I-Actrapid NM Penfill yisidakamizwa esingavinjelwa esinomphumela we-hypoglycemic ekwelapheni isifo sikashukela i-mellitus sohlobo lokuya nge-insulin.
Igama Lezwe elingafanele
Insulin womuntu.
Igama lomhlaba jikelele elingewona ophathi wezidakamizwa i-Actrapid NM Penfill ngumuntu we-Insulin.
I-ATX
I-A10AB01 - insulin esebenza ngokufushane.
Khipha amafomu nokwakheka
Isixazululo sokufaka, kucacile, akukho umbala. Into eyinhloko: i-insulin yokuqunjelwa umuntu ngofuzo I-100 IU iqukethe u-3.5 mg, i-1 IU iqukethe i-insulin eyi-0.035 i-insulin. Izithako ezingeziwe: i-sodium hydroxide (2,5 mg), amanzi wokujova (1 mg), i-hydrochloric acid (1.7 mg), i-zinc chloride (5 mg), glycerin (16 mg), metacresol (3 mg).
Isenzo se-Pharmacological
Isakhi esisebenzayo singena ngaphakathi kwamaseli emalungeni awo, sisebenzisana nama-membrane receptors, sisebenzisa i-phosphorylation yamaprotheni eseli.
Ukuxhumana ne-receptor ethize ye-plasma membranes kusheshisa ukungena kwe-glucose kumaseli, kuthuthukise ukufakwa kwayo kwizicubu ezithambile zomzimba, kanye nokuwohloka okusheshayo ku-glycogen. Umuthi ukhulisa ukuqina kwe-glycogen ebambezelekile emithanjeni yemisipha, ivuselela inqubo ye-peptide synthesis.
I-Pharmacokinetics
Izinga lokumunca lincike ekutheni umuthi wawuphathwa kanjani (intramuscularly noma intravenously), nendawo yokujova - emsipha wethanga, isisu noma amabhuzu.
Umphumela wokuqala wokulawulwa kwezidakamizwa wenzeka engxenyeni yehora, ngemuva kobukhulu bamahora angama-1-3. Isikhathi somphumela wokwelapha amahora angama-8.
Umphumela wokuqala wokuphathwa kwe-Actrapid NM Penfill wenzeka engxenyeni yehora, ubuningi bamahora angama-1-3.
Izinkomba zokusetshenziswa
Isetshenziselwa ukwelapha i-Type I bese uthayipha i-II mellitus. Ezinye izinkomba:
- ukumelana nomzimba kwezinye izidakamizwa ze-hypoglycemic spectrum yesenzo;
- ukukhulelwa
- isikhathi sokuhlunyeleliswa ngemuva kokuhlinzwa.
Ekwelashweni okuhlanganisiwe, kuyasetshenziswa uma isiguli simelana ngokwengxenye nezinye izidakamizwa kuleli qembu.
Contraindication
Umyalo ukhombisa imikhawulo enjalo ekusetshenzisweni kwe-Actrapid NM Penfill:
- i-hypoglycemia;
- insulinoma.
Kwenqatshelwe ukusebenzisa umuthi uma isiguli sinomkhuba wokuphendula okwenziwa yi-insulin.
Ngokunakekela
Ngokulungiswa kwamthamo ngamunye nokuqapha njalo impilo, kunikezwa iziguli ezinezifo zesibindi nezinso, ukuphazamiseka kwesimo se-pituitary, adrenal gland kanye ne-yegilo yegilo.
Ungayithatha kanjani i-Actrapid NM Penfill
Esigulini ngasinye, udinga ukukhetha umthamo wakho we-insulin. Uma ukuphathwa komuthi okuphathelene nomuthi kuyadingeka, udokotela onguchwepheshe kuphela ongafaka umjovo. Isilinganiso esiphakanyiselwe umthamo ngosuku ngu-0.3-1 IU nge-1 kg yesisindo sesiguli. Ukunyuswa komthamo kuvunyelwe kubantu abatholakala ukuthi banokuphikiswa okukhulu kwe-insulin, ngokwesibonelo, intsha noma abantu abanesisindo ngokweqile (ukukhuluphala ngokweqile).
Ukuze wenze umjovo, kufanele ufake i-insulin cartridge kwipeni ekhethekile yesirinji. Ngemuva kokufaka, shiya inaliti ngaphansi kwesikhumba imizuzwana engama-5-6, cindezela ipiston ye-pen-syringe yonke indlela; lokhu kuqinisekisa ukuphathwa ngokuphelele komuthi.
Ukuze usebenzise ama-cartridge we-Actrapid, kusetshenziswa kuphela i-Innovo, NovoPen 3 ne-NovoPen 3 Demi syringes. Uma i-cartridge ese-syncinge ye-insulin ifakwe kahle, kuzovela umucu wombala wokulawula epeni lesirinji.
Ukwethulwa komjovo we-insulin embhedeni we-venous ngqo kusuka kuma-cartridges kuvunyelwe kuphela ezimweni ezikhethekile. Isixazululo siqoqwa esibayeni se-insulin, esilawulwa ngezikhwama zokufakwa.
Umuthi uphathwa uhhafu wehora ngaphambi kokudla main. Inani lemijovo liyi-3 ngosuku. Ezimweni ezinzima kakhulu zemitholampilo, kuvunyelwe ukuguqula irejimeni yemithamo kuze kube ka-5 no-6 ngosuku.
Ama-cartridge we-Actrapid asetshenziswa kuphela ngamapeni we-Innovo, NovoPen 3 neNovoPen 3 Demi syringe.
Ngoshukela
Isidingo se-insulin yomzimba sisuka ku-0,3 siye ku-1 IU nge-1 kg yesisindo somzimba ngosuku, ihlukaniswe ngemithamo emithathu, ngokushintshwa okungapheli kwendawo yomjovo.
Imiphumela emibi ye-Actrapid NM Penfill
Izimpawu ezimbi zibangelwa ukwephulwa kwe-carbohydrate metabolism ngokuthuthukiswa kwe-hypoglycemia eyingozi futhi ibonakaliswa ku:
- indlala yesikhumba;
- ukujuluka ngokweqile;
- ukuphazamiseka kokulala, ukuqwasha;
- Ukuzamazama komhlaba ophezulu nangaphansi;
- ukuzindla kwenhliziyo.
Ukusabela komzimba ngendlela yokuqhuma kwesikhumba akuvamile ukubonwa.
Umthelela ekhonweni lokulawula izindlela
Imijovo yokumbalwa yokuqala ye-insulin ingadala ukonakala kwesikhashana kokubuka, ukuqina, kanye nokwehla kokuxineka. Kunconywa ukuthi uyeke ukushayela futhi usebenzele nezinqubo eziyinkimbinkimbi ngezizathu zokuphepha.
Imiyalo ekhethekile
Umuthi usetshenziswa ekwelapheni kanye nezinye izidakamizwa eziqukethe i-insulin, kodwa ngemvume yodokotela kuphela. Iziguli ezithola umthamo wansuku zonke we-insulin amayunithi ayi-100, lapho zishintshela kwesinye isidakamizwa kufanele zibe ngaphansi kokuqashwa njalo kodokotela esibhedlela.
Njengoba lokhu kuyi-insulin esebenza ngokufushane, ukusetshenziswa kwayo kuvunyelwe kanye namanye amalungiselelo e-insulin asebenza isikhathi eside. Isingeniso senziwa ikakhulu ngezicubu ezingaphansi odongeni lwesisu. Isinqe noma ihlombe kungenzeka sisetshenziselwe ukuphatha uma lokhu kungadali ubunzima esigulini. Ukwethulwa odongeni lwesisu kunikeza inqubo esheshayo yokufakwa kwe-insulin ukwedlula nokwazisa umuthi kwezinye izindawo.
Indawo efanelekile yomzimba womjovo ozimele yisibaya sesikhumba esidinga ukudonswa kahle emuva. Lokhu kuvimbela ubungozi bokungena ngephutha kwenaliti emunweni.
Ukulungiswa komthamo komuntu ngamunye kungadingeka lapho isiguli sishintshe isilinganiso sokuzivocavoca ngokomzimba noma ukondla. Qiniseka ukuthi ushintsha umthamo we-insulin ngokufakwa kwezinye izidakamizwa ekwelashweni okuyinkimbinkimbi.
Sebenzisa ebudaleni
Uma kungabikho ukuhluleka kwenhliziyo okungapheli nezinye izifo, ukulungiswa komthamo we-insulin akudingekile.
Isabelo sezingane
Akukho mibango yobudala yokusetshenziswa kwe-Actrapid NM Penfill.
Akukho mibango yobudala yokusetshenziswa kwe-Actrapid NM Penfill.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Inani lezidakamizwa ngosuku lonke lokukhulelwa lihlala lilungiswa (njengoba ingane ikhula futhi umzimba wesifazane udinga i-insulin ethe xaxa). Isakhi esiyinhloko nabatholi ekwakhekeni komuthi awudlulisi isithiyo esivikela i-placenta. Umuthi uthathwa ngowesifazane ngenkathi uncelisa ibele ngaphandle kobungozi enganeni.
Isicelo sokusebenza kokulimala kwezinso
Sebenzisa ngokucophelela, ngokuqapha njalo isimo nokusebenza kwesitho.
Sebenzisa umsebenzi wesibindi okhubazekile
Ukunquma inani lemithi ephephile, kuhlolwa isimo nokusebenza kwesitho kwenziwa.
Ukweqiwa kwe-Actrapid NM Penfill
Umthamo owodwa we-muverestimated womuthi ungakhuba ukonakala ngokushesha kwesimo ngokuthuthukiswa kwe-hypoglycemia. Izimpawu ze-overdose: umuzwa onamandla wendlala, umuzwa wokuphamba, wokukhipha izithukuthuku ezibandayo, isikhumba sesikhumba, ukuvusa imizwelo. Imithamo eminingi ingadala isicanucanu nokuhlanza, ikhanda elibuhlungu.
Isigaba esinzima se-hypoglycemia sivusa izinguquko zesikhashana noma ezingenakuphikwa ekusebenzeni kwengqondo, zidinga ukulaliswa esibhedlela ngokushesha ngenxa yezingozi ezinkulu zokufa. Ukwelashwa ngokweqile: uma umuntu ekwazi, uvunyelwe ukudla ushukela ukuze enze ngokwejwayelekile i-glucose egazini. Ezigulini ezingakwazi ukudla ushukela ocolisisiwe, kuphakanyiswa isixazululo soshukela ukuze kubuyiswe ukuqoqwa koshukela egazini.
Ukuxhumana nezinye izidakamizwa
Isenzo se-insulin sikhuphuka ngaphansi kwethonya le-inhibitors ye-MAO, ama-anabolic steroid, ama-antibhicophic aqhamuka eqenjini le-tetracycline, izidakamizwa eziqukethe i-ethanol, sulfonamides nabangakhethi-beta-blockers.
Ukusebenza kokulapha kwe-insulin kuyancipha ngenkathi kuyithatha ngezindlela zokuvimbela inzalo zomlomo, ama-hormone egilo, izidakamizwa eziqukethe i-lithium.
Ushintsho kumphumela we-hypoglycemic wesidakamizwa (kokubili phezulu naphansi) ubonwa ngokusetshenziswa kanyekanye ngama-salicylates ne-reserpine.
Ukuhambisana notshwala
Iziphuzo zotshwala zenqatshelwe ngokuphelele.
Ama-Analog
Ukulungiselela okunokubona okufanayo kwesenzo: IGensulin, Insulin Asset, Insuman Rapid, Farmasulin N, Humodar R, Humulin Regular.
Imibandela yekhefu lekhemisi
Ukuthengiswa kwencwadi kadokotela
Ngingakwazi ukuthenga ngaphandle kadokotela?
Akunakwenzeka.
Intengo
Izindleko kusuka ku-830 rub.
Izimo zokugcina zomuthi
Gcina ama-cartridge esiqandisini ebangeni lokushisa lika + 2 ... + 8 ° С. Ukuqandisa umuthi akuvunyelwe. I-cartridge esetshenziswayo ayinconywa ukuba igcinwe esiqandisini.
Isikhathi sokuphelelwa yisikhathi
Iminyaka engu-2,5. Ukusetshenziswa kwe-insulin ngokuzayo akuvunyelwe.
Umkhiqizi
UNovo Nordisk A / S.
UNovo Alle, DK-2880, Bugswerd, eDenmark.
Ihhovisi Lommeleli Novo Nordisk A / S., eMoscow, eRussia.
Udinga ukugcina ama-cartridge we-Actrapid NM Penfill esiqandisini emazingeni okushisa we- + 2 ... + 8 ° С.
Ukubuyekezwa
UKarina, oneminyaka engama-42, uMurmansk: "Sekuphele iminyaka ngiphila nesifo sikashukela. Sengizame izidakamizwa eziningi kusukela kwatholakala lesi sifo, kepha kuze kube manje sengikhethe i-Actrapide NM Penfill. Ithuluzi elihle elisiza ukuguqula ushukela ngemizuzu, okubaluleke kakhulu lapho isimo siba sibucayi. Akubangeli zimpawu eziseceleni, kufanelekile ukusebenzisa i-cartridge. "
U-Olga, oneminyaka engama-38, uRyazan: "Umama unesifo sikashukela esinolwazi oluningi. Ngenkathi udokotela ebeka lo muthi, kwafakwa ama-insulin amaningi, futhi konke ngandlela-thile kwakungalungeki kahle. Kwakungekho sinyathelo esidingekayo kusuka emijovo, lapho-ke bekukhona izimpawu eziningi eziseceleni. Ukuhlaselwa U-Actrapida NM Penfill uphumelele kakhulu umama wami, akukho ukusabela okungekuhle, kusebenza ngokushesha, intengo efanelekile nokukhululeka kokuphatha. "
U-Andrei, oneminyaka engama-45, uMariupol: "Sekuphele iminyaka emibili ngisebenzisa lesi sidakamizwa. Akukho ukusabela okungathandeki, kusebenza ngokushesha. Odokotela bayamdumisa ngoba yi-insulin yabantu futhi ayisiye isilwane, njengakwezinye izidakamizwa eziningi. Intengo eyamukelekayo inkulu kakhulu. usayizi wama-ampoules, yingakho kungewona wonke amapeni wesirinji angalungelanga, okungenzeka kungabi lula kakhulu kwezinye izindawo. Noma kunjalo, le insulin iyangifanela. "
