I-Attokana 300 - isibuko se-hypoglycemic somuthi, sinqunyelwe ekwelashweni kohlobo lokuncika kwesifo sikashukela i-mellitus insulin.
Igama Lezwe elingafanele
I-Kanagliflozin.
I-Attokana 300 - isibuko se-hypoglycemic somuthi, sinqunyelwe ekwelashweni kohlobo lokuncika kwesifo sikashukela i-mellitus insulin.
I-ATX
I-A10BX11 - iKaragliflozin.
Khipha amafomu nokwakheka
Kunefomu elilodwa kuphela - amaphilisi.
Amaphilisi
Ku-sheath yefilimu. Isakhi esiyinhloko yi-canagliflozin hemihydrate. Izakhi ezisizayo: i-microcrystalline cellulose, i-lactose ye-anhydrous, i-magnesium stearate.
Umbala wezibhebhe umhlophe noma ucishe waba mhlophe. Ngakolunye uhlangothi lwegobolondo kuqoshwe i- "CFZ". Ithebhulethi eli-1 liqukethe i-300 mg yento esemqoka. Abaphathi be-Shell: udayi omhlophe, i-titanium dioxide, i-polyvinyl alcohol.
Amaconsi
Ifomu lokukhipha alikho.
Powder
Ayitholakali.
Isixazululo
Ifomu lokukhipha alikho.
Amakhandlela
Ifomu lokukhipha alikho.
Yindlela eyodwa kuphela yokukhishwa kwesidakamizwa - amaphilisi.
Amafutha
Alikho ifomu elinjalo.
Amakhandlela
Ifomu lokukhipha alikho.
Isenzo se-Pharmacological
Kubantu abanesifo sikashukela, ukwanda kokuhlungwa kwe-glucose glucose kubangelwa inqubo eshesha yokufaka ushukela ezinso. Umuthi othembele ku-sodium, ophethe i-glucose ezingubeni zezinso, ubhekene nale nqubo.
Isithako esisebenzayo siyisithintelo salokhu okuncike ku-sodium, sinciphisa ukumunca ushukela ezinso. Umuthi wehlisela isilinganiso somkhawulo wezinso ushukela ongenayo, ngenxa yokuthi ukucwila kwe-glucose kunciphisa.
Umuthi ubangela umphumela we-osmotic, usebenze inqubo yokwakheka kanye nokuchama komchamo nge-sucrose eyeqile, kunciphisa umfutho wegazi we-systolic. Ukusheshisa kwenqubo yokuhoxiswa kwe-glucose nomphumela obonakalayo we-diuretic kuholela ekulahlekelweni kwamakhalori kanye nokunciphisa umzimba.
I-Pharmacokinetics
Izinga le-bioavailability lingama-65%. Inani elikhulu lamafutha angena emzimbeni ngokudla alithinti izindawo zomuthi we-pharmacokinetic. Kuthululwa kungashintshiwe ngokusebenzisa izinso ngomchamo.
Izinkomba zokusetshenziswa
Kunqunyelwe iziguli ezinesifo sikashukela sohlobo 2. Ukuthola umphumela wokwelapha, umuthi kufanele uhlanganiswe nokudla okufanele nokuzivocavoca umzimba njalo.
Isetshenziswa njengesidakamizwa esizimele ku-monotherapy, kanye nasekwelapheni okuyinkimbinkimbi okuhlanganiswe nezinye izidakamizwa ze-hypoglycemic spectrum yesenzo, kufaka phakathi nokujova kwe-insulin.
Umuthi ubekelwe iziguli ezinesifo sikashukela sohlobo 2.
Contraindication
Amacala wemitholampilo lapho ukwamukelwa kungenzeki:
- ukungabekezelelani komuntu ngamunye kwizakhi ngazinye;
- thayipha i-1 isifo sikashukela;
- ketoacidosis;
- ukwehluleka kwezinso, lapho izinga lokuhlunga le-glomeruli yezinso lingaphansi kwama-45 ml ngomzuzu;
- ukwehluleka okunzima kwezinso;
- ukungabekezelelani kokuzala kwe-lactose;
- ukwehluleka kwenhliziyo okungapheli;
- ukukhulelwa
- inkathi yokuncelisa.
Ukwephulwa kweminyaka yobudala - kuyenqatshelwe ukuthatha lesi sidakamizwa kubantu abangaphansi kweminyaka engu-18.
Ngokunakekela
Ukuba khona komlando we-ketoacidosis yesifo sikashukela.
Ungayithatha kanjani i-Invocana 300?
Isilinganiso esiphakanyisiwe somuthi ekuqaleni kokwelashwa ngu-100 mg ngosuku. Ngemuva kwezinsuku ezingama-7-10 (inqobo nje uma kungekho zimpawu eziseceleni), umthamo ungakhushulwa ufike kuma-300 mg ngosuku, kunconywa ukuthi uhlukaniswe ngemithamo eminingana.
Uma kunesidingo sokudla okwengeziwe kwe-insulin, umthamo we-Attokana kufanele wehliswe.
Ngoshukela
Umuthi we-hypoglycemic ungathathwa womabili esiswini esingenalutho, futhi ngokushesha ngemuva kokudla. Uhlobo olunconyiwe lusekuseni, esiswini esingenalutho ngaphambi kokudla kwasekuseni.
Imiphumela emibi ye-Attokana 300
Izimpawu eziseceleni zenzeka ikakhulukazi ngenxa yemithi engafanele noma ngenxa yomthamo ophakeme. Futhi, ukusabela okungekuhle kungenzeka kubantu abanezifo ezingamahlalakhona nge-exacerbations ngezikhathi ezithile.
Ukuthatha lo muthi kungaholela ekwandeni kokuxineka kwe-potassium, i-creatinine ne-urea, hemoglobin. Uhlu lokuphendula okungahambi kahle lunikezwa ngokuya ngezifundo ezilawulwa yi-placebo.
Amapheshana wesisu
Isicanucanu, ukuqunjelwa, umlomo owomile oqhubekayo.
Isistimu yezinzwa ephakathi
Isiyezi sendalo, ukwehluleka.
Kusuka ohlelweni lomchamo
Ukuthuthukiswa kwe-polyuria, ukutheleleka, ukubukeka kwehluleki lwe-renal.
Kusuka ohlelweni lwezitho zofuzo
I-Candidiasis balanitis, i-vulvovaginal candidiasis, i-vulvovaginitis.
Kusuka ohlelweni lwezinhliziyo
Ukuthuthukiswa kwe-orthostatic hypotension, ukwehla komthamo we-intravascular.
Allergies
Isikhumba ukuqhuma, okhalweni, ukulunywa.
Umthelela ekhonweni lokulawula izindlela
Izifundo zemitholampilo maqondana nomthelela omubi we-Attokana ekhonweni lokushayela imoto noma ukusebenza ngamasu ayinkimbinkimbi awenziwe. Isiguli ngasinye kufanele siqaphele ubungozi be-hypoglycemia ekhuphuka kanye nokwelashwa okuhlanganiswayo ngemijovo ye-insulin.
Uma ukuthatha i-ejog ye-hypoglycemic kuhambisana nokwehla kwethamo le-intravascular, ukusabela okungafuneki kungenzeka ngendlela yesizungu, ikhanda elibi kakhulu nokunakwa okungahambi kahle. Kulokhu, kunconywa ukwenqaba ukushayela.
Imiyalo ekhethekile
Iziguli ezinobunzima be-renal dysfunction zithatha isilinganiso esilinganiselwe se-100 mg ekuqaleni kokwelashwa nama-300 mg kuyo yonke inkambo. Ubunzima obuphakathi besifo sezinso - inani elikhulu ngosuku yi-100 mg. Uma umuthi ubekezelelwa kahle isiguli, ukukhuphuka kancane kancane kuya ku-300 mg kuvunyelwe.
Iziguli ezinenkinga yokusebenza kwesibindi (ngobumnene kuya kobukhulu obulinganiselwe) - umthamo awulungiswa. Ukwehluleka okukhulu kwe-renal - akukho ukuvuma.
Uma isiguli siphuthelwe umthamo owodwa, iphilisi kufanele liphuzwe masisha lapho likhumbula lokhu. Kwenqatshelwe ukuthatha umthamo ophindwe kabili ngasikhathi.
Ngesikhathi sokwelashwa, ukuhlolwa komchamo wokuthola ushukela kuzohlala njalo kukuhle, okuchazwa ngokungathandeki kwe-pharmacodynamics yomuthi.
Ukuvivinywa kokuhlolwa kokubekezelela kwe-glucose ngesidlo sasekuseni esixubile kubonise ukwehla kwe-glycemia: umthamo we-100 mg - 1.5-2.7 mmol, umthamo ka-300 mg - 1 mmol - 3.5 mmol.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Kwakungekho zifundo kwabesifazane abakhulelwe. Akukho datha onomphumela oqondile onobuthi besidakamizwa emzimbeni wowesifazane nowesifazane. Ngokunikwa umthelela omubi womuthi ezithweni zokuzala, kuthathwa ukuthi kuphuzwa amaphilisi esikhathini sokuthambisa nokuzala.
Ukuqokwa kwe-Invocan ezinganeni ezingama-300
Kwenqatshelwe ukwamukela abantu abangaphansi kweminyaka engu-18.
Sebenzisa ebudaleni
Iziguli ezineminyaka engu-75 nangaphezulu akufanele zithathe ngaphezu kwe-100 mg ngosuku. Uma kungekho izifo ezingamahlalakhona kanye nokubekezelela okuhle komuthi, ukukhuphuka komthamo okufika kuma-300 mg kuvunyelwe ngezizathu zezokwelapha.
I-overdose ye-Invocana 300
Amacala we-overdose awaziwa. Umthamo owodwa womuthi ngaphezulu kwama-300 mg ungabonakala ngemiphumela emibi yokuqina okukhulu.
Ukwelapha uma kwenzeka kweqisa ngokweqile kwenziwa ngokuthatha izinyathelo zokususa umuthi owengeziwe emzimbeni - ukugeza isisu, ukuthatha izicubu zomzimba. Qiniseka ukuthi ulawula isimo somtholampilo sesiguli.
Ukuxhumana nezinye izidakamizwa
Yandisa umphumela wokwelapha wezidakamizwa ze-diuretic.
Ama-stimulants we-insulin secretion kanye ne-insulin ngasikhathi sinye ne-Invocana angakudambisa ukwehla okusheshayo kokuxineka kwe-glucose glucose, okubangela i-hypoglycemia.
Ukwemukelwa kwe-enzymatic inducers - i-Phenytoin, i-barbiturates, i-Efavirenza, i-Rifampicin, yehlisa umphumela wokwelapha umuthi.
Ukuhambisana notshwala
Ayihambisani notshwala. Le nhlanganisela ingaholela emiphumeleni emibi kakhulu.
Ama-Analog
Ukulungiselela okunenqwaba yesenzo esifanayo - iBayeta, Viktoza, Novonorm, Guarem.
Imibandela yekhefu lekhemisi
Ukuthengiswa kwencwadi kadokotela
Ngingakwazi ukuthenga ngaphandle kadokotela?
Cha.
Intengo ye-Encokanam 300
Izindleko ziqala kusuka kuma-ruble angama-2400.
Izimo zokugcina zomuthi
Kumazinga okushisa angadluli ku-30 ° C.
Isikhathi sokuphelelwa yisikhathi
Izinyanga ezingama-24.
Umkhiqizi
UJansen-Silag S.p.A. / Janssen Cillag S.p.A., Italy
Ukubuyekezwa mayelana ne-Attokane 300
Odokotela
UMarina, oneminyaka engama-46 ubudala, eMoscow, udokotela obelekelela nge-endocrinologist: "Ngiyazithatha lesi sidakamizwa uqobo. Ngisebenza kahle, akubukeki njengabanye abenzeli be-hypoglycemic. Imvamisa yezimpawu eziphikisayo ezigulini incane uma uphuza umuthi kahle futhi ubala umthamo kahle."
I-Eugene. Uneminyaka engu-35 u-Odessa, i-endocrinologist: "Iningi leziguli liyesabisa izindleko zomuthi. Yebo, umuthi ovela kumenzi wase-Italy ubiza kakhulu kunabalingani basekhaya, kepha lo muthi unobungozi obukhulu bokukhula kwe-hypoglycemia futhi usiza iziguli ezikhuluphele ukuba zenze umzimba ube nokujwayelekile, okuyinto, ezothuthukisa isimo futhi zivikele izingqinamba. "
Iziguli
U-Ana, oneminyaka engama-37, eSt. "akukho okubonakalayo. Kuyikhambi elihle, kepha ngenxa yentengo, ukusetshenziswa kwayo njalo kuyinkinga."
U-Andrei, oneminyaka engama-45, u-Omsk: "Ngiphuze lesi sidakamizwa amasonto ama-3, ngemuva kwalokho ngaqala ukuba nekhanda, ngazizwa ngigula, ngathola ukuqunjelwa kanzima. Ukulungisa umthamo kwaqeda okwesikhashana imiphumela emibi, kodwa kwavela futhi. Lo muthi kwadingeka ukuthi ukhanseliwe, yize wasiza ushukela ngokwejwayelekile" .
U-Elena, oneminyaka engama-39, uSaratov: "Nge-Invocana 300, ngaphatha i-candidiasis yesitho sangasese isikhathi eside, eyavela njengemiphumela emibi. Kepha nalesi sifo esingajabulisi sasifanele umphumela lo muthi owanikeza wona, futhi uyifanele ngokuphelele imali. Ngaphambi kwawo ngasebenzisa ezinye izidakamizwa, kodwa bonke abanamasondo ahlukene baholele ku-hypoglycemia. Futhi lena ayikho. "
