Iziguli ezinesifo sikashukela ziyakwazi ukubaluleka kokulondolozwa kokujwayelekile kweglue glucose. Lokhu kuzogwema imiphumela emibi yesifo. Imvamisa, odokotela be-endocrinologists banquma imishanguzo yokulawulwa ngomlomo, kufaka phakathi i-Diabinax.
Igama Lezwe elingafanele
I-Gliclazide
Umuthi lo unegama elejwayelekile lomhlaba jikelele - iGliclazide.
I-ATX
A10VB09
Khipha amafomu nokwakheka
Umuthi utholakala kuphela ngefomu eliqinile lethebhulethi: uyindilinga, uyisicaba ngebhali emaphethelweni kanye notch ngakolunye uhlangothi, mhlophe. Iyunithi ngayinye yemithi iqukethe i-0.02, 0,04 noma i-0,08 g yezinto ezisebenzayo. Izakhi ezilandelayo zifakiwe njengezinye izithako zamathebulethi:
- I-MCC;
- i-aerosil;
- isitashi ne-sodium starch glycolate;
- i-talc;
- i-povidone;
- sodium methylparaben;
- i-magnesium stearate;
- amanzi.
Iphakethe lekhadibhodi liqukethe ama-1, 2, 3, 4, 5, noma ama-6 amabhulokhi anamaphilisi ayi-10 noma angama-20 ngawodwa.
Isenzo se-Pharmacological
Impahla yokwehlisa ushukela yesidakamizwa isuselwe emandleni ento esebenzayo ukuvimba iziteshi ze-potassium ezixhomekeke ku-ATP zamaseli we-pancreatic incretory cell. Ngenxa yalokhu, iziteshi ze-calcium ziyavuleka kanye nokwanda kwe-calcium ion ku-cytoplasm kuyakhuphuka, lokhu kuholela ekuthuthweni kwama-vesicles nge-insulin kulolwelwesi kanye nokungena kwe-hormone ukungena egazini.
Umuthi unganconyelwa iziguli ezinesisindo esandisiwe, ngoba akubangeli ukuqina kwesisindo.
Into esebenzayo ithinta kakhulu ukukhishwa kokuqala kwe-insulin ekuphenduleni i-hyperglycemia ngemuva kokudla. Lokhu kuhlukanisa kusukela kokunye okutholwe ku-sulfonylurea 2 isizukulwane. Kulokhu, umuthi unganconywa kwiziguli ezinesisindo esandisiwe, ngoba akubangeli ukuqina kwesisindo.
Ngokungezelela secretion ye-insulin ibe yi-plasma, umuthi uyakwazi ukukhuthaza izinqubo zokusebenzisa ushukela ngenxa yokusebenzisa amandla kwe-synthease cell cell glycogen, futhi uyakwazi ukuthonya izinqubo ezilandelayo:
- ukuncipha kokuzwela kwe-vascular adrenergic receptors;
- ukunciphisa ijubane lokunamathela kweplatelet kanye nokuhlangana, ukujwayelekile kwenqubo ye-fibrin lysis;
- ukuncishiswa kwe-cholesterol;
- ukubuyiselwa kokuqina kwemithambo yegazi.
Ngenxa yalezi zindawo, umuthi ungabuyisela i-microcirculation yegazi, ngakho-ke, unganciphisa ukulahleka kwamaprotheni ezinsweni futhi uvikele ukulimala okuthe xaxa emithanjeni ye-retinal ku-mellitus yesifo sikashukela.
I-Pharmacokinetics
I-ejenti yomlomo ye-hypoglycemic igxilwe ngokuphelele emathunjini, ozimele ngaphandle kokudla. Emgodini wegazi, ngaphezu kwe-90% ibopha ama-hemoprotein, ifinyelela okuqukethwe okuphezulu kakhulu ngemuva kwamahora amane ngemuva kokuphathwa.
Isigamu sempilo singamahora ayi-12, ngakho-ke umphumela wezidakamizwa uthatha cishe usuku. Uma sesisehlelweni lwe-hepatobiliary, kuba noshintsho. Enye yezinto ezakhiwe inomphumela ohlelweni lwe-vascular. Cishe i-70% yomthamo owemukelekile ngendlela yama-metabolites itholakala kumchamo, cishe u-12% ezindundwini.
Umuthi usetshenziselwa ukwenza kube yiprofayili ye-glycemic ezigulini ezinesifo sikashukela sohlobo 2.
Izinkomba zokusetshenziswa
Umuthi usetshenziselwa ukwenza kube yiprofayili ye-glycemic ezigulini ezinesifo sikashukela sohlobo 2. Lokhu kusiza ukuvikela imiphumela nezinkinga ezibangelwa i-hyperglycemia.
Contraindication
Ekwelapheni uhlobo lwesifo sikashukela sohlobo 1, ukusetshenziswa kwomuthi akunakwenzeka ngoba kulimale amaseli we-pancreatic beta. Akunconyelwe ukuthi zisetshenziswe ezinganeni, abesifazane abakhulelwe nabancelayo, kanye nakule mibandela elandelayo:
- ukubola kwesifo: i-ketoacidosis yesifo sikashukela, i-coma noma isifo sikashukela;
- ukungasebenzi kahle kwe-renal noma hepatic;
- ama-pathologies lapho isidingo se-insulin sanda kakhulu: izifo, ukulimala, ukushiswa, ukungenelela kokuhlinzwa;
- ukungasebenzi kwe-yegilo;
- ukungabekezelelani kwe-gliclazide;
- ukuphathwa kanyekanye kokukhipha imidazole (i-fluconazole, i-miconazole, njll.).
Ungamthatha kanjani uDiabinax
Umuthi unconywa ukuthi uphuzwe ngomlomo kabili ngosuku amahora angu-0.5-1 ngaphambi kokudla kwasekuseni nangaphambi kwesidlo sasemini, ugezwe phansi ngamanzi. Imithamo yansuku zonke isethwe ngokususelwa kuphrofayili ye-glycemic, ukuba khona kwezifo ezikhona kanye nobunzima bokubonakaliswa kwemitholampilo.
Ungahlanganiswa nabenzeli be-hypoglycemic abavela kwamanye amaqembu (hhayi ama-sulfonylurea derivatives), kanye nokwelashwa kwe-insulin.
Ngoshukela
Kunconywa ukuqala ngemithamo esebenza ngempumelelo okungenani - 20-40 mg ngethamo ngalinye. Umthamo ojwayelekile wansuku zonke yi-160 mg kwimithamo ehlukene emi-2. Umthamo omkhulu ovunyelwe nsuku zonke ngu-320 mg.
Imiphumela emibi yeDiabinax
Ukwelashwa kwe-Toxin-okwehlisa umuthi, ukusabela okunobuthi kungenzeka:
- ukubonakaliswa kwesikhumba: ukuqubuka, ukulunywa, i-urticaria;
- ukuphazamiseka okuguqukayo kohlelo lwe-hematopoietic: thrombocytopenia, leukopenia, anemia;
- ikhanda, isiyezi;
- jaundice.
Into esebenzayo ingangezela ukuzwela emiphumeleni yokufakelwa. Phakathi kwezinye izikhalazo, ukubonakaliswa kwe-dyspeptic, njengoku:
- isicanucanu
- ukuhlanza
- ukwehla kwesifiso sokudla;
- isifo sohudo
- gastralgia.
Kungaba neziqephu zokwehla kweglucose yegazi enezimpawu ezilandelayo:
- ubuthakathaka
- izibuko
- umuzwa wendlala;
- ikhanda;
- ukuthuthumela emzimbeni, njll.
Umthelela ekhonweni lokulawula izindlela
Mayelana nemiphumela emibi engaba khona, isiguli kufanele siqaphele lapho silawula amadivayisi ayinkimbinkimbi kwezobuchwepheshe.
Imiyalo ekhethekile
Ukwelashwa ngomuthi kuyenziwa ngokuhambisana nokudla okuqukethe ushukela ophansi namanye ama-carbohydrate kumkhiqizo. Kepha kuyanconywa ukuthi ukondliwa okujwayelekile kuphelele ngokuya ngokwenziwa komsoco nokuqukethwe kwamavithamini anezinto ezilandelwayo. Isiguli kufanele saziswe ukuthi ngokushintsha kokudla, ukunciphisa isisindo, ukutheleleka okuthe xaxa, ukwelashwa kokuhlinzwa, ukulungiswa komthamo noma ukufakwa kwezidakamizwa kungenzeka.
Sebenzisa ebudaleni
Kudala, ukusetshenziswa kwesidakamizwa kunenzuzo ngokuqhathaniswa nezidakamizwa ezisebenza kudala zaleli qembu. Umuthi ubangela ukukhishwa kwehomoni kusenesikhathi ngenxa yalokho, ubungozi be-hypoglycemia kule minyaka buyancishiswa. Ngokwelashwa okuhlala isikhathi eside, ukwehla kokusebenza kahle kwezidakamizwa kanye nesidingo sokwanda imithamo yansuku zonke kungenzeka.
Isabelo sezingane
Umuthi uphambaniswe ngeminyaka engu-18, ngoba Akunalo ulwazi ngokuphepha kokusetshenziswa.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ngesikhathi sokukhulelwa, ukusetshenziswa kwesizukulwane 2 kokuphathelene nokwenziwa kwe-sulfonylurea akuyona into efiselekayo, ngokusho kwesigaba se-FDA babelwa ekilasini C. Ngokuthola ukungabikhona kwezifundo eziqinisekisa ukungabi bikho kwemiphumela ye-teratogenic ne-embryotoxic enganeni lapho ithatha lo muthi, ukusetshenziswa kwayo kuyaphulwa kwabesifazane abakhulelwe.
Akukho datha ekungeneni kwento esebenzayo iye kubisi lwebele. Uma kunesidingo, ukuqokwa kwayo kwabesifazane abakhipha izisu kukhipha ibele.
Isicelo sokusebenza kokulimala kwezinso
Ngokulimazeka okukhulu kwezinso, okubonakala ngokuncipha kwe-GFR ngaphansi kwe-15 ml / min, umuthi uphambaniswe nemithi. Ukwelashwa kwenziwa ngokucophelela ngokuhluleka okuncane kakhulu kwe-renal, kepha imithamo efanayo isetshenziswa njengoba kuchaziwe kwimiyalo.
Sebenzisa umsebenzi wesibindi okhubazekile
Ngokuphazamiseka kwesistimu ye-hepatobiliary, ukwanda kokuxineka komuthi egazini kungenzeka. Lokhu kwandisa ubungozi be-hypoglycemia. Ngakho-ke, umuthi awunakubekelwa iziguli ezinokwehluleka okukhulu kwesibindi.
Lapho uphuza umuthi ngemithamo edlula kahle kumuntu, kutholakala izimpawu zokuncipha kwe-glycemia.
Ukweqisa kweDeveinax
Lapho uphuza umuthi ngemithamo edlula kahle kumuntu, kutholakala izimpawu zokuncipha kwe-glycemia. Lesi simo sibonisa ukuwohloka kwenhlalo yobunzima obuhlukahlukene: kusuka kubuthakathaka obujwayelekile ukuya ekucindezelekeni kokwazi. Ngokwe-overdose esetshenzisiwe, i-coma ingahle ibe khona.
Ukwelashwa: buyisela ushukela wegazi. Iziguli ezinokulimazeka okuncane kwempilo zinikezwa imikhiqizo equkethe ushukela ngaphakathi, futhi uma kungenzeka ukuthi ungazi kahle, i-glucose kufanele iphathwe ngaphakathi.
Ukuxhumana nezinye izidakamizwa
Izinga lokuncipha kwe-glycemia lenyuka ngokuqokwa kanyekanye nemithi elandelayo:
- ama-tetracyclines;
- ama-sulfonamides;
- ama-salicylates (kufaka phakathi i-acetylsalicylic acid);
- ama-anticoagulants angaqondile;
- ama-anabolic steroid;
- ama-beta-blockers;
- imicu;
- chloramphenicol;
- fenfluramine;
- i-fluoxetine;
- i-guanethidine;
- Mao inhibitors;
- i-pentoxifylline;
- theophylline;
- ikhofi
- phenylbutazone;
- cimetidine.
Lapho kunqunywa i-Gliclazide nge-acarbose, kwaqapheleka isithangami semiphumela ye-hypoglycemic.
Lapho ihanjiswa nge-acarbose, kwaqanjwa isithangami semiphumela ye-hypoglycemic. Futhi ukungabikho noma ukuncipha komphumela wokusetshenziswa kwomuthi kwaqalwa ngokuphathwa kanyekanye nezinto ezilandelayo:
- ama-barbiturates;
- i-chlorpromazine;
- glucocorticosteroids;
- i-sympathomimetics;
- i-glucagon;
- i-nicotinic acid;
- ama-estrogens;
- ama-progestin;
- amaphilisi okulawula ukuzala;
- okokugcobisa;
- i-rifampicin;
- ama-hormone egilo;
- usawoti we-lithium.
Umuthi ukhulisa ukwanda kwe-extricystole ye-ventricular ngesikhathi sokwelashwa nge-glycosides ye-cardiac.
Ukuhambisana notshwala
Ebantwini abasebenzisa i-ethanol ne-glycazide ngasikhathi sinye, izinga le-hypoglycemia lenyuka, kwaba nomphumela ofana nowokungasebenzi kahle. Ngokuqapha, ukwelashwa kuchazwa ezigulini eziphethwe ukuxhomekeka kotshwala.
Ama-Analog
Ngomuthi waseNdiya eRussia, ama-analog alandelayo ento esebenzayo anikezwa:
- UGlidiab;
- Isifo sikashukela;
- I-Gliclazide;
- I-Diabefarm MV;
- I-Gliclazide MV, njll.
Imibandela yekhefu lekhemisi
Umuthi unqunywe ngudokotela futhi unikezwa ngomuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Imithamo edingekayo yokulawula i-glycemic efanele futhi ephephile kufanele ikhethwe esigulini, ngakho-ke lesi sidakamizwa asithengiswa ngaphandle kokuthola umuthi.
Intengo kaDiabinax
Umuthi ubhalwe ku-Vital and Essential Izidakamizwa. Amanani ayo alawulwa. Izindleko zethebhulethi eyi-1 ku-20 mg ngezindleko ezijwayelekile ama-ruble ayi-4,40 mg - ukusuka kuma-ruble ayi-2.4 kuya kwangama-3.07, kanye nama-ruble angama-80 mg - 1.54.
Izimo zokugcina zomuthi
Iphakheji lomuthi ligcinwa emazingeni okushisa angaphansi kuka +25 ° C endaweni evikelwe ukukhanya kwelanga kanye nomswakama. Gwema kude nezingane.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Umkhiqizi
Lesi sidakamizwa senziwa yinkampani yaseNdiya iShreya Life Science, enehhovisi elimele eRussia kusukela ngonyaka we-2002.
Umuthi unqunywe ngudokotela futhi unikezwa ngomuthi.
Ukubuyekezwa mayelana neDiabinax
U-Elizabeth, oneminyaka engama-30, uNizhny Novgorod
Ugogo watholakala enesifo sikashukela eminyakeni engu-5 eyedlule. Kusukela lapho uphuza lesi sidakamizwa amahlandla ama-2 ngosuku. Ngezikhathi ezithile sibheka ukuthi ushukela wegazi lakhe uzila ukudla kangakanani - uhlala kahle ebangeni elijwayelekile. Ugogo ubekezelela ukwelashwa kahle. I-endocrinologist income ukuyithatha njalo.
UStanislav, oneminyaka engama-65, uChelyabinsk
Amaphilisi anqunywe ekuseni ngaphambi kokudla kwasekuseni. Sekuphele unyaka ngisebenzisa lo muthi. Ngizizwa ngingcono: Ngingasebenza futhi, ngikhathele kancane, ukoma kwehle. Sekulindelekile ukuthi uthathe imishanguzo yezinkinga ezinesifo somfutho wegazi.
URegina, oneminyaka engama-53, uVoronezh
Ngenxa yokusebenza kanzima, izinkinga zempilo zaqala: ngokusho kokuhlaziya, bathola ushukela wegazi ophezulu. Ngemuva kokuhlolwa, amaphilisi angu-0,5 omuthi anqunywa ngaphambi kokudla kwasekuseni nangesidlo sasebusuku. Ngikwamukela njalo, kepha qiniseka ukuthi ulandela indlela yokudla. Zonke izibalo zegazi zibuyele kwesejwayelekile.
