Imithi uSiofor noma iMetformin yizifaniso ezimbili ezinesimo sezinto esifanayo esisebenzayo ekwakhekeni kwazo. Ukuthandwa kwabo kungenxa yokuthi bathuthukisa ukubalwa kwegazi, bakhiphe i-cholesterol "embi", baqinise izindonga zemithambo yegazi, futhi banciphise nengozi yesifo senhliziyo. Njengoba ingxenye eyinhloko ingeyochungechunge lwe-Biguanide, ukuqashwa kuyakhonjiswa ezigulini ezinesifo sikashukela kanye nokukhuluphala okuhambisana nalesi sifo.
Ngabe uSiofor usebenza kanjani?
Amathebulethi eSiofor ayisidakamizwa esinamandla esinqunywe kuphela ngudokotela oya kuye. Baboniswa iziguli ezinesifo sikashukela ukwehlisa ushukela wegazi labo.
Imithi uSiofor noma iMetformin yizifaniso ezimbili ezinesimo sezinto esifanayo esisebenzayo ekwakhekeni kwazo.
Ukwakheka kwefomu lethebhulethi:
- metformin hydrochloride (esikhundleni se-insulin okuhloswe ngaso ukucubungula kakhulu i-glucose);
- i-magnesium stearate;
- titanium dioxide;
- i-macrogol;
- i-povidone;
- isigaxa yi-hypromellose.
Izinkomba zokuqokwa:
- Uhlobo 2 ukwelashwa kwesifo sikashukela;
- ukukhuluphala
- ukungasebenzi kahle kwe-endocrine, okutholakala ngokungahambisani nemisebenzi yezindlala ze-endocrine ngokumelene nesifo sikashukela;
- ukubuyiselwa kwezinqubo ze-metabolic.
Kufinyelelwe ezimeni ze:
- i-pathology yohlelo lokuphefumula;
- ukudakwa kotshwala;
- izingqinamba zangemva kokusebenza;
- i-oncology;
- isifo semithambo;
- ukungabekezelelani ngakunye;
- ukungasebenzi kwezinso nesibindi esigabeni esibuhlungu;
- ukukhulelwa
- inkathi yokuhlanza;
- izingane kanye nokuguga.
ISiofor imiselwe ukwelashwa kwesifo sikashukela sohlobo 2.
Imiyalo ekhethekile yokuphuza umuthi:
- ukusetshenziswa kwesikhathi eside kufaka isandla ekungenisweni okungafanele kwe-Vitamin B12, iqhaza elibambe iqhaza ku-hematopoiesis;
- ukungaphumeleli ngohlobo 1 sikashukela;
- njengemiphumela emibi ngomthamo overestimated, izimpawu zokungezwani komzimba (ukuqubuka, ukugwinya, ukuvuvukala) kanye nokugaya (ukuhlanza, uhudo, ukuqunjelwa) kungavela.
Izakhiwo zeMetformin
Lesi sidakamizwa esinciphisa ushukela sikhiqizwa ezibhebheni, ezibandakanya i-metformin esebenzayo, kanye nezinto ezisizayo:
- i-magnesium stearate;
- titanium dioxide;
- i-macrogol;
- i-povidone;
- i-crospovidone;
- ama-binders - i-talc nesitashi;
- isihlahla se-polymer igobolondo.
Ukuqokwa kwakhe:
- ukunciphisa i-glucose ku-mono - noma ukwelashwa okuyinkimbinkimbi;
- i-mellitus yesifo sikashukela ngendlela esethembela ku-insulin;
- i-metabolic syndrome (ukukhuphuka kwevolumu yamafutha);
- ukulungiswa kwamazinga we-carbohydrate;
- ukwephulwa kwe-lipid ne-purine metabolism;
- i-arterial hypertension;
- scleropolycystic ovary.
Contraindication ukusetshenziselwa:
- ukuthunyelwa kwebhalansi ye-acid-base (acute acidosis);
- i-hypoxia;
- ukwehluleka kwenhliziyo;
- infarction myocardial;
- isifo semithambo;
- ukungabekezelelani ngakunye;
- ukwehluleka kwezinso kanye nesibindi;
- ukukhulelwa
- inkathi yokuhlanza;
- izingane kanye nokuguga.
Ukuphendula okungalungile okuvela ngenxa yokungabekezeleli i-metformin nezinye izinto:
- izinkinga zesisu (isifo sohudo, ukuqhakaza, ukugabha);
- ushintsho ekunambithekeni (ukuba khona kokunambitheka kwensimbi);
- i-anemia
- i-anorexia;
- i-hypoglycemia;
- ukuthuthukiswa kwe-lactic acidosis (kubonakaliswa ukungasebenzi kahle kwe-renal);
- umthelela omubi ku-mucosa wesibeletho.
Ukuqhathanisa kweSiofor neMetformin
Umuthi owodwa uthathwa njengento efanayo komunye, ngoba isithako esikhulu esisebenzayo yi-metformin efanayo yesithako. Ukuqhathanisa kwabo akunamsebenzi. Singakhuluma kuphela ngokuqondiswa okufanayo kwesenzo nabakhiqizi abahlukahlukene abaqedela ukwakheka ngezinto ezingefani ezingeziwe futhi babele amagama ahlukahlukene ezohwebo.
Ukufana
Ukufana okuyinhloko kwalawa ma-Biguanides ku-mehendi nesiqondiso sokusebenza. Imizamo ihlose ukwenza ngcono ukusebenza kwezinqubo ze-metabolic ezingeni lamaselula, lapho umzimba uqala ukusabela ku-insulin ngendlela yokuthi kungenzeka ukuthi inciphise kancane kancane umthamo wansuku zonke kuze kube ngaphandle okuphelele. Isenzo se-pharmacological yento esebenzayo ilele emandleni aso wokunciphisa ukugcwala kwe-glucose kumaseli wegazi yi-gluconeogeneis (ecindezela ukwakheka koshukela esibindini).
I-Metformin isebenzisa i-enzyme ekhethekile yesibindi (iprotheni kinase), ebhekele le nqubo. Indlela yokusebenza kwe-protein kinase ayifundiswanga ngokuphelele, noma kunjalo, ucwaningo oluningi lubonisa ukuthi le nto ibuyisela kabusha ukukhiqizwa kwe-insulin ngendlela yemvelo (isebenza njengesiginali ye-insulin okuhloswe ngayo ukufaka izinqubo ze-metabolism zamafutha noshukela).
Imithi inezindlela ezifanayo zethebhulethi. Amanani abo angama-500, 850 kanye no-1000 mg. Ukusetshenziswa kwemali kwenziwa ngendlela efanayo. Izifundo zinikezwe ngezigaba:
- ukujwayelekile kokujwayelekile - 1 ithebhulethi engu-500 mg izikhathi ezingama-1-2 ngosuku;
- ngemuva kwamasonto ayi-1-2, umthamo ukhushulwa amahlandla ama-2 (njengoba kuyalelwe udokotela), okungama-4 ama-pcs. 500 mg ngamunye;
- inani eliphezulu lomuthi ngamathebhulethi ayi-6 ama-500 mg (noma izingcezu ezi-3 ze-1000 mg) ngosuku, i.e. 3000 mg
I-Metformin ayinconywa kubafana lapho sebekhulile.
Njengomphumela wesenzo seMetformin noma iSiofor:
- ukumelana ne-insulin kuyancipha;
- ukuzwela kwamaseli ekhuphukeni kweglucose;
- i-adsorption yamathumbu ushukela iyehla;
- amazinga e-cholesterol ajwayelekile, avimbela ukukhula kwe-thrombosis kushukela;
- ukwehla kwesisindo kuyaqala.
Ama-Metformin awanconywa kubafana njengoba bekhula, ngoba umuthi unciphisa i-dihydrotestosterone, ifomu elisebenzayo le-testosterone yabesilisa, enquma ukukhula ngokomzimba kwentsha.
Uyini umehluko?
Umehluko phakathi kwemithi igama (okuncike kumenzi) kanye nokufakwa kwezinye izinto ezengeziwe. Ngokuya ngezakhiwo zezinto ezisizayo ezikulesi sakhiwo, la ma-ejenti kufanele anqunywe. Ngakho-ke i-crospovidone, eyingxenye yomunye wemithi, yenza ukuthi amaphilisi alondoloze kahle ubuqotho babo, futhi ngasikhathi sinye asetshenziselwa ukukhipha kangcono izinto ezisebenzayo ekwakhiweni okuqinile. Lapho ihlangana namanzi, le ngxenye iyajuluka futhi igcine leli khono ngemuva kokoma.
ISiofor ingumkhiqizo wemithi yenkampani yaseJalimane iBerlin-Chemie / Menarini Pharma GmbH.
ISiofor ingumkhiqizo wemithi yenkampani yaseJalimane iBerlin-Chemie / Menarini Pharma GmbH. Umuthi uhlinzekwa ngaphansi komkhiqizo onjalo hhayi eRussia kuphela, kodwa nawo wonke amazwe aseYurophu. I-Metformin inabakhiqizi abaningi abahlukahlukene, ngokulandelana, kanye nezinguquko egameni:
- Metformin Richter (Hungary);
- Metformin-Teva (Israel);
- Metformin Zentiva (Czech Republic);
- Metformin-Canon (Russia).
ISiofor neMetformin ziyehluka ngentengo.
Yikuphi okushibhile?
Intengo emaphakathi yamaphilisi weSiofor No. 60 anomthamo:
- 500 mg - ama-ruble angama-210;
- 850 mg - ama-ruble angama-280;
- I-1000 mg - 342 rub.
Intengo evamile yamathebulethi weMetformin No. 60 (kuya ngomkhiqizi):
- I-Richter 500 mg - ama-ruble ayi-159., Ama-ruble ayi-850 mg - 193., I-1000 mg - ama-ruble ayi-208 .;
- I-Teva 500 mg - ama-ruble angama-223, ama-ruble ayi-850 mg - 260, ama-ruble ayi-1000 mg - angama-278 .;
- I-Zentiva 500 mg - ama-ruble ayi-118, ama-ruble ayi-850 mg - angu-140, ama-ruble ayi-1000 - ama-176.
- I-Canon 500 mg - ama-ruble ayi-127, ama-850 mg - ama-ruble ayi-150, ama-ruble ayi-1000 - ama-ruble ayi-186.
ISiofor, iMetformin ichazwe njengokungena esikhundleni komunye nomunye, ngakho-ke, akufanelekile ukuqhathanisa amakhono abo - lokhu kuyafana.
Yini engcono iSiofor noma iMetformin?
Imithi ibekelwa indawo yomunye nomunye, ngakho-ke akunakufanisa ukuqhathanisa amakhono abo - bayalingana ngokufanayo. Kepha yikuphi ukwakheka okungcono - udokotela oholayo uzonquma ngesisekelo sezinkomba zesifo, ukuzwela ezithweni ezengeziwe, okuthandwa ngumuntu ngamunye. Zombili lezi zidakamizwa ziphatha isifo sikashukela sohlobo 2 futhi zisize ngokukhuluphala - lezi yizici ezibalulekile lapho ukhetha i-Biguanides Siofor neMetformin.
Ngoshukela
Usebenzisa i-metformin therapy, ungathola ukwehla kweshukela ngo-20%. Uma kuqhathaniswa nezidakamizwa eziningi ezisetshenziselwa ukwelapha isifo sikashukela, lesi sakhi sinciphisa ubungozi bokuhlaselwa yisifo senhliziyo nokufa kwabantu ezigulini ezinesifo sikashukela sohlobo 2. Lesi sifo kunzima ukuselapha. Kodwa uma i-pathology inganqunywa ngokushesha futhi ngokushesha iqale ukwelashwa, ke kunethuba lokululama ngaphandle kwemiphumela.
Imiyalelo yalawa ma-ejenti we-Biguanide ayakhonjelwa ezigulini ezixhomekeke kumijovo ye-insulin, futhi zisetshenziswa njenge-prophylaxis ukusiza ukugwema isifo sikashukela. Izingoma ziqala umsebenzi wazo ngaso leso sikhathi, kusukela kolwamukelo lokuqala izinguquko ezisebenzayo zenzeka kuzo zonke izinqubo. Ngokusebenzisa njalo iMetformin noma iSiofor, ukwelashwa okuhambisana ne-Insulin ngeke kudingeke maduze, imijovo ingaguqulwa ngokuphelele ngokuthatha ama-biguanides kuphela.
Ukwehla kwesisindo
Izidakamizwa zinconywa ukuthi zithathwe ekwelashweni okuyinkimbinkimbi kwesisindo ngokweqile, okunomthelela omubi emzimbeni, okuvusa ama-pathologies enhliziyo ajwayelekile, kanye nokwanda kweglucose yegazi.
Ngaphansi kwesenzo se-Biguanides:
- ukwehla kwesifiso sokudla;
- ushukela omningi ushiya ekudleni;
- okuqukethwe kwekhalori kuncishisiwe;
- i-metabolism icushiwe;
- ukwehla kwesisindo kuza (qaphela ukulahleka kwesisindo esingu-1-2 kg njalo ezinsukwini ezingama-5-7).
Lapho wenza ukwelashwa, kuyadingeka:
- landela ukudla;
- yenqaba ukudla okunamafutha;
- xhuma umsebenzi womzimba.
Ukubuyekezwa kweziguli
UMary, oneminyaka engama-30 ubudala, idolobha lasePodolsk.
ISiofor isiza ukulahlekelwa yi-3-8 kg kg, ngakho-ke ithandwa kakhulu. Umuthi ulungele labo abangakwazi ukubekezelela ukudla okuhlukahlukene. Ungasebenzisa inkambo ejwayelekile ukulwa nokulutha kwamaswidi - lo muthi unikeza lo mphumela.
UTatyana, oneminyaka engama-37, uMurmansk.
I-Metformin inqunywa lapho isifo sikashukela siyimbangela yokukhuluphala ngokweqile. Ukukhuluphala kwezinye izifo (i-yegilo gland, ama-dysfunctions ama-hormone, njll) aliphathwa ngale ngxenye. Kusho udokotela wami. Ngaphambi kokuzinquma, khomba imbangela.
U-Olga, oneminyaka engama-45, uKaliningrad.
IMetformin noma iSiofor yokusetshenziswa okungalawulwa kungatshala isibindi. Ekuqaleni, akazange afake ukubaluleka kokuphulwa okunjalo kuze kube yilapho enaka ukusinda ohlangothini lwesokunene nokukhazimula kwamaprotheni eso. Ungazinikezi noma yini.
AbakwaMetformin noSiofor batusa ukuthatha imishanguzo eyinkimbinkimbi yokukhuluphala ngokweqile.
Ukubuyekezwa kodokotela mayelana neSiofor neMetformin
K.P. I-Titov, i-Therapist, iTver.
I-Metformin yi-INN, futhi iSiofor yigama lokuhweba. Yisiphi isidakamizwa esisebenza kakhudlwana akekho ozokusho. Izizathu zokusebenza noma ukungasebenzi kahle kwezimali zingahluka, kusuka kumaphutha ohlelweni kuya ngesidingo sokuhlanganiswa nelinye iqembu lezidakamizwa elekelela isenzo se-biguanides.
S.A. I-Krasnova, i-endocrinologist, eMoscow.
I-Metformin ayisebenzi njengesidakamizwa esinciphisa ushukela, sinqunyelwe ukwandisa ukumelana ne-insulin. Ngakho-ke, akukho-coma we-hypoglycemic ovela kuye, lapho ushukela wehla kakhulu kangangokuthi isiguli sengozi siwela ku-coma. Lokhu ukuhlanganisa okungenakufinyeleleka kwemikhiqizo equkethe i-metformin.
O.V. UPetrenko, owelaphi, uTula.
I-Metformin Zentiva eshibhile ithandwa kakhulu, kepha ngisho noshukela otholakele akusona isizathu sokuphuza amaphilisi. Ngokusetshenziswa isikhathi eside, iqembu le-Biguanide linciphisa ukubekezelela amasosha omzimba kuma-antigen akhiqizwayo. Kungcono ukubuyekeza ukudla, ungafaki imikhiqizo eyingozi kwimenyu, futhi ungeze enempilo. Ukudla kufanele kube nezithelo nemifino eminingi. Khumbula ukuthi ukuzelapha akuzenqatshelwe, ikakhulukazi ngesifo sikashukela.
