I-cyprolet 250 mg iyisidakamizwa esisebenza ngempumelelo kakhulu se-antibacterial enezinhlobonhlobo zemiphumela yokuthambekela. Isetshenziselwa ukwelapha izifo eziningi ezithathelwanayo. Umuthi ungabekelwa iziguli ezinokuwohloka komzimba okunciphile.
I-ATX
Umuthi ufakwa eqenjini lama-antiinolin wesizukulwane sesibili. Ngokwe-ATX ngezigaba, inekhodi J01MA02.
I-Cyprolet 250 mg isidakamizwa esisebenza ngempumelelo kakhulu se-antibacterial.
Khipha amafomu nokwakheka
Umuthi uyathengiswa ngalezi zinhlobo ezilandelayo zomthamo:
- amaphilisi athambile emafilimu ama-250 noma ama-500 mg;
- Isixazululo sokuphathwa kwe-intravenous kwe-2 mg / ml;
- ophthalmic wehla 3 mg / ml.
I-cyprolet ngendlela yemijovo, ukumiswa, okokugcoba ayenziwa.
Izibhebhe ziyindilinga, i-biconvex, inogobolondo omhlophe, ophuzi ngesikhathi sekhefu. I-Ciprofloxacin hydrochloride yethulwe ekwakhiweni njengento esebenzayo. Ukugcwaliswa okusizayo kufaka i-microcrystalline cellulose, i-anhydrous colloidal silicon dioxide, isitashi, i-croscarmellose sodium, i-stearate ne-magnesium hydrosilicate. Ukuhlanganiswa kwe-enteric kuqukethe i-talc, polyethylene glycol, hypromellose, dimethicone, polysorbate 80, titanium dioxide (E171), ne-sorbic acid.
Kuhlanganiswe amaphilisi ayi-10. emaphepheni ama blister. I-1 blister ifakwe emaphepheni amakhadibhodi kanye nemiyalo yokuyisebenzisa.
Ezinye izinhlobo zomuthi ezilinganisweni ezingama-250 mg azitholakali.
I-Ciprofloxacin yinto esebenzayo ye-Ciprolet 250.
Isenzo se-Pharmacological
Umuthi ukhombisa izakhiwo zama-bactericidal. Njengomuthi osebenzayo, i-ciprofloxacin isetshenziswa - i-antibiotic ye-flurumquinolone ebanzi eminingi. Esitokisini segciwane, isebenza njenge-inhibitor ye-topoisomerase enzymes, lapho i-topology ye-DNA incike khona. Ngenxa yesenzo sayo:
- amaprotheni biosynthesis akhubazekile;
- Ukuphindaphinda kwe-DNA kuvinjelwe;
- Izinguquko zesakhiwo se-membrane;
- igobolondo langaphandle liyachithwa;
- ukukhula kweseli kuyama;
- ukuzalwa kwamagciwane kuba okungenakwenzeka;
- amagciwane amancane ayafa.
Ukusakazeka okusebenzayo kanye nama-bacterium angenayo ayathinteka umuthi. Azikho nhlobo izindlela eziphikelelayo ngemuva kokwelashwa, ngakho-ke ukutholwa kwama-antibiotic okutholwayo kukhiqizwa kancane.
ICyprolet iyaphumelela ekulweni nama-aerobes amaningi.
I-Ciprofloxacin iyasebenza ekulweni nama-aerobes amaningi, i-gram-positive, i-gram-negative, i-intracellular, i-β-lactamase ekhiqiza ubuthi:
- staphylococci;
- ezinye izingqinamba ze-streptococci;
- umkhuhlane wokunamathela;
- Amaprotheni
- ama-vibrioes;
- i-legionella;
- Klebsiella;
- i-enterobacteria;
- i-salmonella;
- I-Escherichia coli;
- izivumelwano;
- i-cytobacteria;
- i-brucella;
- Pseudomonas aeruginosa;
- UShigella
- chlamydia.
I-antibiotic ebi kakhulu ithinta i-anaerobes, ayikwazi ukubekezelela i-Stenotrophomonas maltophilia, Bacteroides fragilis, Burkholderia cepacia, treponema, myco- kanye ne-ureaplasma, i-pneumococcus, bacteroids, ama-pathogens we-pseudomembranous colitis ne-nocardiosis. Ngokuhamba kwesikhathi futhi kuya ngendawo, imizwa yamagciwane ingashintsha.
Ngemidiya ye-otitis, kukhonjiswa iCyprolet 250 mg.
I-Pharmacokinetics
Ukusuka emgodini wokugaya ukudla, umuthi udonswa emahoreni angama-1-2. Okuqukethwe kwe-plasma kwe-ciprofloxacin ngethamo lika-250 mg ngu-1,2 μg / ml. I-Bioavailability icishe ibe ngama-75%. Ukudla kwehlisa izinga lokufakwa emzimbeni wamathumbu amancane, kepha kungathinti ezinye izinkomba. Lapho kufakwa phezulu emzimbeni wesitho sokubona (Amaconsi), ukungena okubuthakathaka ukungena egazini kuyabonakala.
I-antibiotic isatshalaliswa kahle emzimbeni. Lidlula emgodini oyimbotshana, elixoshwe ubisi lwebele, linqunywa kuketshezi lwe-cerebrospinal ngisho noma kungekho ukuvuvukala kwendawo. Okuqukethwe kukho kwezicubu kukhulu izikhathi eziningi kunokugxila kwe-plasma. Ngevolumu ephumelelayo yokwelapha, ingena emaphashini, amachashazi omgogodla, amathe, isibindi, i-bile, isistimu ye-musculoskeletal, uketshezi oluhlanganyelwe, izitho zofuzo, amathambo, izinombolo.
I-Metabolization ayidluli i-30%, eyenziwa isibindi. Yonke imikhiqizo yokubola iyasebenza, kepha faka ukungena kwegazi ekujuleni okuphansi. Ukuhlanza umzimba kuthatha amahora angama-6 kuya kwayi-6. Ama-Metabolites ne-ciprofloxacin engashintshiwe idalulwa ikakhulukazi emchameni. Inani elincane likhishwa ngendle. Ngokuhlukumezeka kwe-renal, impilo yesigamu ngamahora ayi-12. Ubudala abuthinti i-pharmacokinetics.
Okusizayo
I-ejenti yemithi okukhulunywa ngayo isetshenziselwa ukuqeda ukutheleleka ngegciwane, kufaka phakathi okungacacisiwe. Izinkomba ezisetshenziswayo:
- Izifo ze-ENT - i-otitis media, i-mastoiditis, i-sinusitis, i-tonsillitis, i-pharyngitis, i-nasopharyngitis, i-tonsillitis.
- Izilonda zohlelo lokuphefumula - ukulimala komgogodla (ukubuyela emuva kanye nokuqina okungamahlalakhona), ukuqunjelwa kwamaphaphu kanye ne-empnema, i-pleurisy, i-pneumonia, ngaphandle kwesithukuthezi i-preumoniae yeStrecccus
- Izifo zokugaya ukudla - i-campylobacteriosis, ikholera, i-salmonellosis, i-shigellosis, i-typhoid, i -itisitis, i-colitis.
- Ukutheleleka kwezinso nezinqu zomchamo - i-cystitis, nephritis, isifo se-urethral.
- Ukutheleleka ngokobulili - i-oophoritis, ukuvuvukala kwesibindi, i-endometritis, i-adnexitis, chancre emnene, izilonda ze-chlamydial, i-gonorrhea.
- I-Peritonitis
- I-Anthrax (ukutheleleka nge-pulmonary).
- I-Sepicemia.
- Ukulimala emathanjeni, ukuhlangana kwabo, isikhumba nezicubu ezi-subcutaneous - i-osteomyelitis, i-carbuncle, i-furuncle, i-phlegmon, i-abscess, ukutheleleka kokulimala kwezilonda, isifo samathambo we-purulent, bursitis.
I-Ciprolet ingasetshenziswa njengengxenye yokwelashwa okuyinkimbinkimbi ye-antibacterial. Kwesinye isikhathi isetshenziselwa izinjongo zokuvimbela - ngokuhlinzwa, iziguli ezine-neutropenia, iziguli ezithatha imishanguzo ye-immunosuppression, kufaka phakathi ukuvikela ukukhula kwe-anthrax ne-meningitis.
ICyprolet 250 ayinqunyelwe ngesikhathi sokukhulelwa.
Contraindication
Umuthi awunqunyelwe uma kwenzeka:
- ukungabekezeleli ekwakhekeni;
- umlando wokungezwani komzimba kuma-fluoroquinolones;
- ukutholwa kwe-pseudomembranous colitis;
- ukukhulelwa
- ukuncelisa.
Kuphikisiwe kwiziguli ezingaphansi kweminyaka engu-18. Ukusetshenziswa kwaleli gciwane kuma-patatric kuvunyelwe kuphela ezinganeni ezinezinkinga ezithathelwanayo ze-cystic fibrosis noma, uma kunesidingo, ukwelashwa / i-prophylaxis ye-anthrax ye-pulmonary. Lapha umkhawulo wobudala wehliselwa eminyakeni emi-5.
Ngokunakekela
Ukuqapha kufanele kusetshenziswe ekuhlulekeni kwezinso okungamahlalakhona, i-myasthenia gravis enzima, ukulimala kwesibindi, ukuphazamiseka kwegazi okutholakele ebuchosheni, ukuthi kungenzeka ukuthi kuthathwe isifo sokuwa, ukuhlukunyezwa kwezifo zengqondo, nalapho unikeza umuthi iziguli esezikhulile.
I-Ciprolet 250 ichazwe ngokucophelela ngomonakalo wesibindi.
Ungayithatha kanjani iZiprolet 250
Umuthi ubekwa udokotela. Izibhebhe zihlanganiswe ne-membrane evikela i-mucosa esiswini emiphumeleni emibi ye-antibiotic, ngakho-ke akufanele ichotshozwe noma ihlafunwe. Umuthi womlomo uhambisana nesilinganiso esikhulu soketshezi. ICyprolet ayihambelani nemikhiqizo yobisi. Ukudla ukudla kuvimbela ukufakwa kwesithako esisebenzayo. Kulokhu, amaphilisi anconywe ukuba aphuzwe esiswini esingenalutho noma amahora amabili ngemuva kokuphela kokudla.
Imithamo inqunywa ngudokotela, kucatshangelwa ama-nuances ahlukahlukene. Isikhathi sokuncoma esiphakathi kwama-doses singamahora ayi-12. Ngokuphambuka okunzima emsebenzini wezinso, kuthathwa imithamo emincane, imvamisa yokwamukelwa iyancishiswa ibe yizi-1 ngosuku. Kwesinye isikhathi inkambo yokwelashwa kweziguli ezindala iqala ngokungeniswa kokufakwa kwe-ciprofloxacin.
Ngemuva kwalokho isiguli kufanele siphuze i-antibiotic ngomlomo.
I-infusion fluid ihambelana nezixazululo:
- i-sodium chloride 0,9%;
- i-dextrose 5% ne-10%;
- i-fructose 10%;
- Ringer's.
Amaphilisi we-250 mg angasetshenziswa ukwelapha izingane kusuka eminyakeni eyi-5 ukulwa noPseudomonas aeruginosa kanye neBacillus anthracis (ngaphansi kokuqashwa ngokuqinile kwezokwelapha).
ICyprolet 250 ingathathwa lapho kunoshukela.
Inkambo yokwelashwa ingahluka. Imvamisa kuyizinsuku ezingama-5-7, kepha kwesinye isikhathi kuthatha amasonto noma izinyanga ezimbalwa ukuqeda ukutheleleka. Amanye ama-pathogen anokucabanga okuphansi esenzweni somuthi, ngakho-ke kunikezwa izidakamizwa ezingezelelekile zama-antibacterial, ngokwesibonelo, ngezifo ze-streptococcal - beta-lactams.
Kungenzeka yini ukuthi uphuze umuthi onesifo sikashukela
Umuthi okukhulunywa ngawo ungathathwa phambi kwesifo sikashukela. Kodwa-ke, kufanele kukhunjulwe ukuthi kungavusa ukuthuthukiswa kwe-hypo- noma hyperglycemia.
Ukulawulwa kweshukela egazini kuyadingeka.
Imiphumela emibi
Umuthi ungadala ukusabela okuhlukile kusuka ezinhlelweni ezahlukahlukene. Zibukeka njalo, imiphumela ebuhlungu i-sporadic.
Amapheshana wesisu
Ukwehla kwesifiso sokudla noma ukungabikho kwayo, isifo sohudo, isicanucanu nokuhlanza, ubuhlungu besisu, ukulimala kwamathumbu, umsebenzi owengeziwe wama-enzyme wesibindi, i-hepatitis, i-jaundice ngenxa ye-cholestasis, i-hepatonecrosis.
Isicanucanu nezikhathi zokuhlanza kungumphumela we-Ciprolet 250.
Izitho zeHematopoietic
Ukucindezelwa komongo wethambo, ushintsho ekwakhekeni kwegazi kuze kufike kwi-pancytopenia.
Isistimu yezinzwa ephakathi
I-Vertigo, i-migraine, ukulahleka kwamandla, ukucindezelwa, ukukhathazeka, ukuzwela okukhulu, ukuphazamiseka kokuphendula komqondo, ukubona, ukuqwasha, amaphupho amabi, ukuhlukunyezwa komoya, ukulahlekelwa okuyingxenye komzimba, ukukhohliswa kokuqina, ukwethuka, ubuhlungu bemisipha kanye nokuhlangana, ukubukwa, ukuhlukunyezwa, ukuhlukunyezwa kanye nokuhlukumezeka.
Kusuka ohlelweni lomchamo
Ukwehla komchamo okwehlisiwe, ukuvela kokulandela kwamagazi nokufaka amakristali kasawoti kuwo, kanye nomonakalo wokuvuvukala kwezinso.
Kusuka ohlelweni lwezinhliziyo
Ukuxubha kwegazi ekhanda, umuzwa wokushisa, ukuphazamiseka kwesigqi senhliziyo, ukuncipha kwengcindezi yegazi, i-tachycardia ye-ventricular, ukunwetshwa kwezikhathi zokuphumula kwe-QT kuECG, ukukhuphuka kwezinga le-bilirubin, urea, noshukela wegazi.
Ngesikhathi sokulashwa nge-Ciprolet 250, ukuphuza utshwala kuyaphikiswa.
Allergies
I-ukulunywa, i-hyperemia, ukuqubuka, ukuvuvukala, umkhuhlane, ukucasulwa okucashile, isifo seStevens-Johnson, i-bronchospasm, ukusabela kwe-anaphylactoid.
Imiyalo ekhethekile
Ngemuva kokuqeda izimpawu zesifo, amaphilisi kufanele aphuzwe ezinye izinsuku ezingama-2-3.
Njengomphumela wokuthatha umuthi, i-pseudomembranous colitis ingahle ikhule, idinga ukwelashwa okuphuthumayo. Isifo sohudo esihlobene ne-antibiotic asikwazi ukuqedwa ngokucindezela ukuhamba kwamathumbu.
Uma kuvela izimpawu zokulimala kohlelo lwe-hepatobiliary (ubuhlungu besisu, i-jaundice, umchamo omnyama, ukulunywa), kufanele uyeke ukuthatha i-Ciprolet futhi ufune usizo lodokotela.
Kukhona ubungozi be-tendinopathy, ukuqhuma kwe-tendon kungenzeka. Ukuvelela kunganda.
Ngokuthambekela kokuquleka, isithuthwane, ukulimala kobuchopho, i-cerebrovascular atherossteosis, ukulimala kwe-skele futhi ngemuva kokushaywa unhlangothi, umuthi we-antibacterial usetshenziswa ngokuqapha.
Vumela ukuqokwa kweCyprolet 250 kusuka eminyakeni emi-5.
Ukuhambisana notshwala
Ngesikhathi sokulashwa, ukuphuza utshwala kuyaphikiswa.
Umthelela ekhonweni lokulawula izindlela
Ukuvela okungenzeka kusuka ohlelweni oluphambili lwezinzwa, kufaka phakathi isiyezi, ukufiphala, ukubona okumbaxambili, ukuhlangana okungahambi kahle, ukuthathwa kwemizwa. Lapho kuvela lezo zimpawu, ukusebenza ngezinqubo eziyinkimbinkimbi kwenqatshelwe.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukuphepha kwe-ciprofloxacin kosana akuzange kusungulwe, ngakho-ke, esigabeni sokukhulelwa, abesifazane ababekelwe umuthi. Uma kunesidingo sokuthatha i-antibiotic ngumama osenkulisa ngesikhathi sokwelashwa, ingane kufanele idluliselwe ekunikezeni ukudla okungelona iqiniso.
Ukuqokwa uCyprolet izingane ezingama-250
Ingxenye esebenzayo yesidakamizwa ingaqala ukuthuthukiswa kwe-arthropathy, ngakho-ke, kuze kube iminyaka engu-18, kuze kube lapho kwakhiwa izinhlaka ze-cartilage zamathambo, kuyinto engathandeki kakhulu ukusebenzisa i-antibiotic. Ingabekwa ezigulini ezisukela eminyakeni engu-5 ubudala ukucindezela umsebenzi wePseudomonas aeruginosa ku-cystic fibrosis nanjengo-arhente yokwelapha ne-prophylactic ye-anthrax (ukutheleleka kwamaphaphu).
I-analog yeCyprolet 250 yiCitral.
Ukweqisa
Lapho uthatha imithamo ephezulu, izimpawu ezithile aziveli. Izimpawu zobuthi, ikhanda, amakhwehlela, i-hematuria ziyabonakala, ukulahleka kwengqondo kungenzeka. Ngemuva kokuqhuma kwesisu, ukwelashwa okubonakalayo kwenziwa. Usebenzisa i-dialysis, akunakwenzeka ukususa ngaphezu kwe-10% ye-ciprofloxacin.
Ukuxhumana nezinye izidakamizwa
Ukuhlanganiswa kwe-ciprofloxacin nge-tizanidine akwamukeleki. Lokhu kungaholela ekwehleni okubukhali kwengcindezi, isiyezi nokufelwa. Umphumela wesidakamizwa ungathuthukiswa yi-Vancomycin, Clindamycin, Tetracycline, Metronidazole, penicillin ne-aminoglycoside antibiotic, Zinnat namanye ama-cephalosporins. Ebukhoneni bakhe, ukugxila kwe-plasma kwama-anticoagulants, ama-xanthines, ama-hypoglycemic kanye nemithi elwa nokuvuvukala engeyona eye-hormonal (ngaphandle kwe-Aspirin).
Ukufakwa kwe-ciprofloxacin kusuka emgodini wesisu kuthikamezwa ukusetshenziswa kwemithi equkethe i-aluminium, i-zinc, i-iron noma i-magnesium ions, futhi ukuphuma kwayo kuncishisiwe ukuphathwa kwe-Probenecid. Ukusetshenziswa kanyekanye kwalesi sidakamizwa okukhulunywa ngaso ngeCyclosporine kungadala ukwanda kokuhlungwa kwe-plasma creatinine.
UCyprolet 250 umuthi.
Analogs of Tsiprolet 250
Ukufana kwemithi yesidakamizwa:
- I-Ciprofloxacin;
- I-Tsiprova;
- I-Arflox;
- Athenoxime;
- ECypropane;
- ICitral
- I-Medociprine, njll.
Imibandela yekhefu lekhemisi
I-antibiotic ayenzelwe ukuthi ithengiswe mahhala.
Ngingakwazi ukuthenga ngaphandle kadokotela
Umuthi umuthi.
Intengo
Izindleko zamacwecwe ekuhlanganiseni kwe-enteric zivela kuma-ruble angama-56. ama-10 ama-PC.
Izimo zokugcina i-Tsiprolet 250
Ukushisa kwesitoreji - kuze kufike ku- + 25 ° С. Gwema umswakama ophakeme nokuvezwa ukukhanya kwelanga.
Isikhathi sokuphelelwa yisikhathi
Umuthi ungasetjenziswa engakapheli iminyaka emi-3 ukusuka ngelanga lokwenziwa ngawo. Imithi ephelelwe yisikhathi kumele ilahlwe.
Ukubuyekezwa kweTsiprolet 250
Umenzeli wemithi obhekelelwa uthola izibuyekezo ezinhle kakhulu. Izimpendulo ezingezinhle zihlotshaniswa nokulimazeka okungatheni kwe-pathogen noma ukungabekezelelani kabi esimweni esisodwa.
Odokotela
I-Zinovieva T. A., otolaryngologist, Saratov
I-antibiotic enamandla, ngivame ukuyisebenzisa mkhuba wami.
I-Tishchenko K.F., udokotela ojwayelekile, eMoscow
Umuthi omuhle we-antibacterial onhlobo olungelula lomthamo. Ngincoma ukuyithatha ngama-probiotic ukuze ulondoloze i-microflora yamathumbu.
Iziguli
U-Anna, oneminyaka engama-24, uRostov
Ngaphuza amaphilisi e-cystitis. Ngazizwa ngikhululekile ngokushesha. Angibonanga imiphumela emibi.
UTatyana, oneminyaka engama-56, u-Irkutsk
Ithuluzi elingabizi futhi elisebenzayo. Ngayiphuza ngamakhaza amakhulu, bese ngine-furunculosis. Kubekezelelwa kahle, ngokungafani nezinye izidakamizwa zokulwa namagciwane, futhi akubangeli ukugwazwa.
