I-cholesterol engaphezulu kwe-plasma yisimo esiyingozi. Ukuba khona kwamazinga amaningi ale ngxenye emzimbeni kungenye yezinto eziphambili ekubonakala kokuphazamiseka kwentliziyo kanye ne-pathologies.
Ukuvimbela ukuthuthukiswa kwezinkinga ezinkulu kanye nokuphazamiseka kwe-pathological, ukuya kudokotela kunikeza iziguli ukuthatha izidakamizwa ezokwehlisa i-lipid.
Isenzo sezimali ezinje kuhloswe ngaso ukufezekisa ukwehla kwezinga le-cholesterol ku-plasma yegazi lesiguli.
Enye yezindlela zesimanje ezinomphumela wokunciphiswa kwe-lipid ngamathebulethi okwehlisa i-cholesterol Novostat.
Isenzo se-Pharmacological seNovostat
Amacwecwe eNovostat ayisidakamizwa se-hypolipidemic esingeqembu le-statins. Ukusetshenziswa kwaso kusiza ukunciphisa ukugxila kwe-plasma kwe-cholesterol ephelele ne-LDL. Ngaphezu kwalokho, ukwelashwa kweNovostat kunganciphisa inani le-apolipoprotein B ne-triglycerides.
Ukusetshenziswa kwomuthi kunomthelela ekwandeni okungazinzile kwenani lama-lipoprotein aphezulu.
Ngenxa yokwelashwa ngomuthi, umphumela omuhle ubonwa ezinqubweni zokubuyiselwa kwemisebenzi ye-epithelial lapho kukhona ukuphazamiseka kwawo.
Ukusetshenziswa komuthi ngesikhathi sokwelapha kuthuthukisa isimo sodonga lwe-vascular, kusiza ukuthuthukisa izinhlaka ezibekiwe zegazi. Umphumela womuthi emzimbeni unganciphisa amathuba okufa nokufa phambili kwesifo senhliziyo
Ngaphezu kwalokho, isidakamizwa sithe imiphumela ye-antioxidant kanye ne-antiproliferative.
Umphumela we-hypolipidemic wokusetshenziswa kwezidakamizwa uhlotshaniswa nokwehla kwe-cholesterol ephelele ngenxa yokwehla kwenani le-LDL.
Ukwehla kwamazinga aphansi we-lipoprotein kuncike kumthamo futhi kuboniswa hhayi ngoguquko olayini, kepha ngulowo odlulisayo.
Uhlobo lokukhululwa nokwakheka kwalo muthi
Umenzi unikeza iNovostat ezigulini ngendlela yamakhompiyutha aqinile we-opaque gelatin.
INovostat ingumuthi wokwenziwa.
Ingaphezulu lamathebhulethi limhlophe ngombala. I-capsule ngayinye ifakwe i-cap noma ophuzi we-beige cap.
Emaphaketheni, ngokuya ngokufakwa, ama-milligram angama-10, 20, 40 no-80 angaqukatha. Amaphilisi aqukethe okuqukethwe okuhambelana kwe-atorvastatin. Le ngxenye iyisakhi esisebenzayo esiyinhloko. Isithako esisebenzayo kumabhulukwe asesimweni se-atorvastatin calcium trihydrate.
I-capsule ngayinye futhi iqukethe uhla lonke lwamakhompiyutha adlala indima yokusiza.
Lezi zingxenye zingokulandelayo:
- i-lactose monohydrate;
- i-microcrystalline cellulose;
- i-sodium lauryl sulfate;
- i-povidone K-17;
- i-calcium carbonate;
- isitashi se-sodium carboxymethyl;
- i-magnesium stearate.
Ukwakheka kwekhompiyutha yesidakamizwa kunalezi zinto ezilandelayo:
- Udayi uphuzi we-iron oxide.
- I-titanium dioxide.
- IGelatin isisekelo sekhompiyutha.
Ingxenye esebenzayo inhibitor ekhethiwe yokuncintisana ye-3 hydroxy-3-methylglutaryl coenzyme A-reductases (HMG-CoA reductases. Le enzyme iyisici esibucayi esichungechungeni sokuphendula esiguqula i-3-hydroxy-3-methylglutaryl-CoA ukuba ibe yi-mevalonate, okuyisandulelo. iziqu.
Umuthi uthengiswa emaphaketheni; inani lemithi ephaketheni elilodwa lingaba ngamaphilisi ayi-10 kuye kwangama-300.
Izinkomba kanye ne-contraindication ukuze zisetshenziswe
Lapho uthengisa umuthi, iphakethe ngalinye liqukethe imiyalo enemininingwane yokusetshenziswa.
Ngaphambi kokusebenzisa i-Novostat, ukuvakasha okuphoqelekile kudokotela ohambelayo nokuthola izeluleko ngokuziphatha kwemiphumela yokwelapha emzimbeni usebenzisa leli thuluzi kuyadingeka.
Izinkomba zokusetshenziswa ngokuya ngemiyalo luhla lonke lwezimo ze-pathological zomzimba wesiguli.
Izinkomba eziphambili zingokulandelayo:
- i-hypercholesterolemia eyisisekelo ngokusho kukaFredrickson, uhlobo IIa;
- i-hyperlipidemia ehlangene;
- dysbetalipoproteinemia;
- i-endo native hypertriglyceridemia emelana nokudla kwe-hypocholisterin;
- i-homozygous hypercholesterolemia ngempumelelo ephansi yokwelashwa kokudla;
- ukuvimbela okuyinhloko kwezifo zenhliziyo nezemithambo ezigulini ngaphandle kokuba khona kwezimpawu zomtholampilo zesifo senhliziyo, kodwa ngokuba khona kwezinto eziyingozi ekuthuthukisweni kwayo;
- Ukuvimbela kwezifo kanye ne-pathologies yenhliziyo ne-vascular system ukuze kuncishiswe ukufa, ukunciphisa amathuba okuhlaselwa yisifo senhliziyo kanye nesifo sohlangothi.
Ngokuhambisana nemiyalo, umuthi unezinombolo eziningi ze-contraindication ukuze zisetshenziswe njenge-ejenti yokwelapha.
I-contraindication esemqoka yilena elandelayo:
- Ukuba khona kwe-hypersensitivity ezingxenyeni eziyinhloko noma ezisizayo zomuthi.
- Ukuba khona kwezifo zesibindi ezisebenzayo esigulini noma ukutholwa kwama-transaminases wesibindi we-plasma kumuntu.
- Iminyaka yesiguli ingaphansi kweminyaka eyi-18.
- Isikhathi sokukhulelwa nesikhathi sokuncelisa.
- Ukuba khona kokungabekezelelani kwe-lactose kubantu, ukuntuleka kwe-lactase kanye nokuba khona kwe-glucose-galactose malabsorption syndrome.
Ukuqapha okwandayo kumele kuqashelwe lapho kunikezwa imithi ezigulini ezisebenzisa kabi utshwala, iziguli ezinomlando wesifo sesibindi, kanye neziguli ezitholakele zinokuphazamiseka okukhulu ekulinganiselweni kwe-electrolyte, i-endocrine kanye nokuphazamiseka kwe-metabolic, kanye ne-arterial hypertension.
Ngaphezu kwalokho, akunconywa ukusebenzisa umuthi ngemuva kokungenelela okukhulu kokuhlinzwa futhi lapho kukhona ukulimala nezifo zemisipha yamathambo.
Imiyalo yokusebenzisa umuthi
Umuthi wenzelwe ukuphathwa ngomlomo. INovostat ivunyelwe ukuthathwa nganoma yisiphi isikhathi sosuku, noma ngabe ithini irekhodi lokudla.
Ngaphambi kokusebenzisa umuthi, kunconywa ukufeza ukulawulwa kweleveli ye-cholesterol ngokusebenzisa ukudla kokudla okune-cholesterol encane ezingxenyeni zokudla. Ngaphezu kwalokho, kuyanconywa ukuthi ngaphambi kwenkambo yokwelashwa ngezidakamizwa yenze ngokwejwayelekile izinga le-cholesterol emzimbeni ngokukhuphula umthwalo ngokomzimba futhi wehlise isisindo somzimba uma kunokungaphezulu kwalo.
Lapho unquma umuthi, amaphilisi kufanele aphuzwe kanyekanye ngokudla kwe-hypocholesterol. Isiguli kufanele sinamathele ekudleni ngaphandle kwe-cholesterol kuyo yonke inkambo yokwelashwa.
Umthamo weNovostat unga, kuye ngesidingo, ungahluka kusuka ku-10 kuye ku-80 mg kanye ngosuku. Umthamo we-ejenti esetshenziswayo ukhethwa udokotela ohambela yedwa, kucatshangelwa imiphumela yokuhlolwa kanye nezimpawu zomzimba womuntu ogulayo.
Umthamo omkhulu ovunyelwe ukusetshenziswa ngu-80 mg ngosuku.
Esigabeni sokuqala sokwelashwa noma ngokwanda komthamo, amazinga we-cholesterol we-plasma kufanele aqashelwe njalo emavikini angama-2 kuya ku-2. Uma kunesidingo, ngokuya ngemiphumela yokulawula, kwenziwa ukulungiswa komthamo komuthi owenziwayo.
Ukwephulwa kokusebenza kwezinso akuthinti inani lezinto ezisebenzayo kwiplasma yegazi, ngakho-ke, phambi kwama-pathologies anjalo, ukulungiswa komthamo akudingeki.
Lapho usebenzisa umuthi kubantu asebekhulile, ukulungiswa kwamthamo akudingekile kucatshangwe iminyaka yobudala yeziguli.
Endabeni yokwelashwa ngasikhathi sinye neNovostat neCyclosporine, umthamo wokuqala kufanele ungabi ngaphezu kwe-10 mg ngosuku.
Ukuqapha ikakhulukazi kuyadingeka lapho usebenzisa umuthi kanyekanye nama-HIV proteinase inhibitors nama-hepatitis C inhibitors.
Imiphumela emibi ngesikhathi sokwelashwa neNovostat
Yonke imiphumela emibi eyenzeka lapho usebenzisa umuthi ingahlukaniswa ngamaqembu alandelayo - kaningi, kaningi, kaningi, kanqabile, akuvamile futhi ukuthi ikhule kakhulu.
Imiphumela emibi ingathinta isistimu yegazi, izivikeli mzimba, izinzwa, ukuphefumula, ukugaya, izicubu zomzimba, izinhlelo zokuzala.
Ngaphezu kwalokho, imiphumela emibi ingathinta izitho zokuzwa nezitho zombono.
Imvamisa, imiphumela emibi elandelayo yokuphuza umuthi ithuthukisa:
- Uhlelo lwegazi luyi-thrombocytopenia.
- Amasosha omzimba - ukungezwani komzimba, ukushaqeka kwe-anaphylactic.
- Kusukela ohlangothini lwesistimu yezinzwa - ikhanda, isiyezi, i-paresthesia, i-hypesthesia, i-amnesia, imizwa yokunambitheka engafanele, ukuqwasha, i-peropheral neuropathy, imibuso ecindezelayo.
- Engxenyeni yezitho zombono - ukwehla komqondo obonakalayo nokuqonda okungaboni.
- Izitho zokuzwa - i-tinnitus futhi, ezimweni ezingandile, ukulahleka kokuzwa.
- Ukusuka ohlelweni lokuphefumula - i-nasopharyngitis, i-nosebleeds, izinhlungu ku-larynx.
- Ukusuka ohlelweni lokugaya ukudla - umuzwa wokucanuzelelwa kwenhliziyo, ukuthamba ngokweqile, ukuqunjelwa kaningi, idyspepsia, isifo sohudo, ukugoqa, ukunxusa ukuhlanza, izinhlungu esiswini, i-pancreatitis eyingozi.
- Engxenyeni yesibindi, ukuthuthukiswa kwe-hepatitis, cholestasis, ukwehluleka kwesibindi, i-cholestatic jaundice.
- I-Integument - i-alopecia, ukuqubuka kwesikhumba, ukulunywa kwesikhumba, i-urticaria, i-erythema multiforme, i-necrolysis enobuthi.
- Ukusuka ohlelweni lwe-musculoskeletal - i-myalgia, i-atralgia, izinhlungu emilenzeni, ukuqina kwemisipha, izinhlungu emhlane, izinhlungu emsipha, nobuthakathaka bemisipha.
- Uhlelo lokuzala - gynecomastia, ukungabi namandla.
Isidakamizwa esiqondile esiphikisana ne-Novostat overdose asaziwa. Uma kwenzeka lokhu kwenzeka, ukwelashwa okubonakalayo kuyenziwa. I-Hemodialysis ayisebenzi ngenxa yokwakheka kwama-protein phakathi kwe-protein plasma protein ne-atorvastatin.
Analogs nokubuyekezwa mayelana nomuthi
INovostat iyadingeka ukuthi igcinwe kumazinga okushisa angaphezulu kwama-25 degrees ngaphezulu kwe-zero. Indawo yokugcina kufanele ibe yomile futhi ibe mnyama. Futhi, indawo yokubeka akufanele ifinyeleleke ezinganeni nasezilwaneni ezifuywayo.
Impilo yeshalofu yesidakamizwa iyiminyaka emithathu. Ngemuva kwalesi sikhathi, amaphilisi kufanele alahlwe.
Izindleko zalo muthi e-Russian Federation okwamanje zingahluka futhi kuya ngesifunda esithengiswayo kanye nenkampani eqhuba ukuthengiswa, kanye nenani lamaphilisi amaphakethe.
Ngokwesilinganiso, intengo yesidakamizwa isukela kuma-ruble angama-300 kuye kwangama-600.
Ama-analoggs eNovostat emakethe yemithi yilena:
- Atorvastatin;
- Atoris;
- Torvas
- I-Liprimar;
- I-Vazator;
- Tulip;
- I-Anvistat;
- Lipitor;
- I-Ator.
Ukubuyekezwa kweziguli mayelana nomuthi kuxubene, okungenzeka kubangelwa inani elikhulu lemiphumela emibi evela ekusetshenzisweni komuthi kanye nezimpawu zezinto zeziguli ezihlushwa i-cholesterol ephezulu emzimbeni.
Kepha kufanele kwaziwe ukuthi izifundo zemitholampilo ziqinisekisa ukusebenza kahle kwezidakamizwa ekulweni ne-cholesterol ephezulu emzimbeni.
Ukuthi wehlise kanjani i-cholesterol echazwe kule vidiyo kulesi sihloko.
