Ukusetshenziswa kwe-Ofloxin kuyadingeka ezifweni eziningi ezithathelwanayo nezifo ezithinta amasistimu ahlukahlukene omzimba. Umuthi unezinto eziningi ezisebenzayo, kepha une-contraindication futhi ubangela imiphumela emibi, ngakho-ke, ngaphambi kokuqala inkambo yokwelashwa, kufanele uthintane nodokotela wakho.
Igama Lezwe elingafanele
I-Ofloxacin.
Ukusetshenziswa kwe-Ofloxin kuyadingeka ezifweni eziningi ezithathelwanayo nezifo ezithinta amasistimu ahlukahlukene omzimba.
I-ATX
J01MA01. Umuthi ubhekisela kuma-antimicrobial agents wesistimu yesenzo, okuphuma ku-quinolone.
Khipha amafomu nokwakheka
Kunezinhlobo ezi-2 ze-Ofloxin ezitholakala emakethe yemithi: amaphilisi kanye nomjovo. Esimweni sokuqala, lesi sidakamizwa sitholakala kumithamo emibili. Iyunithi ye-antibiotic iqukethe i-200 mg noma i-400 mg yento esemqoka esebenzayo ye -loxacin.
Izibhebhe ezimhlophe ezihlanganiswe ngokuhlanganiswa kwefilimu zinesimo esiyindilinga se-biconvex, ngakolunye uhlangothi zihlukaniswe yi-notch, ngakolunye uhlangothi kuqoshwe okuthile okubonisa umthamo. Kule fomu yemithamo, isidakamizwa sivezwa emaphaketheni okulimaza okubekwe emabhokisini amakhadibhodi.
Isixazululo somjovo uketshezi olucacile olunepende eliluhlaza okotshani. Umuthi uthengiswa kwizivini zeglasi eziyi-100 ml, ngasinye sazo siqukethe ama-200 mg we -loxacin.
Izibhebhe ezimhlophe ezihlanganiswe ngokuhlanganiswa kwefilimu zinesimo esiyindilinga se-biconvex, ngakolunye uhlangothi zihlukaniswe yi-notch, ngakolunye uhlangothi kuqoshwe okuthile okubonisa umthamo.
Isenzo se-Pharmacological
Umenzeli we-antibacterial ungowochungechunge lwe-fluoroquinolone futhi unesibuko esikhulu sezenzo ngokumelene namagciwane we-aerobic wegram-positive ne-gram-negative. Umsebenzi we-Ofloxin ubonakala ngokulwa namagciwane anjenge:
- I-Escherichia coli;
- ISalmonella;
- UShigella;
- I-Proteus;
- Morganella morganii;
- Klebsiella;
- I-Enterobacter;
- I-Citrobacter
- I-Haemophilus influenzae;
- Neisseria gonorrhoeae;
- I-Neisseria meningitidis;
- I-Mycoplasma spp .;
- I-Chlamydia spp .;
- I-Staphylococcus;
- I-Streptococcus.
Umphumela we-antibacterial awusebenzi kumagciwane ama-anaerobic. Izakhi ezisebenzayo ze-Ofloxacin zingena kugxile kokuvuvukala, zivimba ukwakheka kwe-DNA gyrase, okudingekayo ekusebenzeni okujwayelekile kwamaseli we-pathogen. Inqanda ukukhula, ukuthuthukiswa kanye nokuzala kabusha kwamagciwane.
Izakhi ezisebenzayo ze-Ofloxin zingena ekugxiliseni kokuvuvukala, vimba ukwakheka kwe-DNA gyrase.
I-Pharmacokinetics
Umuthi udonswa ngokushesha futhi ngegazi kungena izitho nezicubu ezahlukahlukene. Ukuqoqwa okuphelele kwento esebenzayo kuqashelwa emaminithini angama-60 ngemuva kokuphathwa. Umuthi olwa namagciwane usatshalaliswa emaphashini, umgudu ongaphezulu wokuphefumula, isistimu yomchamo, izicubu zezinso nezitho zangasese, isigaxa senyongo, isikhumba namathambo. I-Ofloxin inezinga eliphakeme lezakhi ezisebenzayo emanzini uketshezi.
I-25% yamakhompiyutha enza i-antibiotic futhi enze imisebenzi yokwelapha abopha amaprotheni e-plasma. Umuthi udonswa umchamo ngesimo esingaguquki. Lokhu kwenzeka ngemuva kosuku lokuphatha. Ngokwengxenye, umuthi ukhishwa emathunjini. Ukuphila kwesigamu kwe-antibacterial agent kungamahora ayi-6. Kubantu abane-lowinine clearance, lesi sikhawu sanda sifinyelela emahoreni angama-13.5.
Umuthi udonswa ngokushesha futhi ngegazi kungena izitho nezicubu ezahlukahlukene.
Izinkomba zokusetshenziswa
Umuthi ubonakale usebenza ngempumelelo ekulweni nezifo eziningi ezithathelwanayo nezivuvukisayo ezibangelwa i-pathogenic microflora ezwela i-Ofloxin. Izinkomba zokusetshenziswa kwamagciwane alwa:
- izilonda ezinzima zamagciwane zepheji lokuphefumula elingaphezulu namaphaphu (i-bronchitis eshubile nesingamahlalakhona, i-pneumonia);
- izinqubo zokuvuvukala ezithweni ze-ENT (i-sinusitis, i-otitis media, i-sinusitis, i-pharyngitis, i-laryngitis);
- ukutheleleka kwamapheshana emathunjini kanye nepheshana le-biliary (ngaphandle kwe-bacterial enteritis);
- izilonda zesikhumba, amalunga namathambo;
- izifo zezinso nezinso zomchamo (pyelonephritis, cystitis, urethritis);
- ukuvuvukala kwesibindi
- ukutheleleka kohlelo lokuzala (i-orchitis, colpitis, i-gonorrhea, chlamydia);
- i-meningitis
- ukulimala kwamagciwane emehlweni;
- ukuvimbela ukuvuvukala ekungeneleleni kokuhlinzwa;
- izifo ezahlukahlukene kubantu abane-immunodeficiency;
- Ukwelapha okuyinkimbinkimbi kwesifo sofuba.
Umuthi olwa namagciwane unqunywa ngudokotela ngemuva kokuhlola isiguli nokuthola ukuthi uzwela kanjani ama-ejenti athelelekile kulo muthi.
Contraindication
Ukukhulelwa nokukhulelwa kungukuphula umthetho. Umuthi awuvunyelwe ngokubekezelela ngakunye kwezinto ezakha ukwakheka, kanye nokuzwela okwengeziwe kwe-fluoroquinolones.
Musa ukusebenzisa umuthi ezigulini ezine-glucose-6-phosphate dehydrogenase yokushoda. Umuthi uyingozi kulabo abaye bahlaselwa isifo sohlangothi noma abanomlando wama-CNS pathologies okwehlisa umkhawulo wokubanjwa. Isithuthwane sisohlwini lwe-contraindication. I-antibiotic ayibekelwe izingane ezingaphansi kweminyaka engu-18.
Ngokunakekela
Ngezilonda ze-organic zesistimu yezinzwa ephakathi ne-pathologies enzima yezinso, kungcono ukunikeza ukukhetha komunye umuthi. Umuthi ubekwa ngokuqwashisa kubantu abaphethwe yi-arteryosulinosis yendawo yokugula kanye nezinye izifo ezihambisana nokujikeleza okungajwayelekile.
Kwi-pathologies yezinso ezinzima, kungcono ukunikeza ukukhetha komunye umuthi.
Ungayithatha kanjani i-Ofloxin
Umthamo, irejimeni kanye nesikhathi sokwelashwa kunqunywa udokotela ngokuya ngemiphumela yokuhlaziywa kwesiguli, iminyaka yakhe kanye nolwazi kuma-pathologies ahlobene nawo. Izibhebhe kufanele zigwinywe ngaphandle kokuhlafuna ngenani elikhulu lamanzi. Isixazululo sokungeniswa sisebenza ngokuphathwa ngesandla nge-drip.
Ngokutheleleka okulula kwesistimu ye-urinary, i-100 mg ye -loxacin kufanele ithathwe izikhathi eziyi-1-2 ngosuku. Nge-pyelonephritis nezinqubo zokuvuvukala ezithweni zangasese, ama-100-200 mg anqunywa ngezikhathi ezithile njalo ngosuku.
Ukulimala kwamagciwane ohlelweni lokuphefumula, kanye nokutheleleka okuthinta izindlebe, umphimbo kanye nekhala, i-pathologies yezicubu ezithambile nezendlalelo ezingenhla ze-epidermis, amathambo kanye nokuhlangana kuphathwa nge-Ofloxin, kusetshenziswa izikhathi ezingama-200 mg 2 ngosuku. Ezimweni ezinzima zalesi sifo, ama-400 mg we-antibiotic avunyelwe kabili ngosuku.
Ngomonakalo wesibeletho kanye nokutheleleka kwe-septic, isiguli siphathwa ngendlela efanayo.
Ukuvimbela ukuthuthukiswa kokutheleleka kubantu abane-immunodeficiency, ama-infusions ayenziwa. Kulokhu, i-200 mg ye -loxacin kumele ixutshaniswe ne-5% ushukela. Isikhathi sokufakwa kwe-intravenous imizuzu engama-30.
Uma isiguli sinomlando wesifo sezinso noma sesibindi esingapheli, imiyalo iphakamisa ukuncipha kwethamo le-antibiotic.
Ngoshukela
Esikhathini sikashukela, ukuqapha njalo kwamazinga kashukela egazini kuyadingeka, ngoba lapho kuhlanganiswa ne-Ofloxin nezidakamizwa ezilawula okuqukethwe ushukela, i-hypoglycemia ingaqala ukukhula.
Uma weqa umthamo
Uma isiguli singazange siphuze i-antibiotic ngesikhathi esifanele, kufanele uphuze iphilisi lapho kutholakala umuthi olahlekile.
Uma isiguli singazange siphuze i-antibiotic ngesikhathi esifanele, kufanele uphuze iphilisi lapho kutholakala umuthi olahlekile.
Imiphumela emibi
Ngesikhathi sokwelashwa ngochungechunge lwe-fluoroquinolone, ukusabela okuhlukahlukene okungalungile komzimba kwenzeka.
Amapheshana wesisu
Ezigulini ngesikhathi somuthi olwa namagciwane, isicanucanu, ukuhlanza, isifo sohudo, noma ukuqunjelwa kungenzeka. Imisipha ebuhlungu yesisu ayikhishwa. Ezinye iziguli zikhononda ngokuthopha, ukushisa kwenhliziyo, nomlomo owomile. Ezimweni ezingavamile, ukopha kwenzeka emgodini wokugaya ukudla, kukhona ukwanda komsebenzi we-hepatic transaminases, hepatitis kanye ne-cholestatic jaundice, i-pseudomembranous enterocolitis ikhula.
Izitho zeHematopoietic
Isenzo se-antibiotic sivusa izinguquko emingceleni yesistimu yegazi, okubangela i-anemia, agranulocytosis, thrombocytopenia. Ukopha okungenzeka. Ithonya elibi kwinqubo ye-hematopoiesis yomongo wamathambo ayibonakali kangako, kukhuphuka isikhathi se-prothrombin.
Isistimu yezinzwa ephakathi
Kwezinye iziguli, ukusabela okunamandla okuvela ohlelweni lwezinzwa oluyinqaba alunqunyelwe. Abantu bakhala ngesiyezi kanye ne-migraines, ukwephula ukunambitheka nephunga, bazizwa bedidekile, bazizwa bekhathazekile. Ukudangala, imicabango yokuzibulala, i-phobia, i-paranoia ayikhishwa ngaphandle. Ezimweni ezimbi kakhulu, ukweqiwa, ukucatshangelwa kwemizwa, i-paresthesia, ukukhuluma okungenampilo nokuxhumana kungenzeka.
Njengemiphumela emibi, izinkinga ngohlelo oluphambili lwezinzwa azikhishwa.
Kusuka ohlelweni lwe-musculoskeletal
Ukwemukelwa kwemithi elwa namagciwane e-fluoroquinolone kungadala ukwanda kwe-myasthenia gravis, arthralgia, tendonitis. Ubuthakathaka bemisipha nokukhula kwe-myalgia kuyaphawulwa.
Kusuka ohlelweni lokuphefumula
Ukuphendula okungalungile kuvela ngesimo sokukhwehlela. Ezinye iziguli ziba nokuphuma komlonyeni. Ezimweni ezingavamile, i-bronchospasm kanye nokuboshwa kokuphefumula kungenzeka.
Engxenyeni yesikhumba
Ukuthuthukiswa kokwenza izithombe akukhishwa. Umuthi olwa namagciwane ungadala ukwanda kwe-pigmentation futhi uvuse ukuqubuka kwesikhumba.
Kusuka ohlelweni lwezitho zofuzo
Umuthi ubangela i-dysuria ne-hematuria, i-nephritis, amatshe ezinso, ukubambezeleka noma ukwanda kokuchama. Ubuhlungu nokuqhaqha esifundeni se-urogenital, i-vaginitis, i-candidiasis akuhlanganisiwe.
Kusuka ohlelweni lwezinhliziyo
Lapho uthatha umuthi, i-tachycardia ingaqhamuka, kungahle kube nokwanda okubukhali noma ukwehla komfutho wegazi. Ezimweni ezingavamile, i-pulmonary edema nokuboshwa kwenhliziyo kwenzeka.
Lapho uthatha umuthi, izinkinga ngohlelo lwezinhliziyo zingaqala ...
Uhlelo lwe-Endocrine
Umuthi uvusa ukuphazamiseka kwe-metabolic. Iziguli ziphawula ukoma, ukunciphisa umzimba. Ku-diabetesics, ukukhuphuka okubukhali noma ukwehla kwamazinga kashukela wegazi kungenzeka (ngenkathi uthatha izidakamizwa ezifanele). Ku-serum, kunganda i-cholesterol, i-TG ne-potassium.
Allergies
Ukusabela okujwayelekile komzimba ku-antibiotic yi-urticaria, pruritus kanye nokuqhuma. I-Conjunctivitis, izinhlobo ezahlukahlukene ze-erythema, angioedema, ukushaqeka kwe-anaphylactic azivamile.
Umthelela ekhonweni lokulawula izindlela
Umuthi unomphumela omubi wokushayela nangezinye izindlela eziyinkimbinkimbi zobuchwepheshe, ngoba wehlisa ijubane ukusebenza kwe-psychomotor futhi ubangele ukuvezwa okungafuneki kusuka ohlelweni lwezinzwa oluphakathi.
Umuthi unomphumela omubi wokushayela nangezinye izindlela eziyinkimbinkimbi zobuchwepheshe.
Imiyalo ekhethekile
Kunemibandela lapho umuthi uvinjelwe noma ukhawulelwe kakhulu.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Izakhi ezisebenzayo ziwela umgoqo we-placental futhi zikhishwa kubisi lwebele. Izinto ezisebenzayo zidala ukungafani ezinganeni. Ngakho-ke, ngesikhathi sokukhulelwa futhi lapho uncelisa, awukwazi ukusebenzisa i-antibiotic. Ngenkathi yokuqunjelwa, uma kunesidingo, inkambo yokwelashwa kunina wengane kufanele idluliselwe ekunakekelweni kokudla okwenziwe ngokungemthetho.
Ukunquma i-Ofloxin ezinganeni
Umuthi lo uphulwe ezinganeni ezingaphansi kweminyaka engu-18.
Sebenzisa ebudaleni
Ngesikhathi sokwelashwa kweziguli esezikhulile, kubalulekile ukuthi ziqaphele njalo izimpawu ezibalulekile. Esikhathini esiningi, kunconywa ukulungiswa komthamo, ngenxa yobungozi bomonakalo esibindini, izinso kanye nama-tendon asebekhulile.
Ngesikhathi sokwelashwa kweziguli esezikhulile, kubalulekile ukuthi ziqaphele njalo izimpawu ezibalulekile.
Isicelo sokusebenza kokulimala kwezinso
Ngokucaciswa okuphansi kwe-creatinine, ivolumu yansuku zonke ye-antibiotic iyancishiswa. Ukwelashwa nge-fluoroquinolone yama-pathologies ezinso kungaphansi kokuqashwa kochwepheshe.
Sebenzisa umsebenzi wesibindi okhubazekile
Kwezifo zesibindi ezingalapheki, umuthi ubekwa ngokuqapha.
Ukweqisa
Uma ivolumu ephakanyisiwe yesidakamizwa idlulwa, ukugabha, isiyezi, ukuhlangana okungahambi kahle kokunyakaza, ukudideka nokudideka kuyabonakala. Ayikho i-antidote ethile. Lapho udonsa inani elikhulu le-antibiotic, ukuqubuka kwesisu kwenziwa. Ngemuva kwalokho yenza ukwelashwa okubonakalayo.
Ukuxhumana nezinye izidakamizwa
Umuthi olwa namagciwane ukhulisa ukuqina kwe-theophylline egazini. Ama-antacid kanye namalungiselelo aqukethe i-magnesium, i-calcium, i-potassium nensimbi kunciphisa ukumuncwa kwe-Ofloxin, ngenxa yalokho, lezi zinhlobo zemithi kufanele zithathwe ngemuva kwamahora ama-2.
Izidakamizwa ezingezona ezokwehlisa ukuvuvukala zivusa ukwehla kwezandla uma kwenzeka zilawulwa kanyekanye ngama-fluoroquinolones. I-Glucocorticosteroids ikhulisa ubungozi bokuqhuma kwe-tendon. Umuthi we-antibacterial usetshenziswa ngokuqapha ngokuhlangana nezidakamizwa ze-hypoglycemic. Le nhlanganisela ingadala ukwehla okukhulu kweglucose yegazi.
I-Methotrexate ne-loop diuretics yandisa ubuthi be -loloacacin. Uma kuthathwa ndawonye nama-anticoagulants angaqondile, kunengozi yokopha.
Ukuhambisana notshwala
Ngesikhathi sokulashwa kwe-antibiotic, awukwazi ukuphuza utshwala. Utshwala bandisa ubunzima bemiphumela emibi futhi busebenzise umuthi ukusebenza ngempumelelo kwawo.
Ama-Analog
Ama-analogues wesakhiwo somuthi wengxenye eyinhloko izidakamizwa ezinjenge-Ofloxacin, i-Ofloks, iGlaufloks, iTaritsir, i-Uniflox. Izithasiselo ze-antibiotic zingaba izidakamizwa eqenjini le-fluoroquinolones: INolitsin, Norfloxacin, Levofloxacin, Glevo.
Imibandela Yokuphumula Yeholide ka-Ofloxin's
Amathebulethi nekhambi lokungeniswa kusatshalaliswa emakhemisi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Umuthi olwa namagciwane uthengiswa lapho kwethulwa ifomu elibhalwe udokotela eliqinisekiswe udokotela.
Intengo ye-Ofloxin
Izindleko zomuthi zincike kumthamo kanye nevolumu. Intengo isukela kuma-ruble ayi-160 kuye kwangama-280.
Izimo zokugcina zomuthi
Umuthi kumele ugcinwe kude nezingane ungafinyeleleki kuwo. Ukuvezwa ukukhanya nokukhanya kufanele kube nomkhawulo.
Isikhathi sokuphelelwa yisikhathi
Umuthi kumele usetshenziswe kungakapheli iminyaka emi-3 ukusuka ngosuku lokukhiqizwa.
Umenzi we-Ofloxin
Umuthi lo ukhiqizwa eCzech Republic nguZentiva A.C.
Umuthi kumele usetshenziswe kungakapheli iminyaka emi-3 ukusuka ngosuku lokukhiqizwa.
Ukubuyekezwa kwe-Ofloxine
Umenzeli we-antibacterial uthole izibuyekezo eziningi.
Odokotela
U-Igor Vetrov, uchwepheshe wezengqondo, uMinsk
I-Ofloxin iyi-antibiotic enamandla, kungcono ukuyinikeza ezimweni ezinzima kuphela. Ngokutheleleka okuthe xaxa kuya kokuphakathi, izidakamizwa ezinobuthi zingasetshenziswa.
U-Irina Rozanova, otolaryngologist, Volgograd
Umuthi uyasebenza, kepha udinga umlando ophelele kanye nokukhethwa okufanele komthamo.
Iziguli
U-Angelina, oneminyaka engama-27, uMichurinsk
Ngemuva komkhuhlane, kwaqala ukwenziwa i-bronchitis. I-Ofloxin yanqunywa. Izinga lokushisa lehla ngosuku. Ukukhwehlela kumile cishe izinsuku ezintathu. Kepha manje angikwazi ukuqeda i-dysbiosis kanye ne-thrush.
U-Anton, oneminyaka engama-34, uYaroslavl
Amaconsi aleli gciwane asindiswe emaphinini. Ubesesibhedlela izinsuku eziyishumi.Imiphumela emibi ayimnandi, kepha ungasinda esiswini esidabukisayo ukuze ungene ngezinyawo zakho.
