I-Glucophage ene-ovic polycystic iyingxenye yokwelapha okuyinkimbinkimbi kwalesi sifo, okuhloswe ngaso ukuqeda ukwakheka kwe-cystic, ibuye iqale umsebenzi we-ovulatory wezitho zomzimba kanye nekhono lowesifazane lokuzala.
Umuthi ubekelwe abesilisa nabesifazane abalungile, abanesifo sikashukela futhi abakwazi ukukhulelwa.
Iqiniso ngukuthi kuvame ukuntuleka kwe-insulin kanye ne-hyperglycemia okuholela ekwakhiweni kwama-cysts amaningi kuma-ovari. I-Glucophage 500 ku-gynecology isiza ukuguquguqula izinqubo zokuvuthwa kwamaqanda futhi iqale kabusha ukuya esikhathini. Ukuthola imiphumela emihle yokwelashwa, odokotela banquma lesi sidakamizwa kwabesifazane kusukela ngosuku lwe-16 kuye kosuku lwama-26 lomjikelezo.
Yini i-Glucophage?
IGlucophage iyi-monopreparation eyi-antidiabetes, isakhi esiyinhloko sayo i-metformin biguanide. Yehlisa inani le-glucose ku-plasma yegazi ngaphambi nangemva kokudla, ngaphandle kokuthinta ukukhiqizwa kwe-insulin ngamanyikwe.
Ukulungiselela i-Glucophage
Umuthi osebenzayo usebenza ngezindlela ezilandelayo:
- kuvimbela ukwephulwa kwe-glycogen esibindini, okunciphisa izinga likashukela egazini;
- kwandisa ukuzwela kwe-insulin, okufaka isandla ekuthatheni kangcono ushukela osuka kwiziqongo;
- imisa ukufakwa kwama-carbohydrate alula ethambekeni lamathumbu.
Ngaphezu kwalokho, i-Glucophage ivuselela ukwakheka kwe-glycogen kusuka ku-glucose futhi inomphumela omuhle ekusebenzeni kwe-lipid compounds.
Izinkomba zokusetshenziswa kwomuthi:
- thayipha isifo sikashukela esi-2 kubantu abadala (ikakhulukazi esihambisana nokukhuluphala) nesihlobo noma ukungasebenzi kahle kokulashwa kokudla;
- i-hyperglycemia, okuyindlela ebeka engcupheni ushukela;
- ukubekezelela i-glucose engalungile.
Izici zokusetshenziswa kwalesi sidakamizwa se-polycostic ovary syndrome
I-Polycystic ovary syndrome noma i-PCOS yisifo esivame kakhulu emkhakheni wokuzala wabesifazane abaneminyaka engu-16 kuye kwengama-45.
I-Pathology isho inani lezinkinga ze-endocrine, ezisuselwa ku-hyperandrogenism yemvelaphi ye-ovarian kanye nomjikelezo we-anovulatory. Lezi ziphazamiso zibangela ukwahlukahlukana okunotha kokuya esikhathini, i-hirsutism futhi imbangela eyinhloko yokungazali kwesibili.
I-Polycystic Ovary Syndrome
Ososayensi bakwazile ukuqaphela iphethini yokuthi abesifazane abaphethwe yi-PCOS bakhuluphele emaphesheni angama-70% emitholampilo futhi cishe oyedwa kwabane kubo utholakala ukuthi ubekezelelekile ukubekezelela ushukela noma isifo sikashukela i-mellitus.
Lokhu kwaholela odokotela emcabangweni olandelayo. I-Hyperandrogenism ne-hyperglycemia kuyizinqubo ezimbili ezihlangene. Ngakho-ke, ukuqokwa kwe-Glucofage ku-PCOS, ukunciphisa ukumelana ne-insulin, kwenza sikwazi ukwengeza umjikelezo wanyanga zonke, ukuqeda ama-androgens ngokweqile, futhi kuvuse ama-ovulation, okungahle kube nomphumela wokukhulelwa.Ngokusho kocwaningo oluningi kule ndawo, kutholakele:
- ngemuva kwezinyanga eziyisithupha zokuthatha umuthi kwabesifazane, izinga lokusebenzisa ushukela egazini likhuphuka kakhulu;
- ngemuva kwezinyanga eziyisithupha zokwelashwa, kungenzeka ukuthi kusungulwe umjikelezo wokuya esikhathini njalo nge-ovulation cishe ezingamaphesenti angama-70 eziguli;
- Owesifazane oyedwa kwabayisishiyagalombili one-PCOS ukhulelwa ekupheleni kwenkambo yokuqala yokwelashwa okunjalo.
Contraindication
Ngeshwa, akuzona zonke iziguli ezingathatha i-Glucophage nge-ovary polycystic, ngoba umuthi unezindlela eziningi zokuphikisana okufanele zisetshenziswe, kufaka phakathi:
- i-ketoacidosis ecasulwe yisifo sikashukela i-mellitus;
- izinkinga ezinzima zesifo sikashukela;
- ukwehluleka kwezinso kanye nesibindi;
- ubuthi obunobungozi obukhulu kanye notshwala;
- ukungabekezelelani komuntu ngamunye ezingxenyeni zomuthi;
- izimo ezi-pathological eziyingozi ezenzeka ziphikisana nesizinda sokungasebenzi kahle kwezinso (i-chic, ukuphuma komzimba);
- Izifo ezidala izicubu ezinkulu ze-hypoxia, okuwukuthi: ukwehluleka ukuphefumula, ukumanzana okukhanyayo kwe-myocardial, ukushaqeka kwengozi.
Ukuphendula okungafani nomuthi
Uma ukholelwa ukuthi ukubuyekezwa mayelana nokwelashwa nge-Gluconage PCOS, lapho esezigabeni zokuqala zokuthatha umuthi, kungadala ukusabela okuningi okungadingi ukuthi kukhishwe futhi kudlule okwabo izinsuku eziningana.
Phakathi kwemiphumela engathandeki yokwelashwa, iziguli zihlukanisa i-nausea, ukugabha kwe-episodic, ukubukeka kobuhlungu esiswini, isihlalo sokucasuka, ukulahleka kwesifiso sokudla.
Ngenhlanhla, ukusabela okunjalo akwenzeki kaningi futhi akunangozi ekusebenzeni okujwayelekile komzimba. Imiphumela emibi ejwayelekile evela emgudwini wokugaya ukudla, obonakaliswa yi-dyspepsia, izinhlungu ezingxenyeni ezihlukene zesisu, nokuphazamiseka kwephango.
Zonke lezi zimpawu zihamba ngemuva kwezinsuku ezimbalwa kusukela kuqale ukwelashwa. Ungazigwema uma usebenzisa umuthi emithamo eminingana (kunconywe izikhathi ezingama-2-3 ngosuku) ngemuva noma ngesikhathi sokudla. Iziguli ezimbalwa nazo zinokuphazamiseka kohlelo lwezinzwa, okungukuthi ukunambitheka.
I-Glucongage ene-ovic polycystic ingavusa ukubukeka kokuphazamiseka kwe-metabolic ngesimo se-lactic acidosis.
Futhi, ngokusetshenziswa isikhathi eside kwezidakamizwa eqenjini leMetformin, kuyabonakala ukwehla kokufakwa kwe-cyancobalamin (uvithamini B12), okuholela emuva kwalokho ekuthuthukiseni i-megaloblastic anemia.
Kuqabukela kakhulu kubantu besifazane ukutholakala nemiphumela engemihle evela esibindini kanye nasegunjini lokuphefumula, kanye nesikhumba. Ukuphazamiseka ekusebenzeni kohlelo lwe-hepatobiliary kuboniswa yi-latent hepatitis, enyamalala ngemuva kokumisa umuthi. I-Ethethema, ukuqubuka kubomvu nokuqina redness kungavela esikhunjeni, kepha lokhu kuyaqabukela kunokujwayelekile.
Ukuxhumana nezinye izidakamizwa notshwala
I-Glucophage ku-PCOS kufanele isetshenziswe ngokuqapha kanye nezidakamizwa ezinesenzo esandisa amazinga kashukela egazi, njengama-glucocorticosteroids nama-sympathomimetics.
Ungasebenzisi umuthi ngokuhambisana ne-loop diuretics.
Izenzo ezinjalo zikhulisa ubungozi be-lactic acidosis ngenxa yokuncipha kokusebenza kwezinso.
Ngaphambi kokwenza izifundo ze-x-ray ngokulawulwa okuhlanganisa i-iodine equkethe umehluko, kubalulekile ukukhansela i-Glucofage ezinsukwini ezimbili ngaphambi kwenqubo. Ukunganakwa kwalesi sincomo ezimweni eziningi kubangela ukuthuthukiswa kokuhluleka kwezinso.
Ukubuyekezwa
Ezimweni eziningi zemitholampilo mayelana ne-Glucofage ene-polycystic ovary ukubuyekeza kukhona okuhle.Ngokusho kwabo, umuthi ubekezelelwa kahle ngumzimba, hhayi umlutha futhi ngokuqhubeka kwesikhathi ungafinyelela umphumela owufunayo usebenzisa izindlela zokwelapha ezizungezile kuphela.
Umzuzu kuphela, isigamu seziguli esazama umuthi saba nemiphumela emibi ekuqaleni kokwelashwa, kepha zadlula ngokushesha ngaphandle kwesidingo sokukhansela lesi sikhathi sokuthatha umuthi.
Amavidiyo ahlobene
Ukudla kuyiphuzu elibalulekile ekwelashweni okuyinkimbinkimbi kwe-ovary polycystic:
Ukubuyekezwa okuningi okuhle kwe-Glucophage ende ku-PCOS kusikisela ukuthi lesi sidakamizwa siyasebenza ngempela ngokumelene nezilonda ezi-polycystic ovarian kanye ne-hyperandrogenism ehlobene ne-genesis efanayo. Ukusetshenziswa kwesidakamizwa isikhathi eside kuvumela abesifazane ukuthi bangagcini nje kuphela ukususa inkinga yokwenziwa kwe-cyst, kepha futhi ukuthi baphinde baqale umjikelezo ojwayelekile wokuya esikhathini, bavuselele i-ovulation futhi, ngenxa yalokho, bakhulelwa, ngisho nokuxilongwa okufanayo kwesifo sikashukela.
