I-Glucophage - ikhemisi nokusetshenziswa komuthi

IGlucophage isidakamizwa sokuqala sase-French antidiabetesic esuselwa ku-metformin hydrochloride. Ngaphambi kokuthi lo muthi uvele emakethe yemithi, inkampani yaseFrance iMerck Sante yathuthukisa futhi yawuphenya iminyaka eyi-10. Akusikho nje ukuthi iGlucophage yasekuqaleni ibiza kancane kunama-generics akhiqizwe amafemu athenge ilungelo lobunikazi.

IGlucophage ihamba phambili, ngoba yafundwa ngokufanelekile ekwakhiweni lapho kuthengiswa khona, kufaka phakathi igobolondo, abathola lona. Imikhiqizo yohlobo olujwayelekile isebenzisa ezinye izimbongi nazo zonke izinhlobo zezinhlanganisela, ngaphandle kokucabanga ocwaningweni lokusebenza kwazo, ngakhoke umphumela ungabikezelwa.

Ukuqanjwa nefomu lomthamo

Isakhi esisebenzayo somuthi yi-metformin hydrochloride (metformin hydrochloride). Ngokuya ngomthamo, ithebhulethi eyodwa yesidakamizwa ingaqukatha 500, 850 noma i-1000 mg yale nto. Ngaphezu kwesithako esiyisisekelo, i-Glucofage yezidakamizwa iqukethe nama-excipients (i-povidone K 30, i-magnesium stearate). Igobolondo lenziwa nge-hypromellose ne-macrogol.

Amacwecwe we-convex angama-Round (1000 mg oval) avikelwe igobolondo. Ngaphezu kwe-notch yokuhlukanisa, kukhona ukuqoshwa komthamo. Ahlanganiswe kumaseli we-blister wezingcezu eziyi-15-20. Kwiphakheji lekhadibhodi kungahle kube namapuleti amabili kuya kwayi-4.

Khipha umuthi kadokotela. Ku-Glucofage, intengo incike kumthamo, isifunda, uhlobo lwenethiwekhi yokusabalalisa. Kunoma yikuphi, ishibhile impela: ngokwesibonelo, izindleko ezijwayelekile zamathebulethi angama-30 ama-500 mg - kusuka kuma-ruble ayi-100 kuye kwangama-130. Bakhipha isidakamizwa sokuqala esinamakhono okuhlala isikhathi eside - Glucophage Long.

Impilo yeshelufu lomuthi incike emthonjeni: kwamabhulashi angama-500 noma ama-850 mg iminyaka emi-5, ama-1000 mg ngeminyaka emithathu. Umuthi ugcinwa kwiphakheji yawo yangempela, imiyalo yokusebenzisa ayisho imibandela ekhethekile ye-glucophage.

Ikhemisi

Umuthi obhebhekile we-hypoglycemic ungowokweqembu lama-biagunids futhi ungommeleli wawo kuphela. I-Metformin, isakhi esiyinhloko se-Glucofage, ivimbela ukufakwa kweglue endaweni yokugaya ukudla kanye nokukhiqizwa kwayo esibindini. Ngaphezu kwalokho, lo muthi usheshisa ukusetshenziswa kwama-carbohydrate. IGlucophage iqhathanisa kahle nezinye izidakamizwa ezi-antidiabetic zamanye amakilasi ukuthi ayinakubangela i-glycemia, ngoba indlela esebenza ngayo ayinikezi ukukhuthaza kokuqalwa kwe-insulin yendawo.

I-Metformin isebenza ngezinkomba ezintathu:

• Yehlisa ukukhiqizwa koshukela esibindini, kuvimbela i-gluconeogeneis ne-glycogenolysis;
• Kuthuthukisa ukuzwela kwama-cell receptors kuma-hormone, ukuqinisekisa ukucubungula okuphelele kwama-carbohydrate;
• Kuvimba ukufakwa kwamashukela ezindongeni zamathumbu.

I-Pharmacokinetics

Lapho igxotshwa ipheshana lesisu, i-metformin igxiliwe ngentshiseko, ngokutholwa kokudla kanyekanye, izinga lokufakwa kwalo muthi liyehla. Ukuqongelelwa okuphezulu kwesidakamizwa ku-serum yegazi kubonwa ngemuva kwamahora we-2 nohhafu.

I-bioavailability engafani iyahluka phakathi kuka-50-60%. Ucwaningo lwenziwe ngokubamba iqhaza kwamavolontiya anempilo aphuza i-glucophage ku-500-850 mg.

IBiguanide ibopha buthakathaka kumaprotheni e-plasma, ihlangana namaseli abomvu egazi. IVolumu yokusabalalisa isebangeni lamalitha angama-63-276.

Ama-Metformin metabolites emzimbeni awatholakalanga, akhishwa ikakhulu yizinso, amanye (aze afike ku-30%) angena emathunjini. Ukuqedwa kwesigamu sempilo kuyisilinganiso samahora ayisithupha nesigamu. Ngokungasebenzi kahle kwe-renal, imvume ye-metformin iyancipha ngokulingana nezinkomba ezibonisa ukuncipha kokuvunyelwa kwe-creatinine (CC).

I-Glucophage - izinkomba zokusetshenziswa

Umuthi unqunyelwe abanesifo sikashukela ngohlobo lwesibili lwesifo, uma ukuguqulwa kwendlela kunganikeli i-100% glycemic control. Ezigulini ezikhuluphele, i-glucophage isebenza kakhulu kunamanye ama-antidiabetesic agents. Kuyasetshenziswa:

• Nge-monotherapy noma ngokuhlangana nezidakamizwa ezinciphisa ushukela kwamanye amaqembu wemithi noma ngokuhambisana ne-insulin
• Njengomuthi wokuqala noma ohlanganiswe ne-insulin yokulawulwa kwesifo sikashukela sohlobo 2 ezinganeni;
• Lapho umisa i-metabolic syndrome;
• Ngokuvimbela ukuguga (ngemuva kweminyaka engama-45).

IGlucophage nayo isetshenziselwa i-ovary polycystic. Ukuguga komzimba kubangelwa ukwanda kokugxila kwe-glucose glucose: amaprotheni aswelayo, imithambo yegazi emigodini egcwele amanoni aminyene, imibimbi esikhunjeni. I-molecule ngayinye yoshukela engafinyeleleki iguqulwa iba ngamangqamuzana amabili aqatha.

Ngokushintsha izinkomba ze-glycemic, i-atherossteosis ingavinjelwa, umfutho wegazi ungalungiswa, ngoba amaprotheni angenalo uswidi ahlala isikhathi eside. Ngokuvimbela ukuguga, i-glucophage isetshenziswa kumthamo we-250 mg / ngosuku. Kwesinye isikhathi i-glucophage isetshenziswa ekwakheni umzimba noma ukulungiswa kwesisindo kuphela.

I-Glucophage isidakamizwa esisetshenziswa kuyo yonke indawo: ichazwa ngabelaphi kanye nama-endocrinologists, abezenhliziyo nabadokotela bezengqondo, odokotela bezitho zamehlo nodokotela wezingane.

Contraindication kanye nemikhawulo

I-Glucophage iyindlela ethembeke kunazo zonke yezidakamizwa zesifo sikashukela, njengoba ukusebenza kwayo nokuphepha kuqinisekiswe ngeminyaka eminingi yokusebenza komtholampilo kanye nezifundo eziningi zesayensi. Kepha, njenganoma yimuphi umuthi, unemibandela yakhe yokuphambana nesikhathi nemikhawulo yesikhathi:

• Ukukhulelwa nokukhulelwa (kunconyelwe ukushintshela ku-insulin);
• Izinsuku ezimbili ngaphambi kokuhlinzwa okukhulu nezinsuku ezimbili emva kwazo, i-metformin ithathelwa indawo nge-insulin;
• Ngezivivinyo zokuqhathanisa ze-X-ray usebenzisa amaki asuselwa ku-iodine, ukulinganiselwa okufanayo;
• Ekwelapheni ukulimala kanye nokushiswa okukhulu, kunconywa futhi ukushintshwa kwesikhashana kwe-insulin;
• Ukungasebenzi kwesibindi;
• Ukwehluleka kwe-Renal (CC ngaphezulu kwe-0.132 no-0.123 kwabesilisa nabesifazane, ngokulandelana);
• Izimo ezisongela impilo ezivusa ukukhula kwe-lactic acidosis;
• Ezinganeni ezincane (ukuya kufinyelela eminyakeni eyi-10) ezinganeni - abukho ubufakazi bokuphepha nokusebenza ngempumelelo;
• Isondlo se-Hypocaloric (esingaphansi kuka-1000 kcal / usuku) siyingozi ngokuthuthukiswa kwe-ketoacidosis ye-metabolic ngenxa yokuqina komzimba.

Ingxaki eyingozi kakhulu (ngenhlanhla, hhayi evamile) ekwelashweni nge-metformin yi-lactic acidosis. Izici ezilandelayo zinomthelela ekukhuleni kwayo:

• Ama-pathologies ama-Renal angavumeli ukukhishwa ngokuphelele kokungcola ngendlela yemvelo;
• I-Alcoholism kanye nobuthi obudakayo obukhulu;
• Izifo eziphazamisa ukuphefumula kwezicubu (isifo senhliziyo, ukushaya kwenhliziyo, izifo ezithathelwanayo zohlelo lokuphefumula);
• Isifo sikashukela sikashukela;
• Izifo ezithinta umzimba eziqeda ukomisa ezihambisana nohudo, ukuhlanza nomkhuhlane.

Imiphumela yokusebenzisana neminye imithi

Akuhlanganisiwe ukuhlanganisa

Ekwelapheni i-Glucofage, utshwala bunqatshelwe ngokuphelele ngazo zonke izindlela.

Ubuthi obunobungozi buyandisa ingozi yokuthola i-lactic acidosis, ikakhulukazi ngokuntuleka kwesibindi, indlala, ukungondleki. Imithi eyenziwe ngotshwala nayo ayikhonjiswanga.

Ukulawulwa kwe-intravenous kwama-ejenti asuselwa ku-iodine, asetshenziswa ezifundweni ze-x-ray, kungadala izinkinga zezinso, futhi, ngenxa yalokho, ukunqwabelana kwe-metformin, okucasulayo ukwenzeka kwe-lactatocidosis. IGlucophage ithathelwa indawo yi-insulin amahora angama-48 ngaphambi kokuhlolwa namahora angama-48 ngemuva. Uma i-GFR> 60 ml / min / 1.73 sq. m, ukuhlolwa okwengeziwe kwesimo sezinso kuyadingeka.

Izinkimbinkimbi ezidinga ukusetshenziswa ngokucophelela

Eminye imishanguzo (i-sympathomimetics, corticosteroids) ingavusa i-hyperglycemia. Ekuqaleni kwesifundo, ukulungiswa komthamo we-Glucofage nokubheka njalo i-glycemia kuyadingeka.

Ama-diuretics (ikakhulukazi, i-loop) adala umthwalo owengeziwe ezinso, ngakho-ke, avuse i-lactic acidosis.

Izincomo ezingeziwe

I-Lactic acidosis yisimo esingavamile kodwa esiyingozi kakhulu ngokushona okuphezulu, ikakhulukazi ngokulaliswa esibhedlela ngokungazelele. Ukweqiwa kwe-metformin emzimbeni, okubangelwa ukungasebenzi kahle kwezinso, kuthuthukisa ukukhula kwayo.

Ezinye izimbangela zibuye zibangele i-lactic acidosis: uhlobo lwes 2 sikashukela esilawulwa ngokungafanele, ukusetshenziswa kabi kotshwala, i-ketosis, i-hepatic pathologies, ne-tishu hypoxia.

Ungasibona lesi simo nge-asthenia enzima, ukushesha komoya, i-hypothermia, ukuphazamiseka kwamapheshana emathunjini, izinhlungu ze-epigastric, imisipha yokuncipha. Uma ngaphambili i-Glucofage ingabanga nemiphumela emibi kakhulu, lonke ushintsho kufanele lubikwe ngokushesha ku-endocrinologist. Kuze kube lapho imbangela icacisiwe, i-metformin iyakhanselwa futhi iphinde iqale ngemuva kokuhlolwa kwezinso. I-Lactic acidosis iyingozi equkethe ingozi yokufa, ngakho-ke kudingeka umuntu olaliswe esibhedlela lapho esolwa okokuqala. Lapho wenza irejimeni yokwelashwa, udokotela kufanele azise onesifo sikashukela mayelana nezinkinga kanye nezimpawu ze-lactic acidosis.

Inkambo yokwelashwa nge-metformin yesifo sikashukela yinde, ngakho-ke isimo sezinso kufanele sihlolwe njalo: ngezinso ezinempilo - 1 r. / Year, nge-QC enezinkomba zemingcele esejwayelekile kanye nasebudaleni - 2-4 r. / Year. Uma i-CC ingaphansi kuka-45 ml / min., I-Glucophage ikhanseliwe. Kwizazi zesifo sikashukela esezikhulile, ukwehla kokusebenza kwezinso kuvame ukwenzeka ngokufana. Izidakamizwa ze-antihypertensive, ukomisa, i-diuretics, ama-NSAID nazo zithinta isimo sazo. Ngaphambi kokuqokwa kweGlucofage emacaleni anjalo, kuyadingeka ukuthi ayohlolwa.

Ngokuvamile, i-metformin ithinta kahle isimo semithambo yegazi, kufaka phakathi inhliziyo. ICanadian Diabetes Association incoma nokusetshenziswa kwe-Glucophage yezifo zenhliziyo zokuqina okulingene ngokubhekisisa njalo isimo senhliziyo nezinso. Kepha ngesimo esibi futhi esingazinzile, ukuthuthukiswa okuyingozi kwe-hypoxia, i-glucophage is contraindified.

Lapho i-Glucophage ibekelwe izingane, ukuxilongwa (uhlobo 2 sikashukela) kufanele kube sekutholakele futhi kwaqinisekiswa. Izifundo zeminyaka eyodwa zokwelapha azange ziveze imiphumela elimazayo ye-glucophage ekukhuleni nasekufikeni kwezingane. Kepha ekuhambeni kwesikhathi, imiphumela yokwelashwa ibingakahlolwa, ngakho-ke, abazali badinga ukuqapha ngokucophelela isimo sezingane ezinesifo sikashukela, ikakhulukazi lapho sisebenzisa umuthi okwenziwa yintsha.

I-Glucophage ayikwazi ukudala izimo ze-hypoglycemic ngesikhathi se-monotherapy, kepha ekwelashweni okuyinkimbinkimbi nge-meglitinides, izidakamizwa zeqembu le-sulfonylurea kanye nezinye izidakamizwa ze-antidiabetic ngomshini ohlukile wesenzo kune-metformin, ukulungiswa kwamthamo nokuqapha njalo kwe-glycemia kuyadingeka.

I-Glucophage iyisidakamizwa esibucayi se-antidiabetes, kepha kufanele isizwe. Ngaphandle kokubheka imigomo yokudla okuphansi kwe-carbohydrate, ukuvivinya umzimba okwanele nsuku zonke, ukulawula i-glycemic, isimo somzwelo, ukulala nokuphumula, isinxephezelo sikashukela esingu-100% ngeke sibalwe.

I-Glucophage nokukhulelwa

Kungakhathalekile ukuthi hlobo luni (olujwayelekile noma lomthambo), isifo sikashukela esingakhokhelwa ngesikhathi sokukhulelwa sandisa amathuba okukhula okungejwayelekile kwesibeletho kanye nokushona kwe-perinatal. Ucwaningo oluhlukile aluzange luqophe ukuphambuka ekukhuleni kwesibeletho kanye nesimo sempilo yabomama, kanye nomphumela wokuzalwa kwengane nokusinda kwezingane ezisanda kuzalwa. Futhi, noma kunjalo, ukukhulelwa nokukhishwa kusesimweni sohlu lwe-contraindication, ngakho-ke, esigabeni sokuhlela kwengane kubalulekile ukushintshela ku-insulin.

Sekutholwe ukuthi i-metformin idlulela obisini lwebele, futhi yize isezinsana, ngokusho kwemibiko, leli qiniso alizange libangele ukukhubazeka okuthuthukayo, umyalo uncoma ukudlulisela izinsana ekuzondleni okungezona ezokwelapha noma nge-insulin kukamama osenkulisa. Kunoma yikuphi, ingozi engaba khona yemiphumela engathandeki evela ku-metformin nokushiywa kobisi lwebele ingane iyacatshangelwa.

Umphumela we-metformin wenzalo wavivinya ezilwaneni. Ngomthamo ka-600 mg / ngosuku. (lokhu kuphindeke kathathu kunomkhawulo ophezulu wesimo esijwayelekile, kucatshangelwa indawo engaphezulu yomzimba), amathuba okukhulelwa kubantu besifazane ahlala esezingeni elifanayo.

Umthelela ekuphathweni kwemishini nokuhamba

Nge-Glucofage monotherapy, ijubane lokuphendula esondweni noma ukunakwa kokukhiqizwa okuyingozi alishintshi, ngoba umuthi awubeki i-hypoglycemia.

Uma i-Glucofage isetshenziswa ekwelashweni okuyinkimbinkimbi, ikakhulukazi ngezidakamizwa zochungechunge lwe-sulfonylurea, i-insulin, i-meglitinides engadala izimo ze-hypoglycemic, ukuqaphela kufanele kusetshenziswe lapho kusebenza ukuphakama, ukuphatha izindlela eziyinkimbinkimbi nokuhamba.

Izindlela zokusebenzisa

Abadala

Nge-monotherapy noma ekwelashweni okuyinkimbinkimbi usebenzisa izidakamizwa ezinciphisa ushukela ngomshini ohlukile wesenzo kune-metformin, umthamo wokuqalisa awudluli ku-500-850 mg. Umuthi uthathwa u-2-3r. / Usuku. ngokudla noma emva kokudla. Ngemuva kwamaviki amabili, hlola umphumela bese ulungisa umthamo, ugxile ekuzila ukudla kanye noshukela we-postprandial.

Ukungena kancane kancane komthamo kuvumela umzimba ukuthi uvumelane kalula nezimo ezintsha futhi kunciphise ubungozi bemiphumela emibi, ikakhulukazi kusuka kwipheshana lesisu.

Lapho unquma imithamo ephezulu, ungaphuza amabili ama-500 mg esikhundleni sethebhulethi eyodwa enesisindo esingu-1000 mg. Isilinganiso esiphezulu sansuku zonke singama-3000 mg, sisatshalaliswa kwimithamo emithathu.

Lapho ushintshela eGlucophage ngenye indlela yokwelapha ye-antidiabetic, irejimenti yangaphambi kokwelashwa kanye nezinga lesinxephezelo se-glycemic kuthathwa lapho kubalwa umthamo.

Uma amakhono we-Glucofage enganele isinxephezelo se-100% glycemic, ukwelashwa okuphelele nge-metformin kuhlangene namalungiselelo we-insulin kungenzeka. Ngalesi kwelashwa, umthamo wokuqala ungaphansi (500 mg) noma 850 mg, ukusetshenziswa kukathathu. Izinga le-insulin lilungiswa ngokuhambisana nokufundwa kwe-glucometer, okumele ibhekwe njalo.

IGlucophage ibekelwe iziguli ezivuthiwe zibheka isimo sezinso, okufanele zihlolwe njalo. Ngokuhluleka okulinganiselayo kwe-renal (CC 45-59 ml / min.) Futhi uma kungekho ezinye izinto ezivusa i-lactic acidosis, i-metformin iphathwa kanye ngosuku ngethamo lika-500-850 mg. Ekuphenduleni okujwayelekile kulo muthi, umthamo ungakalwa kuze kufike ku-1000 mg / ngosuku, uwusabalalisa izikhathi ezi-2. Njalo ezinyangeni ezingama-3-6, ukusebenza kwezinso kuhlolwa.

Izingane

Ngeke umangaze noma ngubani othola isifo sikashukela sohlobo 2 ebusheni nasebusheni: ukungasebenzi ngokomzimba, ingcindezi, ukudla okune-carb ephezulu ... I-United States nakwamanye amazwe athuthukile baphula amarekhodi kulokhu. IGlucophage ibekelwe izingane ezineminyaka eyi-10. Umthamo wokuqala we-metformin ufinyelela ku-850 mg / ngosuku. Baphuza amaphilisi kanye, abazali banesibopho sokuqinisekisa ukuthi ingane iphuza umuthi ngasikhathi sinye futhi ihlale “ibamba” umuthi ngewantshi noma ibhulakufesi eligcwele.

Ngokwemiphumela yokuhlolwa kwegazi, okufanele kuqashelwe nsuku zonke kudayari yesifo sikashukela, umthamo ungashintshwa ngesigamu senyanga. Bayandisa kancane kancane ukugwema imiphumela engathandeki yendlela yokugaya ukudla. Inani eliphakeme ebuntwaneni nasebusheni yi-2000 mg / usuku. nokusatshalaliswa kwawo wonke amaphilisi izikhathi ezi-2-3.

Izinketho ze-overdose

Ngokusebenzisa okukodwa kweGlucophage enanini lama-85 g, izimpawu ze-hypoglycemic bezingaqoshwa. Ezimweni ezinjalo, i-lactic acidosis iyakhula.Ukwedlula okukhulu komthamo we-Glucofage noma inhlanganisela engaphumelelanga nama-ejenti we-hypoglycemic kuyingozi engcupheni yokuthola i-lactic acidosis - isimo esibi esidinga ukulaliswa esibhedlela ngokushesha.

Indlela ephumelela kakhulu yokususa i-lactate yi-hemodialysis.

Imiphumela emibi

IGlucophage, njengesidakamizwa sokuqala, ibangela ukusabela okungafuneki (ngokuqhathaniswa ne-generics). Izimo ezivame kakhulu ukuphazamiseka kwe-dyspeptic, discmfortfort, kanye nokuphazamiseka kwesigqi sokuphamba. Izimpawu ezifanayo, njengomthetho, zidlula ngokuzimela ngemuva kokuba umzimba uguqukele ezimweni ezintsha. Kwezinye izimo, ukuhoxa kwezidakamizwa kuyadingeka.

Ngokuya kwesigaba se-WHO, imvamisa yokuphendula okungalungile ihlaziywa esikalini esinjengalesi:

• Imvamisa kakhulu -> 0,1;
• Imvamisa - kusuka ku-0,01 kuye ku-0.1;
• Akuvamile, ukusuka ku-0.001 kuya ku-0,01;
• Kuyaqabukela - kusuka ku-0.0001 kuya ku-0.001;
• Akwaziwa - uma izibalo zingavumeli ukucacisa imvamisa yemicimbi.

I-Glucophage analogues

I-Glucophage evela kumenzi Merck Sante isidakamizwa sokuqala saseFrance esinekhwalithi ephezulu. Ngezindleko kungabikwa ukuthi kubhekwe nezidakamizwa. Kepha kwezinye izimo (ukukhulelwa, ukusebenza kanzima, ukulimala, ukungabikho kobukhona kwenethiwekhi ekhemisi), kufanele kukhanseliwe.

IMetformin yiyona kuphela engummeleli eqenjini elikhulu le-Biguanide, kepha yinkampani yezemithi eyivila kakhulu nebonayo iDemo kuphela engakhiqizi izidakamizwa ezijwayelekile ezenziwe nge-metformin. Kunezinhlobo ezingaphezu kweshumi le-analogues ze-Glucofage, odokotela abaningi kanye nabanesifo sikashukela basebenzisa:

• I-Argentine Bagomet;
• IGerman Siofor neMetfogamm;
• I-Russian Formethine, iGlatini, iNovoformin, iMetformin-Richter;
• I-Serform Metformin;
• I-Israeli Metformin Teva.

Ama-analogues ashibhile kakhulu weGlucofage yabakhiqizi baseChina nabaseNdiya, kodwa ikhwalithi yabo ilungile. Isakhi esiyisisekelo esiyisisekelo, ngesisekelo lapho kukhethwe khona ama-analogues (metformin hydrochloride), asetshenziswa futhi emithini ehlanganisiwe, isibonelo, i-Glibomet, i-Gluconorm, iGalvus Met, i-Yanumet, i-Amaril M. Uma kufanele uvotele umuthi wakho nempilo yakho nge-ruble yakho, gxila kwi-Glucofage yasekuqaleni futhi Isilinganiso seGenerations, kepha igama lokugcina ekukhetheni isidakamizwa kufanele ngaso sonke isikhathi libe nodokotela oholayo.

I-Glucophage yokunciphisa umzimba

IGlucophage ichazwa yi-endocrinologist, ngoba yandisa ukuzwela kwama-cell receptors ku-insulin. Kulokhu, i-hormone iguqula i-glucose ngokuqinile ibe izicubu zezidingo zamandla omzimba, futhi ingazifaki kudepho, ziyiguqula ibe ngamafutha. Amathebulethi avimba ukumuncwa kwe-glucose eyeqile emathunjini, enza ushukela wokuzila usujwayelekile. Uma ushukela wokuzila ukudla kanye ne-glycated hemoglobin kuyinto evamile, futhi kune-insulin ethe xaxa emzimbeni, lokhu kusho ukumelana ne-insulin kwehormone.

Kulokhu, iGlucophage inqunyelwe. Akuthinti ngqo isendlalelo samafutha, kepha, esiza ekwenzeni ngokwejwayelekile amazinga we-glycemia kanye ne-insulin, uyaqinisekisa ukuthi i-hormone ayithinti i-hepatocytes. I-diabetes ayigcwele ushukela wegazi, kepha iqoqo le-insulin elikhula ngokushesha, futhi liyasiza ukulawula i-glucophage.

Futhi inezinye izinzuzo eziningi, ngokwesibonelo, ukuvimbela umdlavuza, kepha kulabo abafuna ukunciphisa isisindo nge-Glucofage, kubalulekile ukukhumbula: umuthi awudalelwanga ukunciphisa umzimba, yize ukukhuluphala ngokweqile kungahamba uma inkinga yakho, evusa ukukhuluphala, ukumelana ne-insulin, isifo se-metabolic, ushukela Uhlobo 2 sikashukela. Uma imbangela yesisindo ngokweqile ifa, udinga ukuphumelela ukuhlolwa kofuzo, uma inkinga iku-gland yegland noma ama-hormone e-adrenal cortex, khona-ke iGlucophage nayo ayisiye umsizi.

Ukubuyekezwa kwe-Glucophage

Mayelana nokubuyekezwa kwe-Glucofage yokunciphisa umzimba kanye nesifo sikashukela kuyaphikisana. Labo ababala ezibhebheni bodwa ngomzamo omncane wokuxazulula zonke izinkinga zabo bakhala ngokungasebenzi kahle kwe-metformin. Ngendlela ebucayi, lapho umuthi uthathwa ngaphansi kokuqashwa ngudokotela, ngokuya ngokudla okuphansi kwe-carb kanye nokuzivocavoca komzimba, imiphumela mihle.

I-Glucophage iyindinganiso yegolide, ebaluleke kakhulu kuzo zonke izigaba zokulawula isifo sikashukela sohlobo 2. Ngaphezu kwalokho, nge-30% yehlisa inani lokushona okuphelele, ukufa kusuka ezinkingeni zesifo sikashukela, ukuvimbela umdlavuza kanye ne-pathologies yenhliziyo. I-Metformin inciphisa isifiso sokudla, ikhipha umphumela wokunciphisa okuqukethwe kwekhalori kokudla - indlela ethembekile yokwelula impilo yabo bobabili abanesifo sikashukela nabantu abanempilo.