I-Pentilin iyi-antispasmodic enobubanzi besenzo, okungeqembu le-purines. Izindlela ezi-2 zokukhishwa, kufaka namathebulethi, adinga ukunikezwa umuthi. Lapho umuthi usetshenziselwa izinhloso zephrophylactic nezokwelapha, i-lumen ye-vascular iyanda, izindonga ziyaqina. Umphumela ozuzisayo kwimisipha yokuphefumula. Ngokwakheka kwefomu ngalinye kunezinto eziyisisekelo nezinsizanayo ezihambisana. Ukusetshenziswa kwenziwa ngokuya ngemiyalo. Imiphumela emibi ingenzeka, ikakhulukazi uma kukhona ama-contraindication.
Igama Lezwe elingafanele
INN yesidakamizwa yi-pentoxifylline.
I-Pentilin iyi-antispasmodic enobubanzi besenzo, okungeqembu le-purines.
I-ATX
Umuthi wanikezwa ikhodi ye-ATX yomuntu ngamunye - i-C04AD03 nenombolo yokubhalisa - Cha. RK-LS-5№004325 kusuka ngo-16.10.2101.
Khipha amafomu nokwakheka
Umuthi uthengiswa ngendlela yamathebulethi kanye nesisombululo sokuphathwa kwe-intravenous noma intraarterial. Ukwakheka kwalezi zinhlobo zomthamo kuqukethe izinto ezisebenzayo, lapho zingena emzimbeni wesiguli, lokhu noma ukuthi umphumela wokwelapha uyatholakala. Izinto ezisizayo azithinti i-bioavailability yomuthi futhi isebenze njengabazinza.
Amaphilisi
Ifomu lomthamo liqukethe i-400 mg ye-pentoxifylline. Izibhebhe zihlanganiswa nefilimu-ifilimu, equkethe:
- titanium dioxide;
- i-macrogol;
- i-hypromellose;
- i-talcum powder.
Uhlobo lomthamo we-Pentilin uqukethe i-400 mg ye-pentoxifylline.
Izici ezisizayo zifaka:
- i-magnesium stearate;
- i-anhydrous silica colloidal;
- i-macrogol.
Amhlophe, i-biconvex, amaphilisi we-oblong athengiswa ngamaphakethe ayi-10.
Inani lamabhuloksi ebhokisini lekhadibhodi - akukho ngaphezu kwama-2 ama-PC.
Ngemuva kwebhokisi kukhona ukumaka okufanele. Imiyalo esetshenzisiwe ifakwe ngaphakathi kwephakeji.
Isixazululo
Uketshezi lwe-infusions olungena ngaphakathi kanye ne-intraarterial luqukethe i-100 mg yesithako esisebenzayo.
Uketshezi lwezokwelapha lwePentilin luyaqhubeka luthengiswa kuma-ampoules we-5 ml.
Luwuketshezi ocacile, ongenawo umbala noma ophuzi ngaphandle kwezinhlayiya zakwamanye amazwe. Izinto ezingeziwe ekwakhiweni kwefomu lomthamo:
- i-sodium dihydrogen phosphate dihydrate;
- i-sodium hydrogen phosphate dihydrate;
- amanzi wokujova;
- i-sodium chloride;
- edetate disodium.
I-ketshezi ithengiswa kuma-ampoule angama-5 ml. Kwiphakethe lamakhadibhodi ama-ampoules ama-5 abekwe ku-blister. Imiyalo yokusebenzisa ngendlela ipheshana nokumaka ngemuva kwebhokisi iyatholakala.
Isenzo se-Pharmacological
Into esebenzayo ekwakhiweni kwanoma yiluphi uhlobo lomthamo ithinta kahle uhlelo lwenhliziyo, uhlelo lokuphefumula, uhlelo lokuzala nokuchama. Ukusetshenziswa okungenzeka ku-otolaryngology, gynecology kanye ne-urology. Ngokusetshenziswa njalo, ukugeleza kwegazi kuvamile, izakhi zofuzo zegazi ziyathuthuka.
Into esebenzayo ekwakhiweni kwanoma yiluphi uhlobo lomthamo wePentilin luthinta kahle uhlelo lwenhliziyo.
Umgomo wokusebenza kwanoma yiluphi uhlobo lomthamo usekelwe ekuvinjelweni kwe-phosphodiesterase. Ngasikhathi sinye, kukhona ukwanda kwezinga le-cyclic AMP kuma-platelet kanye ne-ATP kumaseli abomvu egazi. I-vasodilation iba ngenxa yokugcwala kwamandla wamandla, ukumelana kwemithambo yegazi yokwehla. Ngomthamo owandayo we-stroke, izinga lokushaya lihlala lingashintshiwe.
Umphumela we-antianginal utholakala ngenxa yekhono lomuthi ukwandisa imithambo ye-coronary, eqinisekisa ukuhamba kwegazi eligcwele i-oksijini liye ku-myocardium. I-oxygenation oxygenation itholakala ngokwandisa ukukhanyiswa kwemithambo ye-pulmonary.
Ngokusetshenziswa njalo, ithoni yesiphambano nemisipha yesifunda sangaphakathi iyakhuphuka.
I-microcirculation yegazi iyathuthuka, ukuqina kwamaselula okwenyuka kwamangqamuzana amaseli abomvu egazi kuyakhuphuka. Igazi liba ngaphansi kwe-viscous. Ukulimala kumithambo yethambo kungadala ukuthuthukiswa kokuqanjwa kwemibono ngezikhathi ezithile. Kulokhu, ukusetshenziswa kwalesi sidakamizwa kuqeda izinhlungu nokugoba emisipha yamathole, ikakhulukazi ebusuku.
I-Pharmacokinetics
Noma yiluphi uhlobo lokukhishwa lungenwa ngokushesha kungakhathalekile ukuthi luyisiphi isicelo. Ifomu lethebhulethi alicasuli ulwelwesi lwe-mucous lwesisu, amathumbu. Ukuhlushwa okuphezulu kwe-pentoxifylline ku-plasma yegazi kunganqunywa emahoreni ama-3-4 ngemuva komthamo wokuqala. Ukuhlanganiswa kwamaprotheni egazi akwenzeki.
Uhlobo lwethebhulethi lwePentilin alucasuli i-mucosa yamathumbu.
Isenzo eside sefomu lethebhulethi sisuselwa ekukhululweni okuqhubekayo kancane kancane kwento esebenzayo nokufakwa kwayo ngokushesha. Akuwunciphisi umsebenzi wama-enzyme wesibindi, naphezu kweqiniso lokuthi imetabolism yenziwa ngalo mzimba. Ama-Metabolites (i-carboxypropyl ne-hydroxyhexyl dimethylxanthine) athathwa njengasebenza.
Uma usingathwa kahle, umuthi unomthamo omkhulu wokusabalalisa nokuvunyelwa okuphezulu. Isigamu sempilo singamahora ayi-1.5. AmaMetabolites ashiya umzimba ngomchamo (aze afike ku-95%). Ingxenye encane (3-4%) ikhishwa amathumbu. Iyakwazi ukungena ubisi lwebele.
Izinkomba zokusetshenziswa
Izinkomba eziphambili zokusebenzisa ama-pathologies ahambisana nokuphazamiseka kokujikeleza. Lokhu kufaka phakathi:
- ukuphazamiseka kwe-vascular genesis yezinzwa;
- ukwehluleka okukhulu kokujikeleza kwe-acute, subacute nokuhlala njalo kanye nokunye ukuphazamiseka okubukwayo;
- ingozi yesifo sokuqina kwemizwa;
- ukwehlukanisa endarteritis;
- ukuphazamiseka kokujikeleza kokujikeleza kwengqondo okucasulwa yisifo sikashukela i-mellitus kanye ne-atherosclerosis;
- i-angiopathy;
- Isifo sikaRaynaud;
- i-paresthesia;
- ukuphazamiseka kokujikeleza kwe-venous and arterial ngenxa ye-frostbite, gangrene, trophic ulcers;
- isifo sokuqina kwemizwa kanye ne-dyscirculatory encephalopathy.
I-antispasmodic ivunyelwe ukuthi isetshenziswe ku-gynecology ngesikhathi se-premenstrual syndrome.
Contraindication
Ukusetshenziswa kwesidakamizwa akwamukeleki uma isiguli sine-contraindication ebekiwe emiyalweni. Lokhu kufaka phakathi:
- i-corrhea hemorrhage;
- ama-retinal hemorrhages;
- ukulahleka kwegazi okukhulu, kufaka phakathi ukopha kwezifo zesibeletho;
- i-hemorrhagic stroke (i-acute and subacute);
- arrhythmias enzima;
- i-hypertension ye-arterial;
- infarction myocardial;
- i-porphyria;
- ukulimala okukhulu emithanjeni nasemithanjeni;
- isikhathi sokuzala ingane;
- ukuncelisa;
- izingane nentsha (kuze kube iminyaka eyi-18);
- hypersensitivity.
Umuthi une-infraindication eziningana, lapho ukusetshenziswa okuvunyelwe kuvunyelwe.
Ukusetshenziswa kwesidakamizwa akwamukeleki ekuphatheni i-hemorrhage ku-retina.
Ngokunakekela
I-contraindication ehlobene ne-peptic ulcer yesisu ne-duodenum. Ukwehluleka kwenhliziyo, i-pathologies enzima yezinso nesibindi kudinga ukusetshenziswa ngokucophelela. Uma isiguli sinomlando we-hemorrhage wangaphakathi nangaphakathi, ukuphathwa kwenziwa ngaphansi kokuqashwa kukachwepheshe.
Ungayithatha kanjani iPililin
Ifomu lomthamo elihlose ukuphathwa ngomlomo lingathathwa kancane uma imithamo yemithamo idinga lokho. Kunconywa ukuyiphuza ngengilazi yamanzi abilisiwe endaweni yokushisa yasekamelweni. Ukwelashwa okwenziwa nsuku zonke - akukho ngaphezu kwamaphilisi ama-3 ngosuku, ithebhulethi engu-1 kanye ngemuva kokudla ngakunye.
Isikhathi sokusebenza sinqunywa ngawodwana, ezimeni eziningi kungamaviki angama-7-8.
Isixazululo sifakwa emthanjeni noma emithanjeni usebenzisa i-dropper. Inkambo yokwelashwa inqunywa ngokuya ngenhlala kahle yeziguli. Ngaphambi kokuphatha ukumnika, isiguli kufanele silale phansi. Azikho ngaphezu kwama-300 mg (ama-ampoules ama-3) ezenziwa kanye. Isikhathi sokungeniswa yihora eli-1, ngosuku - akukho nqubo engaphezu kwezingu-2.
Isixazululo sePentilin sifakwa emthanjeni noma emithanjeni usebenzisa i-dropper.
Ukuthola imiphumela ephezulu, ungazithatha zombili izinhlobo zemithamo. Esikhathini sosuku, isiguli sinikezwa isisombululo, ngaphambi kokulala, ungathatha i-1 ithebhulethi.
I-antispasmodic ingahlanganiswa nezinye izixazululo zokufakwa ngemuva kokuhlolwa.
Imithamo yezixazululo zokungenelela (i-Ringer, 0,9% i-sodium chloride) nazo zinqunywa ngokuhlukile.
Ngoshukela
Iziguli ezinohlobo 2 nohlobo lwe-3 mellitus yesifo sikashukela zidinga ukuthatha umuthi ngaphansi kokuqashwa kukachwepheshe. Ukulungiswa komthamo kungadingeka.
Imiphumela emibi yePentilin
Ezigulini ezi-hypersensitive kanye ne-regimen ekhethwe ngendlela engafanele, ingozi yokwenqatshwa kwezidakamizwa yanda ngomzimba. Izimpawu eziseceleni zibonwa engxenyeni yezitho zangaphakathi, amasistimu wezinzwa okuphakathi nesikhumba.
Ngemuva kokuthatha iPentilin, isifo sohudo singenzeka.
Engxenyeni yesitho sombono
Ukulimazeka okubonakalayo, izinkomo kuthiwa zinemiphumela emibi.
Amapheshana wesisu
Engxenyeni yezitho zokugaya, isisu sohudo, i-xerostomia, ukulahleka kwesifiso, isicanucanu kanye nokuhlanza kuyabonakala. I-Cholecystitis ingakhula futhi i-anorexia ingakhula.
Izitho zeHematopoietic
Imiphumela emibi evela ohlelweni lokujikeleza kwezisu ivezwa ngesimo se-pancytopenia, i-thrombocytopenia, i-leukopenia kanye nokuphuma kwegazi emathunjini.
Isistimu yezinzwa ephakathi
Kusukela ohlangothini lwesistimu yezinzwa ephakathi kukhona isiyezi, ukwehluleka, umuzwa wokukhathazeka, ukuqwasha ne-migraine.
Kusuka ohlelweni lokuphefumula
Imiphumela emibi kulesi sigaba ifaka phakathi ubunzima bokuphefumula.
Ukuthatha i-Pentilin kungadala ukuphefumula.
Engxenyeni yesikhumba
Imiphumela emibi esikhumbeni ibonakala ngendlela ye-hyperemia. Ipuleti lesikhonkwane ezandleni liba brittle xaxa.
Kusuka ohlelweni lwezinhliziyo
Ngasohlangothini lohlelo lwezinhliziyo, isiguli sakha i-tachycardia, i-cardialgia ne-arrhythmia. Hypotension ingahle ikhule.
Allergies
Ukuphendula kwe-allergic kuboniswa ngesimo se-urticaria, isikhumba somzimba, ukulunywa nokushiswa. Ezimweni ezingavamile, ukwethuka kwe-anaphylactic kungahle kube khona.
Umthelela ekhonweni lokulawula izindlela
I-antispasmodic ayithinti ijubane lokuphendula kwe-psychomotor, ngakho-ke ukushayela imoto ngenkathi ulashwa ngomuthi kungenzeka.
Imiyalo ekhethekile
Ngesikhathi sokufaka isicelo, kuyadingeka ukuqapha umfutho wegazi. Iziguli ezinomfutho wegazi ophakeme zingadinga ukunciphisa uhlobo lwesilinganiselo.
Ngesikhathi sokusetshenziswa kwePentilin, kuyadingeka ukubheka umfutho wegazi.
Ukuhambisana nokuhlanzeka komuntu ngesikhathi sokulashwa kuyimpoqo, kepha amanzi kufanele agwenywe endaweni yomjovo.
Sebenzisa ebudaleni
Iziguli esezikhulile zidinga umuthi wokucophelela ngokulungiswa kwendlela yemithamo.
Isabelo sezingane
Iminyaka yezingane ibhekwa njengokuphula umthetho ngokuphelele.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ngesikhathi sokuncelisa nokuzala ingane, kwenqatshelwe ukuthatha i-antispasmodic.
Isicelo sokusebenza kokulimala kwezinso
Ama-patologies wezinso abhekwa njengokwephula umthetho okuhlobene, ukusetshenziswa kuleli cala kufanele kube ngokucophelela.
Ngama-pathologies ezinso, umuthi kufanele usetshenziswe ngokuqapha.
Sebenzisa umsebenzi wesibindi okhubazekile
Umsebenzi wesibindi ongasebenzi kahle udinga ukuphathwa ngokucophelela.
I-Pentilin Overdose
Ukuphindaphinda okwejwayelekile kwesimo sokwelapha kucasukela ukwakhiwa kwe-overdose. Izimpawu zalo zokuziphatha zibandakanya:
- ukwehluleka
- ukopha emgodini wokugaya ukudla;
- ukwehla okukhulu komfutho wegazi;
- ubuthakathaka obujwayelekile;
- ukuphazamiseka kokulala (ukozela, ukuqwasha);
- ukweqile ngokomzwelo.
Ukufaka isikhalazo esikhungweni sezokwelapha kuyimpoqo, kunikezwe ukwelashwa okubonakalayo. Usizo lokuqala luqukethe ukugeza isisu sesiguli. Futhi, kufanele anikezwe noma iyiphi i-enterosorbent.
Ukuxhumana nezinye izidakamizwa
Ngokuphathwa kanyekanye kwe-antispasmodic nezidakamizwa ezinciphisa umfutho wegazi, ingozi yokuqhuma kwemithambo yegazi iyanda.
I-Pentilin iyakwazi ukuthuthukisa umsebenzi wama-antibiotics.
Umuthi uyakwazi ukuqinisa umsebenzi wama-antibiotics. I-insulin nezinye izidakamizwa ze-hypoglycemic, kanye nomuthi, zivusa ukuthuthukiswa kwe-hypoglycemia. Izithasiselo kanye nama-vitamin complexes ngasikhathi sinye njenge-antispasmodic ngcono imiphumela emibi evela emgodini wokugaya ukudla.
Ukuhambisana notshwala
Umuthi unokuhambisana okungalungile nanoma yisiphi isiphuzo esinezidakwa.
Ama-Analog
Umuthi unezifanekiselo eziningana zesakhiwo ezinokwakheka okufanayo futhi ufaka okunye esikhundleni sokwelapha. I-antispasmodic enegama elifanayo nelasekuqaleni, inesiqalo esithi "Buyisela" futhi iyatholakala ngohlobo lwethebhulethi.
Isetshenziselwa ukuphazamiseka kokujikeleza, kune-contraindication efana nekhambi lokuqala.
I-Agapurin ibizwa nge-generics. I-Angioprotector enomphumela we-vasodilating. Kutholakala ngesimo samathebulethi nekhambi lokufakwa. I-Pentoxifylline (400 noma 600 mg) ikhona. Izindleko zama-analogues ekhemisi ziyahlukahluka kusuka kuma-ruble angama-280-400.
Imibandela yekhefu lekhemisi
Noma yiluphi uhlobo lokukhishwa kwe-antispasmodic ludinga ukunikezwa kadokotela emakhemisi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Imithi ayikwazi ukuthengwa ngaphandle kokuthola umuthi ngesi-Latin.
Intengo yePentilin
Izindleko zamathebulethi kanye nesisombululo se-antispasmodic kumakhemisi ziyehluka ngokuya ngamaphoyinti athengiswayo. Umuthi awubhalisiwe esifundeni seRussia Federation.
Izimo zokugcina zomuthi
Umuthi kufanele ugcinwe ekhabetheni elingaphezulu lekhabethe kude nezilwane nezingane. Indawo kufanele yomile futhi ipholile.
Isikhathi sokuphelelwa yisikhathi
Isitoreji sanoma yiluphi uhlobo lokukhululwa kusuka esikhathini sokuvula iphakethe - azidluli izinyanga ezingama-60.
I-Pentilin analog - I-Agapurin ingathengwa ngaphandle kokuthola umuthi.
Umkhiqizi
Umuthi wokuqala wenziwa eSlovenia. Ama-analogues asondele kakhulu akhiqizwa eRussia.
Ukubuyekezwa kwePentilin
Ukubuyekezwa kodokotela neziguli mayelana ne-antispasmodics kulungile.
UDaniil Sviridov, udokotela ohlinzeka ngemithambo, i-Ekaterinburg
Ngisebenzisa lo muthi iminyaka emithathu. Akulula ukuthola kumakhemisi; isidakamizwa sithengiswa kuphela ngamanani amakhulu. Umuthi uyasebenza, ukuthuthukiswa kwenzeka ngemuva kwamaviki ama-3-4 wokudla njalo. Igazi liba lingabonakali kangako, izindonga zemikhumbi emikhulu ziba namandla kakhulu. Isebenzisana kabi nezidakamizwa eziningi, kuyilapho angikukhuthazi ukuthatha imishanguzo ngasikhathi sinye ...
UValentina, oneminyaka engama-47, uNovorossiysk
Uqale ukuphuza umuthi ezinyangeni eziyisithupha ezedlule. Uhlinzwe ngamehlo emgqonyeni we-retina wamehlo, esibhedlela, kwadonswa isixazululo. Ngemuva kokukhishwa bekufanele ngiphuze amaphilisi, kepha inani lentengo lalibonakala liphezulu, ngakho-ke ngathenga i-analogue eshibhile. Okuzisola cishe ngokushesha.
Umuthi wokuqala ungcono. Ukuthuthuka kufike ngokushesha, naphezu kwemiphumela emincane emincane eye yaya yodwa ngemuva kwezinsuku ezi-4.
