U-Augmentin ungowezidakamizwa ezilwa ne-antibacterial zochungechunge lwe-penicillin. Kuyi-beta-lactamase inhibitor. Kutholakala ngezindlela eziningi, kufaka phakathi ukuphathwa ngomlomo. Umgomo wesidakamizwa usekelwe emandleni wokungena ezingxenyeni zamaseli zezinto eziphilayo ezingama-pathogenic futhi uthinte izinga le-protein biosynthesis.
I-ATX
J01CR02.
U-Augmentin ungowezidakamizwa ezilwa ne-antibacterial zochungechunge lwe-penicillin. Kuyi-beta-lactamase inhibitor.
Khipha amafomu nokwakheka
Umuthi uthengiswa ngohlobo lwamathebulethi, i-powder yokulungiselela isiraphu ne-lyophilized powder, lapho kulungiswa khona isixazululo somjovo. Ekubunjweni kwanoma yiliphi uhlobo lomthamo, izingxenye ezi-2 eziphambili ziyi-clavulanic acid ne-amoxicillin trihydrate. Ukuqoqwa kwengxenye esebenzayo kuncike kwifomu lokukhululwa.
U-Augmentin 125 wethulwa ngendlela yethebhulethi. Ukuqanjwa kwefomu lomthamo kuqukethe ama-500 noma ama-875 mg we-amooticillin trihydrate kanye ne-125 mg ye-potassium clavulanate. Umenzi uhlinzeka ngezingxenye ezengeziwe ezandisa i-bioavailability yomuthi:
- usawoti we-magnesium we-stearic acid;
- isodium carboxymethyl cellulose;
- i-polysorb;
- E460.
Ithebhulethi ngayinye ihlanganiswe nefilimu-igobolondo, eliqukethe:
- I-E171;
- hydroxypropyl methylcellulose;
- i-macrogol;
- uwoyela abicah.
Ukufakwa kwamaselula okwenziwe nge-polyethylene futhi okuhlanganiswe ngengqimba ye-foil e-lamised ephethe amaphilisi angaba ngu-7-16. Emabhokisini amakhadibhodi - 1 blister nge-silica gel (1 isachet). I-abstract ifakwe ngaphakathi, ukumaka kukhona ngemuva kwephakeji. Izimbotshana zokulungiselela ama-syrups kanye nokumiswa kokuphathwa kwe-intravenous and intramuscular kuyathengiswa emabhodleleni engilazi. Isiraphu inokunambitheka okumnandi nephunga ngenxa yobukhona bokunambitheka kwezithelo (i-orange).
Umuthi uthengiswa ngohlobo lwempuphu yokulungiselela isiraphu.
Isenzo se-Pharmacological
I-antibiotic elikwiqembu le-penicillin liqukethe izinto ezi-2 - i-clavulanic acid ne-amoxicillin. Lesi sakamuva siyi-semi-synthetic antimicrobial esebenzayo ngokulwa nabameli abathile be-pathogenic. I-Clavulan iyi-b-lactamase inhibitor ekhethiwe evikela ama-enzyme amaningi angamagciwane.
Ukuba khona kwe-clavulan kunwebeka ukubukeka kwesenzo somuthi olwa ne-antibacterial. Kuyasiza ukuvikela ukubhujiswa kwe-amoxicillin ngama-enzyme angamagciwane. Umuthi usebenza ngokulwa namagciwane amancane amaningi. Ingxenye engabalulekile yama-pathogenic agents ine -okwemvelo noma ithole ukumelana kwezinto ezisebenzayo zomuthi.
I-Amoxicillin ehlanganiswe ne-b-lactamase inhibitor isebenza ngokulwa ne-gram-negative, i-gram-positive, i-anaerobic namanye ama-bacteria.
Ama -organices wegram-positive:
- I-Staphylococcus spp .;
- Bacillus anthracis;
- I-Staphylococcus saprophyticus;
- I-Enterococcus faecalis;
- Staphylococcus aureus;
- Listeria monocytogene;
- I-Streptococcus spp .;
- I-Nocardia asteroides;
- I-streptococcus agalactiae;
- IStreptococcus pyogene.
Amagciwane angakhi gram:
- Vibrio cholerae;
- Bordetella pertussis;
- Pasteurella multocida;
- I-Haemophilus influenzae;
- Moraxella catarrhalis;
- Helicobacter pylori;
- Neisseria gonorrhoeae.
Amagciwane we-anaerobic gram-positive:
- I-Peptostreptococcus spp .;
- I-Clostridium spp .;
- I-Peptostreptococcus micros;
- Peptococcus niger;
- I-Peptostreptococcus magnus.
Amagciwane angenayo i-Anaerobic gram-negative:
- I-prevotella spp .;
- Ama-bacteriides fragilis;
- Porphyromonas spp .;
- Ama-bacteriides spp .;
- I-Fusobacterium spp .;
- ICapnocytophaga spp .;
- I-Fusobacterium nucleatum;
- Eikenella corrodens.
Ezinye izinto ezincane ezibucayi ezingxenyeni ezisebenzayo ze-antibiotic zifaka iTreponema pallidum, Borrelia burgdorferi kanye neLeptospira icterohaemorrhagiae. Ukumelana kwemvelo kubonwa eCitrobacter freundii, Hafnia alvei, Yersinia enterocolitica, Chlamydia psittaci naseMycoplasma spp.
Ukumelana Klebsiella oxytoca, Klebsiella spp., Proteus vulgaris, Salmonella spp., Corynebacterium spp., Streptococcus pneumoniae neShigella spp. kubhekwa njengokutholakele.
Ngokuphikisana nesizinda sokusetshenziswa isikhathi eside kwanoma yiluphi uhlobo lokukhishwa kwezidakamizwa, ubungozi bokuncika kwezidakamizwa luyanda.
I-Pharmacokinetics
Ifomu lomlomo ligxishwe ngokuphelele kusuka emgudwini wesisu. Izinga lokumunca ngokuqondile lincike ebukhoneni bokudla esiswini. Ukuhlungwa kwe-plasma okuphezulu kufinyelelwa ngemuva kwamahora angu-1-1.5 ngemuva kokuthatha amaphilisi. Ukusatshalaliswa kuyafana, ngokugxila okuncane kutholakala kwezicubu ezithambile, izicubu namathambo, uketshezi (peritoneal, synovial), izicubu ze-adipose ne-bile.
Ibopha ngamaprotheni egazi ngezinga elincane. Akuhlanganisiwe. Ihlula umgoqo we-placental, itholakala ubisi lwebele. Ehlelweni lokuguqulwa kwezinto eziphilayo, kwenziwa i-penicillic acid (i-metabolite engasebenzi) esibindini. Umuthi ukhishwa ngezindlela ezi-3:
- kanye nomchamo (izinso);
- kanye nezindunduma (amathumbu);
- kanye nomoya okhipha umoya (isikhutha).
Isikhathi sokuqeda amahora angama-3-5.
Izinkomba zokusetshenziswa
Ukusetshenziswa kwe-antibacterial ngezinhloso zokwelapha kanye ne-prophylactic kwenziwa lapho kutholakala isiguli ngezifo ezithile ezinama-causative agents awo angama-microorganisms abhekene nomuthi. Ama-pathologies athathelanayo futhi ayathelela emvelweni. Lokhu kufaka phakathi:
- izifo zokuphefumula kakhulu nezingamahlalakhona zomgudu wokuphefumula (sinusitis, sinusitis, bronchitis, bronchopneumonia);
- ukutheleleka kwamathambo kanye nokuhlangana kubandakanya osteomyelitis;
- ukutheleleka kwesikhumba nezicubu ezithambile (i-dermatitis, ukumunca isifo ngemuva kokulimala kwezinambuzane);
- ukutheleleka kwezitho zangasese nomgudu wokuchama (cystitis, urethritis).
Ukusetshenziswa kwe-antibiotic ngezinhloso zokwelapha kanye ne-prophylactic kungenzeka maqondana nama-microorganisms azwela i-cephalosporins.
Kungenzeka yini ngesifo sikashukela
Ku-mellitus yesifo sikashukela, ukusetshenziswa kwe-antibiotic kungenzeka ngezizathu zempilo. Imithamo yokugaya ekuqaleni kokulashwa iyathandwa.
Contraindication
Uma kwenzeka umsebenzi we-renal ophazamisekile, ubukhona (umlando) we-jaundice ngemuva kokusetshenziswa okuhlangene kwe-amoxicillin ne-clavulan, i-hypersensitivity kanye / noma ukungabekezelelwa kwezakhi ngazinye, ukusetshenziswa komuthi akuvunyelwe ngokuphelele. Ubudala bezingane babuye babhekwe njengokwephula umthetho ngokuphelele: ukuthatha imishanguzo yezingane ezingaphansi kweminyaka engu-12 ubudala nesisindo somzimba esingaphansi kwama-35-40 kg kuvinjelwe.
Ama-pathologies wesibindi angamacala aphambili, adinga ukusetshenziswa ngokucophelela.
Ungayithatha kanjani i-Augmentin 125
Amaphilisi we-antibiotic kumele athathwe ngokuya ngohlelo olujwayelekile: ngaphandle kokuphula, ngaphandle kokuqhekeka kukoketshezi futhi aphuze amanzi amaningi. Uhlobo lomthamo lunqunywa ngudokotela oya kuye ngokuya ngezimpawu zomzimba ngamunye. Ukwehlisa ubungozi bemiphumela emibi nokusebenzisa umuthi isikhathi eside, kufanele uphuze umuthi imizuzu embalwa ngaphambi kokudla.
Amaphilisi we-antibiotic kumele athathwe ngokuya ngohlelo olujwayelekile: ngaphandle kokuphula, ngaphandle kokuqhekeka kukoketshezi futhi aphuze amanzi amaningi.
Imithamo yomuthi yansuku zonke yabantu abadala nentsha ayidluli kuma-1500 mg, okulingana namathebulethi ama-3 ane-500 mg / 125 mg noma amaphilisi ayi-6 ka-250 mg / 125 mg. Inkambo yokwamukelwa iyizinsuku eziyi-10-14. Isimo sokwelashwa sehlukaniswe ngemithamo emi-3, isikhawu phakathi kwamahora angama-5-6.
Imiphumela emibi
Ngokuphikisana nesizinda sokusetshenziswa isikhathi eside futhi ngenxa yezimpawu ezithile zomzimba wesiguli, imiphumela emibi ingahle ibe khona.
Amapheshana wesisu
Imvamisa, ukuphazamiseka kohlelo lokugaya ukudla kuvezwa ngesimo sokucanuzelelwa kwenhliziyo, ukuhlanza, ukuphazamiseka kwesitulo (isifo sohudo).
Kusuka ohlelweni lwegazi nolwe-lymphatic
Ukusuka ohlelweni lokujikeleza, i-hemolytic anemia (eguqukayo), i-leukopenia, i-thrombocytosis, i-thrombocytopenia, i-agranulocytosis iyabonakala.
Isistimu yezinzwa ephakathi
I-Hyperacaction, ukukhathazeka, i-migraine, isiyezi, ukuphazamiseka kokulala kuthiwa yimiphumela emibi evela ohlelweni lwezinzwa oluphakathi.
Kusuka ohlelweni lomchamo
IHematuria, amakristali ayabonakala.
Isikhumba nolwelwesi lwe-mucous
Imiphumela yokungezwani komzimba ibonakala ngendlela yokuqunjaza esikhunjeni, ukulunywa nokushiswa kwayo.
Isibindi nepheshana elihlanganisiwe
I-Cholestatic jaundice, i-hepatitis egcwele, ukwanda komsebenzi wokudluliswa kwesibindi kubangelwa yimiphumela emibi evela emgudwini wesibindi ne-biliary.
Imiyalo ekhethekile
Ngesikhathi sokubonisana, uchwepheshe uphoqelekile ukuba axoxe nesiguli ngokuningiliziwe futhi aqoqe i-anamnesis. Lokhu kuzokhomba ukungahambisani okungenzeka futhi kudwebe uhlobo lokwelashwa olufanele. Ukusabela kwe-Anaphylactic kungabulala. Uma kwenzeka imiphumela emibi, umuthi kufanele ume ngokushesha.
Ukukhiqizwa okusheshayo kwama-microorganisms amelana nemithi kungabangelwa ukusetshenziswa kwesikhathi eside kwe-antibiotic. Noma yikuphi ukusabela kwe-allergic kudinga ukukhishwa ngaphandle kwesidakamizwa ekwelashweni. Ngenxa yobuthi obuphansi be-penicillin, umuthi ubekezelelwa kahle yiziguli.
Ukuhambisana notshwala
Utshwala abuhambelani nemithi elwa namagciwane.
Umthelela ekhonweni lokulawula izindlela
Ukushayela izimoto kumele kuqaphele.
Sebenzisa ebudaleni
Ezigulini esezikhulile, ukuphatha ngokucophelela kuyadingeka. Ukwehla okungenzeka kwezibonelelo zansuku zonke zokwelashwa.
Umthamo wezingane
Amacwecwe awabekelwe izingane ezingaphansi kweminyaka engu-12. Ukumiswa kuyatholakala kubo.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukuqokwa ngenxa yezizathu zezempilo. Ukwemukelwa ngokucophelela kuyadingeka ngaphansi kokuqondisa kukachwepheshe.
Iziguli ezingasebenzi kahle isibindi
Lokhu kungukuphula umthetho okuhlobene. Ukuphatha ngokucophelela ngokulungiswa okungenzeka kohlobo lomthamo kukhethwa.
Iziguli ezinenkinga yezinso umsebenzi
Ukwelashwa ngama-antibiotic kuleli cala akwamukeleki.
Ukweqisa
Ukwephulwa kokulingana kwamanzi-electrolyte, i-crystalluria ne-dyspepsia kuyizimpawu ezibonakalayo zokweqisa. Kudinga ukuqubuka kwesisu kanye nokudlulisela phambili esikhungweni sezokwelapha, lapho udokotela azokhetha khona ukwelashwa okubonakalayo.
Ukuxhumana nezinye izidakamizwa
Ubungozi bokuthola imiphumela yokungezwani komzimba bukhuphuka ngokusetshenziswa kanyekanye kwe-ejenti ye-antibacterial kanye ne-Allopurinol. Umuthi ohambisana nezinye izidakamizwa ze-penicillin ubambezela ukuqedwa kwe-amooticillin ne-clavulanic acid emzimbeni. Umuthi uthinta i-microflora yemvelo yamathumbu futhi uvusa ukuthuthukiswa kwe-dysbiosis.
Imidwebo ye-Augmentin 125
Izithasiselo ze-antibiotic zivezwa ngendlela yethebhulethi. Zisegumbini lentengo elihlukile. Ama-analogues wesakhiwo afaka zonke izidakamizwa ezihlobene neqembu le-penicillin. Lokhu kufaka phakathi:
- Amose. Kwifomu lethebhulethi - amoxicillin trihydrate (500 mg). Ezinye izinto ezisebenzayo azinikezwa ngumenzi. Izindleko - kusuka kuma-ruble angama-35.
- I-Verklav. I-analogue yesakhiwo, ukwakheka kuyafana nokwasekuqaleni. Ukugxila kuyahlukahluka (1000 mg / 200 mg). Intengo - kusuka kuma-ruble angama-70.
- I-Ecoclave. Ifomu lomthamo wethebhulethi liqukethe i-amooticillin (250 mg, 500 mg ne-875 mg) ne-clavulanic acid (62,5 mg no-125 mg). Izindleko - kusuka kuma-ruble ayi-150.
Onke ama-analogues anomthelela we-bacteriostatic emzimbeni futhi asatshalaliswa ngesiLatin.
Imibandela yekhefu lekhemisi
Ikhishwe ngumbhalo.
Intengo
Izindleko zefomu lethebhulethi emakhemisi zivela kuma-ruble ayi-130.
Izimo zokugcina i-Augmentin 125
Amathebhulethi aguquliwe noma amanzi kufanele alahlwe. Amabhola ane-antibiotic agcinwa emaphaketheni awo okuqala kude nezingane, umlilo, umswakama nokukhanya kwelanga.
Isikhathi sokuphelelwa yisikhathi
Akudluli izinyanga ezingama-36 kusukela ngosuku lokwenziwa.
Ukubuyekezwa kwe-Augmentin 125
Odokotela
UGennady Evstigneev, udokotela wamazinyo, udokotela ohlinzayo osezingeni eliphezulu, iKhabarovsk
Umuthi uzifakazele ngokwedlule kuma-pathologies we-purulent-inflammatory. Umuthi uwububanzi obukhulu bezenzo, ngiwusebenzisa iminyaka emi-5 eyedlule. Kubekezelelwa kahle iziguli, izikhalazo zemiphumela emibi azilandeleki. Angikukhuthazi ukuyinikeza izingane ngenxa yobuthakathaka besitho esibuthaka.
Svetlana Zeytullaeva, otolaryngologist, Kostanay
Iziguli ezinesifo sikashukela zivame ukutholakala nezifo zokuphefumula. Kulokhu, ngivame ukukunikeza i-penicillin antibiotic, isebenza kakhulu kwi-laryngitis, i-tonsillitis, i-pharyngitis ne-sinusitis. Ezinye iziguli zinemizwa eguliswa yilesi sifo eqedwa nganoma yisiphi isithambiso se-antihistamine.
Uma kwenzeka imiphumela emibi, umuthi kufanele ume ngokushesha.
Iziguli
UValentina, oneminyaka engama-24, e-Ekaterinburg
Ezinyangeni ezimbalwa ezedlule, kwatholakala ukuthi sinusitis enecala elilodwa. Lesi sifo sasicishe sibe i-asymptomatic - ngisho neqondo lokushisa lalingasilimazi kancane. Ukugeza akuzange kusize, ngemuva kokuthi kubonakale ubandlululo. Udokotela wanquma umuthi olwa namagciwane. Ngesikhathi esifanayo nokuthatha amaphilisi, ngangivame ukugeza ikhala lami ngesisombululo. Ngemuva kwezinsuku ezi-2, izimpawu zaba ngaphansi, izinhlungu zacishe zaphela. Isikhathi sokwelashwa kwakuyizinsuku eziyi-10.
UmRoma, oneminyaka engama-41 ubudala, uNovorossiysk
I-tonsillitis engapheli ibikhathaza kusukela ebuntwaneni. Angikwazi ukususa ama-tiles ngenxa yokungezwani komzimba ngenxa ye-anesthesia, ngakho-ke ngizama "ukushayela" lesi sifo sisheshe sithethe. Bengilokhu ngizisindisa nge-antibiotic iminyaka eminingana manje. Isebenza masinyane, izinhlungu lapho iginya amazinyane ngemuva kwamahora angama-4-5. Imiphumela emibi - dysbiosis nezinye izinkinga ngamathumbu. Dlula ngokuzimela ezinsukwini ezingama-2-3.
