo yethulwa ilula kakhulu.

Ukunquma i-aminopeptide esikhundleni se-liraglutide kusebenza kuphela uma umzimba wesiguli ubona ukwelashwa ngomuthi obiza kakhulu, unganaki iVictoza esebenzayo.

UViktoza notshwala

Ukuhlanganiswa kwanoma yimiphi imikhiqizo ye-pharmacological kanye notshwala ngokuvamile kuyathandeka. Kwabashukela, isimo sabo se-pathological siyingxenye ebalulekile yempilo. Kufanele ubhekane ne-glucose engazinzile ngaso sonke isikhathi, okusho ukuthi udinga ukuzikhawulela njalo ekudleni nakotshwala.

Ukudakwa kotshwala ngohlobo lwe-2 yesifo sikashukela kucacisiwe ikakhulukazi. Ukuphuza utshwala kungaholela ekutheni isiguli sizothola ngokungazelelwe izimpawu ze-hypoglycemic - izinga le-glucose egazini lehla kakhulu.

Lo mphumela udalulwa ikakhulukazi uma kuphuzwa utshwala esiswini esingenalutho, nokudla okuncane, noma inani lotshwala uqobo lihlaba umxhwele impela.

Noma yimiphi imikhiqizo equkethe utshwala ithuthukisa isenzo semithi equkethe i-insulin namathebulethi anciphisa i-insulin. Ngaphezu kwalokho, izinto ezimbalwa eziqukethwe otshwaleni zinomphumela okhethekile esibindini - kwehlisa ijubane ukwakheka kweglucose.

Ingozi ye-hypoclycemia (ngisho ne-hypoglycemic coma) ikhuphuka nangokwengeziwe uma, ngemuva kokuphuza utshwala nokungazidli ukudla, isiguli sibhekene nokuzivocavoca okunzima komzimba. Kwenqatshelwe ngokuphelele ukuthatha imithamo emikhulu yotshwala kusihlwa futhi uphathe noma yiziphi izidakamizwa ukwehlisa ushukela. Esimweni sokulala, uhlobo olukhulukazi lwe-hypoglycemia lungakhula.

Yize umuthi i-Victoza uhlukaniswa uhlobo olukhethekile lwethonya lamakhemikhali futhi "uhlakaniphile" ulawula zonke izinqubo emzimbeni, umuntu akufanele akhohlwe ukuthi ukuhlanganiswa kwemithi notshwala kuhlale kunosongo.

Ukubuyekezwa mayelana nomuthi Victoza