Ama-antibacteria we-Fluoroquinolone asetshenziselwa izinhloso zokwelapha kanye ne-prophylactic ezifweni zemvelo ezithathelwanayo. Le mishanguzo ifaka i-ciprinol. Ukuqoqwa kwento eyinhloko ekwakhekeni komuthi kuyahluka ngokuya ngesimo sokukhishwa. Imithi kadokotela isetshenziswa ngokuya ngerejimeni yemithamo ekhethiwe, enciphisa ubungozi bokuthola izimpawu zomuntu okweqisa.
Igama Lezwe elingafanele
I-Ciprofloxacin.
Ama-antibacteria we-Fluoroquinolone asetshenziselwa izinhloso zokwelapha kanye ne-prophylactic ezifweni zemvelo ezithathelwanayo. Le mishanguzo ifaka i-ciprinol.
I-ATX
J01MA02.
Inombolo ekhonjiswe kusitifiketi sokubhalisa - LS-000047 - P N014323 / 01. Usuku lokubhaliswa - 07.22.08.
Khipha amafomu nokwakheka
Kumakhemisi, izindlela eziningana zokukhipha umuthi we-antimicrobial ziyafezeka. Lawa ngamathebulethi, ukugxila kanye nokujova. Zonke izinhlobo zemithamo zihlanganiswa neqiniso lokuthi ziqukethe i-ciprofloxacin monohydrate hydrochloride - isakhi esiyinhloko. I-Ciprinol 500 itholakala kuphela kwifomu lethebhulethi, okuqukethwe kwengxenye esebenzayo kungama-500 mg.
Ukugxila nesisombululo kudinga ukuphathwa kwe-intravenous (Drip or stream). Ukugxila kusetshenziselwa futhi njengesifutho ekwelapheni ama-suture we-postoperative kanye nokwehla kwamehlo. Uketshezi (ngazo zombili izinhlobo) luyabonakala futhi alunamabala. Ngaphansi kaningi, ikhambi liluhlaza okotshani (kuya ngomenzi).
Okuqukethwe kwezithako okusebenzayo kwifomu lethebhulethi kungama-250 mg, 500 mg no-750 mg. Ukugxila kunqunywa ngumenzi. Izakhi ezisizayo izimbangi ezandisa ukwanda kwe-bioavailability yento esemqoka futhi zisheshise izinga lokufakwa. Ithebhulethi ngayinye ifakwe kumafilimu. Uhlu lwezinto ezingeziwe:
- isodium carboxymethyl cellulose;
- isilika;
- i-primellose;
- i-acid entshontsha;
- I-MCC;
- polyvinylpyrrolidone.
Igobolondo liqukethe:
- hydroxypropyl methylcellulose;
- titanium dioxide;
- utshwala bokugaya ukudla;
- i-talcum powder.
Imiyalezo equkethwe iqukethe amaphilisi ayi-10 oval biconvex. Ngamunye une notch (ngakolunye uhlangothi). Ebhokisini lekhadibhodi - akukho ngaphezu kwesikhala se-1 se-mesh. Imiyalo esetshenzisiwe ifakiwe.
Isenzo se-Pharmacological
Into esebenzayo ekwakhiweni kwanoma yiluphi uhlobo lomthamo inempahla ebizwayo ye-antibacterial. I-antibiotic ingeyeqembu le-fluoroquinolones yesizukulwane sesibili. Ukukhetha i-topoisomerase inhibitor, kuthinta i-DNA ye-pathogenic microorganisms. Inqanda i-biosynthesis yamaprotheni.
Ukuzwela kwezinye kwamagciwane athile kungenxa yomthelela we-bacteriostatic. Umuthi usetshenziswa njengengxenye ye-mono-futhi eyinkimbinkimbi yokwelapha ezindaweni eziningi zemithi. Ukusebenza kahle okuphezulu ngokumelene nama-microorganisms e-anaerobic akukho.
Amagciwane a-gram-positive azwela i-ciprofloxacin:
- Neisseria gonorrhoeae;
- Pseudomonas aeruginosa;
- I-Neisseria meningitidis;
- I-Escherichia coli;
- I-Salmonella spp;
- I-Shigella spp.
Amagciwane angenayo i-grram-negative azwela umuthi:
- I-Enterococcus spp;
- I-legionella spp;
- I-Staphylococcus spp;
- I-Chlamydia spp;
- I-Campylobacter spp;
- I-Mycobacterium spp;
- I-Mycoplasma spp.
Into esebenzayo ekwakhiweni kwanoma yiluphi uhlobo lomthamo inempahla ebizwayo ye-antibacterial.
Ama -organic we-Anaerobic okuvela kuwo ukumelana nobufakazi kuye:
- Clostridium Hardile;
- I-Nocardia asteroides;
- Ureaplasma urealyticum.
Ama-microorganisms akhiqiza i-beta lactamase athambekele ekutholeni umuthi.
I-Pharmacokinetics
Inqubo yokuqhekeka kwethebhulethi yenzeka emgudwini wesisu. Ukudla okuthethwe ngaphambilini akuthinti ukumuncwa kanye ne-bioavailability nganoma iyiphi indlela (akukho ngaphezu kwama-75% kwifomu lethebhulethi). Ukuhlushwa okuphakeme kakhulu kwento esemqoka kunganqunywa ngemuva kwemizuzu engama-90-120 ngemuva komthamo wokuqala. Into esebenzayo isatshalaliswa ngegazi futhi isatshalaliswa ngokulinganayo phezu kwawo wonke izicubu ezithambile zesikhumba semithambo, indlela yokuchama nokuphefumula.
Ngokufakwa kwe-intravenous, izinga lokufaka lihlala lingashintshiwe. I-Biotransformation iyenzeka esibindini. Ama-Metabolites awasebenzi.
Uma isiguli singenakho ukwephulwa okuvela ohlangothini lwezinso nohlelo lomchamo, ukususwa kwomuthi (kanye nomchamo) kuthatha amahora angama-3-6. Lapho uthola ukuhluleka kwe-renal nezinye i-pathologies, isikhathi sokukhipha ngokuzenzekelayo sanda size sifinyelele emahoreni ayi-10-12. Intestine ayikhishwa.
Ingena ngesithintelo se-placental futhi iye kubisi lwebele.
Yini esiza?
Ukusetshenziswa kwe-antibiotic yeqembu le-fluoroquinolone ngezinhloso zokwelapha kwenziwa lapho kutholwa isiguli nge-pathologies ye-etiology ethelelekayo nezifo ezingamahlalakhona ezingapheli. Izinkomba ezilandelayo zikhonjisiwe kwisichasiselo:
- ukutheleleka kwesikhumba (ithumba, izilonda, ukushiswa, izidumbu ezitheleleke ngemuva kwezinqubo zokuhlinzwa);
- izifo ezithathelwanayo zezitho zangasese sowesilisa nowesifazane (i-prostatitis, chlamydia, i-salpingitis);
- izifo ezithinta ukuphefumula (i-pneumonia, i-bronchitis);
- Izifo ze-ENT (i-tonsillitis, i-sinusitis, imidiya ye-otitis);
- izifo ezithinta umchamo (urethritis, pyelonephritis, cystitis);
- ukutheleleka komgudu wokugaya ukudla (ukuphazamiseka kwamathumbu, cholangitis);
- ukutheleleka kwezicubu zamathambo kanye nokuhlangana (isifo samathambo, osteomyelitis);
- njenge-prophylaxis yezinqubo zokutheleleka nokuvuvukala emzimbeni ngemuva kokuhlinzwa.
Ukuthatha amaphilisi okubulala amagciwane i-Ciprinol 500 iba nzima ku-trimester yokugcina yokukhulelwa.
Contraindication
Ukuphuza amaphilisi e-antibiotic kuba nzima uma isiguli sine-contraindication ngokuphelele. Lokhu kufaka phakathi:
- ama-trimesters okugcina okukhulelwa (2-3);
- ukungabekezeleli ingxenye enkulu;
- Ukusetshenziswa okufanayo kwe-tizanidine ne-ciprofloxacin;
- iminyaka yezingane (kuze kube iminyaka eyi-18).
Okuhlukile kungaba yizinkinga ezitholakala ezinganeni ezineminyaka engu-6 kuya ku-17 futhi zibangelwa nguPseudomonas aeruginosa.
Ngokunakekela
Ukufakwa komuthi ekwakhiweni kokwelashwa kufanele kuqaphele maqondana neziguli ezinama-pathologies alandelayo:
- i-cerebrovascular atherosulinosis;
- isithuthwane
- ukugula kwengqondo;
- ukulimazeka okukhulu kwe-renal kanye ne-hepatic.
Ukwephulwa kwe-microcirculation yegazi ebuchosheni kubhekwa njengokuphula umthetho okuhlobene nokusetshenziswa kwomuthi.
Ungayithatha kanjani i-Ciprinol 500?
Ifomu lomthamo lithathwa ngomlomo izikhathi ezingama-2-3 ngosuku. Isimo semihla ngemihla sezinto eziyinhloko akufanele singeqi ku-1500 mg. Amathebulethi kufanele adakwe njalo emahoreni ayi-6, kungakhathaleki ukuthi kudliwe kangakanani Isikhathi sokwelashwa sifinyelela ezinsukwini eziyi-14. Inkambo kanye nethamo lokwelapha lingandiswa ngemvume kadokotela ohambelayo.
Ukuphathwa kwe-Intravenous kungaba jet ne-Drip. Okokugcina kuyathandwa. Umthamo womjovo owodwa ungama-200 mg, ngokukhuculula - hhayi ngaphezu kwama-400 mg. Ukugxila kanye nekhambi, lapho kufakwa i-dropwise, kuxutshwa nekhambi lokufakwa (i-dextrose, i-fructose) kwivolumu edingekayo.
Ngoshukela
Isifo sikashukela sidinga ukuvuma ngokucophelela. Ukulungiswa kwerejimeni yemithamo kwenzeka ngokuya kokuncipha kwayo. Ukuqashwa kwezokwelapha kuyadingeka.
Imiphumela emibi
Noma yikuphi ukugula okuvela ngesikhathi somuthi olwa namagciwane kuhlobene nemiphumela emibi. Zivela engxenyeni yokugaya ukudla, isistimu yezinzwa ephakathi, izinzwa zemizwa, amasistimu we-urogenital kanye nemisipha.
Noma yikuphi ukugula okuvela ngesikhathi somuthi olwa namagciwane kuhlobene nemiphumela emibi.
Amapheshana wesisu
I-Dyspepsia, i-anorexia, i-pseudomembranous colitis, ukuphazamiseka kokunambitha, ukulahleka kwesifiso sokudla, i-hepatitis egcwele, i-hepatonecrosis ihlobene nemiphumela emibi evela emgodini wokugaya ukudla.
Izitho zeHematopoietic
Izitho zeHematopoietic secrete anemia, thrombocytopenia, leukopenia, leukocytosis, thrombocytosis.
Isistimu yezinzwa ephakathi
Imiphumela emibi yesidakamizwa ohlelweni oluphambili lwezinzwa iboniswa ngendlela yokuqunjelwa ikhanda, ikhanda, isiyezi, ukudangala, ukwehluleka, imizwa yokukhathazeka nokubona okubonakalayo.
Kusuka ohlelweni lomchamo
Ukusuka ohlelweni lomchamo, i-crystalluria, i-polyuria, i-hematuria, ukopha okungaphakathi (kuyaqabukela) kuyabhekwa.
Kusuka kwizitho zemizwa
Kukhona ukwephulwa kwephunga, ubumpumputhe besikhashana kanye nokungezwa, i-tinnitus encane.
Imiphumela emibi yesidakamizwa i-Ciprinol 500 ohlelweni lwezinzwa oluphakathi ibonakala ngendlela yokuthathwa.
Engxenyeni yesikhumba
Imisebe ivela esikhunjeni, ihambisana nokulunywa nokushiswa. AmaPapules angakheka. Izithelo zifakwa endaweni yokuqhekeka kwemithambo yegazi emincane.
Kusuka ohlelweni lwe-musculoskeletal
Ukusuka ohlelweni lwamathambo we-musculoskeletal system, i-myalgia, ukuvuvukala ne-arthralgia kukhula. Ingozi yokuqhekeka kwe-tendon iyanda.
Kusuka ohlelweni lwezinhliziyo
Imiphumela emibi yesidakamizwa ohlelweni lwezinhliziyo ivezwa ngokwanda kwenhliziyo, kwehlise umfutho wegazi kanye ne-tachycardia.
Allergies
Ukungezwani komzimba kulo muthi kuvezwa ngesimo se-urticaria, ukwakheka kwamaqhubu, i-exanthema. Ukwanda kokujuluka nobuthakathaka obujwayelekile buvela ku-12% weziguli.
Imiyalo ekhethekile
Uma iziguli zine-contraindication ehlobene (isithuthwane, isifo se-cerebrovascular), umuthi olwa namagciwane ubekelwa izizathu zezempilo kuphela. Uma isifo sohudo sihambisana nokwelashwa nomuthi kuyo yonke le nkathi yokuphatha, khona-ke kuyadingeka ukuthi kuhlolwe i-pseudomembranous colitis. Lapho uqinisekisa ukutholwa, kuyadingeka ukumisa ukusetshenziswa kwalesi sidakamizwa ngokushesha okukhulu.
Ukuvivinya umzimba ngokweqile kumele kuqedwe ngokuphelele. Ukuhlala isikhathi eside elangeni akwamukeleki. Ukwanda okuzimele kwesimo sezinsuku zonke kukhulisa ubungozi be-crystalluria.
Ukuhambisana notshwala
Umuthi unokuhambisana okungalungile notshwala. I-Ethanol ehlangene ne-ciprofloxacin icasisa ukudakwa okukhulu.
Umthelela ekhonweni lokulawula izindlela
Ngenxa yokuntula ukozela, ochwepheshe bavumela ukushayela ngokucophelela nezinye izimoto.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Akunconyelwe ukufaka umuthi olwa ne-antibacterial ekwelapheni. Isetshenziswa ezimweni ezihlukile futhi kuphela ngenxa yezizathu zezempilo.
Kunquma i-Ciprinol ezinganeni ezingama-500
Kuze kube yiminyaka eyi-18 aqokiwe. Okuhlukile yi-anthrax ne-pulmonary cystic fibrosis, eyatholakala kudala ezinganeni ineminyaka engama-5 kuya kwengama-17.
Sebenzisa ebudaleni
Iziguli esezikhulile kufanele ziqale ngomthamo wesigamu. Ukwemukelwa kwenziwa ngaphansi kokuqondisa kukachwepheshe.
Isicelo sokusebenza kokulimala kwezinso
Ukwamukela ngokuqapha ngaphansi kokuqondisa kukachwepheshe.
Sebenzisa umsebenzi wesibindi okhubazekile
Ukuphula umthetho okuhlobene. Ukunakekelwa kumele kuthathwe.
Ukweqisa
Izimpawu ezisetshenziswayo zokweqisa ngokweqile zivezwa ngendlela yokuhlanza, yokuhoxa, ikhanda, ukulahleka kokudideka, izinhlungu esifubeni nasesiswini, ukubona okuzwakalayo nokuzwakalayo kokuzwa. Ukwelashwa kunqunywa ngokubonakalayo udokotela ohambelayo. Ukulondolozwa kwesisu nokuphathwa kwe-enterosorbent kuyadingeka.
Izimpawu ezisetshenziswayo zokweqisa kwe-Ciprinol 500 zivezwa njengokuhlanza.
Ukuxhumana nezinye izidakamizwa
I-Didazonin yehlisa isilinganiso sokufakwa kwe-antibiotic. Ama-theophyllines nama-xatin akhishwa kancane emzimbeni ngenkathi ephuzwa ngemithi elwa namagciwane. Inkomba ye-thrombopropin ingancipha ngokusetshenziswa komuthi ngokuhlanganiswa nezidakamizwa ze-hypoglycemic. Ingozi yokuthola umkhuhlane kanye nokuquleka inyuka ngokusetshenziswa kanyekanye kwezidakamizwa ezingezona ezika-anti -idalidal kanye nemithi elwa namagciwane.
Imithi enciphisa amazinga e-uric acid futhi inesandla ekuqothulweni kwayo ngokushesha ingandisa isikhathi sokuqothulwa kwe-ciprofloxacin emzimbeni. Isikhathi phakathi kokuthatha ama-antacid kanye ne-antibiotic amahora angama-4-5.
Ama-Analog
Umuthi ohlobene ne-fluoroquinolones une-analogues eziningana enomphumela ofanayo wokwelapha. Lokhu kufaka phakathi:
- I-Syphlox. Ifomu lethebhulethi liqukethe 250-500 mg we-ciprofloxacin. Intengo - kusuka kuma-ruble ayi-150.
- Iqiniso. IGeneric, equkethe i-hemifloxacin mesylate (160-320 mg). Intengo - kusuka kuma-ruble angama-950.
- Lefoktsin. Ukukhishwa ifomu - amaphilisi. I-Levofloxacin hemihydrate (250-500 mg). Intengo - kusuka kuma-ruble angama-300.
Ukuzikhethela komuntu okungenela umuntu obekiwe akufakiwe.
Izimo zeholide le-Zipronol 500 kusuka emakhemisi
Iholide elinikezwa.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Awungeke uthenge umuthi ngaphandle kadokotela.
Intengo
Izindleko zefomu lethebhulethi emakhemisi zivela kuma-ruble angama-63.
Awungeke uthenge umuthi ngaphandle kadokotela.
Izimo zokugcina zomuthi
Gcina kude nezilwane, izingane, umlilo, ukukhanya kwelanga kanye nomswakama.
Isikhathi sokuphelelwa yisikhathi
Hhayi ngaphezulu kweminyaka engu-5.
Umkhiqizi u-Cipronol 500
ISlovenia, ukukhathazeka kwe-KRKA.
Ubufakazi bodokotela neziguli mayelana ne-Ciprinol 500
Samokhvalov Arkady, dermatologist, Krasnodar
Amathuba okuthola ukugula ngenxa yokusebenzisa i-antibiotic aphansi, ngakho-ke ngivame ukukunikeza iziguli. Ngenxa ye-bioavailability yayo ephezulu, umphumela wokwelapha ubonwa emavikini angama-1-1,5 emva kohlelo lokuqala. Isebenzayo ngokumelene ukutheleleka kwesikhumba nezicubu ezithambile.
U-Oksana Sapozhnikova, oneminyaka engama-36, uSamara
Iminyaka eyi-2 edlule ihlukunyezwa yi-bronchitis. Ku-mellitus yesifo sikashukela, wonke ama-antimicrobial agents kufanele athathwe ngokucophelela, ngakho-ke ukuthatha i-fluoroquinolone ye-antibhayoriki kwaqala ngemithamo engxenye. Ukukhululeka kuza ngemuva kwezinsuku ezi-2, ukushibilika kwengqondo kunyamalale. Ukusabela okuncane komzimba kwabonwa, ukulunywa kuqedwe ngamafutha e-antihistamine onomphumela opholile. Ngigculisekile ngemiphumela.
