I-Plevilox iyisidakamizwa se-bactericidal antimicrobial enezinto eziningi ezibanzi ezivela eqenjini le-fluoroquinolones lesizukulwane sesine.
Igama Lezwe elingafanele
I-Moxifloxacin (Moxifloxacin).
I-Plevilox iyisidakamizwa se-bactericidal antimicrobial enezinto eziningi ezibanzi ezivela eqenjini le-fluoroquinolones lesizukulwane sesine.
I-ATX
Ikhodi ye-ATX yiJ01MA14, okusho ukuthi umuthi ungoweqembu lezidakamizwa ze-antibacterial elithathwe ku-quinolone.
Khipha amafomu nokwakheka
Umuthi uyatholakala ngesimo samathebulethi, efakwe kumafilimu. Izibhebhe zigcwele emabhulashini afakwe emabhokisini amakhadibhodi.
Into esebenzayo yePlevilox yi-moxifloxacin hydrochloride ku-400 mg. I-Microcrystalline cellulose, i-croscarmellose sodium, i-lactose monohydrate, i-magnesium stearate, i-copovidone, i-polydextrose, i-polyethylene glycol, i-capste ne-capric acid triglycerides, i-titanium dioxide, i-quinoline varnish ne-iron iron oxide esetshenziswa njengezinto ezisizayo.
Isenzo se-Pharmacological
Umuthi uyakwazi ukuvimbela i-topoisomerase IV ne-DNA gyrase - ama-enzyme abhekele ukuphindaphindwa, ukubhala, ukulungisa nokuphinda wenze i-bacterial DNA. Inomphumela we-bactericidal ngenxa yekhono le-moxifloxacin ukuphazamisa ukwakheka kwe-DNA yamangqamuzana amancane.
Umuthi uyatholakala ngesimo samathebulethi, efakwe kumafilimu.
Isebenza ngokumelene namagciwane amancane wegram-positive ne-gram-negative, kanye nama-bacterium e-anaerobic, amelana ne-acid nezinhlobo ze-atypical, njengeLegionella spp., Chlamydia spp. kanye ne-Mycoplasma spp. Isebenza ngempumelelo emelana namagciwane ahlangabezana nama-beta-lactams nama-macrolide. Isebenza ngokuchasene nobunzima obuningi bama-microorganisms: I-graphyitive Staphylococcus aureus (kufaka phakathi engazwisisi i-methicillin), i-Streptococcus pneumoniae (kufaka phakathi ukumelana nama-penicillin nama-macrolides), ama-Streptococcus pyogene A-amaqembu.
I-Pharmacokinetics
Umuthi ubonakala ngokufakwa okuphezulu, kungakhathalekile isikhathi sokudla, inkomba yawo eyi-bioavailability cishe icishe ibe ngu-90-91%.
Ukulawulwa okukodwa komlomo kwe-moxifloxacin kukuvumela ukuthi uzuze i-Cmax esegazini lika-3.1 mg / l, kungakapheli imizuzu engama-30 - amahora angama-4.
I-Pharmacokinetics iqondile ngomthamo owodwa we-50-1200 mg nokwelashwa kwezinsuku eziyi-10 ngomthamo we-600 mg / ngosuku.
Izindawo zokugcotshwa okuphezulu kakhulu kwezidakamizwa ngamaphaphu, ama-macrophage we-alveolar, ulwelwesi lwama-mucous lwama-sinuses ne-bronchi.
Umuthi ungachazwa njengomkhiqizo ongasebenzi we-metabolic futhi ngesimo sawo sokuqala ngomchamo nezindunduma.
Ubulili nobudala azithinti imingcele ye-pharmacokinetic (ukuhlolwa akukwenziwe ezinganeni), futhi akukuthinti ukungasebenzi kahle kwezinso.
Izinkomba zokusetshenziswa
Umuthi unqunyelwe ekwelashweni kwezifo ezithinta ipheshana lokuphefumula elingaphezulu nelingezansi: i-bacterial sinusitis, i-pneumonia etholwa ngumphakathi kanye nokwanda kwe-bronchitis engapheli. Futhi, umuthi ukhombisa ukusebenza kahle okuphezulu ekwelapheni izifo zesikhumba nezicubu ezithambile.
Contraindication
Kuyenqatshelwa ukusebenzisa ezinganeni nakwentsha engaphansi kweminyaka engu-18 ubudala, okubandakanya, ngesikhathi sokukhulelwa, i-lactation kanye ne-hypersensitivity ku-moxifloxacin nanoma yikuphi okutholwayo ekwakhiweni kwePlevilox.
Ngokunakekela
Ukuqashelwa ikakhulukazi ukuqokwa kwePlevilox kudinga umlando we-syulsive syndrome, ukwehluleka kwesibindi, ukwelula isikhathi sokuphumula kwe-QT, i-bradycardia, i-myocardial ischemia, isifo sohudo kanye ne-pseudomembranous colitis.
Umuthi awuvunyelwe ukusetshenziswa ezinganeni nakwintsha eneminyaka engaphansi kwengu-18.
Ngenxa yolwazi olwanele ngohlelo lokusebenza kanye nezifundo zamacala eziqhubekayo, ukuqaphela kudinga ukunquma umuthi ezigulini ezise-hemodialysis. Ekwelashweni okufanayo ne-glucocorticosteroids nezidakamizwa ezenza ukuthi ijubane lihambise kahle umsipha wenhliziyo (ama-antiarrhythmics, ama-antidepressants ama-antipsychotic), ukugadwa kochwepheshe kuyadingeka.
Ungayithatha kanjani iPlevilox
Thatha ngomlomo isikhathi esisodwa ngosuku umthamo we-400 mg. Isikhathi sokwelashwa kuya ngesifo:
- esigabeni sokwanda kwe-bronchitis engapheli - izinsuku ezi-5;
- nge-pneumonia etholwe ngumphakathi - izinsuku eziyi-10;
- nge-sinusitis esibuhlungu, ukutheleleka kwesikhumba nezicubu ezithambile - izinsuku eziyi-7.
Ngoshukela
Ucwaningo luye lwabonisa ukuthi ukwelashwa kwe-fluoroquinolone kwandisa ingozi yemiphumela emibi kwisifo sikashukela, futhi ikakhulukazi ukuthuthukiswa kwe-dyslexemia. Ukuqokwa kwama-antibiotics kwamanye amakilasi kuyanconywa: i-beta-lactams nama-macrolides.
Kodwa-ke, kwezinye izimo (ngokwesibonelo, ngezinkinga ezithathelanayo ezitholakala endaweni yezinyawo zeziguli ezinesifo sikashukela), ukusetshenziswa kwalesi sidakamizwa kunesizathu. Ekuhlinzeni, i-pathologies enjalo iyimbangela evame kakhulu yokunqunywa okungeyona eyethusayo, lapho kunakwa kakhulu ekwelashweni kwama-antibiotic okwanele (kufaka phakathi izidakamizwa eziqukethe i-moxifloxacin).
Ukwelashwa kwe-Plevilox kwandisa ingozi yemiphumela emibi kushukela.
Imiphumela emibi yePleviloksa
Kusuka ezicutshini zemisipha
Mhlawumbe ukubonakala kobuhlungu emhlane, ukuthuthukiswa kwe-arthralgia kanye ne-myalgia.
Amapheshana wesisu
Imiphumela emibi evela emgudwini wesisu ivezwa ngobuhlungu besisu, isicanucanu, isisu, ukugabha, i-dyspepsia, i-flatulence, ukuqunjelwa, umsebenzi owengeziwe we-hepatic transaminases, ukuhlanekezela kwemizwa yokunambitha.
Izitho zeHematopoietic
Kukhona ithuba lokuthuthukisa i-leukopenia, i-eosinophilia, i-thrombocytosis, i-thrombocytopenia kanye ne-anemia.
Isistimu yezinzwa ephakathi
Imiphumela emibi evela ohlelweni lwezinzwa oluphakathi ibonakaliswa ngendlela yesiyezi, ukuphazamiseka kokulala, uvalo, ukukhathazeka okukhuphukayo, i-asthenia, ikhanda, ukuthuthumela, i-paresthesia, izinhlungu zomlenze, ukuqunjelwa, ukudideka nesimo sokudangala.
Imiphumela emibi yePlevilox evela ohlelweni lwezinzwa oluphakathi ibonakaliswa ngendlela yesiyezi.
Engxenyeni yesikhumba
Ukuqhuma esikhunjeni, ezimweni ezingavamile kakhulu, imfiva ye-nettle kungenzeka.
Kusuka ohlelweni lwezitho zofuzo
Kukhona ubungozi be-candidiasis kanye ne-vaginitis.
Kusuka ohlelweni lwezinhliziyo
Ukwanda okungenzeka kwengcindezi yegazi, ukuvela kwe-tachycardia, i-edema ye-peripheral, i-palpitations nobuhlungu endaweni yesifuba.
Allergies
Ukusabela kwe-allergic ngendlela yokumiswa nokuqunjelwa kwaphawulwa, amacala okuqothuka kwe-anaphylactic ayengandile kakhulu. Ngokufakwa, ukusabela kwendawo kungenzeka kwenzeke: izinhlungu endaweni yomjovo, ukuvuvukala nokuvuvukala.
Umthelela ekhonweni lokulawula izindlela
Lapho uthatha umuthi, ukungaphatheki kahle kanye nokukhubazeka okungajwayelekile kungazwakala, kulezi zimo, ukuphathwa kwezinqubo akunconywa.
Lapho uthatha umuthi, ukungaphatheki kahle kanye nokukhubazeka okungajwayelekile kungazwakala, kulezi zimo, ukuphathwa kwezinqubo akunconywa.
Imiyalo ekhethekile
Sebenzisa ebudaleni
Ngemuva kweminyaka yobudala engama-60, ingozi yokwanda kwe-tendonitis nokuqhuma kwe-tendon iyakhuphuka (i-Achilles tendon, ama-cuffs ajikelezayo wejoyinti lamahlombe, imisipha yezandla, ama-biceps, izithupha, njll.). Lapho kuvela izimpawu zokuqala zokungasebenzi kahle okunjalo, isiguli kufanele siphumule ngokuphelele futhi ezinye izinhlobo zokwelapha zisebenzisa izidakamizwa ezingezona i-quinolone kufanele zixoxwe.
Isabelo sezingane
Ngenxa yokuphepha okungavunyelwe kanye nokusebenza kahle kwalesi sidakamizwa asichaziwe ebuntwaneni, ebusheni nasebusheni (kufinyelela eminyakeni eyi-18). Kufanele kukhunjulwe ukuthi lezi zifundo ziveze ukuxhomekeka ngokuqondile kokuvela kwe-arthropathy ekwelashweni kwezidakamizwa eziqukethe i-moxifloxacin.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukwelashwa kwe-Plevilox kungenzeka kwabesifazane abakhulelwe, uma ukusebenza kwawo kunokwenzeka kungaphezu kwengozi engaba khona ku-fetus, ngoba ucwaningo olwanele nolulawulwa ngokuqinile alukenziwa.
Ngesikhathi sokuqunjelwa, ukuphathwa kwePlevilox kufanele kungafakwa eceleni.
Ngenkathi yokuqunjelwa, i-Plevilox kufanele ingafakwa ngaphandle, ngoba kufakazelwe ukuthi ingangena obisini lwebele kanye nomthelela omubi olandelayo ezinganeni ezisencane.
Isicelo sokusebenza kokulimala kwezinso
Ngokuhluleka kwezinso, sebenzisa ngokuqapha.
Sebenzisa umsebenzi wesibindi okhubazekile
Ukwehluleka kwesibindi namazinga aphakeme wama-transaminase kungukuphikisana kokuphathwa kwe-moxifloxacin ngenxa yesipiliyoni somtholampilo esilinganiselwe.
Ukweqisa kwePlevilox
Akukho mpendulo eqinile eqhubekayo etholakele ngethamo elilodwa lomuthi ngokuxutshwa kwento ngaphakathi kwe-2.8 g.
I-Acute overdose iphathwa ngokugeza isisu nokusebenzisa namalahle ocushiwe. Uma kwenzeka kweqa ngokweqile, kunconywa ukuqapha kwe-ECG, ngoba kungenzeka ukwelulwa kwesikhathi kwe-QT kungenzeka. Udokotela angakunikeza ukwelashwa okubonakalayo.
I-putevidx eyingozi kakhulu ye-Plevilox iphathwa ngokugeza isisu ngokusebenzisa namalahle ocushiwe.
Ukuxhumana nezinye izidakamizwa
Ukusetshenziswa kanyekanye ngama-antacid, amaminerali nama-multivitamini kulimaza ukumuncwa futhi kunciphisa ukugcwala kwento esebenzayo ku-plasma. Ngokulashwa okuhlanganisiwe, kunconywa izikhawu ezilandelayo:
- 2 amahora ngemuva kokuthatha iPleviloksa;
- 4 amahora ngaphambi kokuvunyelwa.
Ukusetshenziswa okuhlanganayo nezinye izidakamizwa zesigaba se-fluoroquinolone kukhuthaza ukuthuthukiswa kokuphendula kwe-Phototoxic.
Ukufakwa kwe-moxifloxacin emithanjeni yegazi kuyancipha ngenkathi kuthathwa i-ranitidine.
Ukuhambisana notshwala
Kuyenqatshelwa ukusebenzisa utshwala ngesikhathi sokwelashwa nge-plevilox ngenxa yokwanda kobunzima bemiphumela emibi (ikakhulukazi evela ohlelweni lwezinzwa oluphakathi). Ngaphezu kwalokho, umsebenzi we-diuretic we-ethanol awuvumeli ukufinyelela ekufakweni okufunwayo kwento esebenzayo egazini, ethinta kabi ukusebenza kahle kwezokwelapha.
Ama-Analog
Izifanekiso zomuthi yilezi:
- I-Avelox;
- I-Aquamox;
- I-Megaflox;
- Moxispenser;
- Moxiflo;
- Moxifloxacin;
- I-Rotomox;
- Simoflox;
- I-Ultramox;
- I-Heinemox.
Imibandela yekhefu lekhemisi
Ngingakwazi ukuthenga ngaphandle kadokotela
Akukho okubhalwe phansi akusatshalwanga.
Intengo
Intengo yokufaka umuthi owenziwe eRussia (amaphilisi ama-5) iqala kuma-ruble angama-500.
Izimo zokugcina zomuthi
Gcina endaweni emnyama, evikelwe umswakama, emazingeni okushisa angeqi ku-25 ° C.
Isikhathi sokuphelelwa yisikhathi
Iminyaka engu-2 ngesitoreji esifanele.
Umkhiqizi
Kumanje kuthengiswa amalungiselelo abakhiqizi baseRussia nabaseNdiya: IFarmasintez OJSC (Irkutsk) nePlethiko Pharmaceuticals Ltd (Indore).
Ukubuyekezwa
USophia, oneminyaka engama-24, uKrasnodar
Ngithathe lo muthi nge-sinusitis eyingozi, wasiza ngokushesha. Ithuluzi okuwukuphela kwalo elaba usizo, ngaphambi kwalokho, neminye umuthi elisebenzayo yasebenzisa amanye ama-antibiotic.
U-Ivan, oneminyaka engama-46, Kazan
Kunemiphumela emibi ekhanyayo kulo muthi. Ubuhlungu bekhanda, ukuqwasha ngokuqwasha, kuqhamuke isicanucanu. Bengicabanga ukuthi ngizojwayela, kuthathe izinsuku ezi-3, kepha akukho ukuthuthuka. Ngiye kudokotela ngiyolanda okunye, futhi ngemuva kokukufaka esikhundleni se-analogue ye-Aquamox njengokufakwa, zonke izimpawu zahamba.
UDmitry, oneminyaka engama-35, uLyantor
Ngakwazi ukwelapha i-bronchitis engapheli kuphela nge-plevilox. Edolobheni lakithi bekunzima ukuyithola, yayala kwa-Surgut, kepha akazange azisole ngayo, ngoba umphumela wavela ngokushesha.
UMarina, oneminyaka engama-36, uVladivostok
Udokotela unikeze lesi sidakamizwa i-sinusitis esibuhlungu, wathi kufanele abhekele ngokucophelela ukubonakaliswa kwemiphumela emibi, ngoba ukwelashwa bekuyalelwe ngesikhathi sokukhulelwa. Kuhle ukuthi ngixwayise, ngoba isicanucanu saba namandla, kepha ngicabanga ukuthi lokhu kuyizibonakaliso ze-toxicosis. Futhi ngakho-ke ngokushesha kwathathelwa indawo inkambo yokwelashwa, konke kwahamba kahle.
