UMUTHI WOKUGOMELA ISIFO SIKASHUKELA - INTUTHUKO YESAYENSI YAMANJE

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Uhlobo lwesifo sikashukela sohlobo 1 senzeka ngenxa yokubhujiswa kwamasosha omzimba we-beta cell pancreas, akhiqiza i-insulin, ehlisa ushukela wegazi. Uhlobo lokuqala lwesifo sikashukela lune-5% yenani lilonke leziguli ezinesifo sikashukela.

Isibalo seziguli ezinesifo sikashukela sohlobo loku-1 emhlabeni wonke cishe silinganiselwa ezigidini ezingama-30, futhi izinga lokufa kwabantu lonyaka kusuka kulolu hlobo lesifo linabantu abayi-150,000.

Ngabe umuthi wokugomela isifo sofuba uzoselapha isifo sikashukela?

Namuhla kunezindlela eziningi ezingabakhona zokubhekana nalolu hlobo lwesifo sikashukela, iningi lazo lisuselwa emgomeni wokucindezela amasosha omzimba abhubhisa amaseli we-insulin, noma ekwakheni kabusha umsebenzi wawo ukuze uhlelo "luwele" iseli le-beta.

Ngeshwa, lezi zindlela ziphethe inqwaba yemiphumela emibi nokutshalwa kwezimali okukhulu. Ngakho-ke, ososayensi kanye nezazi zezinto eziphilayo ezivela emhlabeni wonke abayeki ukufuna indlela ephumelelayo yokulwa nalokhu kugula, okuzoba nomphumela omuhle nemiphumela emibi emincane emzimbeni womuntu.

Ngakho-ke ososayensi be-American Diabetes Association benza ucwaningo ngenhloso yokuthola ukuthi umuthi wokugoma osetshenziswa ekwelashweni kwesifo sofuba uthinta kanjani uhlobo lwesifo sikashukela sokuqala.

Ukuhlolwa kocwaningo, obekuhanjwa ngabantu abayi-150 abanesifo sikashukela kusukela kwabaneminyaka eyi-18 kuye kwengama-60, kukhombisa ukuthi umuthi wokugomela isifo sofuba unomphumela omuhle wokwelapha.

Udokotela wezokwelapha waseMelika, uDenise Faustman, ukholelwa ukuthi umjovo wokulwa nesifo sofuba onikezwe abantu abanesifo sikashukela 1 ungakuqeda ukubhujiswa kwama-T cell, okubhubhisa amaseli athwala ama-antigen angaphandle. Ucwaningo luye lwabonisa ukuthi imijovo yokulwa nesifo sofuba, eqhutshwa njalo emavikini amabili, iyamisa ukufa kwamaseli abalulekile.

Maduze nje, kuhlelwe ukuthi kuqhubeke ucwaningo ngomjovo wokugomela i-TB kubantu abaningi abagulayo.

AmaNanoparticles - Abavikeli Beseli beBeta

Ngasikhathi sinye, izazi zesayensi yaseSpain ezivela e-Autonomous University of Barcelona zizama amagundane, zihlola umuthi awudalile, osuselwa kuma-nanoparticles anamafutha

AmaNanoparticles alingisa amangqamuzana e-pancreatic beta afa ngokuchayeka emasosheni omzimba, azithintithe bese asindisa amaseli we-beta.

Ososayensi bazamile ukudala izinhlayiya ezithi ekubunjweni nasosayizi wazo ngokunembe ngangokunokwenzeka ukuphindaphinda kwamaseli e-beta afa athinteka amasosha omzimba.

AmaNanoparticles - ama-liposomes, adalwe ngendlela yokwehla kwamanzi, embozwe ngegobolondo elincanyana elinamafutha futhi aqukethe ama-molecule wezidakamizwa, aba yinto ekuhlosiwe ngayo, ngenxa yalokho amaseli we-beta anempilo mancane kakhulu amathuba okubhujiswa amasosha omzimba, asebenzisa isikhathi sawo kumaseli we-beta wamanga.

Ngenxa yalolu cwaningo, ososayensi abasebenzisa i-liposomes bakwazile ukwelapha amagundane ocwaningo kusuka kuhlobo lwe-mellitus yesifo sikashukela sokuqala ngokuvikela amaseli we-beta womzimba futhi bawanikeze ithuba lokuzilungisa.

Ngemuva kokuthola umphumela omuhle womphumela wama-nanoparticles kumaseli womuntu othathwe kwishubhu yokuhlola, ososayensi bahlela ukwenza uchungechunge lwezifundo olususelwa ekuhlolweni kweziguli ezinesifo sikashukela esizobamba iqhaza ngokuzithandela ocwaningweni.

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