ISaroten Retard ingeyeqembu lama-anticepressants ama-tricyclic. Isidakamizwa sisetshenziswa kwezokwelapha ukuqeda ukukhathazeka nokukhathazeka okuvela esimweni sokudangala. Ochwepheshe bangabeka umuthi ngesimo esingapheli sobuhlungu bokukhubazeka kanye nokuthuthukiswa kokucindezeleka nge-schizophrenia. Amakhandlela awenzelwe ukuthi asetshenziswe ebuntwaneni futhi awabekelwe abesifazane abakhulelwe.
Igama Lezwe elingafanele
I-Amitriptyline.
I-ATX
N06AA09.
ISaroten Retard ingeyeqembu lama-anticepressants ama-tricyclic.
Khipha amafomu nokwakheka
Umuthi wenziwa ngesimo samaphilisi ngethoma isikhathi eside. I-Amitriptyline hydrochloride 50 mg isetshenziswa njengento esebenzayo kumayunithi antidepressant. Okuqukethwe kwama-capsules kusekelwa ngamakhompiyutha asizayo:
- imikhakha kashukela;
- i-povidone;
- i-acid entshontsha;
- igobolondo.
Igobolondo langaphandle liqukethe i-gelatin ne-titanium dioxide. I-tint ebomvu ngombala obomvu emaphaketheni inika ubukhona bedayi obususelwa ku-iron oxide.
Isenzo se-Pharmacological
Umuthi ungowokulwa nama-antidepressants anomphumela wesikhathi eside wokuvuselela kuhlelo lwezinzwa oluphakathi. I-izidakamizwa esebenzayo i-amitriptyline ngasikhathi sinye inqanda ukuthathwa kwe-norepinephrine ne-serotonin ngaphambi kokufaka i-synapse. Umkhiqizo oyinhloko we-amitriptyline metabolism (nortriptyline) unomphumela omkhulu wokwelapha. Njengomphumela wesenzo somuthi, umsebenzi we-H1-histamine receptors nama-M-cholinergic receptors uyancipha. Isiguli siphuma ekucindezelekeni, ukukhathazeka nokukhathazeka kuyanyamalala.
Ngenxa yomthelela wokuphamba, umuthi uvimbela isigaba sokulala se-REM, ngaleyo ndlela ukwandisa isikhathi sesigaba saso esijulile.
I-Pharmacokinetics
Ngemuva kokuphathwa ngomlomo, igobolondo le-gelatin liyancibilika emathunjini, i-amitriptyline iyakhishwa futhi idonswa yi-60% ye-microvilli encane yamathumbu. Ukusuka odongeni lwesitho, into esebenzayo ingena egazini, lapho okuhlushwa nge-plasma kufinyelela inani layo eliphakeme kungakapheli amahora angama-4 kuya kwayi-10. I-Amitriptyline ibopha amaprotheni e-plasma ngo-95%.
I-metabolism yesakhiwo esisebenzayo idlula esibindini nge-hydroxylation ngokwakhiwa kwe-nortriptyline. Ukuphila kwesigamu umuthi kungamahora angama-25-27. Izinto zokwelapha zishiya umzimba unamafutha ngokusebenzisa uhlelo lomchamo.
Izinkomba zokusetshenziswa
Isidakamizwa sinqunywe phambi kwesimo sokucindezela kanye ne-neurosis, ikakhulukazi ezimweni lapho ukwephulwa kokulinganisela okungokomzwelo kuhambisana nokukhathazeka, ukuphazamiseka kokulala, ukuyaluza. Ama-antidepressants angafakwa ekwelapheni inhlanganisela ye-schizophrenia.
Contraindication
I-antidepressant ayivunyelwe nakancane ukuthi isetshenziswe lapho kukhona ukungahambi kahle kwezinto ezakha ifomu lomthamo. Umuthi awubekelwe abantu abanohlobo lokuthola ukungabekezelelani kwe-fructose, malabsorption we-glucose ne-galactose, kanye nokushoda kwe-isomaltase.
Ngokunakekela
Ukunakekelwa kumele kuthathwe lapho kuthathwa uSaroten kulezi zimo ezilandelayo:
- ukuphazamiseka okukhokhisayo
- ukulimala okukhulu kwesibindi nohlelo lwenhliziyo;
- ukukhuphuka kokuqothuka kwe-hormonal gland;
- isifuba somoya;
- amathambo hematopoiesis ukuphazamiseka;
- ukukhuphuka kwengcindezi ye-intraocular;
- ukuhoxiswa kotshwala;
Ngenxa yokuvela kokukhubazeka kwemisipha ebushelelezi yokugaya ukudla, lesi sidakamizwa asinconywa kuma-peristalsis angasebenzi kahle.
Ungayithatha kanjani iSaroten Retard?
Amakhompiyutha noma okuqukethwe (ama-pellets) kunconyelwa ukuphuza uketshezi oluningi ngaphandle kokuhlafuna. Ekucindezelekeni, kufaka phakathi isimo sokunganaki ngokumelene nesizinda se-schizophrenia, kuyadingeka ukuthatha i-1 capsule ngosuku ngamahora ama-3-4 ngaphambi kokulala, ngokwenyuka okulandelayo komthamo njalo ngeviki kuya ku-100-150 mg. Lapho umphumela wezokwelapha ozinzile utholwa, umthamo wansuku zonke wehliswa ube ubuncane bama-50-100 mg.
Umphumela we-antidepressant ubizwa ngemuva kwamasonto angu-2 - 2. Ukwelashwa kwezidakamizwa kumele kuqhubeke, ngoba ukwelashwa kuyizimpawu ngesikhathi esinqunywe udokotela ohambelayo. Ukuvimbela ukubuyela emuva, kunconywa ukuthi uqhubeke nokwelashwa izinyanga eziyisithupha. Ekucindezelekeni okukodwa, izidambisigciwane zithathwa iminyaka eminingana njengezindlela zokwelapha ukuvikela ukubuyela emuva.
Ngoshukela
Abantu abanesifo sikashukela kufanele baphuze amaphilisi ngokuqapha, ngoba i-amitriptyline ingaguqula umsebenzi osebenza we-insulin ekugxileni kwe-plasma kashukela egazini. Ngokushintshwa kwe-glucose, kuyadingeka ukulungisa umthamo we-insulin kanye ne-hypoglycemic agents.
Imiphumela emibi yeSaroten Retard
Kwezinye izimo, imiphumela emibi ejwayelekile (isiyezi, ukuncipha kokukhula, ukwethuka, ukubambezeleka kwe-metabolism, ikhanda) kungaba yizimpawu zokuxineka.
Amapheshana wesisu
Isifiso siyancipha noma siyakhuphuka, umuzwa wokucanuzelelwa kwenhliziyo futhi womile emgodleni womlomo uyavela, ubukhulu bezindlala ze-salivary buyanda, umsebenzi we-hepatocytic transaminases uyanda.
Isistimu yezinzwa ephakathi
Imiphumela emibi yokudangala kwe-CNS ibonakaliswa njenge:
- ukozela
- ukuzamazama kwemilenze;
- ukuphazamiseka kokunambitheka, ama-tactile kanye nama-receptors e-olodoory;
- ukuqwasha
- ukudideka, ukukhathazeka namaphupho amabi;
- isiyezi nokudideka;
- ukuphazamiseka kwengqondo;
- imicabango yokuzibulala;
- isimilo se-manic;
- ama-hallucinations ngokumelene nesizinda sokucindezeleka kwe-schizophrenic.
Ukushintsha ukunambitheka kungenye yemiphumela emibi yesidakamizwa.
Ezigulini ezinesifo sokuwa, ukubanjwa ngamandla ziba njalo.
Kusuka ohlelweni lomchamo
Ukugcinwa kwe-urinary kungenzeka.
Engxenyeni yesikhumba
Ngokuphulwa kwemali esele ye-electrolyte ngenxa yokuthatha uSaroten, ukuthuthukiswa kwesikhumba, i-alopecia kungenzeka.
Kusuka ohlelweni lwezitho zofuzo
Ukuphazamiseka kohlelo lokuzala kubonwa kuphela emadodeni, kuboniswe ngesimo sokungasebenzi kahle kwe-erectile kanye nokuvuvukala kwezindlala zezinso.
Kusuka ohlelweni lwezinhliziyo
Ngokuthuthuka kokusabela okungekuhle, isiguli singase sizwe ukushaya kwenhliziyo, ukucindezela kunciphe, kuvela i-tachycardia. Ingozi ye-atrioventricular blockade, ukuphazamiseka kwesingeniso ku-bundle yokwanda Kwakhe. Ngokuvinjwa kohlelo lwe-hematopoietic, i-agranulocytosis kanye ne-leukopenia ithuthukisa.
Allergies
Ezigulini ezichazwe ngaphambilini, ukuvela kwesikhumba, i-urticaria, ukulunywa, i-erythema kungenzeka. Ezimweni ezingavamile, i-Quincke edema nokuzwela amandla okuthuthukisa.
Umthelela ekhonweni lokulawula izindlela
Uma sisetshenziswe ngokungafanele, umuthi ungadala ukozela nokudangala kohlelo lwezinzwa, ngakho-ke ngenkathi ulashwa nge-antidepressant kuyanconywa ukuthi ungashayeli imoto, usebenze ngamadivaysi ayinkimbinkimbi futhi uhlanganyele kweminye imisebenzi edinga ukushesha okukhulu kokuphazamiseka kwe-psychomotor kanye nokuhlushwa.
Imiyalo ekhethekile
Isiguli kufanele saziswe ukuthi kungenzeka ukuthi kunemiphumela emibi evela ohlelweni lwezinhliziyo.
Ukudangala kufaka isandla ekuthuthukiseni ukuthambekela kokuzibulala. Imicabango yokuzibulala ingaqhubeka kuze kube yilapho inhlala-kahle iyonke ithuthuka, ngakho-ke ukuqapha isiguli ngokuphuza umuthi kuyadingeka ngesikhathi sokwelashwa. Lokhu kuyadingeka esigabeni sokuqala sokwelashwa, lapho ukuwohloka okubukhali kwesimo kungenzeka, kanye nokuthuthukiswa kokuthambekela kokuzibulala ngokumelene nakho. Esimweni esinjalo, kuyadingeka ukukhawula ukusetshenziswa komuthi.
Lapho kuvela isimilo se-menic, ukwelashwa kuyamiswa.
Umuthi umiswa ngaphambi kokuhlinzwa okuhleliwe. Uma kudingeka ukuhlinzwa okuphuthumayo, udokotela obulala izinzwa udinga ukuxwayiswa ngokuthatha imishanguzo. Ama-anesthetics angadala i-hypotension.
Ngokuyeka okuqinile kokuthatha uSaroten ngokumelene nesizinda sokwelashwa okuhlala isikhathi eside, kwezinye izimo, kuqale ukuvela isifo. Ukunciphisa ingozi yokusabela, kuyadingeka ukunciphisa kancane kancane umthamo womuthi ngaphezu kwamaviki ama-4-5.
Umuthi uvunyelwe ukusetshenziswa ezinganeni ezingaphansi kweminyaka engu-18.
Sebenzisa ebudaleni
Abantu abangaphezu kweminyaka engama-65 kufanele bathathe i-1 capsule engu-50 mg kusihlwa.
Ukuqokwa kukaSarotin Return kwabantwana
Umuthi uvunyelwe ukusetshenziswa ezinganeni ezingaphansi kweminyaka engu-18.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ama-antidepressants avinjelwe abesifazane ngesikhathi sokukhulelwa, ngoba i-amitriptyline ingaphazamisa ukubekwa kwezitho eziphambili nezinhlelo ngesikhathi sokuthuthukiswa kombungu, ikakhulukazi ku-trimester yesithathu.
Lapho uthatha imishanguzo yokudambisa izidakamizwa, ukunqunqa akukhanselwa uma kunesidingo ngokomtholampilo. Ngesikhathi sokulashwa, ukuqapha isimo somntwana osanda kuzalwa ngenyanga yokuqala yokuphila kwakhe kuyadingeka.
Sebenzisa umsebenzi wesibindi okhubazekile
Iziguli ezinenkinga yesibindi somsebenzi kufanele ziqaphele futhi, uma kungenzeka, zilawule ukugcwala kwe-amitriptyline ku-serum.
Lapho uthatha imishanguzo yokudambisa izidakamizwa, ukunqunqa akukhanselwa uma kunesidingo ngokomtholampilo.
Ukweqa ngokweqile kweSaroten retard
Ngomthamo owodwa womthamo omkhulu womuthi ihora, ungahle uhlangane:
- ukozela
- imibono;
- ukuvuka
- ukuvuvukala kwengane;
- umlomo owomile
- ukwethuka nokudangala kohlelo oluphambili lwezinzwa;
- isimo esizithandayo, isiphithiphithi;
- i-metabolic acidosis, ukuncipha kokuhlushwa kwe-potassium;
- ukuzindla kwenhliziyo;
- Izimpawu ze-cardiotoxicity: ukwehla kwengcindezi yegazi, ukwethuka kwe-cardiogenic, ukuhluleka kwenhliziyo.
Isisulu sidinga ukulashwa ngokuphuthumayo esibhedlela. Ezimweni zokuma, kuyadingeka ukugeza isisu unikeze i-adsorbent ukuvimbela ukumuncwa komuthi okuqhubekayo.
Ukwelashwa kuhloswe ukubuyisela umsebenzi wokuphefumula nowenhliziyo, ekuqedeni izimpawu zokweqisa. Ukuqapha umsebenzi wezinhliziyo kuyadingeka kungakapheli izinsuku ezingama-3-5.
Ukuxhumana nezinye izidakamizwa
Ukusetshenziswa okufanayo kwe-amitriptyline neminye imithi kunikeza ukusebenzisana okulandelayo:
- Ngokuhambisana ne-monoamine oxidase inhibitors, kuvela i-serotonin syndrome, ebonakala ngokudideka, i-myoclonus, umkhuhlane, ukuzamazama komhlaba. Ukwehlisa amathuba okuthi ukudakwa kwezidakamizwa, uSaroten unqunywa kuphela ngemuva kwamasonto amabili kusukela ekugcineni kokwelashwa ngama-inhibitors angama-AMO angaguquki noma amahora angama-24 ngemuva kokusebenzisa kabusha kwe-monoamine oxidase blockers.
- Umphumela wokwelapha wama-barbiturates uyathuthukiswa.
- Ukwanda kokubonakala kokuvinjwa kwamathumbu ngenxa yokuvinjwa kwe-peristalsis yemisipha ebushelelezi yesisu lapho uthatha ama-antipsychotic noma ama-anticholinergics. Nge-hyperthermia, ukudonswa kwamathumbu kuhambisana ne-hyperpyrexia. Lapho uthatha ama-antipsychotic, umkhawulo wokulungela ukweyisa uyancipha.
- I-Amitriptyline ithuthukisa i-cardiotoxicity ye-anesthetics, ama-decongestants, i-ephedrine ne-phenylpropanolamine. Ngenxa yomonakalo ongaba khona ohlelweni lwezinhliziyo, izidakamizwa ezinjalo azinqunyelwe njengendlela yokwelapha ehlanganayo.
- Into esebenzayo yeSaroten yehlisa umphumela we-hypotensive weMethyldopa, iGuanethidine, i-Reserpine nezinye izidakamizwa ze-antihypertensive. Ngokuphathwa kanyekanye kwe-amitriptyline, udinga ukushintsha umthamo wezidakamizwa wehlisa umfutho wegazi.
- Amaphilisi okulawula ukuzala nezidakamizwa ezinama-hormone ocansi abesifazane akhulisa i-bioavailability ye-amitriptyline, edinga ukwehliswa komthamo wazo zombili lezi zidakamizwa. Uma kunesidingo, ukuhoxiswa kweSaroten kungadingeka.
Ngokuhlanganiswa ne-acetaldehydrogenase inhibitors, amathuba okukhula kwezimo zengqondo, ukudideka kanye nokulahlekelwa ukwazi kuyanda.
Ngesikhathi sokulashwa kwezidakamizwa, kufanele uyeke ukuphuza utshwala.
Ukuhambisana notshwala
Ngesikhathi sokulashwa kwezidakamizwa, kuyadingeka ukuyeka ukuphuza utshwala. I-Ethyl alcohol inganciphisa umphumela we-antidepressant, ikhuphule noma ikhulise izehlakalo zokungaphenduki kahle. Ikakhulu maqondana nohlelo lwezinzwa, ngoba i-ethanol inomphumela ocindezelayo ohlelweni lwezinzwa oluphakathi.
Ama-Analog
Ukufakwa esikhundleni kweSaroten kufaka phakathi ama-ejenti aphindaphinda ukwakheka kwamakhemikhali we-antidepressant kanye nezakhiwo ze-pharmacological:
- I-Amitriptyline;
- Clofranil;
- I-Doxepin;
- I-Lyudiomil.
Ukufakwa esikhundleni muthi kwenziwa kuphela lapho kungekho mphumela omuhle, ngemuva kokubonisana nodokotela.
Imibandela yekhefu lekhemisi
Amaphilisi athengiswa ngomuthi.
I-Clofranil iyi-analogue yeSaroten.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Ama-antidepressants angokwesigaba sezidakamizwa ze-psychotropic, ngakho-ke uma esetshenziswa ngokungafanele, angadala ukudangala kohlelo lwezinzwa oluphakathi. Ngenxa yalokhu, ukuthengiswa kwamahhala kukhawulelwe.
USarotin Buyisela Intengo
Izindleko ezijwayelekile zamaphilisi ama-ruble angama-590. EBelarus - ama-ruble ayi-18.
Izimo zokugcina zomuthi
Amakhompiyutha kufanele agcinwe endaweni enomswakama ophansi, ovikelwe elangeni, emazingeni okushisa angeqi ku-25 ° C.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Umkhiqizi
H. Lundbeck AO, eDenmark.
Ukubuyekezwa kweSaroten retard
UTaras Evdokimov, oneminyaka engama-39, uSaransk.
Ubhekene nengcindezi yesikhathi eside. Angikwazanga ukuphuma kulesi simo ngedwa, ngakho ngaphendukela kudokotela wezifo zengqondo ukuze athole usizo. Udokotela unqume uSaroten. Ngibheka umuthi njengosebenza, ubhekana kahle nemizwa yokukhathazeka futhi usiza ukuqeda ukuqwasha. Amaphilisi kufanele aphuzwe ntambama ngomthamo ka-50 mg nangesikhathi sokulala, 100 mg. Ngemuva kwesonto, kusetshenziswa umthamo wobusuku kuphela. Angibonanga imiphumela emibi, uma kungenjalo ukozela. Kepha uyadingeka ukubhekana nokuqwasha.
U-Angelica Nikiforova, oneminyaka engama-41, eSt.
I-psychotherapist inqume amakhompiyutha eSaroten maqondana nezimo zokukhathazeka. Uma isetshenziswa kahle, ngokuqinile ngokwemiyalo, iba nomphumela oqinile. Ngincoma ukuthatha iphilisi lokugcina kuze kube ngu-20: 00. Uma lokhu kungenziwa, kimi, ukuvela kwesistimu yezinzwa nokuqwasha kuqale. Uma i-tachycardia ivela, ishayela ukulala, bese inciphisa umthamo, futhi izimpawu zanyamalala.Uthole umphumela omuhle ozinzile lapho uthatha ama-50 mg izikhathi ezi-2 ngosuku kanye ne-50 mg eyengeziwe ebusuku. Kubalulekile ukukhetha umthamo ofanele ngokubonisana nodokotela wakho.
