ILantus ingesinye sezimpawu zokuqala ezingenasisekelo ze-insulin yomuntu. Kutholakala ngokufaka esikhundleni se-amino acid i-asparagine nge-glycine endaweni yama-21 ye-A chain futhi kufakwa ama-acid amabili we-arginine amino acid ku-B chain endaweni ye-amino acid ebulalayo. Lesi sidakamizwa senziwa yinhlangano enkulu yemithi yaseFrance - iSanofi-Aventis. Ekuqhubekeni kwezifundo eziningi, kwafakazelwa ukuthi i-insulin Lantus ayigcini nje ngokunciphisa ubungozi be-hypoglycemia ngokuqhathaniswa nezidakamizwa ze-NPH, kodwa futhi ithuthukisa umzimba we-carbohydrate metabolism. Ngezansi kunemiyalo emfushane yokusetshenziswa nokubuyekezwa kwabanesifo sikashukela.
Okuqukethwe yi-athikili
- 1 Isenzo sezeMithi
- 2 Ukwakheka
- 3 amafomu wokukhishwa
- Izinkomba ezi-4
- 5 Ukuxhumana nezinye izidakamizwa
- 6 Contraindication
- 7 Ukushintshela kuLantus kusuka kwamanye ama-insulin
- 8 Izinhlamvu
- I-Insulin Lantus ngesikhathi sokukhulelwa
- 10 Ungagcina kanjani
- 11 Lapho ukuthenga, intengo
- Ukubuyekezwa
Isenzo se-Pharmacological
Into esebenzayo yeLantus yi-insulin glargine. Sitholakala ngokuhlanganiswa kabusha kofuzo kusetshenziswa uhlobo lwe-k-12 le bacterium Escherichia coli. Esimweni esingathathi hlangothi, i-soluble kancane, endaweni eyi-acid iyancibilika ngokwakhiwa kwe-microprecipitate, ekhipha i-insulin kancane futhi kancane kancane. Ngenxa yalokhu, iLantus inephrofayili yesenzo eshelelayo ehlala amahora angama-24.
Izici main wemithi:
- I-adsorption ehamba kancane nephrofayili yesenzo esingenathemba kungakapheli amahora angama-24.
- Ukucindezelwa kwe-proteinolysis ne-lipolysis kuma-adipocytes.
- Ingxenye esebenzayo ibopha kuma-insulin receptors izikhathi ezi-5-8 ngokuqina.
- Ukulawulwa kwe-glucose metabolism, ukuvimbela ukwakheka kwe-glucose esibindini.
Ukwakheka
Ku-1 ml weLantus Solostar uqukethe:
- I-3.6378 mg ye-insulin glargine (isuselwa ku-100 IU ye-insulin yabantu);
- 85% glycerol;
- amanzi wokujova;
- i-hydrochloric enzelwe i-asidi;
- m-cresol ne-sodium hydroxide.
Khipha ifomu
I-Lantus - isisombululo esicacile somjovo we-sc, siyatholakala ngohlobo lwe:
- ama-cartridge wesistimu ye-OptiClick (ama-5pcs ngephakethe ngalinye);
- 5 isirinji amapeni uLantus Solostar;
- Ipeni lesirinji le-OptiSet kwiphakethe elilodwa ama-5 ama-pcs. (amagxathu 2 amayunithi);
- I-10 ml vials (amayunithi ayi-1000 ngebhodlela ngalinye).
Izinkomba zokusetshenziswa
- Abantu abadala nezingane kusuka eminyakeni eyi-2 abanesifo sikashukela sohlobo 1.
- Thayipha isifo sikashukela sohlobo 2 (esimweni sokungasebenzi kahle kwamalungiselelo wethebhulethi).
Ngokukhuluphala, ukwelashwa okuxubayo kuyasebenza - uLantus Solostar noMetformin.
Ukuxhumana nezinye izidakamizwa
Kukhona izidakamizwa ezithinta i-carbohydrate metabolism, ngenkathi zanda noma zinciphisa isidingo se-insulin.
Yehlisa ushukela: ama-antidiabetic womlomo, ama-sulfonamides, ama-inhibitors e-ACE, ama-salicylates, ama-angioprotectors, ama-inhibitors ama-monoamine oxidase, ama-dysopyramides e-antiarrhythmic, ama-narcotic analgesics.
Khuphula ushukela: ama-hormone e-thyroid, ama-diuretics, ama-sympathomimetics, ama-contracepitas omlomo, ama-phenothiazine, ama-proteinase inhibitors.
Ezinye izinto zinomphumela we-hypoglycemic nomphumela we-hyperglycemic. Lokhu kufaka phakathi:
- ama-beta blockers nosawoti we-lithium;
- utshwala
- i-clonidine (izidakamizwa ze-antihypertensive).
Contraindication
- Kwenqatshelwe ukusebenzisa ezigulini ezingakubekezeleli ukufaka i-insulin glargine noma izingxenye zosizo.
- I-Hypoglycemia
- Ukwelashwa kwe-ketoacidosis yesifo sikashukela.
- Izingane ezingaphansi kweminyaka engu-2 ubudala.
Imiphumela yokusabela engemihle engajwayelekile yenzeke, imiyalo ithi kungahle kube:
- I-lipoatrophy noma i-lipohypertrophy;
- ukungezwani komzimba (i-edema kaQuincke, ukwethuka komzimba, i-bronchospasm);
- Ubuhlungu bemisipha nokulibaziseka emzimbeni wama-ion sodium;
- dysgeusia kanye nokukhubazeka okubukwayo.
Ukushintshela kuLantus kusuka kwamanye ama-insulin
Uma umuntu onesifo sikashukela esebenzisa insulini ephakathi nendawo, lapho-ke eshintshela eLantus, umthamo nemodi yomuthi iyashintshwa. Ukushintshwa kwe-insulin kufanele kwenziwe esibhedlela kuphela.
Uma ama-NPH insulins (i-Protafan NM, Humulin, njll) aphathwe amahlandla ama-2 ngosuku, khona-ke uLantus Solostar uvame ukusetshenziswa isikhathi esingu-1. Ngasikhathi sinye, ukuze sinciphise ubungozi be-hypoglycemia, umthamo wokuqala we-insulin glargine kufanele ube ngaphansi ngo-30% uma uqhathaniswa ne-NPH.
Ngokuzayo, udokotela ubheka ushukela, indlela yokuphila yesiguli, isisindo bese elungisa inani lamayunithi alungiselelwe. Ngemuva kwezinyanga ezintathu, ukusebenza ngempumelelo kwendlela enqunyelwe kungabhekwa ngokuhlaziywa kwe-glycated hemoglobin.
Imiyalo yevidiyo:
Ama-Analog
| Igama lokuhweba | Into esebenzayo | Umkhiqizi |
| Tujeo | insulin glargine | EJalimane, Sanofi Aventis |
| I-Levemir | insulin detemir | IDenmark, uNovo Nordisk A / S |
| Islar | insulin glargine | India, Biocon limited I-PAT "Farmak" |
E-Russia, bonke abantu abanesifo sikashukela esincike e-insulin badluliswa ngenkani besuka eLantus bayiswa eTujeo. Ngokusho kocwaningo, lo muthi omusha unengozi ephansi yokuqhamuka ne-hypoglycemia, kodwa ekusebenzeni iningi labantu bakhala ngokuthi ngemuva kokuguqukela eTujeo ushukela wabo wagxuma kakhulu, ngakho-ke kufanele bazithengele bona ngokwabo iLantus Solostar insulin.
I-Levemir isidakamizwa esihle kakhulu, kepha inento ehlukile esebenzayo, noma ubude besikhathi besikhathi sinamahora angama-24.
U-Aylar akazange ahlangane ne-insulin, imiyalo ithi le yiLantus efanayo, kepha umenzi nayo ushibhile.
I-Insulin Lantus ngesikhathi sokukhulelwa
Izifundo ezingekho emthethweni zokwelashwa kweLantus nabesifazane abakhulelwe azenziwanga. Ngokusho kwemithombo engekho emthethweni, lesi sidakamizwa asithinti kabi inkambo yokukhulelwa kanye nengane uqobo.
Ucwaningo lwenziwa ezilwaneni, phakathi lapho kwafakazelwa ukuthi i-insulin glargine ayinawo umthelela onobuthi ekusebenzeni kokuzala.
Ukukhulelwa kweLantus Solostar kungabekwa uma kwenzeka ukungasebenzi kahle kwe-insulin NPH. Omama besikhathi esizayo kufanele baqaphele ushukela wabo, ngoba ku-trimester yokuqala, isidingo se-insulin singehla, futhi ku-trimester yesibili neyesithathu.
Ungesabi ukuncelisa ingane ibele; imiyalelo ayiqukethe imininingwane uLantus angaludlulisela ebisini lwebele.
Ungayigcina kanjani
Isikhathi sokuphelelwa yisikhathi seLantus yiminyaka emi-3. Udinga ukugcina endaweni emnyama evikelwe ukukhanya kwelanga elangeni lokushisa elingu-2 kuya ku-8 degrees. Imvamisa indawo efaneleke kakhulu yisiqandisi. Kulokhu, qiniseka ukubheka umbuso wezinga lokushisa, ngoba ukunqunyelwa kwe-insulin Lantus kwenqatshelwe!
Kusukela ukusetshenziswa kokuqala, umuthi ungagcinwa inyanga endaweni emnyama endaweni yokushisa engeqi ngama-25 degrees (hhayi esiqandisini). Ungasebenzisi i-insulin ephelelwe yisikhathi.
Lapho ungathenga khona, intengo
ILantus Solostar inqunywa mahhala ngomuthi ngudokotela we-endocrinologist. Kepha kuyenzeka futhi ukuthi umuntu onesifo sikashukela azithengele lesi sidakamizwa yedwa ekhemisi. Intengo ephakathi ye-insulin ingama-ruble angama-3300. E-Ukraine, iLantus ingathengwa ngo-1200 UAH.
Ukubuyekezwa
Isifo sikashukela sithi i-insulin enhle impela, ukuthi ushukela wabo ugcinwa ngaphakathi kwemikhawulo ejwayelekile. Nakhu abantu abakushoyo ngeLantus:
Iningi lishiya izibuyekezo ezinhle kuphela. Abantu abaningana bathi iLevemir noma iTresiba ilungele bona kangcono.
