I-Meldonium ithathwa njengesidakamizwa se-antiarrhythmic, futhi siyindlela yokwenza kusebenze imetabolism. Imithi enale nto esebenzayo inezindlela ezahlukahlukene zokukhishwa futhi ithandwa kakhulu ekwelapheni kwezimo ezifana nesifo senhliziyo nesifo sokujikeleza kwengqondo ebuchosheni. Ayikwazi ukubekelwa indawo futhi ekugcokeni ngokomzimba nangokomzwelo.
UMeldonius wayethandwa kakhulu ngabasubathi. Kepha ngonyaka ka-2016 kwaqashelwa njengezintambo futhi manje sekuvinjelwe ukusetshenziswa kwalabo ababamba iqhaza emiqhudelwaneni.
Le nto yatholakala engxenyeni yesi-2 yekhulu lama-20 futhi ekuqaleni yayisetshenziswa kwezolimo njengesivuseleli sokukhula kwezitshalo nemfuyo.
Igama Lezwe elingafanele
IMeldonium (Meldonium).
I-ATX
C01EV22 - Ezinye izidakamizwa zokwelapha inhliziyo.
I-Meldonium ithathwa njengesidakamizwa se-antiarrhythmic, futhi siyindlela yokwenza kusebenze imetabolism.
Khipha amafomu nokwakheka
IMeldonium 500 iyatholakala ngesimo samaphilisi, afaka i-500 mg yento efanayo esebenzayo. Ahlanganiswe emabhulini izingcezu eziyi-10. Isidakamizwa sithengiswa emabhodini amakhadibhodi, ngalinye lazo liqukethe ama-3 noma ama-6 amabhliki.
Umthamo ofanayo uku-ampoule equkethe i-5 ml yomjovo. Ama-Ampoules afakwa emabhulashini epulasitiki wezingcezu ezi-5 noma eziyi-10 futhi athengiswa emaphepheni amakhadibhodi we-5, 10, 20, 50, 75 noma i-100 ampoules.
Isenzo se-Pharmacological
IMeldonium iyi-analogue ye-gamma-butyrobetaine. Iyakwazi ukwanelisa isidingo esandayo samaseli okuhamba komoya-mpilo kanye nokususwa kwemikhiqizo ye-metabolic evela emithwalweni eyandisiwe. Ngenxa yalokhu, inomthelela ovikela ohlelweni lwezinhliziyo, uvimbela ukuhlaselwa kwe-angina, futhi inezindawo ze-antihypoxic.
Le nto ivimbela ukuhlanganiswa kwe-carnitine, kusebenze i-glycolysis. Uyakwazi ukunikeza umphumela olandelayo wokwelapha:
- Ngokuhlaselwa yisifo senhliziyo - yehlisa ijubane ukwakhiwa kwesifunda se-necrotic.
- Ngokuhluleka kwenhliziyo - thuthukisa ukuzimelela kwe-myocardial kanye nokubekezelela ukuzivocavoca.
- Nge-cerebral ischemia, thuthukisa ukuhamba kwegazi endaweni ethintekile.
- Ngotshwala obungamahlalakhona, susa ukuphazamiseka kokusebenza kohlelo lwezinzwa oluphakathi.
IMeldonium - ukusetshenziswa okuyikho kwezemidlaloIMeldonium: Unjiniyela Wamandla Wangempela
I-Pharmacokinetics
Umuthi ubonakala ngokufakwa ngokushesha okuphuma emgodini wokugaya ukudla. I-bioavailability yayo ilinganiselwa kuma-78%. 2 amahora emva kokulawulwa ku-plasma, ukugxilisa okukhulu kufinyelelwa. Isigamu sempilo sincike kumthamo othathwe futhi ungafinyelela amahora ayi-6. Umuthi uqhekeka ungene kuma-metabolites ama-2 bese ukhishwa emchameni.
Izinkomba zokusetshenziswa
Imithi ene-meldonium njengento esebenzayo inesilinganiso esibanzi. Ukuqokwa kukhonjiswa ku:
- isifo senhliziyo;
- imivimbo
- ukungasebenzi kahle kwe-cerebrovascular;
- ukwehla kokusebenza;
- ukucindezela ngokomzimba;
- i-abstinence syndrome;
- isikhathi sokuvuselelwa ngemuva kokusebenza;
- izimo ze-asthenic, i-syndrome yokukhathala okungamahlalakhona.
Lesi sidakamizwa sisetshenziswa kumithamo emincane naku-ophthalmology ekuphatheni kwe-parrambar uma kwenzeka ukuphazamiseka kokujikeleza kwegazi ku-retina ye-etiologies ehlukahlukene.
Ukusetshenziswa kwe-meldonium kwezemidlalo
Isenzo seMeldonium kuhloswe ngaso ukubambezela izinqubo zokukhiqizwa kwamandla, sisebenzisa amanoni acid njengomthombo waso futhi siholele ekujuleni kwesigqi senhliziyo. Le nto isiza umzimba ukuthi wehlise umthwalo ku-myocardium ngokushintshela esimweni sokuthola amandla eglucose ne-oxygen.
Kubantu ababamba iqhaza kwezemidlalo, izindawo ezinjenge-meldonium zibalulekile njengokulandelayo:
- kusebenze kwezinqubo zokuvuselela izicubu ngemuva kokuzivocavoca;
- umphumela omuhle esilinganisweni sokuphendula;
- amandla okulinganisa ukusabela komzimba ekusebenzeni ngokweqile.
Lezi zimfanelo ziyasebenza kunoma yimuphi umdlalo, kepha umphumela wawo ubonakala kakhulu ngesikhathi sokuzivocavoca okwenziwa isikhathi eside nge-aerobic. Ngaphandle kokuthi le nto ibhekwa njenge-doping, ayifaki sandla ekuqoqweni kwesisindo semisipha kanye nokwenza ngcono kwezinkomba zamandla.
Odokotela abasebenza ngemithi yezemidlalo bayaphawula ukuthi ukuthatha i-Meldonium ngeke kuhlanganiswe nokudla okunamafutha aphezulu ne-carbohydrate.
Contraindication
I-Meldonium ayikwazi ukunqunywa ngokukhuphuka kwengcindezi ye-intracranial okubangelwa yizo zombili i-neoplasms ehlukahlukene kanye nokwephulwa kwe-venous ukuphuma.
Futhi, ukwephulwa kokuphuza umuthi yile mibandela elandelayo:
- ukungabekezelelani komuntu ngamunye eMeldonium;
- ukukhulelwa
- ukucaphuka.
Akunconyelwe ukusetshenziswa ngabantu abangaphansi kweminyaka engu-18.
Ungayithatha kanjani iMeldonium 500
Umthamo owodwa, inani lemithamo ngosuku kanye nesikhathi sokwelashwa kunqunywa esigulini ngasinye ngudokotela wakhe ohambele. Athembeli ekutholakaleni kweziguli kuphela, kodwa futhi esimweni esejwayelekile somzimba wakhe. Umenzi kwimiyalo yesidakamizwa uncoma le mikhakha elandelayo yokuthatha iMeldonium kumthamo ka-500 mg:
- Ukuze uthole ingozi yokungasebenzi kwe-cerebrovascular: i-1 capsule noma umjovo ngosuku. Isikhathi sesifundo somjovo kuyizinsuku eziyi-10, isikhathi sokuphathwa komlomo singaphezulu kwamasonto ama-3.
- Ekungapheni kwenhliziyo okungamahlalakhona: okokuqala, ngokuqinisa noma nge-intramuscularly, kuze kufike ku-1000 mg wesidakamizwa ngosuku amaviki ama-2. Ngemuva kwalokho - kwibhokisi le-4 izikhathi / ngosuku. Inkambo yokwelashwa ingafinyelela amasonto ayi-6.
- Nge-Cardialgia: ngokungena noma ngokuxakaniseka 1 isikhathi / usuku kumaviki ama-2. Bese unikeza i-capsule ngomthamo ophansi.
- Ngezimpawu zokuhoxa: i-capsule izikhathi ezi-4 / ngosuku izinsuku ezingeqile kwezi-10. Uma kunesidingo, ukumfaka okuphathelene nomuthi kungenziwa kungabi ngaphezu kwe-1 g / ngosuku.
- Ngemithwalo ekhuphukayo: ku-capsule izikhathi ezi-2 / ngosuku, ubude besifundo yizinsuku eziyi-10-14.
Umthamo owodwa, inani lemithamo ngosuku kanye nesikhathi sokwelashwa kunqunywa esigulini ngasinye ngudokotela wakhe ohambele.
Ngaphambi noma ngemuva kokudla
Imiyalo yokuthi iMeldonium kumele ithathwe ngaphambi noma ngemuva kokudla ayikho emiyalweni eyenziwe ngumenzi. Kodwa-ke, ucwaningo luye lwabonisa ukuthi ukuthatha isisu esigcwele kunciphisa i-bioavailability yomuthi, yize kungathinti ukusebenza kwawo kahle. Uma kwenzeka ubhekene nengozi yokuthola ukuphazamiseka kwe-dyspeptic, ungaphuza amaphilisi imizuzu engama-30 ngemuva kokudla. Lapho wenza ukwelashwa okuhlanganisa, kufanele kuthathwe imizuzu engama-15 phakathi kokuthatha iMeldonium kanye nezinye izidakamizwa.
Ngokuphathwa kwe-intravenous noma kwe-intramuscular of the drug, akukho ukuxhumana nokudla okutholakele okutholakele.
Umthamo wesifo sikashukela
I-Meldonium iyanconywa ukuthi isetshenziswe kwisifo sikashukela i-mellitus, kungakhathalekile ukuthi hlobo luni. Lokhu kungenxa yamandla ayo okwehlisa ushukela wegazi nokwenza kusebenze imetabolism. Kuyadingeka ukuphuza amaphilisi we-1-2 ngosuku. Ukwelashwa okuphindaphindwe kaningi ngonyaka kunconywa. Ukulinganiselwa kwezikhathi zezikhathi zokusebenzisa umuthi kanye nekhefu phakathi kwezifundo kunqunywa ngudokotela.
Ngokuthuthukiswa kokuphazamiseka kwengqondo i-dyspeptic, ungaphuza amaphilisi imizuzu engama-30 ngemuva kokudla.
Imiphumela emibi yeMeldonium 500
Imiphumela emibi lapho uthatha iMeldonium ayivelakancane. Iziguli ziphawule imiphumela emibi yokwelapha nalesi sidakamizwa njenge:
- i-tachycardia;
- gxuma ekucindezelweni kwegazi;
- ukuphazamiseka kwengqondo
- dyspepsia, ukubonakaliswa kwako okungahle kufane nezimpawu zokutheleleka kwamathumbu;
- ukubonakaliswa okuhlukahlukene komzimba.
Umthelela ekhonweni lokulawula izindlela
IMeldonium ayinciphisi amandla okugxilisa ingqondo, ayithikamezi ukunakwa futhi ayibangeli ukozela. Ngokuvumelana nalokho, lapho semukelwe, asikho isidingo sokunciphisa umsebenzi ngezindlela eziyinkimbinkimbi.
Ukuphazamiseka kwengqondo kwe-Psychomotor kungenzeka njengethonya lemiphumela.
Imiyalo ekhethekile
Ngenxa yokuthi umuthi unomphumela omnandi, kungakuhle ukuwuphuza ekuseni. Ezimweni lapho kukhonjiswa khona imithamo eminingana ngosuku, kufanele ukuthi isiphuzo sokugcina sidakwe ngaphambi kuka-17,00. Lesi sincomo sisebenza ngomjovo.
Lapho uthatha iMeldonium, kufanele kuqashelwe ezimweni zezifo zesibindi nezinso. Ngezifundo ezinde, ukubhekwa kwezokwelashwa kanye nokuqashwa kwamapharamitha welebhu kuyadingeka.
Sebenzisa ebudaleni
Abantu asebekhulile bavame ukuthatha inqwaba yemithi ehlukile. Ngenxa yokuthi iMeldonium inamandla okuqhakambisa umphumela wezokwelapha kanye nemiphumela emibi yezidakamizwa eziningi, ngaphambi kokuqala ukuyisebenzisa, umuntu osekhulile kufanele abonane nochwepheshe okwaziyo ukuhlola ukuhambelana kwalesi sidakamizwa nabanye nokuphepha kokuqokwa kwesiguli okunjalo.
Kunquma iMeldonium ezinganeni ezingama-500
Akukho datha ezifundweni zomtholampilo zemiphumela ye-Meldonium emzimbeni wezingane. Ngakho-ke, lesi sidakamizwa asinqunyelwe iziguli ezingaphansi kweminyaka engu-18.
Abantu abadala bayelulekwa ukuba babonane nodokotela ngaphambi kokusebenzisa i-meldonium.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi awuvunyelwe ukusetshenziswa ngabesifazane abakhulelwe nababambisayo.
I-overdose ye-Meldonium 500
Amacala okweqisa kwe-Meldonium awarekhodwanga.
Ukuxhumana nezinye izidakamizwa
IMeldonium iyakwazi ukuthuthukisa umphumela wezidakamizwa eziningi:
- yakhelwe ukubhekana nengcindezi elengisiwe;
- isetshenziselwa ukwelapha i-angina pectoris;
- imithi ye-herbal ekwazi ukusebenzisa umphumela we-antiarrhythmic (i-cardiac glycosides).
Ukuhlanganiswa nezidakamizwa ezilwa nomfutho wegazi ophakeme nezinto ezithinta i-lumen yemikhumbi yengozi kungadala ukukhula kwe-tachycardia kanye nokwehla okukhulu kwengcindezi.
Ukuphuza uphuzo oludakayo ngesikhathi sokwelashwa nge-Meldonium kuqinisekisiwe.
Ukuhambisana notshwala
Ukuphuza uphuzo oludakayo ngesikhathi sokwelashwa nge-Meldonium kuqinisekisiwe. Le nhlanganisela ayinciphisi kuphela ukusebenza kwezokwelapha, kepha futhi yandisa amathuba emiphumela emibi. Akufanele ishiywe hhayi kusuka ku-vodka nakwezinye iziphuzo ezinamandla kuphela, kepha futhi nakuma-cocktails obhiya nakotshwala abaphansi.
Ama-Analog
Analogs of Meldonium zonke izidakamizwa aqukethe into efanayo esebenzayo. Zingaba nendlela efanayo yokukhishwa noma ibe isiraphu, amaphilisi, izixazululo ezifakelwayo noma amakhompiyutha omthamo ohlukile.
Izidakamizwa ezidume kakhulu zemikhiqizo elandelayo:
- I-Mildronate;
- Idrinol;
- I-Angiocardyl;
- I-Flowerpot;
- Midrocard N.
Imibandela yekhefu lekhemisi
Kunzima ukuthola isidakamizwa emakhemisi enegama lokuhweba iMeldonium futhi sikhiqizwe ngesimo samaphilisi angama-500 mg, yize iqiniso lokuthi umnikazi wesitifiketi sokubhalisa yinkampani yaseRussia i-Pharmstandard-Leksredstva OAO. Amanethiwekhi amaningi anikezela ukuthenga ama-analogues awo. Umuthi ofanayo kuma-ampoules ungathengwa ngaphandle kosesho olude.
Ngingakwazi ukuthenga ngaphandle kadokotela
Emiyalweni yazo zonke izidakamizwa eziqukethe i-500 mg ye-Meldonium, abakhiqizi bakhombisa ukuthi lo muthi kufanele usatshalaliswe kuphela lapho kwethulwa umuthi. Ukuqina kokulandela lo mthetho ekhemisi elithile kuncike kwinqubomgomo yesikhungo. Umkhuba ukhombisa ukuthi osokhemisi bavame ukuya kubathengi.
IMildronate iyi-analogue yeMeldonium.
Intengo yeMeldonium 500
Umuntu ofuna ukuthenga umuthi oqukethe ama-500 mg we-meldonium ku-capsule kungenzeka acelwe ukuthi akhethe i-Mildronate. Izindleko zalesi sidakamizwa emakhemisi online ziqala kuma-ruble angama-514.
Intengo yephakeji lama-ampoules ayi-10 e-Meldonium ngesimo sesisombululo somjovo okhiqizwe i-JSC Biochemist ngama-ruble angama-240. Umuthi ofanayo owenziwe yi-LLC Grotex uzodla ama-ruble ayi-187.
Izimo zokugcina zomuthi
IMeldonium kufanele igcinwe emazingeni okushisa afinyelela ku + 25 ° C. Amakhebuli nama-ampoules akumele aqandiswe iqhwa. Kwenqatshelwe ukushiya umuthi endaweni efinyeleleka ezinganeni.
Isikhathi sokuphelelwa yisikhathi
Amaphilisi angagcinwa iminyaka engu-3, ​​isixazululo - iminyaka emi-4.
I-500 mg ye-meldonium iyinkinga impela ukuthola kumakhemisi, ngakho-ke ihlala ithathelwa indawo ngama-analogues.
Umkhiqizi
Isidakamizwa esinegama lokuhweba iMeldonium kanye nento efanayo esebenzayo kumakhompiyutha kungenziwa kukhiqizwe i-Pharmstandard-Leksredstva OJSC.
Ama-Ampoules anesixazululo somjovo akhiqizwa yizinkampani i-Biochemist JSC neGrotex LLC.
Ukubuyekezwa mayelana neMeldonia 500
Ukubuyekezwa okuningi kwabantu abathatha iMeldonium kulungile.
Izazi zezenhliziyo
USvetlana, eMoscow: "Ngaso sonke isikhathi ngiwanikeza lo muthi nge-angina pectoris. Iziguli zami zibika ukwehla kwezikhathi zokucwilisa. Enye yezinzuzo eziphambili zemithi yikhono lazo lokunciphisa isidingo se-nitroglycerin."
Iziguli
U-Andrey, oneminyaka engama-48, uNizhny Novgorod: "Ngiye kudokotela ngenxa yokuphelelwa amandla. Njengoba sengiphasile ekwelashweni elinqunyelwe lokwelashwa neMeldonium, ngiyakwazi ukubona ukusebenza kwalo okuphezulu. Ngizizwa ngijabule usuku lonke."
