Uma udinga ukukhetha i-Orlistat noma i-Xenical, izidakamizwa ziqhathaniswa nohlobo lwento esebenzayo, umthamo wayo. Uma usebenzisa umkhiqizo ngenombolo encane ye-contraindication nemiphumela emibi, ukwelashwa ngeke kuholele ekwakhiweni kwezinkinga.
Isici se-Orlistat
Umkhiqizo wakhiqizwa yi-KRKA (Slovenia) futhi uyingxenye yeqembu lezidakamizwa elinomgomo wokusebenza osuselwa ekuvinjelweni kwe-lipases esiswini. I-Orlistat iyatholakala kumakhompiyutha aqukethe into eyenziwe nge-granular. Ingxenye yegama elifanayo ikhombisa umsebenzi (umthamo we-120 mg ku-1 capsule). Ukuqanjwa kubandakanya izinto ezingasebenzi:
- i-microcrystalline cellulose;
- isitashi se-sodium carboxymethyl;
- i-sodium lauryl sulfate;
- i-povidone;
- i-talcum powder.
Umphumela owufunayo nge-Orlistat therapy unikezwa ngokungahambisani nomsebenzi wama-enzyme asesiswini.
I-Orlistat ivelele ngokumelene nezinhlanganisela ezifanayo ngenxa yomsebenzi wayo wokubopha kakhulu kuma-lipases (pancreatic, gastric). Lokhu kwakha isibopho sokubambisana nama-serines abo. Ngenxa yalokhu, inqubo yokuguqulwa kwama-triglycerides avela emafutheni angena emzimbeni nokudla okuhlanganiswe nakho okuhlanganiswe yizindonga zendlela yokugaya: i-monoglycerides, amafutha e-acid avinjelwe. Umphumela owufunayo nge-Orlistat therapy unikezwa ngokungahambisani nomsebenzi wama-enzyme asesiswini.
Ngenxa yezinqubo ezichaziwe, amafutha aguqulwa abe yizinto ezingadonswa yizindonga zendlela yokugaya futhi adalulwe ngesikhathi sokuhamba kwamathumbu, le nqubo ayithathi izinsuku ezingaphezu kwezi-5.
Umphumela omuhle wokwelashwa unikezwa ngenxa yokushoda kwe-calorie okuvela ekuphulweni kwe-metabolism yamafutha. Lokhu kuvusa inqubo yokunciphisa isisindo.
Umuthi uvimba ukuguqulwa kwamafutha esimweni samafutha acid kanye ne-monoglycerides hhayi ngokuphelele, kodwa kuphela ngama-30%. Ngenxa yalokhu, umzimba uthola isamba esanele sezakhi zomzimba ezidingekayo ukuze ulondoloze impilo, kepha ulahlekelwe ukuthambekela kokuqongelela amafutha ngokweqile.
Ocwaningweni oluningi ngomphumela we-Orlistat ekusebenzeni kwezitho zangaphakathi nezinhlelo, umphumela ongemuhle ekujuleni kokukhula kwamaseli wamathumbu nokusebenza kwe-gallbladder akubonakali. Ukwakheka kwe-bile, kanye nezinga lokunyakaza kwamathumbu, akushintshi. Izinga le-acidity yejusi yesisu libuye lihambisane nokwasekuqaleni. Ngesikhathi sokufunda, ezinye izifundo zikhombise ukwehla okuncane kokuqukethwe kwezinto eziningi eziwusizo: i-calcium, i-magnesium, i-zinc, i-iron, ithusi, i-phosphorus.
Ezigulini ezinokukhuluphala kanye namanye ama-pathologies, kuthuthukiswa jikelele. Lokhu kungenxa yokwehla kwesisindo somzimba, i-normalization yezinqubo ze-biochemical. Ngemuva kokuphela kokwelashwa nge-Orlistat, kunengozi yokubuyisa isisindo sokuqala. Kodwa-ke, ucwaningo luye lwabonisa ukuthi ezinye iziguli kuphela zithola ukubuyela kancane kancane kwamapharamitha abo omzimba wangaphambilini. Umuthi unconywa isikhathi eside. Isikhathi esijwayelekile sesifundo sisuka ezinyangeni ezi-6 kuye kweziyi-12.
Isibonakaliso sokusetshenziswa kwe-Orlistat yisidingo sokunciphisa isisindo (ngokwesibonelo, ngokukhuluphala ngokweqile). Umphumela omuhle ukulahleka kwezicubu ze-adipose ebangeni lama-5- 10% wesisindo somzimba esiphelele. Ngaphezu kwalokho, lesi sidakamizwa sinqunyelwe ukunciphisa ingozi yokuthola isisindo kwesangempela, uma isiguli sesivele sisenkingeni yokulahlekelwa isisindo. Contraindication:
- iminyaka yezingane (engaphansi kweminyaka eyi-12);
- i-malabsorption syndrome;
- cholestasis;
- hyperoxaluria;
- nephrolithiasis;
- isikhathi sokukhulelwa, ukuncelisa;
- ukungabekezelelani komzimba ngamunye wezinto ze-Orlistat.
Ngesikhathi sokwelashwa, isisindo singehla kakhulu, kepha ngasikhathi sinye, imiphumela emibi iyabonakala:
- indle iba ngunoyela;
- ukunxenxa ukuwohloka kuyanda, okungenxa yokuchithwa okwandayo kwezinto ezivela emzimbeni ezingangeni kuguquko futhi ezingathinti izindonga zamathumbu ngenxa yokuvimba inqubo ye-metabolism yamafutha adliwayo;
- ukwakhiwa kwegesi kuyaqina;
- ukungahambi kahle kwefecal kwesinye isikhathi kuyaphawulwa.
Ekuqaleni kokwelashwa kwe-Orlistat, umuzwa wokukhathazeka ungavela.
Imvamisa, esigabeni sokuqala senkathi yokwelashwa, kuvela izibonakaliso ezilinganiselayo ezingumphumela womphumela ongemuhle ohlelweni lwezinzwa oluphakathi: ikhanda, isiyezi, ukukhathazeka, ukuphazamiseka kokulala. Lokhu kusabela kubuye futhi kube ngumphumela wokushiswa okukhulu kwenqwaba yamafutha ngokwanda kwesilinganiso sokushintshana kwamandla womzimba.
Izici ze-Xenical
Umenzi walo muthi nguHoffmann la Roche (Switzerland). Leli thuluzi libhekwa njenge-analogue eqondile ye-Orlistat, ebangelwa ukwakheka okufanayo (isakhi esisebenzayo yi-orlistat ekuqoqweni okungama-120 mg). Isenzo se-Xenical, njenge-Orlisat, sincike ekuvinjelweni kwe-lipases esiswini. I-Xenical inikezwa ngefomu lokukhishwa eli-1 - ngesimo samaphilisi.
Ingxenye esebenzayo ayingeni egazini, ikhishwa ingashintshiwe ivela emzimbeni (83% womthamo ophelele).
Ukwenza ngcono isimo sesiguli kuyabonakala ezinsukwini zokuqala ngemuva kokuqala kwenkambo yokwelashwa. Umuthi ukhishwa kungakapheli izinsuku ezintathu. Ingxenye esebenzayo isetshenziswa emzimbeni odongeni lwamathumbu, kuthi kuhlanganiswe amakhompiyutha ama-2. Uma kuqhathaniswa ne-orlistat, la ma-metabolites akhombisa ukusebenza okubuthakathaka, okusho ukuthi athinta i-lipases esiswini kuya ngezinga elincane.
Izinkomba zokuqokwa:
- ukukhuluphala noma ukukhuluphala ngokweqile lapho kunezici zobungozi ezifaka isandla ekuzuzeni isisindo;
- ukwelashwa kweziguli ezinesifo sikashukela sohlobo lwe-2 mellitus ezithambekele ekuzuzeni isisindo (BMI kusuka kuma-27 kg / m² noma ngaphezulu).
Esimweni sesibili, i-Xenical iyanconywa ukuthi isetshenziswe njengengxenye yokwelapha okuyinkimbinkimbi kanye nama-hypoglycemic agents. Kulokhu, iMetformin, i-Insulin noma amalungiselelo asuselwa kokuphuma kwe-sulfonylurea asetshenziswa kaningi. I-Xenical ayinqunyelwe izimo ezinjalo ze-pathological:
- cholestasis;
- i-malabsorption syndrome;
- ukungabekezeleli izingxenye zomuthi.
Ukuphendula okungalungile kuvame ukwenzeka uma inani elikhulu lamafutha lifakiwe ekudleni kweziguli. Inani Lansuku zonke nalo lingadala imiphumela emibi. Ukugwema ukungaphenduki okuhle kulo muthi, kunconywa ukulandela indlela yokudla ephansi emafutheni.
Ezigulini ezinesifo sikashukela, ubungozi bokwehlisa ushukela wegazi bukhula - lokhu kungumphumela wesinxephezelo esithuthukisiwe se-carbohydrate metabolism. I-Xenical ingadala ukopha emathunjini. Ngesikhathi sokwelashwa, ukumuncwa kwamavithamini kuyaphazamiseka. Ngalesi sizathu, kuyinkimbinkimbi yamavithamini anqunywa amahora ama-2 ngemuva kokuthatha umuthi okukhulunywa ngawo.
Ukugwema ukungaphenduki okuhle kulo muthi, kunconywa ukulandela indlela yokudla ephansi emafutheni.
Ukuqhathanisa kwe-Orlistat ne-Xenical
Ukufana
Ngohlobo lwento esebenzayo, futhi ngenxa yesenzo se-pharmacological, ama-ejenti afana. Zisetshenziselwa ukwelashwa okuhlala isikhathi eside. Umthamo wengxenye esebenzayo uyafana.
Zombili lezi zidakamizwa zivusa ukuthuthukiswa kwemiphumela emibi efanayo.
I-Xenical ne-Orlistat zitholakala ngendlela ye-capsule. Lezi izidakamizwa ezisebenzayo, ezibonakaliswa ijubane elifanayo lezinto.
Uyini umehluko
Imithi iyahlukahluka ngezindleko.
Umkhiqizi uXenical akancomi ukuthatha leli khambi ngokuhambisana nesizinda sezimo ezithile zephathi, ngenkathi i-Orlistat iboniswa yimikhawulo ethe xaxa uma isetshenziswa.
Yikuphi okushibhile
I-Xenical ingathengwa ngama-ruble ayi-1740. (iphakethe liqukethe amakhompiyutha angama-42). Intengo ye-Orlistat ingama-ruble angama-450. (inombolo efanayo yamaphilisi). Ngokunikezwe ukuthi lezi zimali zidinga ukuthatha isikhathi eside, ukwelashwa okushibhile nge-Orlistat.
Yikuphi okungcono: Orlistat noma Xenical
Le mishanguzo iqukethe ingxenye efanayo esebenzayo, umthamo wayo awuguquki. Ngakho-ke, bayaziveza ngokulinganayo lapho behlisa isisindo. Akukho mehluko wesilinganiso sezenzo zale mishanguzo. Ukuqala komphumela wokwelapha kuncike ekusetshenzisweni kwezinye izidakamizwa (ngokwesibonelo, noma yisiphi isidakamizwa esisetshenziselwa i-urology, ama-hypoglycemic agents, njll.). Zombili lezi zidakamizwa zibekezelelwa kahle. Uma isetshenziswa njengengxenye yokwelashwa okuyinkimbinkimbi, akukho miphumela emibi kwezinye izidakamizwa.
Uma uthenga, inqubo ebalulekile yindleko yomkhiqizo. Uma uqondiswa yile pharamitha kuphela, ukukhetha kufanele kwenziwe kuthandwe yi-Orlistat.
Ukubuyekezwa kodokotela
INazemtseva R.K., udokotela wezifo zabesifazane, uSamara
I-Xenical isidakamizwa esisebenza kahle. Ngokungafani nalawa mathuluzi amaningi, ngosizo lwawo ungathola umphumela owuthandayo lapho ulahlekelwe isisindo. Ukwehla kwesisindo kuhamba kancane, ngenxa yalesi sizathu i-Xenical iyanconywa ukuthi isetshenziswe isikhathi eside.
Belodedova A. A., umondli wezempilo, uNovomoskovsk
Ngiyaqiniseka ukuthi izindlela ezikhethekile zokunciphisa umzimba azidingeki. Kulokhu, ukudla okuhlanganiswe kahle kwanele. Ukuqina kokuzivocavoca komzimba nakho kudlala indima ebalulekile. Kusho njengo-Orlistat, ngicabanga ukuthi kunesidingo, kuphela uma kuvela izifo ezingathi sína, ngokwesibonelo isifo sikashukela, lapho ukutholakala kwesisindo esingalawuleki. Ngaphezu kwalokho, izidakamizwa zaleli qembu zichaziwe, inqobo nje uma inani lamafutha ekudleni linciphile.
Ngokunikezwe ukuthi lezi zimali zidinga ukuthatha isikhathi eside, ukwelashwa okushibhile nge-Orlistat.
Ukubuyekezwa kwabanciphisi neziguli mayelana ne-Orlistat ne-Xenical
U-Ana, oneminyaka engama-35, iKrasnoyarsk
Endabeni yami, umuthi i-Xenical awuzange usize, ngoba ngemuva kokuphela kwenkambo yokwelashwa (kwathatha amaphilisi ezinyanga eziyi-1.5), isisindo sanda. Ngeke ngiphinde ngiyisebenzise.
UMarina, oneminyaka engama-41, uVladimir
Okokuqala uthathe uXenical, wabe eseshintshela ku-Orlistat. Eyesibili yezindlela ishibhile, kepha benza ngendlela efanayo. Isisindo sehlile ngokushesha ngenkathi kuthathwa isembozo. Ngemuva kwesifundo, amakhilogremu angeziwe aqala ukubuyela kancane kancane, kepha ngathatha izinyathelo ngesikhathi: Nginciphise inani lamakhalori nsuku zonke, ngandisa ukusebenza komzimba. Ngenxa yalokho, ngibala ama-3 kg kuphela alahlekile, okusobala ukuthi akwanele ngesisindo sami (90 kg).
