I-Rosinsulin isidakamizwa saseRussia esisetshenziselwa ukwelashwa kokulondolozwa kwabantu abaxhomekeke ku-insulin abanesifo sikashukela. Umehluko omkhulu phakathi kwamafomu wayo wokukhishwa yisikhathi somsebenzi wento esebenzayo.
Igama Lezwe elingafanele
NgesiRussia - Insulin Yobuntu. NgesiLatini - iRosinsuline.
I-Rosinsulin isidakamizwa saseRussia esisetshenziselwa ukwelashwa kokulondolozwa kwabantu abaxhomekeke ku-insulin abanesifo sikashukela.
I-ATX
A10AC01
Khipha amafomu nokwakheka
Lo muthi unezinhlobo ezingama-3 zokukhishwa, ezikhonjiswe ngezinhlamvu ezahlukahlukene egameni:
- "P" - ikhambi eliqukethe i-insulin enganyibiliki;
- I- "C" ukumiswa okuqukethe i-insulin isophan;
- I- "M" ingxube yazo zombili izinhlobo ze-insulin ngokwesilinganiso esingu-30/70.
Ngayinye yalezi zinhlobo zokukhishwa iqukethe i-1 ml ye-100 IU ye-insulin. Uketshezi lubekwa kuma-cartridge we-3 ml noma ku-5 noma 10 ml vials.
Isenzo se-Pharmacological
I-insulin ibopha kuma-cell wall receptors, ikhuthaza ukusebenza kwe-incracellular enzyme synthesis izinqubo. Umphumela we-glycoglycemic wesidakamizwa kungenxa yekhono laso:
- khuphula ukuthuthwa kweglucose kumaseli futhi kugqugquzele ukuthathwa kwayo;
- ukuqinisa izinqubo ze-lipogenesis kanye ne-glycogenogeneis;
- vimbela ukukhiqizwa koshukela isibindi.
Umuthi lo unezindlela ezi-3 zokukhishwa, ezikhonjiswe ngezinhlamvu ezahlukene egameni, enye yazo ngu- "P" - isisombululo esine-insulle insulin.
I-Pharmacokinetics
Izinga kanye nezinga lokufakwa komuthi kuncike kusayithi lomjovo nomthamo. I-soluble insulin, okuyingxenye yeRosinsulin R, iqala ukusebenza ngemuva kwemizuzu engama-30, ubude besikhathi somphumela wezokwelapha amahora angama-8. Ukuhlushwa okuphezulu kutholakala emahoreni angama-1-3 ngemuva kokuphatha.
Isenzo se-isofan insulin siqala emahoreni angama-1.5 ngemuva kokuphathwa, ubude bomphumela wokwelapha ufinyelela ngosuku. Umphumela omkhulu ubonwa ngesikhathi samahora angama-4 kuya kwayi-12.
Umuthi, okuyingxube ye-insulin esheshayo naphakathi, uqala ukusebenza isigamu sehora ngemuva kokuphathwa futhi uhlala usebenza kuze kube usuku.
Lo muthi ubonakala ngokusatshalaliswa okungalingani kuzicubu, awukwazi ukungena ku-placenta futhi ungene ebisini lwebele. Kuthunyelwe nge-insulinase, ekhishwe emzimbeni yizinso.
Izinkomba zokusetshenziswa
Izinkomba zokusebenzisa iRosinsulin ziwuhlobo lwe-1 yesifo sikashukela kanye nohlobo 2 lwesifo sikashukela esiteji sokumelana okuphelele noma okuyingxenye kwemithi ye-hypoglycemic ekhiqizwa ngendlela yamathebhulethi, kanye nokuhambisana nezifo ezihambisana nawo.
Ngaphezu kwalokho, isixazululo seRosinsulin sinqunyelwe ezigulini ezinesifo sikashukela sohlobo 2 ezimeni ezinjalo:
- isifo sikashukela sikashukela;
- isifo sikashukela;
- ngaphambi kokuhlinzwa;
- izifo ezihambisana nomkhuhlane onamandla.
Lesi sidakamizwa siyasebenza nakwisifo sikashukela esicasulwa ukukhulelwa. Kusetshenziswa ezimweni lapho ukwelashwa kokudla kunganiki umphumela.
Contraindication
Ayinqunyelwe i-hypersensitivity kulolu hlobo lwe-insulin, kanye ne-hypoglycemia.
Ngokunakekela
Ukukhetha idosi kufanele kwenziwe ngokuqapha ekwelashweni kweziguli ezinalo:
- amacala wengozi ye-cerebrovascular ngokohlobo lwe-ischemic;
- Isifo senhliziyo esishubile;
- i-arterial stenosis;
- proliferative retinopathy.
Ungayithatha kanjani iRosinsulin
Kudingeka umjovo usebenzisa amapeni wesirinji, ulandela ngokuqinile imiyalo yomenzi onikezwe emiyalweni. Kubalulekile ukuthi ungayisusi inaliti ngaphambili kwemizuzwana eyi-6 ngemuva kokuphela kokufaka futhi ungayikhiphi inkinobho yesibambo kuze kube yilapho isisuswe ngokuphelele. Lokhu kuzoqinisekisa ukuphathwa okufanele komthamo futhi kuvimbele i-ingress yegazi kusisombululo.
Lapho usebenzisa amapeni okusebenziseka kabusha ngemuva kokufaka i-cartridge, qiniseka ukuthi umucu onemibala uyabonakala ngewindi lesibambi.
Ngaphambi kokwethulwa kweRosinsulin C noma iRosinsulin M, kuyadingeka ukuwunyakazisa ngokucophelela umuthi ukufeza ukufana ngokuphelele kokumiswa.
Kudingeka umjovo usebenzisa amapeni wesirinji, ulandela ngokuqinile imiyalo yomenzi onikezwe emiyalweni.
Ngoshukela
Ubungako bemithamo bunqunywa ngokuhlukile kwisiguli ngasinye. Ngokwezibalo, isilinganiso esifanele somuthi wansuku zonke ngu-0.5 - 1ME nge-1 kg yesisindo sesiguli. Ukukhetha kufanele kususelwe ekugxileni kwe-glucose egazini. Izilinganiso kufanele zithathwe ngaphambi kokudla namahora ama-1-2 ngemuva kokudla.
Imijovo ye-insulin yenziwa imizuzu engama-20 ngaphambi kokudla. Umuthi olungiselelwe kufanele ube nokushisa kwegumbi.
Imijovo yeRosinsulin P ingahlanganiswa nezidakamizwa ezisebenza isikhathi eside. Ingahanjiswa ngokubandakanyeka noma ngemithambo yegazi. Kuyadingeka ukuyikhipha kathathu ngosuku, ngoba inesikhathi esifushane sokwenza.
Izinhlobo ezahlukahlukene zeRosinsulin "C" ne "M" ziveza imijovo yokufakelwa engaphansi kanye ngosuku. Ngaphambi komjovo, ukulungiswa okuhlangene kufanele kuhlanganiswe ngobumnene kuze kube yilapho ikhambi lingahambi kahle.
Imiphumela emibi yeRosinsulin
Engxenyeni yezitho zombono
Ukuthatha umuthi kungahle kwehle ukwehla kwezimpawu ezibonakalayo. Lo mphumela wecala uhlala umzuzwana.
Uhlelo lwe-Endocrine
Mhlawumbe ukuthuthukiswa kwe-hypoglycemia, ebonakala ngezimpawu ezilandelayo:
- pallor
- izibuko
- ukuthuthumela
- ukuphazamiseka kokulala.
Ngaphezu kwalokho, kungenzeka ukwanda kwe-titer yemizimba elwa ne-insulin kanye nokuvela kokugomela okwenziwe nge-insulin yomuntu.
Allergies
Ukusabela okungezwani nomuthi kungenzeka ngendlela:
- i-urticaria;
- umkhuhlane
- ukuphefumula
- ukuncishiswa kwengcindezi;
- i-angioedema.
Umthelela ekhonweni lokulawula izindlela
Umuthi uqobo awuthinti amandla okugxilisa nokulawula izindlela. I-Hypoglycemia, engaqhamuka ngesikhathi sokwelapha ngalesi sidakamizwa, ilimaza ikhono lomuntu lokulawula izindlela.
Umuthi uqobo awuthinti amandla okugxilisa nokulawula izindlela.
Imiyalo ekhethekile
Ngesikhathi sokwelashwa kwe-insulin, indawo yomjovo kufanele iguqulwe njalo ukuvikela i-lipodystrophy endaweni yomjovo. Ngaphezu kwalokho, uma umthamo owodwa ungaphezu kwe-0,6 IU / kg, inani elitholakalayo lomuthi kufanele lihlukaniswe ngemijovo emi-2.
Izici eziningana zingaholela ekuthuthukisweni kwe-hypoglycemia, ngakho-ke, lapho zivela, ukulungiswa kwedosi kuyadingeka. Lokhu kufaka phakathi:
- ukukhuphuka komzimba;
- ukweqa ukudla;
- ukugabha nohudo;
- ukuguqulwa kwezidakamizwa noma indawo yokuphatha;
- ukwehla kwesidingo se-insulin okubangelwa izifo ze-gland yegilo, isibindi, izinso, njll.
- ukuqalwa kwezokwelapha ngomuthi osebenzisana ne-insulin.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi uvunyelwe ukusetshenziswa ngesikhathi sokukhulelwa nokuqunjelwa. Kulokhu, kuyadingeka ukulungisa umthamo uthatha izinguquko ezidingweni zomzimba womuntu wesifazane zokuthola i-insulin ngezikhathi ezihlukile zokukhulelwa. Isibonelo, ku-trimester yokuqala, kuyadingeka ukunciphisa inani lomuthi olungiselelwe. Ngokuzayo, umthamo kufanele unyuswe kancane kancane.
Umuthi uvunyelwe ukusetshenziswa ngesikhathi sokukhulelwa.
Ngesikhathi sokuqunjelwa, ukuqapha kwamazinga kashukela wegazi kuyadingeka kuze kube yilapho umthamo odingekayo usuzinzile.
Ukunquma iRosinsulin ezinganeni
Ukunquma lesi sidakamizwa ezinganeni kuyinto eyamukelekayo, kepha ukukhetha umthamo kufanele kwenziwe ngaphansi kokuqashwa ngudokotela.
Sebenzisa ebudaleni
Eminyakeni engu-65 ubudala, kulungiswa umthamo. Lokhu kudalwa yizinguquko emzimbeni, ikakhulukazi, ukonakala ekusebenzeni kwezinso, kulandelwe ukubambezeleka kwe-insulin.
Isicelo sokusebenza kokulimala kwezinso
Umsebenzi wezinso ongasebenzi kahle wehlisa i-insulin excretion, nayo engadala i-hypoglycemia. Ngakho-ke, ukukhethwa komthamo wesidakamizwa kufanele kwenziwe ngokuqapha.
Sebenzisa umsebenzi wesibindi okhubazekile
Ukuphazamiseka kwesibindi kuholela ekunciphiseni ekukhiqizeni ushukela. Ngokuphikisana nesizinda sokwelashwa kweRosinsulin, lokhu kungaholela ekushodeni kwe-glucose emzimbeni. Kulokhu, umthamo wesidakamizwa otholwa yiziguli ezinezifo zesibindi kufanele uncishiswe.
Ngokuphikisana nesizinda sokwelashwa kweRosinsulin, lokhu kungaholela ekushodeni kwe-glucose emzimbeni.
I-Rosinsulin overdose
I-overdose yalesi sidakamizwa iholela ekuthuthukisweni kwe-hypoglycemia. Ukudla okunconyelwe kakhulu okuphezulu kuma-carbohydrate. Ngakho-ke, abantu abasebenzisa i-insulin njalo bayalulekwa ukuba baphathe njalo amaswidi noma ijusi yezithelo uma kwenzeka ukwehla okungamukeleki koshukela wegazi. Ezimweni ezinzima kakhulu, ukuphatha okungenayo kwekhambi le-glucose kungadingeka.
Ukuxhumana nezinye izidakamizwa
Umphumela weRosinsulin uyathuthuka lapho uthathwa ndawonye nezidakamizwa ezinjengokuthi:
- I-MAO, ACE, phosphodiesterase kanye ne-carbonic anhydrase inhibitors;
- ama-beta-blockers anomphumela ongakhethi;
- ama-anabolics;
- ama-tetracycline ama-antibiotic kanye nama-sulfonamides;
- ama-antitumor agents;
- okuphuma ku-amphetamine ukulawula isifiso sokudla;
- ama-dopamine receptor stimulants;
- I-Octreotide;
- ama-anthelmintic agents;
- i-pyridoxine;
- izidakamizwa ezokwehlisa i-lipid.
Umphumela weRosinsulin uyathuthuka lapho uthathwa ndawonye ne-Octreotide.
Izinto eziningi kunciphisa ukusebenza kwe-Rosinsulin therapy. Phakathi kwazo kukhona:
- ama-hormone egilo;
- ama-diuretics we-thiazide ne-loop isenzo;
- i-heparin;
- i-glucagon;
- ama-estrogens, kufaka phakathi lawo aqukethe izindlela zokuvimbela inzalo ngomlomo;
- antidepressants zeqembu lesithathu;
- ama-blockers ama-histamine receptors kanye neziteshi ze-calcium ezihamba kancane;
- izidakamizwa ze-antiepileptic eziqenjini ze-hydatoin;
- analogues of adrenaline.
Ukuhambisana notshwala
Ukwelashwa kwe-insulin kunciphisa ukumelana komzimba notshwala. Ngakho-ke, utshwala buhlukaniswa kulabo abadinga ukwelashwa kwe-insulin.
Ama-Analog
Izindatshana zokuqothuka zibandakanya leyo mithi. njengo:
- I-Humulin ejwayelekile;
- I-Biosulin;
- I-Rinsulin;
I-analogue yeRosinsulin M yisidakamizwa esihlanganisiwe i-NovoMiks.
Imibandela yekhefu lekhemisi
Ngingakwazi ukuthenga ngaphandle kadokotela?
Cha. Lesi sidakamizwa singenye yemithi kadokotela.
Intengo yeRosinsulin
Izindleko zalo muthi ziyehluka ngokuya ngesifunda sezwe nenqubomgomo yamanani entengo yokuphuma. Isibonelo, ikhemisi elidumile le-inthanethi linikeza izintengo ezilandelayo zokufaka zeRosinsulin kusuka kuma-cartridge angu-5 we-3 ml ngayinye, ifakwe esibayeni sokulahla esilinganayo
- "P" - ama-ruble ayi-1491.8;
- "C" - ama-ruble ayi-1495.6;
- "M" - ama-ruble ayi-1111.1.
Izimo zokugcina zomuthi
Umuthi kufanele ugcinwe endaweni eyomile neyibandayo, lapho ukufinyelela kwezingane kunqunyelwe. Ipeni lesirinji, elisebenzayo, lingagcinwa emazingeni okushisa asekamelweni, kodwa hhayi isikhathi esingaphezu kwamaviki ama-4.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Umkhiqizi
I-LLC Plant Medsintez
Ukubuyekezwa mayelana neRosinsulin
Odokotela
UDmitry, oneminyaka engama-35, uNizhny Novgorod: "Ngikholwa ukuthi ukungathembani okuvame ukukhonjiswa yiziguli emithini yaseRussia akunakulungiswa. Lo muthi uyakwazi ukugcina izinga elijwayelekile likashukela futhi ungaphansi kwabalingani bangaphandle. Ngibhala uma kunesidingo sokulungisa isimo ngokufakwa kwe-insulin yangaphandle."
USvetlana, oneminyaka engama-40, uKirov: "Ngithatha lo muthi njengezindlela ezinokwethenjelwa zokwelapha i-insulin kwiziguli ezinesifo sikashukela. Ukwelashwa kwami kukhombisa ukuthi ngemuva kokuphela kwesikhathi sokusebenzisa umuthi omusha, abantu abaningi baphawula ukuqina kwamazinga kashukela."
Isifo sikashukela
URosa, oneminyaka engama-53, u-Uchaly: "Ngashintsha lesi sidakamizwa njengoba ngangiyalelwa udokotela ezinyangeni ezi-2 ezedlule. UShukela waqala ukweqa ngezikhathi ezithile. Ngisaqhubeka nokushintsha umthamo njalo."
UVictor, oneminyaka engama-49, uMurom: "Sekuphele unyaka ngenza imijovo yeRosinsulin, selokhu kwatholakala lesi sifo. Ngokwesethulo ngisebenzisa ipeni lesirinji elikhethekile leComfort Pen elinikezwe umenzi.
UKristina, oneminyaka engama-40, eMoscow: "Isikhathi eside bengizama ukuthola umthamo ofanele walo muthi. Kepha angikwazanga ukuzinza izinga likashukela. Ngishintshele kwesinye isidakamizwa."
