Ungayisebenzisa kanjani izidakamizwa i-gabapentin 300?

IGabapentin 300 iyinhlangano yamakhemikhali enomphumela we-anticonvulsant. Umuthi uyingxenye yesidakamizwa futhi uthengiswa ngaphansi kwamagama ajwayelekile: Neurontin and Gabagamm. Isithako esisebenzayo sisetshenziselwa ukwelapha ukubanjwa kwezithuthwane ezinganeni kusuka eminyakeni emi-3 ubudala kanye nokususa ubuhlungu be-neuropathic ezigulini ezindala. Umuthi awuvunyelwe ukusetshenziswa ngendlela yemijovo.

Igama Lezwe elingafanele

UGabapentin.

IGabapentin 300 iyinhlangano yamakhemikhali enomphumela we-anticonvulsant.

I-ATX

N03AX12.

Khipha amafomu nokwakheka

Umuthi uyatholakala ngefomu lomthamo wethebhulethi nangefomu le-capsule yokuphathwa komlomo. Akukhiqizwe kuma-ampoules omjovo.

Amaphilisi

Ithebhulethi emhlophe inesimo se-elliptical futhi ihlanganiswa ngefilimu ye-enteric. Kunobungozi nokuqoshwa kwenkampani yokukhiqiza ezinhlangothini zombili zeyunithi yezokwelapha. Ithebhulethi eyi-1 iqukethe u-800 mg wento esebenzayo - i-gabapentin nezinto ezengeziwe, ezibandakanya:

• i-crospovidone;
• isitashi sommbila;
• i-magnesium stearate;
• poloxamer 407.

I-membrane yefilimu iqukethe i-candelila (i-herbal wax), i-talc ne-hyprolose. Amacwecwe agcwele izingcezu eziyi-10 emabhulashini. Isixha sekhadibhodi singaba namaphakethe weseli ongu-2, 5 noma u-10.

Amakhandlela

Amaphilisi ahlanganiswe negobolondo le -gelatin elikhuni ngombala oluhlaza. Ngaphakathi nefomu lomthamo liqukethe i-powder emhlophe, okuyinhlanganisela yabazitholelayo kanye nesakhiwo esisebenzayo - 300 mg we-gabapentin. Njengezithako ezingeziwe ezisetshenziselwa ukwenziwa kwe:

• macrogol 6000;
• i-magnesium stearate;
• isitashi samazambane;
• dihydrogenated calcium hydrogen phosphate.

Umzimba we-capsule wakhiwa nge-titanium dioxide ne-gelatin. Ingxube yedayi: i-quinoline ephuzi ne-indigo carmine inika umbala oluhlaza egobolondweni.

IGabapentin iyatholakala ngefomu le-capsule.

Isenzo se-Pharmacological

Isakhi se-gabapentin siphinda isakhiwo se-morphological se-gamma-aminobutyric acid (GABA), esisebenza njenge-neurotransmitter emzimbeni. Kulokhu, into esebenzayo ihlukile kune-neurotransmitter esenzakalweni semithi. IGabapentin ayihlanganisi kuma-barbiturates, ama-GABA aminotransferase blockers, ama-valproic acid kanye nokutholakala kwe-γ-aminobutyric acid, ngaleyo ndlela kungathinti ukugcinwa nokuqhekeka kwe-GABA.

Ekuqhubekeni kwezifundo zemithi, kwaphawuleka ukuthi into esebenzayo yakha inkimbinkimbi ngokufakwa kwe-alpha2-delta subannit yeziteshi ze-calcium, ezibandakanyeka ekuthuthukiseni ubuhlungu be-neuropathic. Ngenxa yesenzo seGabapentin, isivuno se-calcium ion singene esikhaleni se-interellular siyancipha, ukukhululeka kwe-gamma-aminobutyric acid kuyanda, ukufa kwamaseli wezinzwa kusuka ekuvezweni kwe-glutamic acid kuyancipha, futhi ukuqothuka kokukhishwa kwama-neurotransmitters eqembu lama-amine kwenzeka. Ngenxa yalokhu, izinhlungu ze-neuropathic azenzeki.

I-Pharmacokinetics

Lapho ihanjiswa ngomlomo, isakhi esisebenzayo sifinyelela inani laso ku-plasma kungakapheli amahora ama-2 kuya kwengama-3. I-Bioavailability ingama-60%. Amatafula namaphilisi aqeda ulwelwesi lwawo engxenyeni esondelene yamathumbu amancane ngaphansi kwesenzo sama-enzyme akhethekile (ama-esterases). Into esebenzayo igxiliswa odongeni lwepheshana lamathumbu, ukusuka lapho ihluka khona emithanjeni.

Umuthi awuguquki kumaseli wesibindi.

Ukudla okuphezulu emafutheni akwehlisi isilinganiso sokumuncwa kanye ne-bioavailability yomuthi. Embhedeni we-vascular, ngaphansi kwe-3% yamakhemikhali asebenzayo abopha amaprotheni e-plasma. Umuthi awuguquki kumaseli wesibindi. Ukuqedwa kwesigamu sempilo kufinyelela kumaphakathi kwamahora angama-5-7. UGabapentin ushiya umzimba ngohlelo lobuchwephesha ngendlela lwayo lwangempela.

Isetshenziselwa ini?

Umuthi usetshenziswa njenge-monotherapy ezinganeni kusuka eminyakeni eyi-12 kuye kweli-18 futhi ufakwa ekwelapheni okuhlanganisiwe kubantu abadala. Umuthi uyadingeka ukuze uqede ukubanjwa okuyingxenye kwesendlalelo sokuwa isithuthwane. Iziguli ezineminyaka engaphansi kwengu-12 ziyelashwa, kungakhathalekile ukuthi kukhona ukuvunyelwa kwesibili noma ukungatholakali kwayo. Ezimweni ezingavamile, i-gabapentin ichazwa ngefomu elizinzileyo lesithuthwane ezigulini ezingaphezulu kweminyaka emi-3.

Umuthi uvunyelwe ukusetshenziselwa ukuvimba ubuhlungu be-neuropathic ezigulini ezisukela eminyakeni engu-18 ubudala.

Contraindication

Kwenqatshelwe ukuthatha amaphilisi kanye namaphilisi lapho kukhona khona ukwanda kwezicubu zomzimba ezingxenyeni ezisebenzayo nezisizayo.

Ngokunakekela

Kufanele kuqashelwe uma kwenzeka umsebenzi wezinso ongahambi kahle.

Kufanele kuqashelwe uma kwenzeka umsebenzi wezinso ongahambi kahle.

Ungayithatha kanjani i-gabapentin 300

Izinhlobo zama-dosage zenzelwe ukuphathwa ngomlomo ngaphandle kokuhlafuna. Ukugaya ngomshini kuholela ekuncipheni kokufakwa komuthi. Lapho ushintshela kwesinye isidakamizwa, akufanele uyeke ngokushesha ukuthatha i-Gabapentin. Ukubuyiselwa esikhundleni kwenziwa ngokunciphisa kancane kancane komthamo ngaphezu kwezinsuku eziyi-7.

Ukuqeda inqubo ye-pathological ohlelweni lwezinzwa lwe-somatosensory olubangela ubuhlungu be-neuropathic, kubalulekile ukuthatha i-900 mg ngosuku. Umthamo wansuku zonke uhlukaniswe ngemithamo emi-3. Ngomthelela ophansi wokwelapha, umthamo ungakhuphuka kancane kancane ufike kokuphezulu okuvumelekile - 3,6 g ngosuku. Ukwelashwa ngezidakamizwa kuqala ngo-900 mg / ngosuku noma enye indlela yokwelashwa. Esimweni sokugcina, umthamo wansuku zonke uyakhula kancane kancane ufike ku-0,9 g edingekayo ngaphezulu kwezinsuku ezi-3:

• 1 usuku oluthathwe kanye 0,3 g;
• okwezinsuku ezi-2, imvamisa yokusetshenziswa yi-2 times 300 mg;
• ngosuku 3, 900 mg athathwe, ahlukaniswe ngemithamo emithathu.

Ukufeza umphumela we-antiepileptic, iziguli ezingaphezu kweminyaka eyi-12 kudingeka ukuthi zithathe kusuka kuma-900 kuye kuma-3600 mg ngosuku. Isikhathi sokuphumula esiphakathi kwemithamo yamathebulethi noma amaphilisi kufanele singeqi amahora angama-12 ukuvimbela ukuthuthukiswa kokuqunjelwa.

Ngokuphikisana nesizinda sokwehluleka kwezinso, udokotela ushintsha umthamo wansuku zonke ngokuya nge-Cl (i-creatinine imvume).

Umuthi osebenzayo awuthinti ukusebenza okusebenzayo kwama-islets we-Langerhans we-pancreas.

Ezigulini ze-hemodialysis kunconywa ukuthatha ama-300-400 mg ngosuku lokuqala lokwelashwa, imithamo elandelayo izoba ngu-0-0-0.3 g amahora ama-4 ngaphambi kwenqubo.

Ngoshukela

Umuthi osebenzayo awuthinti ukusebenza okusebenzayo kwama-islets we-Langerhans we-pancreas futhi awakhiqizi umphumela we-glycemic ekugxambeni kwe-plasma ye-glucose egazini. Ngakho-ke, iziguli ezinesifo sikashukela azidingi ukulungiswa okwengeziwe komthamo onconyiwe.

Imiphumela emibi

Imiphumela emibi yenzeka ngomthamo ongafanele wesidakamizwa. Uma kwenzeka kuphakama i-gabapentin, kuyadingeka ukuyeka ukuthatha lo muthi futhi ufune izeluleko zezokwelashwa.

Amapheshana wesisu

Izinguquko emgudwini wokugaya ukudla zihambisana nokuthopha, ubuhlungu be-epigastric, isifo sohudo. Ngokuphikisana nesizinda sokuphazamiseka kokugaya ukudla, i-anorexia noma isifiso sokudla esingahle sikhule. Ezimweni ezingavamile, kuqhathaniswa ukuvela koqweqwe lwawo lwamazinyo, kuqhamuke umlomo owomile, amanyikwe nesibindi kukhanyiswe, kuphakama izinga le-bilirubin nomsebenzi we-hepatocyte aminotransferases.

Izitho zeHematopoietic

I-Thrombocytopenic purpura, i-leukocytopenia kanye nokuntuleka kweplatelet kungenzeka.

Isistimu yezinzwa ephakathi

Ukucindezelwa kohlelo lwezinzwa kuboniswa izimpawu ezifana:

• Isiyezi
• ukuntuleka kwezikhonkwane kuma-tendon;
• ukuphazamiseka kwemizwa;
• ukulahleka kokulawulwa okungokomzwelo (ukudangala, ukukhathazeka);
• imibono;
• ukozela
• ukuzamazama kwemilenze;
• ubuthakathaka obujwayelekile.

Ezimweni ezingavamile, i-ataxia, i-nystagmus, i-choreoathetosis yenzeka.

Ukudana komoya kungenzeka ngenxa yokusebenzisa isidakamizwa uGabapentin.

IGabapentin ingadala isifo sohudo.

IGabapentin ingakubangela ukulunywa.

IGabapentin ibangela ukozela.

IGabapentin ibangela isiyezi.

IGabapentin ingadala i-anorexia.

Kusuka ohlelweni lokuphefumula

Ngokusebenzisa isikhathi eside umuthi, ukukhwehlela owomile, ukuphefumula, ukuqubuka kwamakhala, kanye nokutheleleka kohlelo lokuphefumula kungavela.

Engxenyeni yesikhumba

Ukushintshwa kwesikhumba: umqubuko, ukuvuvukala, ukuqubuka, kanye nesifo sakwaStevens-Johnson.

Kusuka ohlelweni lwezinhliziyo

Imisipha ebushelelezi odongeni lwe-vascular iyavuseleleka, umfutho wegazi uyenyuka futhi nenhliziyo iyanda.

Allergies

Uma isiguli sinengqikithi yokubonakaliswa kokungahambi kahle komzimba, ukuthuthukiswa kwe-angioedema yomphimbo kanye ne-larynx, i-bronchospasm kanye ne-anaphylactic shock kungenzeka. Ngama-allergia amnene ngokulingana nobukhulu obulinganiselayo, ukuthuthukiswa kokuvela kwesikhumba nokuvuvukala kobuso kungenzeka.

Imiyalo ekhethekile

Ngesikhathi sokuhlolwa kwezidakamizwa, kwakungekho zimpawu zokuhoxa ekuqedweni kokuphathwa kwezidakamizwa. Ukwehla kancane kancane komthamo kuyadingeka ukunciphisa amathuba okubanjwa kokuqunjelwa kanye nokuthwalwa lapho umuthi we-antiepileptic ukhanseliwe.

Umuthi awubekelwe isithuthwane ngama-paroxysms aqinisekisayo.

Ukuhlolwa kwe-urinalysis okujwayelekile kungakhombisa ukungamanga okuhle kwe-proteinuria. Ukuze ugweme ukuhlolwa okuphindaphindiwe ukuthola iprotheni emchini, kuyadingeka ukuxwayisa abasebenzi abasebenza elabhorethri ngokuthatha iGabapentin. Ochwepheshe bazokwenza ucwaningo besebenzisa i-sulfosalicylic acid.

Ukuhlolwa kwe-urinalysis okujwayelekile kungakhombisa ukungathembeki kwamanga kwe-proteinuria ezigulini ezithatha i-gabapentin.

Sebenzisa ebudaleni

Abantu abaneminyaka engaphezu kwengu-65 ubudala abadingi ukuguqula kabusha uhlobo lomthamo.

Kuchaza uGabapentin ezinganeni ezingama-300

Ezinganeni ezineminyaka engaphezu kwengu-12 ubudala, kuthathwa umthamo ojwayelekile wama-900 mg ngosuku ekwelapheni ukugwazwa okuyingxenye.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Ukuthatha umuthi ngesikhathi sokukhulelwa akunconywa. Ucwaningo olwanele lomtholampilo lwekhono lweGabapentin lokuwela umgoqo we-placental alwenzelwa, ngakho-ke kukhona ubungozi bokukhubazeka kwezicubu ngesikhathi sokukhula kombungu lapho uphuza umuthi.

Ngesikhathi sokulashwa nge-gabapentin, ukuncelisa ibele kufanele kumiswe.

Ukweqisa

Ngokuhlukumeza umuthi, ukuthuthukiswa:

• Isiyezi
• ukozela
• ukuphazamiseka komsebenzi wokukhuluma;
• ubuqili;
• idiplopiki.

Isisulu kufanele sihlambe isisu sinikeze i-adsorbent. Ukuqeda izimpawu ze-overdose, ukwelashwa okubonakalayo kuyenziwa.

Uma kwenzeka okweqa ngokweqile, ohlukunyeziwe kufanele ahlambe isisu.

Ukuxhumana nezinye izidakamizwa

Ngokusetshenziswa okufanayo kwe-gabapentin neminye imishanguzo, kusabela okulandelayo kuyabonakala:

1. Into esebenzayo ayithinti amapharamitha we-pharmacokinetic wezindlela zokuvimbela inzalo zomlomo eziqukethe ama-hormone ocansi abesifazane noma i-ethinyl estradiol.
2. IMorphine ithathwa amahora ama-2 ngaphambi kokusebenzisa iGabapentin, ngoba lapho izidakamizwa zombili zithathwa ngasikhathi sinye, i-AUC ejwayelekile ye-gabapentin inyuswa ngama-43%. Umbundu wobuhlungu wanda. Amanani ayisigamu sempilo kanye nokufinyelelwa kwenani elikhulu kakhulu le-plasma of Morphine akuzange kushintshe, ngenxa yalokho, ekusebenzeni ngokomtholampilo, lo mphumela awuzange uthinte inhlala-kahle yesiguli.
3. I-Phenobarbital, i-Mexicoidol, i-Valproic acid kanye nezinye izidakamizwa ze-antiepileptic azithinti imingcele yemithi yeGabapentin.
4. Ngokuphathwa okufanayo kwama-antacid nama-ejenti aqukethe usawoti we-aluminium ne-magnesium, ukwehla kokuwohloka kwe-bioavailability kweGabapentin ngama-22% kwaqoshwa. Ngenxa yalokhu, i-anticonvulsant ithathwa amahora ama-2 ngemuva kokuthatha ama-antacid.
5. I-probenecid ayithinti ukuthunyelwa kwe-renal yaseGabapentin.

Ngesikhathi sokwelashwa neGabapentin, kuyenqatshelwe ngokuphelele ukuphuza utshwala. I-ethyl utshwala ikhulisa amathuba okucindezeleka kwesistimu yezinzwa ephakathi futhi inyusa izehlakalo zemiphumela emibi. Ngokuphikisana nesizinda sethonya elibi le-ethanol ekusebenzeni kohlelo lokujikeleza kwegazi, buthaka umphumela wezokwelapha weGabapentin uyabonakala.

Ama-Analog

Izidakamizwa ezingangena esikhundleni seGabapentin ngomshini wokusebenza nokwakhiwa kwamakhemikhali zifaka:

• Katena
• Convalis;
• Neurontin;
• Tebantin;
• IGabagma

Ukushintshela kwesinye isidakamizwa kwenziwa ngaphansi kokuqashwa okuqinile kwezokwelapha ngenxa yengozi yokubanjwa okuyingxenye.

Izimo zeholide Gababentina 300 kusuka ekhemisi

Umuthi awuthengiswa ngaphandle kwemithi yezokwelapha ngesiLatini.

Ngingakwazi ukuthenga ngaphandle kadokotela

Umuthi olwa nama-anticonvulsant awunakuthengwa ngaphandle kwezeluleko eziqondile zezokwelashwa, ngoba uma uthatha ngokungahambi kahle kweGabapentin, ungathola ukwehla kokusebenza okuxakile, ukubonakala kobuhlungu be-neuropathic nemiphumela emibi.

Malini i-gabapentin 300

Intengo ejwayelekile yesidakamizwa iyahlukahluka kusuka kuma-ruble angama-349 kuya kwangama-464.

Izimo zokugcina zomuthi

Kunconywe ukuthi amaphilisi kanye namaphilisi amaGabapentin 300 agcinwe endaweni enomswakama ophansi futhi emazingeni okushisa afinyelela ku + 25 ° C.

Isikhathi sokuphelelwa yisikhathi

Iminyaka emithathu

Umkhiqizi uGabapentin 300

ICJSC Canonfarm Production, eRussia.

UKatena uthathwa njenge-analogue yesidakamizwa uGabapentin.

UConvalis uthathwa njenge-analogue yomuthi uGabapentin.

INeurontin iyi-analogue ye-gabapentin.

I-Tebantin kwesinye isikhathi ibekelwa esikhundleni somuthi uGabapentin.

IGabagamm ithathwa njenge-analogue yomuthi uGabapentin.

Ukubuyekezwa ku-Gabapentin 300

Kumaforamu ezokwelapha kukhona imibono eyakhayo evela ezigulini mayelana nomuthi kanye nezincomo zabachwepheshe bezinzwa.

Odokotela

URamil Dzhumabaev, udokotela wezifo zemizwa, oneminyaka engama-44, u-Omsk

Umphumela wokwelapha utholakala ngokushesha. Ngicabanga ukuthi uGabapentin ungomunye wezidakamizwa ezishibhile zokukhululeka kobuhlungu be-neuropathic futhi uzuze imiphumela ebangelwa yi-anticonvulsant. Kepha ezimweni eziningi, ngiphawula imiphumela engemihle yokuzijwayeza: i-myalgia, izinhlungu zangemuva, ukwaphuka kwezitho zomzimba, ezimweni ezinzima, kuye kukhula i-amnesia.

U-Ivan Tikhonov, udokotela wezifo zemizwa, oneminyaka engu-51 ubudala, uKrasnoyarsk

IGabapentin inciphisa kahle izinhlungu ze-neuropathic zokwenziwa kwasendaweni okuhlukahlukene, okungenakukhubazeka ukuvimba ngemithi engeyona eye-steroidal elwa nokuvuvukala. Ngokusebenzisa isikhathi eside, kufanele uqaphele. Iziguli zibika ukuphazamiseka nokucindezelwa. Imithamo kanye nemvamisa yokuphatha kufanele isungulwe kuphela ngudokotela oya kuye.

Iziguli

U-Anastasia Koshkina, oneminyaka engama-34, eMoscow

Ngithatha i-gabapentin ngokuxilongwa kwe-sensory-motor diabetesic neuropathy. Uma uthatha, kuba nomphumela we-analgesic, kepha awunamandla. Ngemuva kokuthi ngiphuze amaphilisi, ngizwa ngineyezi, ngiphelelwa amandla okunyakaza, ukungasebenzi kahle. Ngincoma ukulala phansi ngemuva kwamatafula ihora.

ULilia Alekseeva, oneminyaka engama-42, uTomsk

Umuthi usiza kakhulu lapho unesithuthwane. Ngiyemukela ngokuqinile ngokwemiyalo. Inomphumela ophansi we-anticonvulsant. Akuzange kube nokuhlaselwa ngenkathi uphuza umuthi. Lapho ngithatha ikhefu, baqala ukuphinda futhi. Emiphumeleni emibi, ngingaqokomisa isiyezi, esiya sikhula ekuseni.