I-Amoxicillin 250 amaphilisi: Imiyalo esetshenzisiwe

Amathebhulethi e-Amoxicillin 250 mg ayi-antibiotic ebanzi ebanzi ye-beta-lactam. Kodwa-ke, umphumela wabo we-antimicrobial ulinganiselwe, ngoba lesi sidakamizwa sichithwa ngaphansi kwethonya le-penicillinase ekhiqizwa ngamagciwane athile.

Igama Lezwe elingafanele

I-INN yesidakamizwa yi-Amoxicillin.

Amathebhulethi e-Amoxicillin 250 mg ayi-antibiotic ebanzi ebanzi ye-beta-lactam.

I-ATX

Umuthi okukhulunywa ngawo unekhodi ye-ATX i-J01CA04.

Ukwakheka

Ingxenye esebenzayo yamathebulethi iyindlela yoxantathu ye-amoxicillin enanini lama-250 mg. Kubandakanya:

• isitashi;
• i-talc;
• i-crospovidone;
• i-magnesium stearate;
• i-calcium stearate.

Amacwecwe asakazwa ngezingcezu eziyi-10. emabhulashini noma ezimbizeni zepulasitiki ezi-10 noma ezingama-20 ama-PC. Ukufakwa kwangaphandle kubukeka njengebhokisi lekhadibhodi. Faka kuwo imbiza eyi-1 noma ama-2 blister plates kanye nepheshana elinemiyalo.

Isenzo se-Pharmacological

Umuthi umuthi wokulwa owenziwe ngochungechunge lwe-penicillin. Ibonisa izakhiwo ze-bactericidal. Umphumela wayo we-antibacterial uqinisekiswa ngokucindezelwa komsebenzi we-transpeptidase kumaseli wamagciwane. Lokhu kuvimba i-biosynthesis ye murein, ephula ukwakheka kodonga lweseli futhi ibangele ukufa kwe-microorganism.

Umuthi umuthi wokulwa owenziwe ngochungechunge lwe-penicillin.

Isenzo salo muthi sifinyelela kuma-pathogens amaningi ama-anaerobic gram-positive nama-gram-negative. I-Amoxicillin iqeda ngempumelelo:

• I-Escherichia coli;
• Helicobacter pylori;
• I-Proteus mirabilis;
• amathumbu kanye ne-hemophilic coli;
• i-salmonella;
• i-strepto ne-staphylococci;
• ama-causative agents e-pneumonia, i-anthrax, i-meningitis;
• ezinye izinhlobo zeKlebsiella neShigella.

Kepha ekulweni nama-mycoplasmas, ama-rickettsia, ama-indole-positive ama-Proteus, izidalwa ezikhiqiza i-β-lactamase namagciwane, akusizi ngalutho.

Izici zamakhemikhali zomuthi ziyefana ne-Ampicillin, kepha i-bioavailability yomlomo we-Amoxicillin iphakeme.

I-Pharmacokinetics

Ukusuka emgudwini wokugaya ukudla, i-antibiotic ingena ngokushesha egazini. Iyamelana nemvelo ene-acid esiswini. Izinga nezinga lokutholwa kwengxenye esebenzayo lizimele ekutholeni ukudla. I-bioavailability yayo ifinyelela kuma-95%. Ukugxila kwe-plasma enkulu kunqunywa emahoreni angama-1-2 ngemuva kokuthatha umthamo ongu-1. Umsebenzi wokwelapha umuthi uthatha cishe amahora angama-8. Izinga lokugcwala kwegazi nomuthi kuncike ngqo kumthamo.

I-Amoxicillin isatshalaliswa kahle emzimbeni. Emavolini okwelapha, ingena ngezicubu ezahlukahlukene kanye noketshezi, kufaka phakathi:

• i-mucosa yamathumbu;
• amaphaphu;
• sputum;
• amathambo
• izicubu ze-adipose;
• isigaxa senyongo;
• bile;
• indlala yesibindi nezitho zohlelo lowesifazane lokuzala;
• umchamo
• uketshezi lwe-pleural ne-peritoneal;
• okuqukethwe ama-blisters.

Idlula kwi-placenta futhi itholakala ubisi lwebele. Izinga lokuxhumana kwalo namaprotheni egazi lifinyelela ku-20%. Uma kungekho ukuvuvukala, akungeni emvinjelweni wegazi-lobuchopho.

Ukutholwa kokunye kokuthile umuthi kwenzeka esibindini.

I-metabolism engxenye yenzeka esibindini. Imikhiqizo yokubola ayisebenzi. Kuze kufike ku-70% wesidakamizwa osuswe ngendlela yaso yoqobo. Ngemuva kokuthatha i-1 ithebhulethi engu-250 mg, okuqukethwe kwento esebenzayo kumchamo kufinyelela kuma-300 μg / ml. Isigamu sempilo amahora angama-1-1,5. Ekwehlulekeni kwezinso, ukumbiwa kwethambo kuvinjelwe. Ingxenye encane yomuthi ishiya umzimba unezindunduma.

Yini amaphilisi e-amooticillin 250 asiza kuwo

Umuthi wenzelwe ekwelashweni kwezifo ezibangelwa amagciwane adalwa yimiphumela yako. Izinkomba zokusetshenziswa kwe-antibiotic:

1. Izifo ze-Otolaryngological - i-sinusitis, i-sinusitis yangaphambili, i-pharyngitis, i-tonsillitis, i-tonsillitis, i-laryngitis, ukuvuvukala kwendlebe ephakathi.
2. Ukwehlulwa kwezinsiza kusebenza ze-bronchopulmonary - bronchitis, kubandakanya okungamahlalakhona, i-pneumonia.
3. Izifo ze-Urogenital - pyelitis, cystitis, pyelonephritis, urethritis, prostatitis, cervicitis, endometritis, salpingitis, gonorrhea.
4. Typhoid, paratyphoid, peritonitis, cholangitis, gastroenteritis, colitis, cholecystitis.
5. Isifo sohudo, isifo sokuqaqamba kwamakhala.
6. I-Meningitis
7. I-Borreliosis
8. Ukunqotshwa kwe-listeria ne-leptospira.
9. I-Sepicemia.
10. I-Erysipelas, impetigo kanye nezinye izifo zesikhumba nezendlalelo ezingaphansi, kufaka phakathi izifo zesibili zamanxeba nokushiswa.
11. Ukuvimbela i-endocarditis yamagciwane kanye nokutheleleka nge-postoperative.

Isifo sohudo, esinegciwane emvelweni, kungenye yezinkomba zokusebenzisa umuthi olwa namagciwane.

Ukutheleleka nge-urogenital kungenye yezinkomba zokusetshenziswa kwe-antibiotic.

I-sinusitis ingenye yezinkomba zokusebenzisa i-antibiotic.

Izifo ze-Otolaryngological - enye yezinkomba zokusetshenziswa kwe-antibiotic.

Ngoshukela

Isifo sikashukela sithinta kabi ukumelana nomzimba, ngakho-ke ukutheleleka ngamagciwane kushukela sikashukela kukhula kaningi. Sebenzisa imishanguzo ezigulini ezinjalo ngokuqapha. Imvamisa, umuthi okukhulunywa ngawo ubekelwe izinkinga zesifo, izifo zezinhlelo zokuphefumula nezokuchama. Kungcono ukwenza ukwelashwa esibhedlela.

Contraindication

Amathebulethi akufanele athathwe uma:

• ukungabekezeleli i-amoxicillin noma izinto ezisizayo;
• umlando wokungezwani nezidakamizwa ze-beta-lactam;
• hay fever, isifuba somoya;
• i-mononucleosis esithathelwanayo;
• i-lymphocytic leukemia;
• i-colitis yezidakamizwa;
• izilonda zesibindi.

Abadakwanga ngesikhathi sokuncelisa ibele futhi abanikezwa izingane ezingaphansi kweminyaka emithathu.

Kufanele kuqashelwe ikakhulukazi lapho kunqunywa umuthi kwabesifazane abakhulelwe nasezigulini ngehluleki lwezinso noma ingozi yokuqhamuka kwegazi.

Ukuqashelwa ikakhulukazi kufanele kusetshenziswe lapho kunikezwa imithi kwabesifazane abakhulelwe.

Ungawaphuza kanjani amaphilisi we-Amoxicillin 250

Leli thuluzi lithathwa njengokuyalelwa udokotela. Imithamo nesikhathi ubude besifundo sinqunywa ngokuhambisana nobudala besiguli, ukutholakala kwe-pathogen, ubungako besifo, nokuguquguquka okubonakalayo.

Ngaphambi noma ngemuva kokudla

Ungaphuza amaphilisi nganoma yisiphi isikhathi. Ukudla akuphazamisi ukumuncwa kwe-amoxicillin. Kunconywa ukusebenzisa umthamo wansuku zonke kumasethi ama-3, uqaphela ukuhlangana okulinganayo phakathi kwemithamo. Izibhebhe zigwenyiwe ziphelele, akufanele zihlafunwe.

Zingaki izinsuku zokuphuza

Isikhathi esilinganiswayo sokwelashwa yizinsuku ezingama-5-12. Uma kunesidingo, inkambo yokwelapha inganwetshwa.

Imiphumela emibi yamaphilisi we-Amoxicillin 250

Ngesikhathi sokwelashwa ngama-antibiotic, ukusabela okuhlukile okuvela ezithweni ezahlukahlukene nezinhlelo zazo kungabonakala.

Amapheshana wesisu

I-colitis kungenzeka, i-stomatitis, i-glossitis, ukwephulwa kokuqonda ukunambitheka, isicanucanu, ukugabha, isifo sohudo, izinhlungu ku-anus, dysbiosis, cholestatic jaundice.

Isistimu yezinzwa ephakathi

Isiyezi, ubuthakathaka, i-migraines, i-overexcitation, ukukhathazeka okukhulayo, ukuphazamiseka kokulala, ukudideka, ukuqina kwemisipha, i-arthralgia kuyabonakala.

I-Amoxicillin ingadala isiyezi.

Kusuka ohlelweni lokuphefumula

Kwesinye isikhathi kuba nobunzima bokuphefumula.

Kusuka ohlelweni lwezinhliziyo

I-Tachycardia ingahle ikhule. Imvamisa kukhona ukwephulwa kwe-hematopoiesis.

Allergies

Imvamisa, kubonakala ukungafani komzimba kwesikhumba: i-urticaria, i-hyperemia, ukuqubuka komzimba, ukulunywa, i-edema ye-Quincke's, ukushaqeka kwe-anaphylactic, ukufana kwesifo se-serum. Amacala okubonakala kwe-erythema yama-multiforme exudative kanye necrolysis enobuthi aqaphelekile.

Imiyalo ekhethekile

Ngenkathi uthatha i-Amoxicillin, udinga ukubheka isimo sezinso, isibindi kanye nohlelo lwe-hematopoiesis.

Uma ukuphathwa kwabazali kwe-antibiotic kunesidingo, kusetshenziswa imijovo ye-Ampicillin.

Ngemuva kokunyamalala kwezimpawu zokuqala, amaphilisi athathwa okungenani izinsuku ezimbili.

Ngenxa yokusetshenziswa komuthi, ukuvelela kungakha. Nge-hypersensitivity kuma-penicillin, ukungahambisani kahle nabamele iqembu le-cephalosporin kungenzeka.

Uma isifo sohudo sikhula ngesikhathi sokwelashwa, ngakho-ke akunakwenzeka ukuba sisebenzise imishanguzo evimba ukuhamba kwamathumbu ukuyilwisa.

Ngenxa yokusebenza okuncishisiwe kokulawulwa kokubeletha, izindlela ezengeziwe zokuvimbela inzalo zingadingeka.

Ungazinikeza kanjani izingane

Ithebhulethi zivunyelwe ukuthatha kusuka eminyakeni engu-3 yobudala. Umthamo we-250 mg wenzelwe iziguli ezineminyaka engama-5 ukuya kweli-10. Izingane zeqembu elincane leminyaka zinconywa ukuthi zinikeze i-antibiotic ngendlela yokumiswa noma isiraphu. Ukusuka eminyakeni eyi-10 nesisindo somzimba esingaphezu kwamakhilogremu angama-40, kufanele kusetshenziswe imithamo efanayo kwiziguli ezindala.

Izingane zeqembu elincane leminyaka zinconywa ukuthi zinikeze i-antibiotic ngendlela yokumiswa noma isiraphu.

Ngokuhlanganiswa ne-metronidazole, umuthi okukhulunywa ngawo awusetshenziswa kuze kube iminyaka eyi-18.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Ngesikhathi sokubeletha nalapho uncelisa ibele, ukuguqukela emithini elwa namagciwane kufanele kube yisinqumo sokugcina. Ukubonisana okokuqala nodokotela nokudluliselwa kwengane okwesikhashana ekunikezelweni okokufakelwa yizimo eziphoqelekile zokwelashwa nge-Amoxicillin.

Ukweqisa

Ukudlula imithamo ephezulu kukhonjiswa ngokuhlanza kanye nohudo, okuholela ekuphelelwa ngamanzi emzimbeni kanye nokungalingani ekulinganisweni kwe-electrolyte. Uma sekudlule amahora angaphezu kuka-1.5 uthathe amaphilisi, khona-ke udinga ukusula isisu (vuselela ukuhlanza noma hlamba) uthathe i-enterosorbent, efana namalahle ocushiwe. Uma kunesidingo, buyisela kabusha izindawo ezigcina amanzi. Ayikho i-antidote ekhethekile, ngenxa yalokho, uma kwenzeka ngokweqile, baphendukela kwinqubo ye-hemodialysis.

Ngokulashwa isikhathi eside, izehlakalo ze-neurotoxic zingavela futhi nezinguquko eziningi ekubunjweni kwegazi zingavela. Isimo sijwayelekile ngemuva kokuphothulwa kwenkambo yokwelapha.

Ukuxhumana nezinye izidakamizwa

Ukugxila kwe-plasma yomuthi okukhulunywa ngawo lapho kukhuphuka i-ascorbic acid futhi kwehle ngaphansi kwethonya le-glucosamine, ama-antacid, ama-aminoglycosides, kanye nama-laxatives. I-Allopurinol, i-Probenecid, ama-NSAIDs, ama-diuretics nama-tubular secretion blockers anciphisa ukuqedwa kwawo.

I-Amoxicillin ithuthukisa umphumela we-anticoagulants engaqondile futhi inciphise ukusebenza kwe-ethinyl estradiol, izidakamizwa ze-bacteriostatic, kanye nezindlela zokuvimbela inzalo ne-estrogen. Ubuthi be-methotrexate bukhuphuka ngokusetshenziswa okuhlanganayo naleli gciwane.

Ukuhambisana notshwala

Ukuphuza utshwala kuyaphikiswa.

Ukuphuza utshwala ngesikhathi sokwelashwa kuyahlukaniswa.

Ama-Analog

Isidakamizwa esilinganisweni sama-250 mg asitholakali kumathebulethi kuphela, kepha futhi ngesimo samagaqa okuhloselwe ukumiswa ngomlomo, kanye nakumakhompiyutha. Ezinye izidakamizwa zinomphumela ofanayo, njenge:

• I-Amoxil;
• Flemoxin Solutab;
• I-Ecobol;
• U-Amosin;
• Ospamox et al.

Ukwanda kwesilinganiso se-antibiotic, kukhiqizwa ama-ejenti ehlanganisayo ne-clavulanic acid, njenge-Amoxiclav.

Imibandela yekhefu lekhemisi

Ukuthola umuthi kukhawulelwe.

Ngingakwazi ukuthenga ngaphandle kadokotela

Umuthi uhanjiswa ngencwadi kadokotela.

Intengo yamaphilisi

Izindleko ze-Amoxicillin 250 mg - kusuka kuma-ruble angama-32.

Izimo zokugcina zomuthi

Umuthi ugcinwa emazingeni okushisa afinyelela ku- + 25 ° C.

Isikhathi sokuphelelwa yisikhathi

Iminyaka emithathu

Umkhiqizi

Umuthi ukhiqizwa eRussia.

Ukubuyekezwa

UValentina, oneminyaka engama-52, uYalta

Kwadingeka ngilahle i-antibiotic, ngoba yabangela ukungezwani okuthe xaxa.

U-Elena, oneminyaka engama-27, uRostov

Isidakamizwa eshibhile futhi esisebenzayo. Kwakuyindodana yami eyayithatha lapho avale izindlebe. Ukuvuvukala kwahamba ngokushesha, akubanga khona ukusabela okubi.