ILevemir Penfill iyi-insulin esebenza isikhathi eside. Umenzeli we-hypoglycemic uhlinzeka ngokusakazeka isikhathi eside kwe-insulin egazini. Lokhu kunomthelela ekunciphiseni okuqhubekayo kwe-glucose yegazi. Isetshenziselwa ukwelashwa okuqondile ezigulini ezinesifo sikashukela i-mellitus.
Igama Lezwe elingafanele
INN: Unembeza we-insulin.
I-ATX
A10AE05.
Khipha amafomu nokwakheka
Umuthi uyatholakala ngesimo sesisombululo esikhanyayo esihloselwe ukuphatha okungaqondakali. Isithako esiyisisekelo esisebenzayo kungukudonswa kwe-insulin kumthamo we-100 IU. Izinto ezengeziwe: i-glycerol, i-zinc acetate, i-metacresol, i-phenol, i-sodium hydroxide, i-dihydrate ne-chloride, amanzi okujova.
I-Levemir Penfill ingumuthi ngendlela yesisombululo esicacile esenzelwe ukuphathwa kwe-subcutaneous.
Umuthi lo ukhiqizwa kuma-cartridges akhethekile (3 ml). Iyunithi eyi-1 yokuthola i-insulin detemir ilingana no-0.142 mg wecala lokuthola insulin. I-1 UNIT ye-insulin detemir - 1 IU ye-insulin yabantu.
Isenzo se-Pharmacological
Kubonakaliswa ngumphumela we-antidiabetesic, isenzo eside. Kuyinto i-analogue encibilika kakhulu ye-insal insulin yabantu. Isixazululo sisebenza ngokufana, akukho msebenzi ophakeme wesidakamizwa obonwa.
Indlela yokusebenza isebenza ngenxa yekhono lama-molecule ento esebenzayo yokubopha kuma-asidi e-fatty. Le nqubo yenzeka ngqo endaweni yomjovo. Umuthi osebenzayo usatshalaliswa kancane ezithweni nezitho zomzimba. Lokhu kungenxa yomphumela wesikhathi eside.
Umphumela we-hypoglycemic kwenzeka ngenxa yokuthathwa ngokushesha kweshukela ngama-cell of izicubu zemisipha ne-adipose. Ngemuva kokubopha i-insulin kuma-receptors, ukukhishwa kwe-glucose yisibindi kuyancipha.
I-Pharmacokinetics
I-insulin ephakeme kakhulu egazini ibonwa ngemuva kwamahora ayi-6. Kusatshalaliswa cishe ngokulinganayo ngaphezulu kwezicubu eziqondiwe. Ujikeleza ngokushesha egazini. I-Metabolism yenzeka esibindini, kepha ama-metabolites awanayo imisebenzi ye-hypoglycemic. Ukuqedwa kwesigamu sempilo kungamahora angama-7, ngenxa yomuthi olungiselelwe.
Izinkomba zokusetshenziswa
Izinkomba eziqondile zokusetshenziswa kweLevemir Penfill yile:
- ukwelashwa kwesifo sikashukela sohlobo 1 kubantu abadala;
- isifo sikashukela i-mellitus ezinganeni kusuka eminyakeni emi-2 nasekuthweni kokukhula.
Contraindication
Ukuphela kokuphulwa okuqondile kokusetshenziswa kwembumbulu ye-insulin ekwelapheni isifo sikashukela yi-hypersensitivity kulolu hlobo lwe-insulin noma enye yezakhi zomuthi. Akukhuthazwa ukuthi unikeze izingane ezingaphansi kweminyaka engu-2 ubudala, njengoba izivivinyo zemitholampilo ezenziwa ezigulini ezikuleli qembu zazingekho.
Ngokunakekela
Ngokuqapha, umuthi ubekelwe iziguli esezikhulile kanye neziguli ezingasebenzi kahle i-adrenal function.
Ngokuqapha, umuthi i-Levemir Penfill unqunyelwe iziguli esezikhulile.
Ungayithatha kanjani i-Levemir Penfill?
Ngokuzenzakalelayo ethangeni, ngaphambili odongeni lwesisu noma ehlombe. Ukusetshenziswa kwangaphakathi akunqatshelwe. Isingeniso kungenzeka nganoma isiphi isikhathi sosuku, uma lwenziwa ngesikhathi 1 ngosuku. Umthamo obekiwe ungahlukaniswa ngemithamo emi-2. Kepha udinga ukubheka ukuthi umthamo wesibili kufanele uphathwe ngaphambi kokudla kwakusihlwa noma ngaphambi kokulala ukuze kudlule amahora ayi-12 phakathi komjovo wokuqala nowesibili.
Ukuze ugweme izinkinga zasendaweni, kungakuhle ushintshe indawo yomjovo.
Umuthi akufanele ube yiqhwa, kufanele ube nokushisa kwegumbi. Uma isixazululo silahlekelwe sobala noma okunye okubonakalayo kubonakala, akunakusetshenziswa.
Ungayisebenzisa kanjani ipeni yesirinji?
I-cartridge yesisombululo isetshenziswa kuphela ngokuhlangana nepeni likaNovo Nordics nezinaliti ezikhethekile zeNovoFine.
Ukusetshenziswa kwama-cartridges kungamuntu ngamunye futhi kuyatholakala. Uma kunesidingo sokusebenzisa izinhlobo eziningana ze-insulin zesenzo eside nesifushane ngasikhathi sinye, khona-ke awukwazi ukuzihlanganisa. Isisombululo ngasinye sizodinga ipeni layo lesirinji.
Ngaphambi komjovo, qiniseka ukuthi isixazululo sikhethwe kahle, nquma ukuthi kufaneleka kanjani ngokubukeka, hlola isirinji nepiston ngomonakalo. Ngaphambi kokuwusebenzisa, hlanza umquba ulwelwesi ngokuphelele ngezixazululo ze-antiseptic, njenge-ethyl alcohol.
Umuthi uphathwa ngokuya ngemiyalo, okufanele ube kwipeni ngalinye lesirinji. Ukuze umthamo ophelele uphathwe, ngemuva komjovo, udinga ukushiya inaliti endaweni yemizuzwana embalwa. Lokhu kuzosiza ukuvikela ukuvuza kwe-insulin esele kwisirinji.
Ukuthatha umuthi wesifo sikashukela
Ukuqapha kuyadingeka kubantu abake basebenzisa ezinye izinhlobo ze-insulin. Ukushintshwa kuhlale kuhambisana nokushintshashintsha kwezimpawu ezibukhali ekuhlushweni kwe-glucose egazini, futhi ngenxa yalokho udinga ukubhekisisa izinguquko kuzo zonke izinkomba.
Imiphumela emibi yeLevemir Penfill
Ngokuyisisekelo, ukubukeka kokuphenduka okubi kuhlotshaniswa nokuguqulwa komthamo. Uma umuthi uphathwe kumthamo owengeziwe, khona-ke i-hypoglycemia kungenzeka. Esimweni esibucayi, ukusabela okunjalo kwaboniswa: i-sympics syndrome, ukulahleka kwengqondo. Iziguli zikhononda ngokungaphatheki kahle komzimba, ukozela, ikhanda, isicanucanu, i-tachycardia, umuzwa ongapheli wendlala.
Ucwaningo luye lwabonisa ukuthi ngokwethulwa kwekhambi esiswini esingenalutho, bekukhona nokuphazamiseka kwe-dyspeptic. Ukuphendula kwasendaweni kwaqapheleka ngendlela yokuvuvukala nokubomvu kwesikhumba, ukulunywa, ubungozi bokuthuthuka ngezicubu zomlomo wesibeletho bukhuphukile.
Kusuka emasosheni omzimba
Kusukela amasosha omzimba kuyabonakala:
- ukuqhuma kwesikhumba okuhambisana nokulunywa;
- ukujuluka ngokweqile;
- ukuphazamiseka kwamapheshana emathunjini;
- ubunzima bokuphefumula.
Lezi zimpawu zivame kakhulu ukubangelwa yi-hypersensitivity ejwayelekile. Ukubonakaliswa okunjalo kwe-anaphylactic kuyingozi.
Engxenyeni ye-metabolism kanye nokudla okunempilo
Iziguli eziningi ziphawule umuzwa onamandla wendlala. Kulokhu, i-metabolism iyaphazamiseka, okuholela ekuzuzeni okungathandeki kwesisindo somzimba.
Isistimu yezinzwa ephakathi
Kuyaqabukela, i-neuropathy ye-peripheral ingahlakulela. Lesi simo siyaphenduka.
Engxenyeni yezitho zombono
Ukulimazeka okwesikhashana nokulimazeka okubukwayo.
Ngemuva kokulawula umuthi, ukugula okwesikhashana okuqabulayo kanye nokukhubazeka okubukwayo kungenzeka.
Engxenyeni yesikhumba
I-Edema, i-hyperemia, i-lipodystrophy yezicubu (inqobo nje yokuthi ukujova kwezicubu endaweni efanayo).
Allergies
Ukuqhuma esikhunjeni, ukulunywa, i-urticaria.
Umthelela ekhonweni lokulawula izindlela
Ngokwelashwa okuhlala isikhathi eside, eminye imizwa engemihle iba nomthelela ongaqondile ekugxiliseni ukunakwa kanye nesivinini sokuphendula kwengqondo. Ngakho-ke, kungcono ukuyeka ukushayela ngokwakho.
Imiyalo ekhethekile
Inomphumela ophikelelayo we-hypoglycemic kune-Isofan Insulin. Uma wethula umthamo we-insulin onganele ngohlobo 1 sikashukela, kungenzeka i-hyperglycemia ne-ketoacidosis yesifo sikashukela. I-Hypoglycemia yenzeka ngomthamo omningi kakhulu.
Ukushayela izimoto akuvunyelwe, njengokwelashwa okuhlala isikhathi eside, imiphumela emibi iyavela ethinta ukunaka nokusabela.
Sebenzisa ebudaleni
Dinga ukulungiswa kwe-glucose nokuguqulwa komthamo.
Ukuyalela uLevemir Penfill ezinganeni
Ukukhawulelwa kuze kube yiminyaka eyi-6.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Namuhla, kukhona ucwaningo olunganele ngomphumela we-insulin kuzingane ezisakhula. Kuyadingeka ukuqapha izinguquko ekugxilweni kwe-glucose. Kuma-trimesters okuqala we-insulin gestation kuyadingeka kancane, futhi ekugcineni - ngaphezulu. Ngakho-ke, ukulungiswa komuntu ngamunye kuyadingeka.
Ngesikhathi sokuncelisa, ukulungiswa kwamthamo we-insulin kuyadingeka.
Isicelo sokusebenza kokulimala kwezinso
Ukuhlolwa kwe-glucose nokulungiswa kwamthamo kuyadingeka.
Sebenzisa umsebenzi wesibindi okhubazekile
Kuzodingeka ushintsho kumthamo we-insulin esetshenzisiwe.
I-Overdose yeLevemir Penfill
Izinga eliphansi le-hypoglycemia limiswa lodwa ngesiqeshana sikashukela noma ukudla kwe-carbohydrate. Izinga elinzima, elihambisana nokulahlekelwa ukwazi, lidinga ukwethulwa kwe-glucagon noma isixazululo se-glucose esisangene emsipha / ngaphansi kwesikhumba. Ngemuva kokuthi ukwazi ukwazi ukubuyiselwa ingqondo, udinga ukunika isiguli ukudla okucebiswe ngama-carbohydrate asheshayo.
Ukuxhumana nezinye izidakamizwa
Kwenqatshelwe ukuhlanganisa nanoma yimuphi umuthi wokujova, hlanganisa nesirinji efanayo nemithi yokufaka. Ukulungiswa komthamo we-insulin kuyadingeka lapho kusetshenziswa ngokuhlangana nemithi eshintsha umsebenzi wayo.
Ukunciphisa umthamo we-insulin kuyadingeka lapho uthatha ama-inhibitors e-MAO, ama-beta-blocker angakhethi, ama-hypoglycemic agents ekuphathweni komlomo, ama-inhibitors e-ACE, ama-salicylates, e-metformin ne-ethanol.
Umthamo we-insulin kufanele ukhushulwe ngokusetshenziswa kwawo kanyekanye ne-hormone yokukhula, ama-adrenergic agonists, ama-hormone egilo, i-glucocorticosteroid, izidakamizwa ze-diuretic neDanazol.
Ukuhambisana notshwala
Ukuhlanganisa umuthi notshwala akuvunyelwe, njengoba ukumuncwa kwento kunciphisa ijubane, futhi ukusabela okubi kusukela ekungenisweni kwekhambi kuyanda kuphela.
Ama-Analog
Kunezimpawu eziningi zeLevemir Penfill:
- Levemir Flekspen;
- I-Actrafan NM;
- I-Insulin Tape GPB;
- Insulin liraglutide.
Imibandela yekhefu lekhemisi
Umuthi ungathengwa emakhemisi kuphela ngemithi ekhethekile evela kudokotela wakho.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Kukhishwe.
Intengo yeLevemire Penfill
Izindleko zivela kuma-ruble angama-2800 kuya kwangama-3100. iphakheji ngayinye futhi kuya ngesifunda sokuthengisa namamakethi ekhemisi.
Izimo zokugcina zomuthi
Esiqandisini ngokushisa kwe- + 2 ... + 8 ° C, kodwa kude nefriji. Ama-cartridge avulekile agcinwa ngaphandle kwesiqandisi.
Isikhathi sokuphelelwa yisikhathi
Iminyaka engu-2,5 kusuka ngosuku lokukhishwa olukhonjiswe kwiphakheji yasekuqaleni. Ama-cartridge ama-cartridge avuliwe agcinwa amasonto ayi-6 emazingeni okushisa angeqi ku-30 ° C. Ungasebenzisi ngemuva kokuphela kosuku.
I-analogue yesidakamizwa ingaba isidakamizwa iLevemir Flekspen.
Umkhiqizi
Inkampani ekhiqiza: "Novo Nordisk A / S", eDenmark.
Ukubuyekezwa Levemire Penfill
Odokotela
UMikhailov A.V., i-endocrinologist, eMoscow: "Ngivame ukukunikeza abantu abanesifo sikashukela sohlobo 1. Ikhambi lihle, kufanele kuqashelwe kuphela ushukela wegazi ukuvimbela ukukhula kwe-hypoglycemia."
U-Suprun I. R., udokotela wezifo zemvelo, uKazan: "Nginikeza imijovo ka Lefemira Penfill ezigulini zami kaningi. Kunabantu abakubekezelela kahle, kepha futhi kunabantu abangavumelani nakho konke. Konke kuncike ohlotsheni lwe-insulin umuntu ayekade eyisebenzisa, okuyinto isengozini yezakhi ngazinye. "
Iziguli
UKarina, oneminyaka engu-35, uVoronezh: "U-Levemir usondele ngokuphelele. Izinga likashukela liyagcinwa, akukho ukweqa. Akukho ukusabela okungekuhle, noma ngizizwa ngingcono kakhulu."
UPavel, oneminyaka engama-49, eMoscow: "Le insulin ayifaneleki. Ijwayela kakhulu ushukela, kwesinye isikhathi kube nokuhlaselwa kanzima kwe-hypoglycemia, ebengingakwazi ukuhlala ngibhekene nayo. Ngakho-ke, kwadingeka ngiyisuse nge-analogue."
UMargarita, oneminyaka engama-42, uYaroslavl: "Kudala ngijola uPenemill noLevemir. Ngiyasithanda lesi sidakamizwa. Kulula ukusikhipha. Idosi elilodwa lanele ngosuku ukugcina ushukela ejwayelekile."
