I-Augmentin isidakamizwa saseYurophu, esiyinhlanganisela ye-antibiotic ene-beta-lactamase inhibitor.
I-ATX
J01CR02.
I-Augmentin isidakamizwa saseYurophu, esiyinhlanganisela ye-antibiotic ene-beta-lactamase inhibitor.
Khipha amafomu nokwakheka
I-Augmentin EC yimpuphu emhlophe enephunga elimenyezelwe lama-sitrobheli, asetshenziselwa ukulungisa ukumiswa. Izithako ezisebenzayo zomuthi yilezi:
- i-amooticillin 600 mg;
- i-clavulanic acid 42.90 mg.
Ukuhlushwa kususelwa ku-5 ml wokumiswa kokuqeda. Kuthengiswa ngamabhodlela angama-50 no-100 ml.
Isenzo se-Pharmacological
I-Pharmacokinetics
Ngemuva kokuphathwa ngomlomo, kukhona ukumuncwa ngokushesha kwazo zombili izingxenye zezokwelapha zomuthi ovela emgodini wokugaya ukudla. Okuqukethwe okuphezulu kwezinto eziqukethwe kuyi-plasma yegazi kufinyelelwa ngemuva kwehora le-clavulanic acid kanye namahora ama-2 e-amoxicillin. Ukuphila kwesigamu kwamahora ayi-1-1,5. Lezi zinto zine-bioavailability ephezulu futhi cishe azibophele kumaprotheni egazi. Bayakwazi ukungena kwezicubu ezahlukahlukene kanye noketshezi lomzimba.
Indlela yokusebenza
I-Amoxicillin isidakamizwa esiyisigamu sokwenza umsebenzi esiphikisana nohlu olukhulu lwamagciwane, kubandakanya izidalwa ezinhlobonhlobo ze-aerobic ne-anaerobic, zombili i-gram-negative ne-gram-positive. I-drawback yayo eyinhloko - ukubhujiswa okusheshayo ngaphansi kwethonya le-beta-lactamases - kudalulwa ngenxa yokuba khona kwe-clavulonic acid, okuyi-inhibitor yalesi sakhi, ekwakhiweni kwe-Augmentin EC. Ngenxa yokuhlanganiswa kwalezi zinto ezimbili, umuthi unezinto eziningi ezisebenzayo, kufaka phakathi ama-microorganisms akhombisa ukumelana nama-penicillin.
Umuthi uyasebenza nge-sinusitis.
Izinkomba zokusetshenziswa
Umuthi uhloselwe ukwelashwa kwezingane ezifweni ezibangelwa ama-microorganisms azwela izakhi zawo. Isebenza nge:
- izifo zokuvuvukala zezitho ze-ENT, kufaka phakathi lezo ezibangelwa yi-streptococcus pneumoniae;
- i-sinusitis, i-tonsillopharyngitis;
- izifo zepheshana lokuphefumula eliphansi;
- izilonda ezithathelwanayo zesikhumba nezicubu ezithambile.
Ngokunakekela
Ngokuqapha, lo muthi kufanele unqunyelwe ukusebenza kwesibindi nokukhubazeka kwezinso okuqinile, kanye nabesifazane abathola umntwana noma abancelisa ibele.
Ingasetshenziselwa isifo sikashukela?
Izakhi ezisebenzayo ze-Augmentin azithinti izici ezinquma izinga kashukela egazini, futhi zingalahlekelwa ukusebenza kwazo ezimweni zokuphazamiseka kwe-metabolic. Ngakho-ke, kuvunyelwe ukunquma lesi sidakamizwa uma kunezinkomba zokwelashwa kwama-antibhaybheli kubantu abanesifo sikashukela.
Kuvunyelwe ukunquma lo muthi uma kunezinkomba zokwelashwa ngama-anti-antibiotic kubantu abanesifo sikashukela.
Contraindication
Ukunquma lo muthi akuvunyelwe uma kunomlando wezinkomba ze:
- i-hypersensitivity kwimithi ye-betalactam;
- i-jaundice noma ukungasebenzi kwesibindi, okucasulwa ukusetshenziswa kwezinto ezifanayo;
- umsebenzi wezinso ongonakalisiwe, obonakala ngokuqanjwa kwe-creatinine ngaphansi kwama-30 ml / min.;
- phenylketonuria.
Ngaphezu kwalokho, lo muthi awubekelwe izingane ezingaphansi kweminyaka engu-3 ubudala.
Ungayithatha kanjani i-Augmentin EU?
I-powder kumele ihlanjululwe ngokushesha ngaphambi kokuqala kwenkambo yokwelashwa. Ukuze wenze lokhu, engeza u-2/3 wethamo lamanzi elidingekayo ebhodleleni, unikine futhi uvumele ukuba lithele imizuzu emi-5. Bese engeza inani elisele lamanzi bese unikine futhi. Lapho ulungiselela ukumiswa, kuyadingeka ukusebenzisa amanzi abilisiwe, abolile.
Imiphumela emibi
Umphumela omubi kakhulu ojwayelekile wokuthatha le antibiotic ukukhula kwe-candidiasis.
Amapheshana wesisu
Ngenxa yokwamukelwa kwe-Augmentin, kungavela lezi zimo ezilandelayo:
- Izimpawu ze-dyspeptic, ukuphazamiseka kokugaya ukudla;
- isicanucanu, ukuhlanza
- i-colitis ye-haratker ehlukahlukene;
- mnyama ulimi.
Kusuka ohlelweni lwegazi nolwe-lymphatic
Ukusabela okungenzeka kakhulu yi-leukopenia eguqukayo ne-thrombocytopenia. Ngaphezu kwalokho, ukuwohloka ekuqineni kwegazi nokwanda kwesikhathi sokuphuma kwegazi, ukuthuthukiswa kwe-eosinophilia, ne-anemia kungenzeka.
Isistimu yezinzwa ephakathi
Ukuphendula okulandelayo kulo muthi kuwuphawu lohlelo lwezinzwa oluphakathi:
- i-hyperacaction kanye nokuqwasha;
- ukukhathazeka, ushintsho ekuziphatheni;
- ikhanda kanye nesiyezi.
Kusuka ohlelweni lomchamo
Ukwelapha ngaleli gciwane kungavusa amandla:
- i-jade;
- i-hematuria;
- i-crystalluria.
Engxenyeni yesibindi ne-biliary
Umphumela wokuthatha lo muthi kungaba ukukhiqizwa okusebenzayo kwama-enzyme ngesibindi, ukwanda kokuhlungwa kwe-bilirubin. Ngaphezu kwalokho, i-hepatitis ne-cholic jaundice ingahle ikhule.
Engxenyeni yesikhumba nezicubu ezingaphansi
Izimo ezingezinhle ezilandelayo zingavela:
- ukuqhuma
- ukulunywa
- i-erythema;
- i-urticaria;
- isikhumba.
Ngokuthuthukiswa kwalezi nezinye izilonda zesikhumba nezicubu ezithambile, ukwelashwa nalesi sidakamizwa kufanele kuyekwe.
Kusuka emasosheni omzimba
Izimpawu zokwaliwa yilezi:
- i-vasculitis;
- i-angioedema;
- isifo esifana nezimpawu zokugula kwe-serum;
- ukusabela kwe-anaphylactic.
Imiyalo ekhethekile
Ukuhambisana notshwala
Ukusetshenziswa kwemithi elwa namagciwane kuhlanganiswe kuhlangene nokuphuza utshwala.
Umthelela ekhonweni lokulawula izindlela
Eminye yemiphumela emibi yokwelashwa kungaba ukukhulisa isiyezi, okuholela ebunzimeni lokulawula izinqubo. Uma ukwamukela i-Augmentin kungahambelani nokusabela okunjalo komzimba, amandla okulawula izindlela awaphazamiseki.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Kuyafakazelwa ukuthi izingxenye ezisebenzayo zomuthi azinamphumela we-teratogenic. Kodwa-ke, lapho uyithatha, kukhona usongo lwe-necrotizing enterocolitis kosanda kuzalwa. Ngesikhathi sokukhulelwa, lo muthi ungasetjenziswa kuphela uma kunesizathu sokukholelwa ukuthi izinzuzo eziya kumama zedlula usongo kumbungu.
Ukwelapha kungenzeka futhi ngesikhathi sokuqunjelwa. Kodwa-ke, ukuncelisa kuyamiswa lapho ingane ithola izimo ezinjengokuthi:
- ukuzwela;
- i-candidiasis yomlomo;
- isifo sohudo
Ukuyalela i-EU Augmentin ezinganeni
Umthamo wansuku zonke kufanele uhlukaniswe ngemithamo emibili. Isikhathi sokwelashwa siyizinsuku eziyi-10. Umthamo owodwa unqunywa yisisindo sengane futhi kufanele ukhethwe ngesilinganiso sokumiswa okungama-0.375 ml nge-1 kg.
Ezigulini ezinesisindo sazo esingaphezu kwamakhilogremu angama-40, ezinye izindlela zomthamo zenzelwe zona, i-Augmentin ngendlela yokumiswa ayikhonjiswa kubo.
Ezigulini ezinesisindo sazo esingaphezu kwama-40 kg i-Augmentin ngesimo sokumiswa azikhonjiswa zona.
Ukuphuza lo muthi kunconywa ekuqaleni kokudla ukuze unciphise amathuba okuba nemiphumela emibi evela emgudwini wesisu.
Sebenzisa ebudaleni
Le ndlela yokukhishwa kwe-Augmentin ihloselwe ukwelashwa kwezingane. Iziguli zabantu abadala zinikezwa ezinye izinhlobo zalo muthi. Kufanele kukhunjulwe ukuthi abantu asebekhulile bathambekele kakhulu ekwakhiweni kwemiphumela emibi evela esibindini.
Ukweqisa
Izimpawu zokweqisa ngokweqile kungaba:
- ukwehluleka kwendlela yokugaya ukudla, okudala ukwehluleka kwebhalthi yama-electrolyte;
- iminyakazo.
Ngenxa ye-overdose, i-crystalluria ingakhula, okungavusa ukwehluleka kwe-renal.
Ukwelashwa kuyimpawu. I-Hemodialysis ingasetshenziswa ukusheshisa ukuqedwa kwesidakamizwa emzimbeni.
Ukuxhumana nezinye izidakamizwa
Ungahlanganisi ne:
- izidakamizwa ezicindezela secretion yeshubhu maqondana nokuwohloka kwe-excretion ye-amoxicillin;
- I-Allopurinol ngenxa yengozi eyengeziwe yokuphendula kwesikhumba;
- I-Warfarin, Acenocoumarol namanye ama-anticoagulants ngenxa yengozi yokwandiswa kwesikhathi se-prothrombin;
- I-Methotrexate ngenxa yokubambezeleka kokuphuma kwayo kanye nobungozi obukhuphukayo;
Ungazihlanganisi neWarfarin ngenxa yobungozi bokukhulisa isikhathi se-prothrombin.
Analogs of Augmentin EU
Izibonelo zifaka amagama anjenge-Amoxiclav ne-Ecoclave.
Imibandela yekhefu lekhemisi
Umuthi uthengiswa ngomuthi onikezwe wona.
Intengo
Izindleko zebhodlela lika-100 ml ekhemisi eliku-inthanethi ngama-ruble angama-442,5. Lapho uthenga ekhemisi emile, intengo ingakhuphuka ngokuya ngenqubomgomo yamanani.
Izimo zokugcina i-Augmentin EU
Powder kufanele igcinwe kude izingane. Ukushisa kwekamelo kuvunyelwe, kepha indawo kumele ifihlwe elangeni eliqondile. Ukumiswa kufanele kugcinwe esiqandisini.
Isikhathi sokuphelelwa yisikhathi
Ungagcina i-powder iminyaka emi-2. Ukumiswa okulungiselelwe kufanele isikhathi esiyizinsuku eziyi-10.
Ukubuyekezwa kwe-EU Augmentin
Odokotela
UVladislav, udokotela wezingane, oneminyaka engama-40 ubudala, uNorilsk: "Lesi sidakamizwa sizisungule njengethuluzi elisezingeni eliphezulu futhi elinokwethenjelwa elilungele ukulwa nezifo ezahlukahlukene. Ngihlala ngiwusebenzisa lapho ngiziphatha. Iziguli eziningi ziyawubekezelela kahle lo muthi."
U-Elena, udokotela wezingane, oneminyaka engama-31, uMagnitogorsk: "Ngiyawethemba lo muthi. Uyasebenza ezifweni eziningi futhi ungasetshenziswa nasezintwaneni"
Iziguli
UZhanna, oneminyaka engu-23, eMoscow: "Ngawuthatha lo muthi ngesikhathi sokukhulelwa. Ngangesaba ukuthi ngizolimaza ingane yami, kepha akubanga khona miphumela emibi."
U-Ekaterina, oneminyaka engama-25 ubudala, eSt.
