Ukwenza ngokwejwayelekile izinga le-glucose egazini, kusetshenziswa izidakamizwa ezahlukahlukene, ezibandakanya iMerifatin. Umuthi we-Hypoglycemic une-contraindication nemiphumela emibi, ngakho-ke ngaphambi kokuqala ukwelashwa, udinga ukuvakashela uchwepheshe futhi ufunde imiyalo.
Igama Lezwe elingafanele
I-Metformin.
Ukwenza ngokwejwayelekile izinga le-glucose egazini, kusetshenziswa izidakamizwa ezahlukahlukene, ezibandakanya iMerifatin.
I-ATX
A10BA02.
Khipha amafomu nokwakheka
Umuthi uyatholakala ngesimo samaphilisi we-500 mg, 850 mg ne-1000 mg camera film. Babekwe izingcezu eziyi-10. ku-blister. Isixha sekhadibhodi singaba nama-1, 2, 3, 4, 5, 6, 8, 9 noma angu-10. Amathebulethi angabekwa embizeni ye-polymer yama-15 ama-pcs, ama-30 ama-pcs., Ama-60 ama-PC. Ama-100 ama-PC. noma ama-pcs ayi-120. Isithako esisebenzayo yi-metformin hydrochloride. Izakhi ezisizayo yi-povidone, hypromellose ne-sodium stearyl fumarate. Ifilimu lefilimu elinyanzelwa ngamanzi liqukethe i-polyethylene glycol, titanium dioxide, hypromellose ne-polysorbate 80.
Isenzo se-Pharmacological
Umuthi uwumuthi we-hypoglycemic womlomo ohlobene ne-Biguanides. Isithako esisebenzayo sisiza ukucindezela i-gluconeogenesis, ukwakheka kwamafutha asimahla kwamafutha kanye ne-oxidation yamafutha. Ngenxa yokuphathwa komuthi, ama-receptors aphathekayo azwela kakhulu i-insulin futhi ukusetshenziswa kwe-glucose ngamaseli kuyathuthukiswa. Inani le-insulin egazini aliguquki, kodwa isilinganiso se-insulin eboshiwe ne-insulin yamahhala siyancipha futhi isilinganiso se-insulin nesilinganiso sokunyuka kwe-proinsulin.
Lapho kuvezwa i-glycogen synthetase, i-metformin ithuthukisa ukwakheka kwe-glycogen. Isenzo saso sihlose ukukhulisa umthamo wokuhamba wazo zonke izinhlobo zabathutha be-glucose kulwelwesi. Umuthi wehlisela phansi inqubo yokufakwa kweglucose emgodini wesisu, wehlise inani le-LDL, i-triglycerides ne-VLDL, futhi uthuthukisa nezakhi zegazi ze-fibrinolytic, ukuvimbela izicubu ze-plasminogen activator inhibitor. Ngesikhathi sokwelashwa kwe-metformine, isisindo sesiguli sihlala sizinzile noma sincipha kancane kancane size sibe yinto evamile lapho sikhona.
Ngokusetshenziswa kanyekanye kokudla, ukumuncwa kwalesi sidakamizwa kunciphisa.
I-Pharmacokinetics
Ngemuva kokuphuza iphilisi, ukumunca kwalo kancane futhi kungapheleli ohlelweni lokugaya ukudla kwenzeka. Ukuqoqwa okukhulu kwento ku-plasma yegazi kuyabonakala ngemuva kwamahora we-2,5. Ngokusetshenziswa kanyekanye kokudla, ukumuncwa kwalesi sidakamizwa kunciphisa. Umuthi osebenzayo ungena kuwo wonke izicubu zomzimba womuntu, ngaphandle kokubopha amaprotheni e-plasma.
Iqongelela ezinsweni, esibindini nasezintweni zamathe. Ukuqedwa kwengxenye ye-metformin kuzothatha amahora amabili kuya kwayi-6. Umuthi udonswa ngaphandle komchamo ngendlela engashintshiwe. Ukuqanjwa kwengxenye esebenzayo kungenzeka ngezinkinga ngezinso.
Izinkomba zokusetshenziswa
Umuthi ubekelwe iziguli ezinesifo sikashukela sohlobo 2 sikashukela, ikakhulukazi ngesisindo ngokweqile, lapho ukudla nomsebenzi wokuzivocavoca kungasebenzi. Ukwelashwa kweziguli ezindala, lungasetshenziswa njenge-monotherapy noma ngokuhlanganiswa ne-insulin noma amanye ama-hypoglycemic agents.
Ezinganeni ngemuva kweminyaka eyi-10, umuthi ungasetshenziswa wedwa noma uhlanganiswe ne-insulin. Ngaphezu kwalokho, kusetshenziswa amaphilisi ukuvikela lesi sifo phambi kwesifo sikashukela nezinye izici eziyingozi zokuthuthukisa isifo sikashukela sohlobo 2, lapho ukulawula okwanele kwamazinga kashukela kungaphumelela ngokushintsha kwendlela yokuphila.
Umuthi ubekelwe iziguli ezinesifo sikashukela sohlobo 2 sikashukela, ikakhulukazi ngesisindo ngokweqile, lapho ukudla nomsebenzi wokuzivocavoca kungasebenzi.
Contraindication
Kuyadingeka ukwenqaba ukwelashwa uma:
- hypersensitivity kuzakhi;
- isifo sikashukela sikashukela;
- isifo sikashukela noma ukoma;
- ukwehluleka kwezinso noma kwesibindi;
- ukomisa;
- izifo ezithathelwanayo ezinzima;
- Izifo ezisesimweni esibi noma esingamahlalakhona, okuholela ku-hypoxia yezicubu.
Ngokunakekela
Bathatha ngokucophelela umuthi wokuhlinzwa okuningana nokulimala lapho kudingekile ukuthatha i-insulin, ukukhulelwa, uphuzo oludakayo noma ubuthi obunobungozi obukhulu, banamathela ekudleni okunekhalori ephansi, i-lactic acidosis, kanye nangaphambi noma ngemuva kokuhlolwa kwe-radioisotope noma kwe-x-ray, lapho i-ejenti equkethe i-iodine ehlukile inikezwa isiguli. .
Ngesikhathi sokukhulelwa, iMerifatin kufanele ithathwe ngokunakekelwa okukhulu.
Ungayithatha kanjani iMerifatin?
Umkhiqizo wenzelwe ukusetshenziswa ngomlomo. Umthamo wokuqala ngesikhathi se-monotherapy kwiziguli zabantu abadala yi-500 mg izikhathi ezingama-1-3 ngosuku. Umthamo ungashintshwa ube ngu-850 mg izikhathi ezingama-1-2 ngosuku. Uma kunesidingo, khona-ke umthamo womuthi unyuselwa ku-3000 mg ngezinsuku eziyi-7.
Izingane ezingaphezu kweminyaka eyi-10 zivunyelwe ukuthatha ama-500 mg noma ama-850 mg kanye ngosuku noma ama-500 mg izikhathi ezi-2 ngosuku. Imithamo ingandiswa ngesonto kuya ku-2 g ngosuku ngemithamo engu-2-3. Ngemuva kwezinsuku eziyi-14, udokotela uguqula inani lemithi, ecabanga ngoshukela wegazi.
Lapho kuhlanganiswa ne-insulin, umthamo weMerifatin ungama-500-850 mg izikhathi ezingama-2-3 ngosuku.
Ngoshukela
Lapho kukhona isifo sikashukela, i-metformin ithathwa ngokohlelo olwenziwa udokotela, kucatshangelwa izici zomuntu ngamunye ogulayo kanye nemiphumela yokuhlolwa okugcwele.
Imiphumela emibi yeMerifatin
Kwezinye izimo, ukusabela okungekuhle kuyabonakala. Ukuphathwa kwamatafula uma kwenzeka imiphumela emibi imisiwe futhi kuvakashelwa udokotela.
Amapheshana wesisu
Ukusuka ohlangothini lokugaya ukudla, isicanucanu, ukuhlanza, isifo sohudo, ubuhlungu besisu nokuntuleka kokudla kuyabhekwa. Izimpawu ezingathandeki zenzeka esigabeni sokuqala sokwelashwa bese zihamba ngokuzayo. Ukuze ungashayisani nabo, kubalulekile ukuqala ngomthamo omncane bese uyandisa kancane kancane.
Izitho zeHematopoietic
Ezimweni ezingavamile, kukhona ukwephulwa kokufakwa kwe-vitamin B12.
Ngasohlangothini lwe-metabolism
Kwesinye isikhathi umuthi ubangela ukukhula kwe-lactic acidosis.
Allergies
Ukusabela komzimba kwenzeka ngesimo sokumiswa, ukuqunjelwa ne-erythema.
Umthelela ekhonweni lokulawula izindlela
Nge-monotherapy, umuthi awuthinti kabi ukuphathwa kwezokuthutha kanye nokwenza izinto ezidinga ukunakwa okwandisiwe kokuphendula kanye nokusabela okukhulu kwe-psychomotor. Ngaphandle kwalokhu, isiguli kufanele siqaphele izimpawu ze-hypoglycemia futhi siqaphele.
Imiyalo ekhethekile
Ngesikhathi sokulashwa, kuyadingeka ukuqapha izinga le-glucose egazini.
Ngesikhathi sokulashwa, kuyadingeka ukuqapha izinga le-glucose egazini.
Sebenzisa ebudaleni
Ezigulini ngemuva kweminyaka engu-60 yobudala, kunobungozi bokuqalwa kwe-lactic acidosis, ngakho-ke umuthi akufanele uthathwe kuleli qembu leziguli.
Isabelo sezingane
Umuthi awubekelwe izingane ezingaphansi kweminyaka eyi-10.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Akunconyiwe ukuthatha amaphilisi lapho uthwala ingane futhi uncelisa ibele, ngoba into esebenzayo ingena kwi-placenta futhi iye obisini lwebele. Ukwelashwa kungabekwa uma inzuzo yokwelashwa idlula ubungozi bezinkinga ezinganeni.
Isicelo sokusebenza kokulimala kwezinso
Akuvunyelwe ukusebenzisa umuthi uma ungasebenzi kahle emzimbeni.
Sebenzisa umsebenzi wesibindi okhubazekile
Kuyaxutshwa nokwenza ukwelashwa ngeMerifatin uma kungasebenzi kahle isibindi.
Kuyaxutshwa nokwenza ukwelashwa ngeMerifatin uma kungasebenzi kahle isibindi.
I-overdose yeMerifatin
Uma usebenzisa kabi inani lemithi elinconyelwayo, kungavela i-overdose, kuboniswe ngesimo se-lactic acidosis. Bayeka ukuthatha lo muthi futhi babonane nochwepheshe obeka ukwelashwa okubonakalayo kanye ne-hemodialysis.
Ukuxhumana nezinye izidakamizwa
Kwenqatshelwe ukuhlanganisa i-metformin nezidakamizwa eziqukethe iodine i-radiopaque. Ngokuqapha, bathatha iMerifatin neDanazole, i-Chlorpromazine, i-glucocorticosteroids, ama-diuretics, ama-agonists angama-beta2 angama-adrenergic nama-antihypertgency agents, ngaphandle kwama-inhibitors we-agiotensin aguqula i-enzyme.
Ukwanda kokuhlushwa kwe-metformin egazini kuyabonakala ngesikhathi sokuxhumana nezidakamizwa ze-cationic, phakathi kwazo i-amiloride. Ukufakwa okwandayo kwe-metformin kwenzeka lapho kuhlanganiswa ne-nifedipine. Izindlela zokuvimbela inzalo ze-Hormonal zinciphisa umphumela we-hypoglycemic umuthi.
Ukuhambisana notshwala
Ngesikhathi sokwelashwa, kwenqatshelwe ukuphuza utshwala nemikhiqizo equkethe i-ethanol, ngenxa yengozi ephezulu ye-lactic acidosis.
Ama-Analog
Uma kunesidingo, sebenzisa izidakamizwa ezifanayo:
- I-Bagomet;
- I-Glycon;
- IGlucophage;
- ILangerine;
- ISiafor;
- IFomu.
Uchwepheshe ukhetha i-analogue, kucatshangelwa ukuthi lesi sifo siqatha kangakanani.
Imibandela yekhefu lekhemisi
Ukuthenga umuthi ekhemisi, uzodinga ukunikezwa umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Umuthi awunakuthengwa ngaphandle kokuthola incwadi kadokotela.
Intengo yeMerifatin
Izindleko zomuthi zincike kunqubomgomo yamanani ekhemisi nezilinganiso ezingama-169 ruble.
Izimo zokugcina zomuthi
Iphakheji enamathebhulethi ibekwa endaweni emnyama, eyomile futhi engafinyeleleki yezingane ezinamazinga okushisa angeqi ku-25 ° C.
Isikhathi sokuphelelwa yisikhathi
Umuthi ugcina izakhiwo zawo iminyaka emi-3 kusukela ngosuku lokwenziwa, ngokuya ngemithetho yokubeka. Ngemuva kosuku lokuphelelwa yisikhathi, umuthi ulahlwa.
Umkhiqizi
I-Pharmasintez-Tyumen LLC ibandakanyeka ekwenziweni kwezidakamizwa eRussia.
Ngesikhathi sokwelashwa, kwenqatshelwe ukuphuza utshwala.
Ukubuyekezwa kweMerifatin
UKonstantin, oneminyaka engama-31, u-Irkutsk: "Ngisebenzisa lesi sidakamizwa njalo. Kwakungekho miphumela emibi. Izindleko zamasudi. Ngincoma."
ULilia, oneminyaka engama-43 ubudala, eMoscow: "Ezinsukwini zokuqala zokwelashwa eMerifatin, kwenzeka isicanucanu nesiyezi. Ngaya kudokotela. Washintsha umthamo. Uzizwe engcono."
