Imiyalo yokusebenzisa i-Glidiab MV

Ukwelapha isifo sikashukela akuyona nje kuphela ushintsho ekudleni, kodwa nasekusetshenzisweni kwemithi ekhethekile.

Ngesifo sohlobo 2, abantu bavame ukubekwa izidakamizwa ukufeza amazinga ajwayelekile we-glycemia. Omunye wekhambi elinjalo yiGlidiab MV.

Imininingwane ejwayelekile, ukwakheka kanye nendlela yokukhululwa

Umuthi uGlidiab MV ungenye yezinto ezithathwe ku-sulfonylurea (izizukulwane ezi-2), ngakho-ke kuhloswe ukuthi kukhuthaze amaseli we-beta akhiwe kumanyikwe.

Umuthi ukhiqizwa esifundeni saseMosophane yinkampani yezokwelapha u-Akrikhin futhi uthathwa njenge-analogue yamathebulethi e-hypoglycemic Diabeteson MV, akhiqizwa eFrance. Umenzeli unefomu lomthamo oboniswa ngokukhishwa okuguquliwe.

Umuthi uyatholakala ngesimo samaphilisi ane-tint emhlophe. Zifana nokubukeka kwamasilinda wefulethi. Umuthi uyatholakala emaphaketheni amaphilisi angama-30 noma angama-60.

Uma kuqhathaniswa neDiabeteson MV, enomthamo ongu-0,06 g, iGlidiab MV iqukethe uhhafu wengxenye esebenzayo (0.03 g).

Ukwakheka:

• I-Gliclazide yinto esemqoka;
• cellulose (microcrystalline);
• hydroxypropyl methylcellulose;
• i-magnesium stearate;
• I-Aerosil;

Iziguli eziningi zimiselwe i-Glidiab 80, equkethe isakhi esisebenzayo, hhayi i-30 mg, kodwa i-80 mg kwithebhulethi ngayinye.

Isenzo se-Pharmacological

Izakhi zeGlidiab MV zithinta umzimba ngale ndlela elandelayo:

• ukusheshisa ukugcinwa kwe-insulin okukhiqizwa kumanyikwe;
• khulisa ukuzwela kwezicubu kwi-hormone ekhiqizwayo;
• ukunciphisa isikhathi sokuphumula kusukela ngesikhathi sokudla okuphezulu kokukhululwa kwe-insulin;
• ngaphansi kwethonya lalesi sidakamizwa, i-insulin secretion ibuyiselwa esigabeni sokuqala uma kuqhathaniswa namanye ama-sulfonylureas;
• thuthukisa i-microcirculation ngenxa yokuqothuka kwamaseli e-platelet, ukubuyiselwa kokuqina kodonga lwamakhemikhali kanye nengozi ephansi ye-micothrombosis;
• ukunciphisa i-glycemia;
• neqhaza ekuqothulweni kwe-protenuria;
• yehlisa ijubane ukukhula kwe-retinopathy;
• neqhaza ekwehliseni isisindo, ngokuya ngokudla okuphoqelelwe.

I-Pharmacokinetics

Inqubo yokumuncwa, ukusatshalaliswa emzimbeni, umzimba kanye nokukhishwa kwezakhi kwenzeka ngale ndlela elandelayo:

1. Ukuhlelwa. Umuthi ucishe ufakwe ngokuphelele emgudwini wokugaya ukudla (ipheshana lesisu). Ukuhlushwa kwayo kukhuphuka ku-plasma kancane kancane, kufinyelela inani layo kusuka esikhathini sokuphatha ngemuva kwamahora ayi-6 noma ayi-12. Imilambo ayithinti izinga lokufakwa. Umuthi usebenza amahora angama-24.
2. Ukusatshalaliswa. Ukuxhumana namaprotheni e-plasma nezakhi zezidakamizwa kusethelwa kuma-95%.
3. Ukukhohlisa umzimba. Le nqubo yenzeka esibindini, ebonakala ngokwakhiwa kwama-metabolites angahambisani nalokhu.
4. Ukuzala. I-Excretion yenzeka ngezinso ngendlela yama-metabolites, yi-1% kuphela yezidakamizwa ephuma nomchamo. Ukuqedwa kwesigamu sempilo yesidakamizwa kwenzeka emahoreni ayi-16.

Izinqubo ze-pharmacokinetic zomuthi ezigulini esezikhulile azishintshi.

Izinkomba kanye ne-contraindication

Amathebulethi eGlidiab MV yizidakamizwa ze-hypoglycemic, ngakho-ke, asetshenziswa ekwelapheni isifo sikashukela sohlobo 2, lapho ezinye izindlela zokunciphisa ushukela zingazange zisibuyisele inkomba emuva kokujwayelekile.

Ukuxhumana kokuphuza umuthi yilezi:

• ketoacidosis;
• umsebenzi wokuphazamiseka kwezinso;
• Uhlobo 1 sikashukela;
• i-coma (isifo sikashukela noma i-hyperosmolar);
• imisebenzi;
• ukulimala
• ukuvinjwa kwamathumbu;
• ukukhulelwa
• izimo ezibangela i-hypoglycemia (ngokwesibonelo, izifo zesifo esithathelwanayo);
• i-leukopenia;
• ukusha okukhulu;
• hypersensitivity kuzinto ekwakhiweni komkhiqizo;
• ukuncelisa.

Imiyalo yokusebenzisa nemiyalo ekhethekile

Umthamo wesidakamizwa uncike ezicini zenkambo yesifo sikashukela nokubonakala kwayo, ngakho-ke kukhethwa udokotela uqobo esigulini ngasinye.

Ekuqaleni kokuthatha umuthi, kunconywa umthamo we-30 mg noma wethebhulethi eyi-1. Ngokuya ngesimo sesiguli ngesikhathi sokwelashwa, inani lezinto ezisebenzayo ngosuku lingakhuphuka lifinyelele ku-120 mg (umthamo omkhulu).

Iithebhulethi zithathwa ngomlomo ngesikhathi sasekuseni (kanye ngosuku). Ukulimazeka okuncane kwezinso (nge-creatinine kusuka ku-15 kuye ku-80 ml / min) akudingi ukulungiswa kwamthamo.

Ekuqaleni kokwelashwa kwezidakamizwa futhi kuze kube kukhethwe umthamo ofanele, iziguli ezivame ukubhekana ne-hypoglycemia akufanele zenze umsebenzi odinga ukuphendula okusheshayo noma ukunakwa okwandayo.

Abesifazane abakwazi ukusebenzisa umuthi ngesikhathi sokuzala ingane, kanye nokuncelisa ibele.

Izinga elikhulu lomonakalo ezinso noma esibindini livimbela ukusetshenziswa komuthi ngisho nakumithamo emincane.

Imithetho Yezicelo:

1. Isidingo sokufeza umphumela wohlelo lokusebenza ukulandela indlela yokudla nokuvivinya umzimba ngokulinganisela. Ekudleni kwansuku zonke, ama-carbohydrate kufanele abekhona ngesilinganiso esincane.
2. Kubalulekile ukuthi i-glycemia ibhekwe ngaphambi nangemva kokudla, ukuze umthamo uguqulwe ngokususelwa emiphumeleni yokulinganisa.
3. Ngokuhlinzwa noma isifo sikashukela esibolile, umuthi kufanele ushintshwe nemijovo ye-insulin.
4. Ukuze ugweme ukuvela kwe-hypoglycemia, kanye nokusabela okufana ne-disulfiram, ungabuphuzi utshwala.
5. Kwenqatshelwe ukweqa ukudla, unganaki ukudla okudla okulula ngesikhathi sokuqalisa kwendlala.
6. Ngaphambi kokusebenza kanzima komzimba, umthamo kufanele wehliswe.

Izidakamizwa ezithinta kakhulu izidakamizwa ze-hypoglycemic yilezi:

• abantu asebekhulile;
• iziguli ezingakwazi ukudla ngokulingana;
• abantu abanomzimba obuthakathaka;
• iziguli ezinesifo esinjenge-pituitary-adrenal insufficiency.

Imiphumela emibi kanye ne-overdose

Ukuthatha amaphilisi kungadala ukusabela okulandelayo kumuntu:

• maqondana nohlelo lwe-endocrine - i-hypoglycemia enezimo zokuzwa kobuhlungu bekhanda, ukujuluka, ubuthakathaka, ukudangala, ukwehla, ukuthuthumela, ukulahleka kwengqondo, ukubona okungalungile nokuxhumana kokunyakaza;
• kusuka ohlangothini lokugaya - i-dyspepsia, i-anorexia, ukuphazamiseka kwesibindi;
• i-leukopenia, i-thrombocytopenia, i-anemia;
• ukubonakaliswa kwe-allergic (ukulunywa, i-rash, noma i-urticaria).

Nge-overdose yesidakamizwa, i-hypoglycemia iyenzeka. Ukuqeda izimpawu zayo, kwanele ukusebenzisa ama-carbohydrate amaningana, inqobo nje uma umuntu eyazi. Ezimweni lapho isiguli singasakwazi ukudla ngokwaso, kufanele sinikezwe isixazululo se-glucose se-intravenous (40%) kanye nomujovo we-glucagon we-intramuscular. Ngemuva kokubuyisa ukwazi komuntu onesifo sikashukela, udinga enye i-snack ukugwema ukwehla okuphindaphindayo kwe-glucose.

Ukuxhumana neminye imithi kanye nama-analogues

Ukusetshenziswa kwezinye izidakamizwa ngokuhlangana noGlidiab MV kungakhulisa noma kwehlise umphumela we-hypoglycemic.

Ukwelapha okuhlanganisiwe nezidakamizwa ezifana:

• Ama-inhibitors e-ACE;
• ama-antifungal agents (fluconazole);
• Ama-NSAIDs;
• ama-antihistamines;
• Izicucu;
• izidakamizwa ezilwa nesifo sofuba;
• Ama-salicylates;
• I-Pentoxifylline;
• I-Ethanol;
• izidakamizwa ezivimba ukuvikeleka kweshubhu.

Umphumela we-hypoglycemic uyacindezelwa uma uhlanganiswa nezidakamizwa ezilandelayo:

• ama-barbiturates;
• i-thiazide diuretics;
• Furosemide;
• ama-hormone wokugcina umsebenzi we-thyroid;
• amalungiselelo e-lithium;
• ama-estrogens;
• izindlela zokuvimbela inzalo ngomlomo.

Phakathi kwezidakamizwa ezinomphumela ofanayo namaphilisi weGlidiab MV, okulandelayo kuvame ukunqunyelwa:

• I-Meglimide;
• I-Altar
• I-Glibetic;
• Udosi;
• I-Glimepiride;
• I-Eglim;
• IGlairie
• I-Glibenclamide;
• I-Glurenorm.