I-Deoxinate ingeyeqembu lama-ejenti we-immunomodulating agents. Umuthi wenziwa ngesimo sesixazululo sokujova nge-intramuscularly and subcutaneously, futhi ngendlela yesisombululo sokusetshenziswa kwangaphandle. Umuthi ukuvumela ukuthi ukhuphule inqubo yokulungiswa kwezicubu ezindaweni ze-necrotic, ukhuphule ukunikezwa kwegazi emkhakheni we-ischemia futhi ukwandise ukuphendula kokuzivikela ezifweni zegciwane kanye namagciwane.
Igama Lezwe elingafanele
I-Sodium deoxyribonucleate.
I-ATX
I-L03AX.
Khipha amafomu nokwakheka
Umuthi wenziwa ngendlela yesisombululo somjovo kanye nokusetshenziswa kwangaphandle. I-1 ml yokugcina iqukethe u-0.0025 g wekhompiyutha esebenzayo - i-sodium deoxyribonucleate eyenziwe ngobisi lwe-sturgeon. Isixazululo sokusetshenziswa kwendawo sibekwa ezilandweni ezingama-50 ml ezingilazi. Kuthengiswe izingcezu emabhokisini amakhadibhodi.
Umuthi wenziwa ngendlela yesisombululo somjovo kanye nokusetshenziswa kwangaphandle.
Ku-1 ml yesisombululo somjovo kungu-5 mg wesithako esisebenzayo. Ukufakwa kwekhadibhodi kuqukethe ama-10 ampoule wengilazi ayi-5 ml ngamunye kanye nommese wokuwavula.
Isenzo se-Pharmacological
Umuthi uvuselela umsebenzi osebenzayo wokuphendula amaselula nokuhlekisa kwamasosha omzimba. Ngenxa yokutholwa komphumela wokwelapha emzimbeni, unomphumela we-antibacterial, antifungal kanye ne-antiviral. Izinto ezisebenzayo ziyakwazi ukwandisa ukumelana nesenzo semisebe ye-radioactive futhi zithuthukise ukuvuselelwa kwezicubu.
Umuthi uthuthukisa isimo se-vasotion endothelium ku-pathologies yesistimu yenhliziyo. Inomphumela wokulwa nokuvuvukala, ubandakanyeka ekucindezelweni kokukhula kwesimila. I-Sodium deoxyribonucleate ivimbela ukuminyana kwegazi. Umuthi osebenzayo ubandakanyeka emthethweni we-hematopoiesis, uletha esimweni sokulingana inani lamaseli egazi:
- amaseli amhlophe egazi;
- amapuleti;
- phagocytes;
- ama-monocytes;
- granulocytes.
Isakhiwo esisebenzayo sisebenza ku-hypoplastic anemia okubangelwa yimisebe noma i-chemotherapy ngemuva kwesizinda se-metastasis ye-neoplasms enobungozi.
I-Deoxinate yesidakamizwa ine-antibacterial, antifungal and antiviral effect.
Uma i-sodium deoxyribonucleate ikhishwa ngemisipha kungakapheli usuku ngemuva kokuthola inqubo yokushiswa kwemisebe ye-ionizing, umuthi usiza ukukhulisa ukubekezelela ukugula kwemisebe ku-II nase-III ukuqina futhi kusheshiswe ukubuyiselwa kwamaseli we-stem emgogodleni nomgogodla. Kulokhu, ukushesha kwe-hematopoiesis amafomu e-myeloid ne-N-lymphoid kuyabonakala. Amathuba okululama kabusha komzimba ngemuva kokuchayeka kwemisebe ekhuphukayo.
Ngesikhathi sokuvivinywa kwemitholampilo, umsebenzi we-leukopoiesis uyanda ngemuva kokulimala okulimazanayo kweziguli ezine-neoplasms ezinobunzima obucindezelwa ukwehla kwamazinga e-plasma we-leukocytes we-III ne-IV yobulukhuni. Iqembu lokulawula laliqukethe amavolontiya ane-febrile neutropenia, ecasulwa yi-chemotherapy ngemithi ye-antitumor, ilandelwa yimisebe.
Iziguli zikhombise ukwanda kokuhlungwa kwe-plasma kwama-granulocytes ngezikhathi eziyisishiyagalombili emikhunjini yangaphandle. Ngesikhathi esifanayo, inani lama-lymphocyte landa, inani eliphelele lamapuleti egazi abomvu labuya ngokumelene nesizinda se-thrombocytopenia kusuka ku-I kuya kokuqina kwe-IV ye-etiology efanayo.
Umuthi ukhulisa ukumelana nomsebenzi womzimba futhi usiza ukuvimbela ukukhula kwezinhlungu ematholeni emilenzeni ngemuva kwesakhiwo sokulimala kwe-ischemic emithanjeni yemikhawulo engezansi, okucasulwa yi-atherossteosis noma isifo sikashukela. Umuthi uvimbela ukulahleka okusheshayo kokushisa ezinyaweni ngenxa yokuphuculwa kwegazi kwizicubu zamaphethelo aphansi.
I-Sodium deoxyribonucleate isheshisa ukuvuselelwa kwezicubu onyaweni lwesifo sikashukela, i-gangrene, izilonda ezisesimweni esijabulisayo. Kwezinye izimo, into esebenzayo ibangela ukwenqatshwa kwezindawo ezinama-necrotic, ama-phalanges wedijithali, ngaleyo ndlela kugwema ukuhlinzwa.
E-coronary isifo senhliziyo, umuthi usetshenziselwa ukwenza ngcono ukusebenza kwemithambo ye-myocardium nemithambo ye-coronary, ukukhulisa ukumelana nomsebenzi womzimba.
Umuthi usiza ukusheshisa ukubuyiselwa kolwelwesi lwama-mucous ngezilonda eziwohlozayo zesisu kanye ne-duodenum, okucasulwe ukukhula kweHelicobacter pylori. Izakhi ezisebenzayo zandisa amathuba okuba nomphumela omuhle ngesikhathi sokudluliselwa kwezitho nezicubu.
I-Pharmacokinetics
Lapho zisetshenziswe ngokweqile, izinto ezisebenzayo ziyafiphala ngokusebenzisa isikhunta nama-mucous kungqimba lwamafutha angaphansi, lapho kuvusa khona ukuphendula kokuzivikela komzimba kanye nokuxubana kwezicubu. Ukuqoqwa okukhulu kwe-plasma kwe-deoxyribonucleate kutholakala kungakapheli ihora. Izinto zokwelapha zishiya umzimba ngohlelo lomchamo phakathi nosuku.
Izinkomba zokusetshenziswa
Umuthi usetshenziswa kulezi zimo ezilandelayo:
- ngokuntuleka kwama-leukocytes namaplatelethi okubangelwa ukwelashwa okuhlanganiswayo nezidakamizwa ze-antitumor noma ama-cytostatics;
- njengesilinganiso sokuvimbela ukucindezelwa kwe-myeloid hematopoiesis ngaphambi kwamakhemikhali, ngesikhathi sokwelashwa nangemva kokuphothulwa kokwelashwa ngama-antitumor agents;
- ukulungisa isimo ngemuva kokuchayeka emisebeni ye-ionizing kanye nokugula ngemisebe II, izinga lobunzima;
- ekwelapheni i-stomatitis, isilonda se-peptic sesisu kanye ne-duodenum, izilonda ze-trophic;
- ukusheshisa ukuvuselelwa kabusha kwezinqubo ze-purulent kanye ne-sepsis, ukushiswa, ukuvula amanxeba okungapholi ngegciwane le-staphylococcal;
- ukwenza ngcono ukuhanjiswa kwegazi kwizicubu ezine-ischemic myocardium nemithambo yegazi emikhawulweni ephansi;
- lapho kulungiswa umzimba wokuthwalwa kwesitho;
- ekwelapheni izinqubo zokuvuvukala;
- ukungasebenzi kwezitho zangasese okubangelwa izifo.
Isixazululo sokusetshenziswa kwangaphandle nangasekhaya singasetshenziswa njenge-prophylaxis kanye nokwelashwa kokuvuvukala kwepheji lokuphefumula elingaphezulu (ukucinana kwamakhala, sinusitis), ukuqeda ama-node hemorrhoidal futhi kusheshiswe ukwenziwa kabusha kolwelwesi lwe-mucous olungapholi ngenxa yenqubo yokubulala amagciwane.
Contraindication
Umuthi akufanele unikezwe abantu abachazwe ekuthuthukisweni kokungahambi kahle komzimba ezingxenyeni ze-deoxynate.
Ungayithatha kanjani i-Desoxinate
Isixazululo somjovo singafakwa ngokungaxhamazeli noma ngokuqina. Ezigulini zabantu abadala, umthamo wansuku zonke onconywayo ngu-5-15 ml wesisombululo se-0.5%. Ukufakwa kumisipha kufanele kufakwe kancane imizuzu engu-1-2. Ukuphumula okuphakathi kwamajekiseni amahora angama-24-72.
Indlela yokuthathwa kwezixazululo zokusetshenziswa kwangaphandle nangokwabazali isungulwa ngokuya ngokuhlolwa kwesithombe somtholampilo walesi sifo udokotela ohambayo nohlobo lwenqubo ye-pathological.
| Indlela yokusebenzisa | Uhlobo lwenqubo ye-pathological | Imodeli yokwelapha |
| Okwabazali | Isifo senhliziyo nesifo se-vascular ischemia emaphethelweni aphansi | Imijovo engu-5-10 / m kufanele isethwe ngokuvalwa kwezinsuku ezingama-1-3. Umthamo wenkambo ejwayelekile yokwelashwa ngu-375-750 mg. |
| Ukwelashwa kokuzala nokungabi namandla okubangelwa izifo ezingamahlalakhona | Imijovo eyi-10 ilawulwa ngezikhathi ezithile ezingamahora angama-24 kuye kwangama-48. Umthamo ophelele wesikhathi sonke sokwelashwa ngu-750 mg. | |
| I-Peptic ulcer yesisu kanye ne-duodenum | Imijovo emi-5 ibekwa ngezikhathi ezithile zezinsuku ezi-2. Umthamo wenkambo yokwelashwa ngu-375 mg. | |
| Ukuqinisa i-leukopoiesis kanye nokwelashwa kwe-acute radiation pharyngeal syndrome | V / m njalo emahoreni angama-48-96 ku-75 mg. Umthamo wenkambo yokwelashwa ngu-150-750 mg, ohlukaniswe waba yimijovo eyi-2-10. Lapho kufakwa amanzi, umthamo ukhuphuka ufike kuma-375-750 mg. Lapho wenza izifundo eziphindaphindwe ze-chemotherapy noma zokwelapha ngemisebe, kudingeka ukuphathwa okwesibili. Ekwelashweni kokulimala kwemisebe ye-acute, kubalulekile ukwethula umuthi kungakapheli usuku ngemuva kokuphela kwenqubo. | |
| Ngaphandle | Izilonda ezingapholi isikhathi eside nezinye izilonda zesikhumba | Ukwelashwa ngezicelo ezinekhambi elihlanjululwe lokuhlushwa okungu-0.25%. Izambatho zisetshenziswa izikhathi ezingama-3-4 ngosuku. Uma kunesidingo, ukwelashwa kuhlanganiswa nemijovo ye-intramuscular. |
| Ukulimala kolwelwesi lwama-mucous lomlomo wesibeletho | Hlanza umlomo ngesisombululo esingu-0,25%, ulandele ukugwinya i-5-20 ml yesisombululo. I-rinse yenziwa kusuka izikhathi ezi-4 kuya kwezi-6 ngosuku. | |
| I-Vaginitis, i-anal fissures | Ngokuvuvukala kolwelwesi lwe-mucous besitho sangasese sangasese noma lwesikhumba, kuyadingeka ukuthambisa uswidi esixazululweni bese ulufaka ekuvulekeni kwesitho sangasese sowesifazane. Ukuphathwa kwe-Rectal kwenziwa kusetshenziswa ama-microclysters agcwaliswe ngo-10-50 ml wesisombululo. Inkambo yokwelashwa kuzo zombili lezi zimo ihluka kusuka ezinsukwini ezi-5 kuye kwezingu-10 kuze kube yilapho ukuvuvukala okubonakalayo kunyamalala ngokuphelele. | |
| I-rhinitis engapheli, i-sinusitis, i-phlebitis, ukuvimbela ama-ARVI | E ndima ngalinye lamakhala lifaka ama-2-3 ehla izikhathi ezingama-3-4 ngosuku. Ukuqeda ukutheleleka ngegciwane, udinga ukuphonsa amaconsi ama-3-5 ngejubane ngalinye ngezikhathi ezithile zemizuzu engama-60. | |
| Ukuvuvukala kwe-sinanas paranasal, nasopharyngitis | I-3-6 yehla esigabeni ngasinye samakhala izikhathi ezingama-3-6 ngosuku. | |
| Ukuqothuka kwemithambo, izilonda ngemisebe | Ukusetshenziswa kwangaphandle ku-3-4 kwehla izikhathi ezi-6 ngosuku. Inkambo yokwelashwa izinyanga eziyisithupha. |
Ngoshukela
Iziguli ezinesifo sikashukela sohlobo 1 nohlobo 2 zidinga ukubheka njalo ukugcwala kwe-plasma ushukela wegazi kuyo yonke le nkathi yokwelashwa kwezidakamizwa. Lokhu kuyadingeka ukuze kulungiswe ukwenzeka kwe-hypoglycemia ngesikhathi futhi kulungiswe umthamo wama-hypoglycemic agents.
Iziguli ezinesifo sikashukela sohlobo 1 nohlobo 2 zidinga ukubheka njalo ukugcwala kwe-plasma ushukela wegazi kuyo yonke le nkathi yokwelashwa kwezidakamizwa.
Imiphumela Emibi Ye-Deoxinate
Ukwanda kwesikhashana kwezinga lokushisa lomzimba liye ezingeni elingaphansi kwe -brfe noma i-febrile kungenzeka emahoreni ama-2 - 2 ngemuva kwamahora ama-3 noma usuku olu-1 ngemuva kokuphathwa komuthi. Kwezinye izimo, ukuvela kungenzeka endaweni yokulimala, kuhambisana nokubomvu, ukudabuka, noma ukuvuvukala. Ukuphendula kwenzeka ngokwabo. Ezigulini ezisengozini, kuba khona ukungadli komzimba ngendlela yokuqhuma kwesikhumba noma ukulunywa, ngokuphendula okukhulu kwe-allergenic, ukushaqeka kwe-anaphylactic noma i-edema kaQuincke.
Umthelela ekhonweni lokulawula izindlela
Umuthi awuthinti kabi ijubane lokuphendula, imisebenzi yokuqonda kanye nokuhlushwa. Ngakho-ke, ngesikhathi sokulashwa kwezidakamizwa, kuvunyelwe ukushayela imoto noma izindlela eziyinkimbinkimbi, uma isimo sesiguli sivumela ukucindezela okunjalo kwengqondo nangokomzimba.
Imiyalo ekhethekile
Ukuphathwa okuphathelene nomuthi kuvinjelwe ngokuphelele. Isixazululo asiphumeleli enkambweni enzima yenqubo ye-pathological, enezilonda ezijulile zesikhumba sendawo enkulu yendawo ye-IV yobukhulu obukhulu.
Umuthi usetshenziselwa i-leukopenia, uma isibalo se-leukocytes singaphansi kwama-3 500 nge-1 μl, ne-thrombocytopenia enamanani angaphansi kwama-150,000 nge-1 μl.
Sebenzisa ebudaleni
Abantu abaneminyaka engaphezu kwengu-60 yobudala akudingekile ukuthi benze izinguquko kwimodeli yokwelapha.
Isabelo sezingane
Ezinganeni ezifika ezinyangeni ezingama-24, umthamo onconyiwe ngu-0.5 ml wesisombululo sokulawulwa kokuncinza noma kokuthamba, kusuka eminyakeni emi-2 kuye kweli-10, udinga ukwandisa umthamo ngo-0.5 ml ngonyaka ngamunye wokuphila, kusuka eminyakeni eyi-10 kuye kweli-18, kusetshenziswa umthamo ojwayelekile kumdala.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi ubekwa ngemishanguzo kwabesifazane abakhulelwe nababolekayo ngenxa yokuntuleka kwemininingwane yokuthi umuthi ungakanani ekukhuleni nasekuthuthukisweni komzimba womuntu ezikhathini zokuphila zombungu nangemva kokubeletha.
Isicelo sokusebenza kokulimala kwezinso
Isixazululo se-Deoxinate sinqatshelwe ukuthi sisetshenziswe ukwehluleka kanzima kwe-renal.
Sebenzisa umsebenzi wesibindi okhubazekile
Abantu abanokungasebenzi kahle kwesibindi kunconywa ukuthi baqaphele.
Ukweqisa kwe-Deoxenate
Ngomjovo owodwa noma ukusetshenziswa kwangaphandle komthamo ophakeme wesidakamizwa, awekho amacala abhalwe ngokweqile aqoshwa. Imiphumela emibi engaba khona noma ukwanda kwabo.
Ukuxhumana nezinye izidakamizwa
Isixazululo sokusetshenziswa asihambelani ngaphandle kwamafutha asuselwa emafutheni anamafutha kanye ne-hydrogen peroxide. Umuthi uyakwazi ukukhulisa ukusebenza kwezidakamizwa ezingama-antiviral ne-antibacterial, unciphise ubude besikhathi sokwelashwa okulondoloziwe. I-Sodium deoxyribonucleate ithuthukisa umphumela wemithi elwa nama-antitumor kanye ne-cytostatics.
Umuthi uyakwazi ukukhulisa ukusebenza kwezidakamizwa ezingama-antiviral ne-antibacterial.
Ukuhambisana notshwala
Ngesikhathi ukwelashwa nge-Deoxinate, kwenqatshelwe ukuphuza utshwala noma ukusebenzisa ama-ethanol aqukethe ama-ejenti. U-Ethanol uyakwazi ukwenza buthaka umphumela wezokwelapha womuthi, abangele ukunqotshwa kwethambo lomnkantsha we-hematopoiesis futhi enze isimo esijwayelekile sesiguli.
Ama-Analog
Izinto ezingaphansi kwesidakamizwa zibandakanya:
- I-Derinat;
- I-Sodium deoxyribonucleate;
- I-Penogen;
- I-Ferrovir
Imibandela yekhefu lekhemisi
Umuthi usatshalaliswa ngokuqinile ngokuya ngencwadi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Uma usetshenziswe ngendlela engafanele, umuthi ungadala imiphumela emibi eguqukayo kungabikho zinkomba eziqondile zokwelashwa. Ngakho-ke, ukuthengiswa kwamahhala kumakhemisi aqinisekisiwe kuyenqatshelwe.
Intengo
Izindleko ezijwayelekile zesidakamizwa cishe ngama-ruble angama-300-500.
Izimo zokugcina zomuthi
Kuyadingeka ukugcina isixazululo emazingeni okushisa we- + 5 ... + 10 ° C endaweni evikelekile emisebeni ye-ultraviolet, ngenhlanganisela encishisiwe yomswakama.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Esikhundleni sezidakamizwa kufaka phakathi umuthi weDerinat.
Umkhiqizi
I-FSUE SPC Pharmzashchita FMBA, eRussia.
Ukubuyekezwa
U-Ekaterina Belyaeva, oneminyaka engama-37 ubudala, eYekaterinburg
Udokotela wezingane unikeze isixazululo se-desicalini yama-topical ukuze isetshenziswe i-topical ekwelapheni izifo ezithinta izifo zokuphefumula kanye nokukhwehlela. Ngaphezu kwalokho, kwakudingeka ukuphuza izidakamizwa ze-antipyretic, kepha kumazinga okushisa kuphela angaphezu kuka-38,5 ° C. Udokotela wathi izinga lokushisa lingakhuphuka isikhambi. Kwakudingeka ukuhlanza i-noseal patity njalo emahoreni ama-2 ngamaconsi ama-3-5 we-Deoxinate, ngemuva kokuthuthukisa lesi simo, ukusikeka kwehliswe kwaba kathathu ngosuku. Indodana yalulama ngemuva kwezinsuku ezi-5. Azange kube nemiphumela emibi.
U-Emilia Ponomareva, oneminyaka engama-45, eMoscow
Ngihlangane neDoxinat kaningi, ngenxa yalokho ngiyithatha njengekhambi elisebenzayo. Indoda nendodana basebenzise ikhambi lokugeza ikhala nge-rhinitis. Ukuqunjelwa ngumyeni wami kwakushesha - ezinsukwini ezi-2, ingane yayigula cishe isonto. Mhlawumbe kungukuzivikela komzimba. Ngixubule kwehla emiseleni yamathole ekuncomweni kukadokotela njengendlela yokuthuthukisa i-microcirculation. Angizwanga siphi isisindo amahora angama-3-5, imilenze yami yayeka ukuvuvukala. Ngizamile ukwelashwa ngamanye amafutha, kepha umphumela waba buthakathaka.
