Isidakamizwa i-Diapiride: imiyalo esetshenzisiwe

I-Diapiride isidakamizwa esinomphumela we-hypoglycemic wesikhathi eside. Umuthi ungowokukhishwa okuningana kwe-sulfonylurea.

Igama Lezwe elingafanele

Izimali ze-INN - Glimepiride.

I-Diapiride isidakamizwa esinomphumela we-hypoglycemic wesikhathi eside.

I-ATX

Ikhodi ye-ATX: A10VB12.

Khipha amafomu nokwakheka

Umuthi wenziwa ngesimo samathebulethi ngemithamo ehlukile yento esebenzayo. Ephaketheni lekhadibhodi kubhebhezelwa amaphilisi angama-30. Ithebhulethi eyi-1 iqukethe u-2, 3 noma u-4 mg we-glimepiride (into esebenzayo). Amathebulethi anomthamo we-2 mg aluhlaza okotshani, ama-3 mg aluhlaza ophuzi, ama-4 mg aluhlaza okwesibhakabhaka.

Ukwakheka kwamathebulethi kufaka phakathi okutholwayo:

• i-lactose monohydrate;
• i-microcrystalline cellulose;
• i-sodium starch glycolate;
• i-povidone;
• i-iron iron oxide;
• i-magnesium stearate;
• indigo carmine.

I-Glimepiride inomphumela we-hypoglycemic ngokukhuthaza ukukhishwa kwe-insulin.

Isenzo se-Pharmacological

I-Glimepiride inomphumela we-hypoglycemic ngokukhuthaza ukukhishwa kwe-insulin. Umuthi usebenza ezinqwabeni zama-β-cell of pancreas, ukuvala iziteshi ze-potassium. Ngenxa yalokhu, la mangqamuzana aya ngokuya ezwela ushukela emzimbeni, futhi i-insulin ikhishwa kalula futhi ngokushesha okukhulu.

Kukhona futhi ukwanda kokuzwela kwamangqamuzana ukuya ku-insulin, futhi ukusetshenziswa kwawo yisibindi kuyancishiswa. Ngaso leso sikhathi, i-gluconeogeneis ivinjelwe. Izicubu ze-Lipid nezicubu zomzimba zibamba ama-molecule eglucose ngokushesha ngenxa yokwanda kwesilinganiso samaprotheni okuhambisa.

Umuthi osebenzayo wehlisela ubungako bokucindezela kwe-oxidative ngokuvuselela ukukhiqizwa kwe-α-tocopherol kanye nokwenza ngcono isenzo sama-enzyme e-antioxidant.

I-Pharmacokinetics

Ngemuva kokuphathwa ngomlomo, i-glimepiride igxilwa ngokushesha emgodini wokugaya ukudla bese ingena egazini. Ukudla akukunciphisi ukumunyisa umuthi. Le nto ifinyelela ekuhlolweni okuphezulu kakhulu kwe-plasma yegazi kungakapheli amahora angama-2-2,5.

Ngemuva kokuphathwa ngomlomo, i-glimepiride igxilwa ngokushesha emgodini wokugaya ukudla bese ingena egazini.

I-Glimepiride ibonakala ngokubopha okuhle kumaphrotheni egazi (99%). I-metabolism yesidakamizwa yenziwa esibindini. Ama-metabolites aphumela lapho adalulwa izinso namathumbu. Umuthi ukhishwa emzimbeni ngaphakathi kwamahora ayi-10-16. Ngenkathi uthatha iDiapiride, ukunqwabelana kwezinto emzimbeni akubhekwa (noma kusetshenziswa isikhathi eside).

Izinkomba zokusetshenziswa

Umuthi usetshenziselwa ukwelapha iziguli ezinesifo sikashukela sohlobo II. Kubekwa amaphilisi lapho kungenakwenzeka ukuguqula ushukela wegazi usebenzisa izondlamzimba ezifanele kanye nokuzivocavoca.

Contraindication

Kuyenqatshelwa ukuthatha umuthi uma kunezimpawu ezilandelayo zokuphula umthetho:

1. Ukungabekezelelani komuntu ngamunye ku-sulfonamides.
2. Hypersensitivity kuzakhi.
3. Coma
4. I-ketoacidosis.
5. Izinhlobo ezinzima zesibindi noma zezinso.
6. Thayipha isifo sikashukela sokuqala.
7. Isikhathi sokukhulelwa nokukhulelwa.
8. Iminyaka yezingane.

Ngokunakekela

Ngaphansi kokuqashwa ngudokotela okuqinile, umuthi usetshenziselwa ukusebenza okuphuthumayo, utshwala, umkhuhlane, umsebenzi we-thyroid okhubazekile, ukungasebenzi kahle kwe-adrenal kanye nezifo ezinzima.

Ngemuva kokungenelela okukhulu kokuhlinzwa, ukulimala, ukusha, iziguli ziyelulekwa ukuba zishintshele ekwelashweni kwe-insulin.

Ungayithatha kanjani i-diapiride?

Umuthi uphuzwa ngomlomo ngamanzi amancane. Kungcono ukuthi uhlanganise ukuthatha amaphilisi nokudla ukuze kuvikeleke ama-pathologies asesiswini.

Kwenqatshelwe ukuphuza umuthi ekhefini.

Akuvunyelwe ukuthatha umuthi lapho ubhekene ne-ketoacidosis.

Kwenqatshelwe ukuphuza umuthi lapho kunezindlela ezinobunzima zesibindi kanye nezinso zezinso.

Kuyenqatshelwa ukuthatha umuthi phambi kwesifo sikashukela sohlobo 1.

Kwenqatshelwe ukuthatha umuthi ngesikhathi sokukhulelwa.

Ukuthatha umuthi akuvunyelwe ngesikhathi sokuqunjelwa.

Kwenqatshelwe ukuthatha umuthi ebuntwaneni.

Ngoshukela

Ukwelashwa kohlobo lwe-II yesifo sikashukela esinga-insulin, lesi sidakamizwa siphuzwa izikhathi eziyi-1-2 ngosuku. Ekuqaleni komthamo, umthamo ngu-1 mg ngokuya nge-glimepiride. Uma kwanele ukuguqula ushukela egazini, khona-ke umthamo awukhuphuki.

Ngomphumela onganele, umthamo wanda kancane kancane uye ku-2, 3 noma 4 mg. Isikhathi esiphakathi kokushintsha umthamo kufanele okungenani sibe izinsuku eziyi-7. Kwesinye isikhathi iziguli zinikezwa i-6 mg ye-glimepiride ngosuku (umthamo ophelele ovunyelwe nsuku zonke).

Odokotela bangahle banikeze ukuphathwa ngokubambisana komuthi nge-metformin noma i-insulin ukufeza umphumela omkhulu. Ukuthatha lezi zidakamizwa kungaholela ekwandeni okuqhubekayo kwe-insulin susceptibility. Kulokhu, umthamo uyancishiswa noma ukhanseliwe ngokuphelele.

Imiphumela emibi ye-Diapyrid

Engxenyeni yesitho sombono

Ngesikhathi sokulashwa, ukuphazamiseka okubonakalayo kwesikhashana (ukuwohloka kwesikhashana) kungenzeka. Imbangela yalomphumela wecala ukushintshwa koshukela wegazi.

Ukwelashwa kohlobo lwe-II yesifo sikashukela esinga-insulin, lesi sidakamizwa siphuzwa izikhathi eziyi-1-2 ngosuku.

Amapheshana wesisu

Umphumela ephepheni lokugaya ukudla:

• isicanucanu nokuhlanza
• isifo sohudo
• izinhlungu zesisu;
• izifo zesibindi (i-hepatitis, ukwehluleka kwesibindi, njll.).

Izitho zeHematopoietic

Imiphumela emibi evela ohlelweni lwe-hematopoietic:

• i-thrombocytopenia;
• i-leukopenia;
• i-anemia
• i-granulocytopenia;
• erythrocytopenia;
• i-agranulocytosis;
• pancytopenia.

Ngesikhathi sokuphuza umuthi, i-nausea ingahle ivele.

Ngesikhathi sokuphuza umuthi, ukuhlanza kungavela.

Ngesikhathi sokuphuza umuthi, isifo sohudo singabonakala.

Ngesikhathi sokuphuza umuthi, ubuhlungu besisu bungabonakala.

Ngesikhathi sokuphuza umuthi, i-hepatitis ingavela.

Ngesikhathi sokuphuza umuthi, ukwehluleka kwesibindi kungavela.

Ngesikhathi sokuphuza umuthi, i-anemia ingavela.

Isistimu yezinzwa ephakathi

Kusukela ohlangothini lwesistimu yezinzwa ephakathi kuyabonakala:

• ikhanda
• Isiyezi
• ukudideka kokwazi;
• ukuqwasha
• ukukhathala;
• amazwe acindezelayo;
• ukuncipha kokuphendula kwe-psychomotor;
• ukukhubazeka kwenkulumo;
• ukuzamazama kwemilenze;
• iminyakazo.

Ngasohlangothini lwe-metabolism

Umphumela ongemuhle kuma-metabolism ubonakaliswa yi-hypoglycemia.

Allergies

Ngesikhathi sokuphatha, ukungahambi kahle komzimba kungenzeka:

• isikhumba esikhanyayo;
• i-urticaria;
• ukuqhuma
• i-alculgic vasculitis.
  

  Isikhathi sokulashwa nomuthi ovela ohlelweni lwezinzwa oluphakathi, kungaqhamuka ikhanda.

  

  Ngesikhathi sokulashwa nomuthi ovela ohlelweni lwezinzwa oluphakathi, isiyezi singabonakala.

  

  Isikhathi sokwelashwa nomuthi ovela ohlangothini lwesistimu yezinzwa ephakathi, ukuvela kungabonakala.

  

  Isikhathi sokulashwa nomuthi ovela ohlelweni lwezinzwa oluyinhloko, ukuqwasha kungabonakala.

  

  Isikhathi sokulashwa nomuthi ovela ohlelweni lwezinzwa oluyinhloko, ukukhathala okuthe xaxa kungavela.

  

  Ngesikhathi sokulashwa nomuthi ovela ohlelweni lwezinzwa oluphakathi, kungavela izimo ezicindezelayo.

  

  Isikhathi sokulashwa ngomuthi ovela ohlelweni lwezinzwa oluphakathi, ukuvela kungabonakala.

Umthelela ekhonweni lokulawula izindlela

Umuthi unganciphisa ijubane lokuphendula kwe-psychomotor futhi ubangele isiyezi. Ekuqaleni kokwelashwa, kanye nalapho ulungisa imithamo, akunconywa ukushayela izimoto nokwenza omunye umsebenzi odinga ukunakwa kakhulu.

Imiyalo ekhethekile

Uma izinga le-glucose egazini lehla ukusuka kumthamo wansuku zonke ophansi (1 mg we-glimepiride), kunconyelwa ukuyeka kancane kancane ukusebenzisa umuthi. Umphumela we-hypoglycemic kuleli cala ungaluthola usebenzisa indlela yokudla (ngaphandle kokusebenzisa umuthi).

Ngesikhathi sokwelashwa, udinga ukubheka ushukela wegazi, i-glycosylated hemoglobin, kanye nesibindi, amaseli amhlophe egazi namaplatelethi egazini.

Sebenzisa ebudaleni

Ithuluzi livunyelwe ukusetshenziselwa iziguli zemikhakha ehlukene yobudala, ngaphandle kwezingane. Kepha abantu asebekhulile abasebenzisa isikhathi eside amaphilisi bangaba ne-hypoglycemia. Ukugwema lokhu kudokotela, odokotela banquma abaguli asebekhulile ukudla okuyisipesheli nemithamo ephansi yomuthi (uma kungenzeka).

Isabelo sezingane

Umuthi uvunyelwe ukuthi usetshenziswe ngemuva kweminyaka eyi-18.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Ngesikhathi sokukhulelwa nokuqunjelwa, ukuthatha lo muthi kuyaphulwa.

Uma izinga le-glucose egazini lehla ukusuka kumthamo wansuku zonke ophansi (1 mg we-glimepiride), kunconyelwa ukuyeka kancane kancane ukusebenzisa umuthi.

Isicelo sokusebenza kokulimala kwezinso

Izifo ezinzima zezinso, awukho umuthi obekiwe. Iziguli ezinjalo zidluliselwa ekwelashweni kwe-insulin. Esigabeni sokuqala sokwehluleka kwezinso, ukusetshenziswa kwamathebulethi kungenzeka ngaphansi kokuqashwa ngokuqinile kodokotela.

Sebenzisa umsebenzi wesibindi okhubazekile

Ama-pathologies wesibindi abukhali awukuphikisana nokusetshenziswa komuthi. Ezigulini zokuqina okuqinile noma okulinganiselayo, ukuphathwa kwawo kumithamo ephansi kungenzeka. Ukwelapha kufanele kuhambisane nokuqapha isibindi.

Ukweqisa kweDiapiride

I-overdose yesidakamizwa iholela ekubonakala kokuphendula kwe-hypoglycemic (ukwehla okunamandla kushukela wegazi). Kulokhu, isiguli sizwa ukukhathala, ukozela, isiyezi. Ukulahlekelwa okungenzeka kokungazi. Ukuqeda izimpawu zokweqisa, baphendukela ekwelashweni kwezimpawu.

I-overdose yesidakamizwa iholela ekubonakala kokuphendula kwe-hypoglycemic (ukwehla okunamandla kushukela wegazi).

Ukuxhumana nezinye izidakamizwa

Umuthi kufanele uphathwe ngokucophelela ngokuhlangana nemithi efana nale:

1. I-Fluconazole
2. I-Phenylbutazone
3. I-Azapropazone.
4. Sulfinpyrazone.
5. I-Oxyphenbutazone.
6. I-Pentoxifylline.
7. Tritokvalin.
8. Ama-Disopyramides.
9. I-Fenfluramine.
10. I-probenecid.
11. Ama-anticoagulants eqenjini le-coumarin.
12. Ama-salicylates.
13. Abanye antidepressants (MAO inhibitors).
14. Izicucu.
15. I-Fluoxetine.
16. ICyclophosphamide.
17. I-Feniramidol.
18. Ifosfamide.
19. I-Miconazole
20. I-Tetracycline ne-quinolone antibiotics.
21. Ezinye izidakamizwa ze-hypoglycemic.
22. Ama-anabolic steroid.
23. Ama-inhibitors e-ACE.
24. I-PASK (para-aminosalicylic acid).

Ukwehla komphumela wesidakamizwa kuyabonakala lapho kuthathwa ndawonye nePhenothiazine kanye nokuphuma kwayo.

Ngokusetshenziswa kanyekanye kwalezi zimali, umphumela we-hypoglycemic of Diapiride uyathuthukiswa. Ukwehla komphumela wesidakamizwa kuyabonakala lapho kuthathwa ndawonye nePhenothiazine kanye nokutholakala kwawo, ama-estrogens kanye nama-progestogens, i-glucagon, i-nicotinic acid, i-corticosteroids, i-barbiturates, i-Phenytoin, i-Acetazolamide, i-diuretics nezidakamizwa zokwelapha indlala yegilo.

Ukuhambisana notshwala

Umuthi awuhambelani kahle ne-ethanol. Iziphuzo zotshwala zingakhuphula futhi zinciphise umphumela wokwelapha we-Diapiride.

Ama-Analog

Kukhona izifanekiselo ezinjalo zomuthi:

1. I-Gliclazide.
2. Maninil.
3. Isifo sikashukela.
4. UGlidiab.
5. I-Glurenorm.

Imibandela yekhefu lekhemisi

Ngingakwazi ukuthenga ngaphandle kadokotela?

Umuthi usatshalaliswa ngugqirha.

Intengo

Izindleko zeDiapiride kumakhemisi zisukela kuma-ruble ayi-110 kuye kwangama-270, kuya ngomthamo wento esebenzayo.

Izimo zokugcina zomuthi

Gcina amaphilisi endaweni eyomile futhi emnyama lapho izingane zingafinyeleleki khona, emazingeni okushisa afinyelela ku + 25 ° C.

Isikhathi sokuphelelwa yisikhathi

Impilo yeshelf iyiminyaka emi-2.

Umkhiqizi

Umkhiqizi uPJSC "Farmak" (Ukraine).

Ukubuyekezwa

ULyudmila, oneminyaka engama-44, Izhevsk.

Ngiqale ukusebenzisa lo makhambi njengoba kuyalelwe udokotela ukunciphisa ushukela wegazi. Umuthi ungabizi futhi usebenza kahle. Kuyasiza ukugcina amazinga kashukela.

U-Alexey, oneminyaka engama-56, eMoscow.

Sekuphele iminyaka engaphezu kwengu-5 ngihlaselwa isifo sikashukela sohlobo 2. Ngiphuza la maphilisi elilinganisweni esincane. Ngokusetshenziswa njalo, izinga loshukela wegazi liqina. Imiphumela emibi ayenzeki. Kepha ngizama ukuhlanganisa umuthi nokudla ukuze ngigweme ukwehla okushukela.

U-Ana, oneminyaka engama-39, uVoronezh.

Isazi se-endocrinologist sincoma ukuthatha lesi sidakamizwa sokulwa nesifo sikashukela. Ngiyawubekezelela umuthi kalula, angizweli ukusabela okungekuhle. Intengo yayo ingifanele ngokuphelele. Ushukela wegazi ungaphakathi kwemikhawulo ejwayelekile. Ngiyayincoma!