IMildronate yenzelwe ukulwa nezifo zesistimu yezinhliziyo nokusekelwa komzimba ezimeni zokuxineka nokuzivocavoca ngokweqile komzimba. Isithako saso esisebenzayo yi-meldonium dihydrate - i-analogue yokwenziwa ye-gamma-butyrobetaine. Uhlobo lokukhululwa okuhloswe ngalo ukuphathwa ngomlomo lungama-capsule kuphela, yize iqiniso lokuthi izinhlobo ezingekho, zokukhishwa, ezifana ne-Mildronate 500 amaphilisi nesiraphu, zivame ukushiwo kunethiwekhi.
Amafomu akhona akhishwe kanye nokwakheka
Kuwebhusayithi esemthethweni yomenzi, kunezinhlobo ezilandelayo zemithi:
- amaphilisi aqukethe i-250 mg ye-meldonium;
- amaphilisi aqukethe i-500 mg ye-meldonium;
- Isixazululo esiqukethe i-500 mg ye-meldonium ku-1 ampoule.
Zonke lezi zinhlobonhlobo zomuthi zivezwa emakhemisi aseRussia futhi ayatholakala ukuze athengwe. Ukuthola ngokuthengiswa kwalo muthi ngesidakamizwa esine-5 ml ka-250 mg we-meldonium akunakwenzeka, ngaphandle kwezinkomba eziningi zale ndlela yokukhishwa ezihlokweni zokubukeza.
Igama Lezwe elingafanele
IMeldonium
I-ATX
I-S01EV
I-Mildronate yenzelwe ukulwa nezifo zesistimu yezinhliziyo nokusekelwa komzimba.
Isenzo se-Pharmacological
Isakhi esisebenzayo seMildronate, lapho singenile, sicindezela izinqubo ezilandelayo:
- umsebenzi we-gamma butyrobetaine hydroxy kinase;
- ukukhiqizwa kwe-carnitine;
- ukudluliselwa kwe-long transmembrane okunamafutha acid;
- ukunqwabelana ku-cytoplasm yeseli yeefomu ezenzakalelayo zama-asidi ezinamafutha.
Ngaphezu kwalokho okungenhla, i-meldonium iyakwazi:
- thuthukisa inqubo yokunikeza izicubu nge-oxygen;
- vuselela i-glycolysis;
- zithinte ukusebenza kwemisipha yenhliziyo nokuqina kwayo;
- thuthukisa ukuhamba kwegazi ebuchosheni;
- thinta imikhumbi ye-retina ne-fundus;
- zinethonya elishukumisayo kuhlelo oluphambili lwezinzwa.
I-Pharmacokinetics
I-bioavailability yesidakamizwa ithambekele ku-80%. Kuboniswa ukumuncwa ngokushesha, okuqukethwe kwayo okuphezulu kwe-plasma kufinyelelwa ihora elilodwa ngemuva kokuvunyelwa. Umzimba obhekele ukwakheka kwento yilesi isibindi. Imikhiqizo yokubola iyadedelwa yizinso. Isigamu sempilo sinqunywa umthamo futhi siyahlukahluka kungakapheli amahora angama-3-6.
Yini i-Mildronate 500?
Izinkomba zokusetshenziswa kwalesi sidakamizwa yilezi:
- ukusebenza okuncishisiwe;
- ukulayisha ngokweqile ngokomzimba;
- ingcindezi kanye nengqondo;
- ukuhoxa kwesifo.
I-Mildronate inconyelwa ukufakwa ekwelashweni okuyinkimbinkimbi kwezifo ezifana:
- isifo senhliziyo;
- ukwehluleka kwenhliziyo okungapheli;
- i-dishormonal cardiomyopathy;
- ingozi ye-cerebrovascular (isigaba esingamahlalakhona futhi esibuhlungu).
Isicelo sezemidlalo
Umuthi kukhonjiswa ukuthi unxephezelela imiphumela yokuzivocavoca ngokweqile yomzimba, ngoba uyasiza ekubuyiseleni umzimba, unciphise izimpawu zokusebenzisa ngokweqile, futhi uyakwazi futhi ukuba nomphumela wokuvikelwa ku-myocardium. Kodwa-ke, ngonyaka we-2016, i-meldonium yafakwa ohlwini lwezinto ezisaphazayo, ngakho-ke ayemukelwa ukuthi isetshenziswe ngabasubathi abangochwepheshe ngesikhathi somncintiswano.
Contraindication
Ukuqokwa kukaMildronate akuvumelekile phambi kwalezi zinto ezilandelayo:
- ukuthambekisa ngakunye kwezingxenye ezisebenzayo noma ezisizayo;
- ama-intracranial tumors noma ukuphazamiseka kokuphuma kwe-venous okuholela ekukhuleni kwengcindezi ye-intracranial;
- iminyaka engaphansi kweminyaka eyi-18;
- ukukhulelwa, ukuncelisa.
Ngaphezu kwalokho, ngokuhlukumezeka okukhonjwe esibindini noma ezinso, lo muthi kufanele unikezwe ngokuqapha.
Ungayithatha kanjani iMildronate 500
Imithamo, eyodwa kanye nosuku, kanye nesikhathi sonke sesikhathi sokwelashwa sincike kulesi sifo futhi sinqunywa udokotela ohambelayo. Imininingwane enikezwe emiyalweni yokusetshenziswa iyeluleka ngokwemvelo futhi ibilungele lokhu okulandelayo:
- I-IHD kanye nokwehluleka kwenhliziyo okungapheli - kusuka ku-0,5 kuye ku-2 g / ngosuku, kuze kufike kumaviki ayi-6;
- i-dishormonal cardiomyopathy - 0.5 g / usuku lwezinsuku eziyi-12;
- imiphumela yokushaywa unhlangothi, ukungasebenzi kahle kwe-cerebrovascular - 0.5-1 g / ngosuku, kuze kube ngamaviki ayi-6, ukwelashwa kwe-capsule kuqala kuphela ngemuva kwemijovo;
- ingozi yokungasebenzi kwe-cerebrovascular - 0.5 g / ngosuku, kuze kufike kumaviki ayi-6;
- ukwehla kokusebenza, ukukhathala okwandisiwe - izikhathi eziyi-0.5 g 2 ngosuku, kuze kufike ezinsukwini eziyi-14;
- isifo sokuhoxa - 0.5 g izikhathi ezi-4 ngosuku, kuze kufike ezinsukwini eziyi-10.
Akunconywa ukuthatha amaphilisi amakhulu ngemuva kuka-17,00. Lokhu kungaholela ekuphazamiseni ngokweqile kanye nokuphazamiseka kokulala.
Isixazululo esinomthamo ofanayo wento esebenzayo ku-1 ampoule singasetshenziselwa:
- imijovo ye-intramuscular and intravenous ekwelapheni izingozi ze-cerebrovascular kanye nesifo senhliziyo esithambile emithanjeni efanayo namaphilisi;
- ukuphathwa kwe-parabulbar ekwelapheni i-retinopathy noma ukuphazamiseka kokujikeleza kwamehlo ka-0.5 ml izinsuku eziyi-10.
Ngaphambi noma ngemuva kokudla
I-Mildronate idakwe kakhulu esiswini esingenalutho. Lokhu kuyadingeka ukuze kuvinjelwe ukwehla kokubandakanyeka kwezinto eziphilayo ezisebenzayo. Uma kwenzeka unezifo zesisu, ukuze wehlise umthwalo emgodini wokugaya ukudla, kungenzeka ukuthatha umuthi isigamu sehora ngemuva kokudla.
Umuthi mhlawumbe uthathwa esiswini esingenalutho.
Umthamo wesifo sikashukela
Ukuqokwa kwe-Mildronate kushukela kungenxa yamandla ayo okuthuthukisa imetabolism. Ngale njongo, umuthi ungasetshenziswa ngenani lama-500-1000 mg ngosuku.
Imiphumela emibi yeMildronate 500
Into esebenzayo i-Mildonate ibekezelelwa kalula ngumzimba. Ukuphendula okungalungile lapho uyithatha akuvamile. Ngokwolwazi olunikezwe ngumenzi, imibandela elandelayo yaphawulwa:
- komzimba ekubonisweni okuhlukahlukene;
- ukuphazamiseka kokugaya ukudla kanye nezimpawu ze-dyspeptic;
- i-tachycardia;
- ushintsho ekucindezelweni kwegazi;
- ukweqisa ngokweqile;
- ubuthakathaka
- ukukhuphuka kwenqwaba yama-eosinophils egazini.
Imiyalo ekhethekile
Iziguli ezinenkinga yokusebenza kwesibindi noma yezinso azikhonjiswa ukusetshenziswa isikhathi eside kwalesi sidakamizwa. Uma kunezimfuneko zokuyisebenzisa isikhathi esingaphezu kwenyanga eyi-1, udinga ukubheka isimo sesiguli.
Imiphumela emibi yokuphuza umuthi ingaba buthakathaka.
Isabelo sezingane
Ukuphepha kokunqunywa kwamakhompiyutha iMildronate ezinganeni ezingama-500 akukaze kufakazelwe, ngakho-ke, akukabekwa kuze kube iminyaka eyi-18.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umphumela we-fetus kanye nomphumela we-dieldrate ye-meldonium esanda kufundwa awuzange ufundwe, ukuphepha kokuvezwa kwezidakamizwa okunjalo akukaze kufakazelwe, futhi ngenxa yalokho lesi sidakamizwa asinqunyelwe abesifazane abakhulelwe. Uma kunesidingo, ukwelashwa ngesikhathi sokondla ingane yalesi sikhathi kudluliselwa ezingxenyeni zokudla.
Ukuhambisana notshwala
Lapho uthatha iMildronate, akufanele uphuze utshwala. I-Ethanol yehlisa umphumela wayo wokwelapha futhi inesandla ekubonakala kokungaphenduki kahle komzimba ekwelashweni.
Umthelela ekhonweni lokulawula izindlela
Ukwemukelwa kwe-Mildronate akubeki ushintsho emandleni wokulawula izindlela, akubangeli ukozela futhi akubeki ukusakazeka kokunaka.
Ukweqisa
Into esebenzayo ye-Mildronate inobuthi obuphansi futhi azange kube nezimo zokusebenzisa ngokweqile uma zithathwa ngomlomo. Uma kwenzeka, kunconywa ukwelashwa okubonakalayo.
Lapho uthatha iMildronate, akufanele uphuze utshwala.
Ukuxhumana nezinye izidakamizwa
Kusungulwa ukuthi iMildronate ithuthukisa isenzo:
- nitroglycerin;
- i-alpha adrenergic blockers;
- inhliziyo glycosides;
- ama-vasolidators aphesheya.
Umuthi ungahlanganiswa ngokukhululeka nezinto ezifana:
- okokugcobisa;
- ama-bronchodilators;
- ama-anticoagulants;
- izidakamizwa ze-antiarrhythmic;
- imishanguzo ye-antianginal.
Akunconyelwe ukusetshenziselwa kuhlangene ne-tinctures enemithi equkethe utshwala.
Ama-Analog
Noma yisiphi isidakamizwa esisetshenziselwa i-meldonium sizosebenza ngokufana neMildronate. Isibonelo umuthi onjengalawa:
- I-Cardionate;
- UMelfort;
- I-Medatern.
ICardionate ingelinye lamagama afanayo.
Imibandela yekhefu lekhemisi
Ngingakwazi ukuthenga ngaphandle kadokotela
Ngokusho kwemiyalo esemiyalweni, umuthi uphakathi kwemithi kadokotela. Kepha ukuzijwayeza kukhombisa ukuthi emakhemisi amaningi, lapho esetshenzisiwe, awadingi isiqinisekiso sokuthi ukusetshenziswa kwalo muthi kunconywe udokotela ohambelayo.
Intengo
Ama-500 mg amaphilisi we-Mildronate athengiswa ngamaphakethe angama-60. Intengo yephakethe elilodwa elinjalo ngokuthengwa kwe-inthanethi iqala kuma-ruble angama-545. Leli nani lingashiyana ngokuya ngesifunda sezwe, kanye nezinga lentengo likhemisi.
Izimo zokugcina zomuthi
Iphakethe elinamaphakethi omuthi kufanele agcinwe ebumnyameni, emazingeni okushisa afinyelela ku-25 ° C. Kungenzeka ukuthi umuthi owela ezandleni zezingane kufanele ungafakwa ngaphandle.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emi-4 kusukela ngosuku lokukhiqizwa
Umkhiqizi
I-JSC "Grindeks"
Ukubuyekezwa
IMildronate isisungule njengethuluzi elisebenzayo neliphephile. Lokhu kufakazelwa izibuyekezo zabodokotela neziguli zombili. Lo muthi uthole ukuthandwa kakhulu njengomsizi ekusebenzeni ngokweqile nasekucindezelekeni.
Izazi zezenhliziyo
UVictor, oneminyaka engama-40, uKaluga: "Nginokuhlangenwe nakho okucebile ekuhlinzweni kwenhliziyo, ngibeka uMildronate ngokujulile kuzo zonke iziguli ezihlinzwe inhliziyo, lo muthi usiza ukusebenza kahle ngokomzimba, uthinte kahle isimo somzimba jikelele."
Uthando, oluneminyaka engama-58, u-Perm: "Ekungeneni komkhuba wami, nginqumela iziguli zaseMildronate njalo. Ngikholwa ukuthi le nto ingakhuthaza ukubekezelelwa kokusebenza ngokomzimba futhi ithuthukise impilo yempilo yesiguli."
Iziguli
U-Oleg, oneminyaka engama-35, uRostov-on-Don: "Udokotela ungeluleke ukuthi ngithathe amaphaphu aseMildronate ngenxa yezikhalazo zokukhathala. Ngemuva kwesonto ngezwa senginamandla amakhulu."
USvetlana, oneminyaka engama-53, uSalavat: "Ngiphuze okokuqala iMildronate. Ngemuva kokwelashwa, ngihlala ngibona ukuthuthuka enhlalakahleni, ukuhlaselwa kwe-angina kuyeke izinyanga eziningi."
