Emhlabebeni wanamuhla, ukukhuluphala kanye nokukhuluphala ngokweqile yizinkinga ezinkulu impela.
Ngokwemibiko yezinhlangano ezahlukahlukene zezokwelapha, yisona sici sokukhuluphala ngokweqile okungenye yezinto ezithinta kabi impilo yabantu.
Ngenxa yalokhu, izifo zenhliziyo nemithambo yegazi iba khona, kufaka phakathi umfutho wegazi ophakeme, isifo sikashukela. Impilo yomuntu okhuluphele iya ngokuya iba nzima, futhi namandla akhe okusebenza ancishiswa kakhulu.
Kulokhu, kudalwe izidakamizwa ezisiza ukunciphisa isisindo somzimba. Enye yezidakamizwa ezijwayelekile kangaka i-Orsoten, imibiko kanye nemiphumela emibi okuzoxoxwa ngayo kule ndatshana.
Isimiso sokusebenza
Zonke izidakamizwa, ukuthathwa kwazo okuholela ekunciphiseni kwesisindo somzimba, zingahlukaniswa ngamaqembu amabili. Iqembu lokuqala - lawa ma-ejenti wokusebenza kwe-metabolic. Iqembu lesibili izidakamizwa ezingavumeli umzimba womuntu ukucubungula amafutha aphuma ekudleni. I-Orsoten ingeyeqembu lesibili lezidakamizwa.
Umuthi u-Orsoten
Into esebenzayo ye-Orsoten yi-Orlistat - into eyinkimbinkimbi yamakhemikhali, isici esiyingqayizivele sokwehlukanisa okuwukuthambekela kwawo kokuthinta ama-enzyme athile akhiqizwa ngumzimba womuntu.
Lapho esesiswini, u-Orsoten ukhipha into esebenzayo, ehlangana nama-lipases, adingekayo ekuqhekekeni kwamafutha ngesikhathi sokugaya. Ama-lipases we-Bound awakwazi ukuthinta ukudla, ngenxa yalokho amafutha angadonswa odongeni lwesisu futhi angangeni egazini. Ngemuva kwalokho, amafutha, kanye nento esebenzayo yesidakamizwa, asuswa emzimbeni ngesikhathi sokuwohloka.
Isenzo somuthi sikuvumela ukuthi udale ukuntuleka kwamafutha emzimbeni.
Ngenxa yokuthi isisu namathumbu omuntu awakwazi ukudonsa amafutha, umzimba uqala ukusebenzisa "izinqolobane" zawo, uqhekeza imali ebekiwe engaphansi. Ngakho-ke, kukhona ukwehla okudingekile kwenombolo yabo kanye nokwehla kwesisindo somzimba komuntu othatha i-Orsoten.
Kulokhu, isenzo sezinto ezisebenzayo sinesikhathi eside. Iqiniso ngukuthi i-Orlistat yephulwe kabi ngaphansi kwesenzo sejusi yesisu, ngenxa yalokho le nto empeleni ingangeni egazini, isasele emgodini wokugaya ukudla futhi iyaqhubeka nokubopha ama-enzyme aqhekeza amanoni. Ukususelwa endaweni lapho isidakamizwa kunciphisa khona ukungqubuzana kwe-Orsoten - ayidlulisi "okokuhlunga" komzimba - isibindi nezinso futhi ayithambekele emiphumeleni emibi enama-receptors ahlukahlukene omzimba womuntu.
Ngisho namahora ayisishiyagalombili emva kokuphathwa, ukulandela umuthi akutholakali egazini. Umuthi wenzelwa kuphela ezindongeni zamathumbu, wakheka inani elincane lezinhlanganisela ezingasebenzi ezinomphumela ophansi kakhulu ezinqubweni ezenzeka ngesikhathi sokumba. Ngokuhambisana nalokhu, amandla we-Orlistat wokungena kumaseli abomvu egazi, nokho, ngamanani amancane kakhulu, atholakala.
Izinkomba zokusebenzisa kanye nemigomo yokuphatha
Izinkomba eziphambili zenhloso yalesi sidakamizwa ukwenzeka kokukhuluphala, noma ukukhuluphala ngokweqile, okuhambisana nokuqinisa ezinye izifo.
Ngokukhula kwesisindo somzimba okungabeki usongo kwangempela esigulini, i-Orsoten imvamisa ayinqunyelwe.
Kuyamukeleka futhi ukunquma lo muthi ezigulini ezinesifo sikashukela sohlobo 2, esihambisana nokwanda kwesisindo nokukhuluphala. Kulokhu, umuthi uboniswa uhlangana nama-glucose-lowering agents. Ukwelashwa kwezidakamizwa kokukhuluphala kuma-diabetesics kwenziwa kanye nokudla okukhethekile kanye nokuzivocavoca okulinganiselayo.
Umuthi uphuzwa ngomlomo. Izibhebhe ziyagezwa ngamanzi amaningi. Ukwemukelwa okwenziwa ngaphambi kokudla, ngesikhathi sokudla nangemva kokudla. Isibalo semithamo yansuku zonke sincike kangaki ngosuku isiguli esidla ngalo. Uma ngesizathu esithile isidlo seqa, khona-ke ukuthatha i-Orsoten nakho akudingekile.
Umthamo owodwa yikhompiyutha eyodwa (120 mg) yesidakamizwa i-Orsoten, noma amaphilisi amabili (60 mg) wesidakamizwa i-Orsoten Slim.
Ukunyusa umthamo akwenziwa - ukwanda kwento esebenzayo engena emzimbeni ngamadosi angaphezu kwama-120 mg akuwuthuthukisi umphumela wokwelapha.
Ukulimala kwesibindi nezinso, kanye nesiguli esikhulile, akusona isizathu sokulungiswa komthamo ohlangothini lokuncishiswa.
Ukwelapha kungahlala isikhathi eside impela. Ukwenza izifundo zokuphuza umuthi izinyanga ezingama-24. Ukungezelela ubude besikhathi sokwelashwa akunconywa. Inkambo encane yokwamukelwa izinyanga ezintathu.
Contraindication
Yize kunomthelela omnene emzimbeni, kukhona imibiko ebonakalisa u-Orsoten, ukuba khona kwakhe okuyisizathu sokwenqaba ukuthatha lo muthi.
I-contraindication evame kakhulu i-glucose-galactose malabsorption.
Lesi simo somzimba siyinzalo eyindlalifa, okuholela ekungeneni kanzima kwezakhi zomzimba emgodini wokugaya ukudla. Lokhu kungenxa yokungakwazi kohlobo lokuhamba oluphethwe yile ndlela yokuhambisa ama-monosaccharides odongeni lwamathumbu. Ukusetshenziswa kwe-Orsoten kungayandisa inkinga futhi kuholele emiphumeleni emibi empilweni yeziguli.
I-Contraindication nayo i-cholestasis - ukunqamuka kokugeleza kwe-bile emgodini wokugaya ukudla ngenxa yokuncipha kokukhiqizwa kwawo. Noma ngabe yiziphi izimbangela ze-cholestasis, ukuthatha umuthi ngokumelene nesizinda salesi sifo kuvinjelwe ngokuphelele - lokhu kungaholela ekushoneni okukhulu kwamavithamini.
Awungeke futhi usebenzise i-Orsoten ngesikhathi sokukhulelwa - lokhu kungathinta kabi i-fetus.
Kuyenqatshelwa ukusebenzisa le khambi ngesikhathi sokukhulelwa. Lokhu kwenqatshelwa akuhlobene nokuthi kungenzeka ukuthi izinto ezisebenzayo zithuthwe ngobisi - lesi simo asikhishwa.
Ukusetshenziswa kwesidakamizwa kungathinta okuqukethwe okunamafutha obisi, ngenxa yalokho ingane engeke ithole izakhamzimba ngenani elidingekayo.
Akunconyelwe ukusebenzisa umuthi kubantu abangaphansi kweminyaka engu-18. Lokhu kungenxa yokushoda kocwaningo ngemiphumela yomuthi ezinganeni. Ekugcineni, i-contraindication yokugcina yi-hypersensitivity ezingxenyeni zalesi sidakamizwa - ukusabela komzimba, ukuphazamiseka, njll.
Imiphumela emibi
Imiphumela emibi ephambili ebonakalisa i-Orsoten ihlotshaniswa nomphumela wayo epheshaneni lesisu. Ukuvela kwazo akuvamile futhi kudlula ngesikhathi esidingekayo ukuze kususwe umuthi emzimbeni. Imiphumela emibi eyenzeka njalo ebonakala i-Orsoten ngokudla okungafanele, okuhambisana nokuthatha umuthi.
Ngokuvamile, ukwamukelwa kwezimbangela ze-Orsoten:
- ukunyuka kwamathumbu;
- ukuthopha;
- ukukhipha amafutha
- ukungahambi kahle kwefecal.
Ukubonakaliswa okulinganiselayo kwemiphumela emibi ngokuvamile akudingi ukulungiswa komthamo noma ukunqanyulwa kwenkambo.
Ukuze unciphise ukubonakaliswa okungathandeki kwesenzo se-Orsoten, kusetshenziswa ukudla okhethekile. Ngokudla kwe-hypocaloric, lapho isilinganiso samafutha sifinyelela kungabi ngaphezu kwama-30% senani lama-kilojoule aqediwe, imiphumela emibi iyaphela ezinsukwini ezimbalwa.
Esikhathini sokuqala isifundo, ezinye iziguli zingathola nemiphumela emibi yesidakamizwa ohlelweni lwezinzwa. Kwezinye izimo, kubhekwa ikhanda, isiyezi, kanye nenausea. Akuvamile ukuthi kube nokuphazamiseka kokulala, amaphupho aphazamisayo, ukukhathazeka.
Uma ubukhulu bomphumela waseceleni bunganciphi kungakapheli amasonto amane, noma udlulela kwifomu elibi, eliphazamisayo kakhulu, umuthi uyamiswa.
Ngokuvamile, imiphumela emibi, noma ngabe isenzekile, ibonakala ngenkambo emnene engazihluphi kakhulu iziguli.
Izibalo eziqoqwe eminyakeni edlule yokuthatha lesi sidakamizwa zikhuluma ngokubekezelela okuhle komuthi ngezigaba ezahlukahlukene zeziguli. Ngokwemibiko, ngaphansi kwe-9% yeziguli ezazinqunywe i-Orsoten bayeka ukuyithatha ngenxa yokuthuthuka kwemiphumela emibi.
Ukuhlanganiswa nezinye izinto
I-Orsoten isetshenziswa kaningi ngokuhlangana nezidakamizwa ezinciphisa ushukela - ukuthuthukisa imetabolism kusuka ekusetshenzisweni kwayo kunciphisa ukugcwala koshukela egazini.
Lokhu kuholela kwesidingo sokudla umthamo ophansi wama-hypoglycemic agents.
Akunconywa ukuthatha i-Orsoten ngama-multivitamini. Phakathi kokudla kwabo kufanele kudlule okungenani amahora amabili.
Isebenzisana ngokugcwele no-Orsoten noPravastanin. Njengomphumela, ukuqoqwa kwalesi sidakamizwa ku-plasma yegazi kungakhuphuka ngo-30%, okumele kubhekwe lapho kuthathwa izidakamizwa ndawonye.
Ukuqoqwa kwe-cyclosporine ngenxa yokuthatha i-Orsoten, kunalokho, kuyancipha. Umphumela ofanayo ubonwa ngokuhlanganiswa kwe-Orsoten ne-Amiodarone.
Umbuzo obalulekile ukuthi ngabe i-Orsoten notshwala ziyahambelana yini. Imiphumela emibi nemiphumela eyandayo yotshwala i-Orsotenom ayibhekwa.
Ngaphandle kwalokhu, i-Orsoten kanye nokuhambelana notshwala akunangqinamba: ukuthatha lesi sidakamizwa ngokuhambisana nesizinda sokuphuza utshwala kunganciphisa ukusebenza kahle kokwelashwa kucishe kube yi-zero.
Ngakho-ke, ngesikhathi sokwelashwa kunconywa ukuthi uphuze utshwala ngokulinganisela, futhi akukho simo - hhayi ngasikhathi sinye sokuphuza amaphilisi. Kungaba okulungile kakhulu ukwenqaba ngokuphelele lezo ziphuzo phakathi nokuthatha i-Orsoten.
Amavidiyo ahlobene
Ukubuyekezwa kokuncipha kwesisindo mayelana nomuthi i-Orsoten:
Ngokuvamile, i-Orsoten iyithuluzi elisebenzayo lokukhuluphala, elisetshenziswa ngokuhambisana nokudla nokuzivocavoca okhethekile. Izici zalo muthi zenza kube nokwenzeka ukuqhuba kabanzi ukuphathwa kwawo kushukela i-mellitus - lokhu kuthuthukisa isimo seziguli futhi kunciphise isidingo semithi ye-insulin.
