I-Protafan NM Penfill ngumenzeli wezokwelapha isenzo sakhe sihlose ekwelapheni isifo sikashukela i-mellitus. Umuthi, uma usetshenziswa kahle, ukuvumela ukuthi unamathele ezingeni elidingakalayo le-glucose egazini, ngaphandle kokulimaza impilo yesiguli.
Igama Lezwe elingafanele
I-insulin yomuntu.
I-ATX
A.10.A.C - ama-insulin kanye nokufana kwawo ngobude besikhathi somsebenzi.
Khipha amafomu nokwakheka
Ukumiswa kokuphathwa kokufakelwa kwe-100 IU ml kuyatholakala ngohlobo lwe: ibhodlela (10 ml), i-cartridge (3 ml).
Ukuqanjwa kwe-1 ml yesidakamizwa kuqukethe:
- Izithako ezisebenzayo: insulin-isophan 100 IU (3.5 mg).
- Izakhi ezisizayo: i-glycerol (16 mg), i-zinc chloride (33 μg), phenol (0.65 mg), i-sodium hydrogen phosphate dihydrate (2.4 mg), protamine sulfate (0.35 mg), sodium hydroxide (0.4 mg ), i-metacresol (1.5 mg), amanzi wokujova (1 ml).
Ukumiswa kokuphathwa kokufakelwa kwe-100 IU ml kuyatholakala ngohlobo lwe: ibhodlela (10 ml), i-cartridge (3 ml).
Isenzo se-Pharmacological
Kubhekiselwa kuma-ejenti we-hypoglycemic anesikhathi esijwayelekile sesenzo. Ikhiqizwa ngobuchwepheshe be-DNA obuyisebenzisa kabusha iSaccharomyces cerevisiae. Isebenzisana nama-membrane receptors, akha i-insulin-receptor eyinkimbinkimbi ethuthukisa ukwakheka kwama-enzyme ahilelekile empilweni (hexokinases, synthetases ye-glycogen).
Umuthi uvuselela ukuthuthwa kwamaprotheni ngamangqamuzana omzimba. Njengomphumela, ukuthathwa kwe-glucose kuyathuthukiswa, i-lipo- ne-glycogeneis iyavuseleleka, futhi ukwenziwa kweglucose ngesibindi kuyancishiswa. Ngokwengeziwe, ukwakheka kwamaprotheni kuyasebenza.
I-Pharmacokinetics
Ukusebenza komuthi kanye nejubane lokuqothuka kwalo kunqunywa umthamo, indawo yomjovo, indlela yomjovo (wokuthambeka, wokubelethisa), okuqukethwe kwe-insulin emithini. Okuqukethwe okuphezulu okungenzeka kwezakhi egazini kufinyelelwa ngemuva kwamahora ama-3-16 emva kokujova ngokunqenqemeni.
Izinkomba zokusetshenziswa
Isifo sikashukela
I-Protafan NM Penfill ngumenzeli wezokwelapha isenzo sakhe sihlose ekwelapheni isifo sikashukela i-mellitus.
Contraindication
Nge-hypersensitivity ku-insulin yabantu noma izinto ezakha umuthi, i-hypoglycemia ayivunyelwe.
Ngokunakekela
Ngokucophelela ngokucophelela uma kungukuthi ukugcinwa kokudla okujwayelekile noma ukusebenza ngokweqile komzimba, njengoba i-hypoglycemia kungenzeka. Ukuqapha kuyadingeka futhi lapho ushintsha usuka kolunye uhlobo lwe-insulin uye kolunye.
Ungayithatha kanjani i-Protafan NM Penfill?
Yenza umjovo we-intramuscular or subcutaneous. Umthamo ukhethiwe kucatshangelwa imininingwane nezimpawu zesifo. Inani elivumelekile le-insulin liyahluka phakathi kuka-0.3-1 IU / kg / ngosuku.
Faka insulin usebenzisa ipeni lesirinji. Abantu abanokumelana ne-insulin bahlangabezana nesidingo esandayo se-insulin (ngesikhathi sokuthuthuka kwezocansi, isisindo somzimba esithe xaxa), ngakho-ke banikezwa umthamo omkhulu.
Ukuze unciphise ubungozi be-lipodystrophy, kuyadingeka ukuguqula indawo yokuphatha umuthi. Ukumiswa, ngokuya ngemiyalo, akuvunyelwe ngokuphelele ukungena ngaphakathi.
Ngoshukela
I-Protafan isetshenziselwa noma yiluphi uhlobo lwesifo sikashukela. Inkambo yokwelapha iqala ngohlobo 1 sikashukela. Umuthi 2 wohlobo 2 unqunyiwe uma kungekho mphumela ovela ku-sulfonylurea, ngesikhathi sokukhulelwa, phakathi nangemva kokuhlinzwa, kanye nama-pathologies ahambisana nomthelela ongemuhle enkambweni yesifo sikashukela.
Imiphumela emibi yeProtafan NI Penfill
Imicimbi engemihle ebonwa ezigulini ngesikhathi senkambo yokwelapha ibangelwa umlutha futhi ihlotshaniswa nesenzo sokhemisi somuthi. Phakathi kokunye ukusabela okubi njalo, i-hypoglycemia iyaphawulwa. Kubonakala njengesizathu sokungahambisani nedosi elinqunyiwe le-insulin.
Kwi-hypoglycemia enkudlwana, ukulahlekelwa ukwazi, ukuqaqanjelwa, umsebenzi wobuchopho obuthakathaka, futhi kwesinye isikhathi ukufa, kungenzeka. Kwezinye izimo, kukhona ukwephulwa kwe-carbohydrate metabolism.
Engxenyeni yamasosha omzimba ayenzeka: ukushesha, i-urticaria, ukujuluka, ukulunywa, ukuphefumula, isigqi senhliziyo, ukunciphisa umfutho wegazi, ukulahlekelwa ukwazi.
Engxenyeni yokusebenza kwamasosha omzimba, kungaba nemiphumela emibi: i-rash, urticaria, ukulunywa.
Uhlelo lwezinzwa nalo lusengozini. Ezimweni ezingavamile, i-peripheral neuropathy yenzeka.
Imiyalo ekhethekile
Umthamo okhethwe ngokungafanele noma ukuyeka ukwelashwa kubangela i-hyperglycemia. Izimpawu zokuqala ziqala ukuvela kungakapheli amahora noma izinsuku ezimbalwa. Uma usizo lunganikezwa ngesikhathi, ingozi yokwanda kwesifo sikashukela sikashukela, esithinta kabi impilo yomuntu, siyakhula.
Ngama-pathologies afanayo aboniswa ngumkhuhlane noma isifo esithathelwanayo, isidingo se-insulin ezigulini siyanda. Uma kunesidingo, shintsha umthamo ungalungiswa ngesikhathi somjovo wokuqala noma ngokwelashwa okuqhubekayo.
Sebenzisa ebudaleni
Iziguli ezineminyaka engu-65 ubudala azinayo imikhawulo yokuphuza umuthi. Njengoba sesifinyelele kulonyaka, iziguli kufanele zibe ngaphansi kokuqondisa udokotela futhi zibheke izinto ezihlobene nazo.
Kuchaza uProtafan NM Penfill ezinganeni
Ingasetshenziselwa izingane ezingaphansi kweminyaka engu-18. Umthamo usungulwa ngamunye ngokwesisekelo senhlolovo. Isikhathi esiningi sisetshenziswa kwifomu elihlanjululwe.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Kusetshenziswa ngesikhathi sokukhulelwa, njengoba ayiwelani kwi-placenta. Uma isifo sikashukela singalashwa ngesikhathi sokutholwa komzimba, ubungozi besiya e-fetus buyakhula.
I-hypoglycemia eyinkimbinkimbi yenzeka ngenkambo ekhethwe ngendlela engafanele, ekhulisa ubungozi bezimpawu enganeni futhi isisongele ngokufa kwe-intrauterine. Kwi-trimester yokuqala, isidingo se-insulin sincane, kanti ku-2 no-3 siyakhula. Ngemuva kokulethwa, isidingo se-insulin siyefana.
Umuthi awubi yingozi lapho uncelisa ibele. Kwezinye izimo, ukulungiswa ohlotsheni lomjovo noma ekudleni kuyadingeka.
Ukweqisa kweProtafan NI Penfill
Imishanguzo eholela ebhebdishini ayikhonjwa. Esigulini ngasinye, ngokubheka imininingwane yesifundo saleso sifo, kunomthamo omkhulu, oholela ekubonakala kwe-hyperglycemia. Njengoba kunesimo esincane se-hypoglycemia, isiguli singabhekana naso ngokwaso ngokudla ukudla okumnandi nokudla okuqukethe inani elikhulu lama-carbohydrate. Akukulimazi ukuhlala unamaswidi asezandleni, amakhukhi, amajusi wezithelo noma nje ucezu kashukela.
Ngefomu elinzima (ukungazi lutho), ikhambi le-glucose (40%) lifakwa emthanjeni, ongu-0.5-1 mg we-glucagon ngaphansi kwesikhumba noma izicubu zomzimba. Lapho umuntu elethwa, ukuze agweme ubungozi bokuphindelela, anika ukudla kwe-carb ephezulu.
Ukuxhumana nezinye izidakamizwa
Izidakamizwa ze-Hypoglycemic zandisa umphumela we-insulin. Ama-inhibitors we-monoamine oxidase, i-carbonic anhydrase ne-angiotensin-eguqula i-enzyme, i-Bromocriptine, i-Pyridoxine, i-Fenfluramine, i-Theophylline, nemithi equkethe i-ethanol, i-Cyclophosphamide ikhulisa ukusebenza kwe-insulin.
Ukusetshenziswa kwezindlela zokuvimbela inzalo ngomlomo, ama-hormone egilo, i-Heparin, iPhenytoin, iClinidine, i-Diazoxide, i-morphine ne-nicotine, i-glucocorticosteroids kuholela ekuthambiseni isidakamizwa. Ama-Reserpine nama-salicylates, iLanreotide ne-Octreotide ayakwazi ukuthuthukisa futhi anciphise imiphumela yezithako ezisebenzayo.
Ama-Beta-blockers afihla izimpawu zokuqala ze-hypoglycemia futhi akwenze nzima ukuqedwa kwawo.
Ukuhambisana notshwala
Utshwala bukhulisa futhi bandisa imiphumela yomuthi.
Ama-Analog
Faka izidakamizwa ezinomphumela ofanayo: I-Protamine-insulin eziphuthumayo, i-Gensulin N, i-Humulin NPH, i-Insuman Bazag GT.
Imibandela yekhefu lekhemisi
Ngokusebenzisa umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Cha.
Intengo
Izindleko zebhodlela lika-10 ml zingama-ruble angama-400-500, ikhareji kungama-ruble angama-800- 900.
Izimo zokugcina zomuthi
Umuthi kufanele ugcinwe endaweni epholile futhi emnyama emazingeni okushisa + 2 ... + 8 ° C (angabekwa esiqandisini, kepha hhayi efrijini). Akukhonjelwa ngaphansi kweqhwa. I-cartridge kufanele igcinwe emaphaketheni ayo ukuze ivikeleke elangeni.
I-cartridge evulekile igcinwa ku-30 ° C izinsuku ezingekho ngaphezulu kwezinsuku eziyi-7. Musa ukugcina esiqandisini. Vimbela ukufinyelela kwezingane.
Isikhathi sokuphelelwa yisikhathi
Iminyaka engu-2,5. Ngemuva kunconywe ukulahla.
Umkhiqizi
I-NOVO NordISK, A / S, eDenmark
Ukubuyekezwa
USvetlana, oneminyaka engama-32, uNizhny Novgorod: "Ngesikhathi ngikhulelwe ngangisebenzisa i-Levemir, kepha i-hypoglycemia yavela njalo. Udokotela owayekhona waya kuncoma ukushintshana ngemijovo yeProtafan NM Penfill. Isimo sizinzile, imiphumela emibi ayizange ibonwe kulo lonke ukhulelwe nangemva kwayo."
UKonstantin, oneminyaka engama-47, uVoronezh: "Ngibe nesifo sikashukela iminyaka eyi-10. Angikaze ngikwazi ukukhetha umuthi ofanele wokugcina ushukela wegazi ngaso sonke isikhathi. Ngazithengela imijovo yeProtafan NM Penfill ezinyangeni eziyisithupha kuphela ezedlule futhi ngijabule ngomphumela. ubunzima nezinkinga ezivelayo ngaphambili azenzi bazizwe. Intengo ishibhile. "
UValeria, oneminyaka engu-25 ubudala, eSt. Bengingathembi ukuthi isimo sizoguquka.
