I-Glucophage isidakamizwa esisebenza kakhulu enhloso yaso eyinhloko ukunciphisa ushukela wegazi futhi silondoloze ezingeni elamukelekayo. Ukusetshenziswa kwesidakamizwa isikhathi eside kufakazele ukusebenza kwayo kwezokwelapha futhi kwenze kwaba yisetshenziswa kakhulu e-endocrinology. Njengoba iGlucophage inempahla yokufisa amandla entuthakusa, iye yasetshenziswa kakhulu ekunciphiseni isisindo. Kule ndlela, umuthi futhi unikeza umphumela omuhle, ikakhulukazi ezimweni lapho umuntu yedwa engakwazi ukubekezelela ukwanda kokudla.
I-ATX
Ngokuya ngokwehlukaniswa kwamazwe ngezidakamizwa (i-ATX), iGlucophage 1000 inekhodi A10BA02. Izinhlamvu u-A no-B, ezikhona kule khodi, ziveza ukuthi umuthi uthinta umetabolism, umgudu wokugaya ukudla nowokwenza igazi.
IGlucophage isidakamizwa esisebenza ngempumelelo kakhulu ukunciphisa ushukela wegazi futhi silondoloze ezingeni elamukelekayo.
Khipha amafomu nokwakheka
Umuthi utholakala kuphela ngesimo samathebulethi, efakwe nge-coating kinga. Ithebhulethi ngayinye inokwakheka okusaqanda (i-convex kusuka ezinhlangothini ezi-2), ubungozi obuhlukanisayo (futhi obuvela ezinhlangothini ezi-2) kanye nombhalo "1000" ohlangothini olu-1
Isithako esisebenzayo somuthi yi-metformin hydrochloride, i-povidone ne-magnesium stearate yizinto ezisizayo. I-membrane yefilimu iqukethe i-hypromellose, macrogol 400 ne-macrogol 8000.
Umuthi ukhiqizwa eFrance naseSpain, kukhona nokufakwa. Kodwa-ke, iRussian LLC i-Nanolek inelungelo lokuphakwa kwesibili (kwabathengi).
Amaphakethe ahlanganiswe emazweni e-EU aqukethe amaphilisi angama-60 noma ayi-120, abekwa uphawu ku-aluminium foil blims. Izicucu zamathebulethi ayi-10 ebhokisini zingaba ngu-3, 5, 6 noma u-12, ezibhebheni eziyi-15 - 2, 3 no-4. Amaphakeji ahlanganiswe eRussia aqukethe amaphilisi angama-30 nangu-60 lilinye. Ephaketheni kungaba nohlobo 2 noma 4 olwaluqukethe amaphilisi ayi-15 lilinye. Kungakhathaleki ukuthi izwe lipakishwa liphi, ibhokisi ngalinye kanye noquza kumakwe uphawu "M", okuyisivikelo ekuqambeni amanga.
Isithako esisebenzayo somuthi yi-metformin hydrochloride, i-povidone ne-magnesium stearate yizinto ezisizayo.
Isenzo se-Pharmacological
I-Metformin inemiphumela elandelayo emzimbeni:
- kunciphisa ushukela wegazi futhi akuholeli ku-hypoglycemia;
- akunagalelo ekukhiqizweni kwe-insulin nokukhula kwe-hypoglycemia kubantu abangahlushwa yizifo ezingamahlalakhona ezinzima;
- kwandisa ukuzwela kwama-insulin receptors;
- kuthuthukisa ukucubungula i-glucose ngamaseli;
- kuvimbela ukwakheka koshukela kanye nokuqhekeka kwe-glycogen kushukela, ngaleyo ndlela kunciphisa ukwenziwa kwesibindi sokugcina;
- kuvimbela inqubo yokufaka i-glucose engxenyeni yamathumbu ohlelweni lokugaya ukudla;
- ivuselela ukukhiqizwa kwe-glycogen;
- kwehlisa izinga lamazinga aphansi we-lipoprotein, i-cholesterol ne-triglycerides egazini, ethuthukisa i-lipid metabolism;
- isiza ukulawula ukuqina kwesisindo, futhi imvamisa ukwehla kwesisindo;
- kuvimbela ukukhula kwesifo sikashukela esigabeni sokuqala kanye nokukhuluphala ezimweni lapho ukuguquka kwendlela yokuphila kungavumeli ukufeza umphumela oyifunayo.
I-Pharmacokinetics
Uma usuphezu kwamapheshana emathunjini, i-metformin icishe igxile ngokuphelele. Amahora angama-2,5 ngemuva kokungenzwa, ukugcotshwa kwomuthi osegazini kufinyelela inani lawo eliphakeme. Uma i-metformin isetshenziswa ngemuva noma ngesikhathi sokudla, khona-ke ukumunca kwayo kuyabambezeleka futhi kuncishiswe.
Umuthi awusetshenziswa kahle emzimbeni futhi uvezwa yizinso. Ukucaciswa kwe-Metformin (inkomba yesilinganiso sokusatshalaliswa kwento emzimbeni nokuphuma kwayo) ezigulini ezingenasifo sezinso siphakeme izikhathi eziphindwe kane kunezivumelwano ze-creatinine futhi zingama-400 ml ngomzuzu. Ukuqedwa kwesigamu sempilo kungamahora ayi-6.5, ngezinkinga zezinso - isikhathi eside. Esimweni sokugcina, ukuqoqeka (ukuqongelela) kwento kungenzeka.
Izinkomba zokusetshenziswa
I-Glucophage isetshenziswa emacaleni ama-3:
- Thayipha isifo sikashukela esi-2 kubantu abadala nasezinganeni ezingaphezu kweminyaka eyi-10. Ukwelapha kungenziwa kusetshenziswa i-Glucofage kuphela futhi kuhlangene nezinye izidakamizwa, kufaka phakathi ne-insulin.
- Ukuvimbela i-mellitus yesifo sikashukela sesigaba sokuqala kanye nesimo se-prediabetes ezimweni lapho ezinye izindlela (zokudla nokuzivocavoca) zinganiki umphumela owanelisayo.
- Ukuvimbela isigaba sokuqala sikashukela kanye ne-prediabetes ezimweni lapho isiguli sisengozini - singaphansi kweminyaka engu-60 ubudala - futhi sine:
- ukukhuphuka kwe-BMI (inkomba yomzimba) olingana no-35 kg / m² noma ngaphezulu;
- umlando wesifo sikashukela sokukhulelwa;
- isakhi sofuzo ekukhuleni kwesifo;
- izihlobo eziseduze ezinesifo sikashukela sohlobo 1;
- ukunyuswa okukhulu kwe-triglycerides;
- ukunakekelwa okuphansi kwamazinga aphezulu we-lipoprotein.
Contraindication
Umuthi awunqunyelwe ezimweni lapho umuntu ehlupheka:
- ukungabekezelelani komuntu ngamunye kunoma yiziphi izingxenye zomuthi;
- i-ketoacidosis yesifo sikashukela noma ikwi-precomatose noma ikoma;
- ukwehluleka kwesibindi noma kwezinso;
- umsebenzi we-renal noma we-hepatic;
- uphuzo oludakayo;
- i-lactic acidosis;
- izifo ezesabekayo noma ezingamahlalakhona ezibandakanya izicubu ze-izicubu, kufaka phakathi i-myocardial infarction, amafomu ashubile enhliziyo noma ukwehluleka kokuphefumula;
- izifo ezithathelwanayo ezinzima;
- ubuthi obukhulu, obuhambisana nokuhlanza noma isiraphu, okungadala ukomisa.
IGlucophage ayinqunyelwe iziguli ezinomsebenzi wezinso ongasebenzi kahle.
IGlucophage ayinqunyelwe ezimweni lapho isiguli:
- ekudleni okuphansi kwekhalori;
- uthole ukulimala okukhulu noma ukuhlinzwa kakhulu, okudinga ukwelashwa kwe-insulin;
- usesimweni sokukhulelwa;
- Ezinsukwini ezi-2 ngaphambi kwalokho, wakuthola ukuhlonza imisebe (i-radiological noma i-radioisotope (ngokwethulwa kwe-iodine) (futhi kungakapheli izinsuku ezi-2 emva kwayo).
Ngokunakekela
Kuyadingeka ukubheka izindlela zokuqapha ezengeziwe ekwelapheni i-glucophage ezimweni lapho isiguli:
- mdala kuneminyaka engama-60, kepha ngasikhathi sinye ukusebenza kanzima ngokomzimba;
- ehlushwa ukwehluleka kwe-renal kanye nama-creatine excretion rate ngaphansi kwe-45 ml ngomzuzu;
- Umama ongumhlengikazi.
Ungayithatha kanjani i-Glucofage 1000?
Umuthi kufanele uphuzwe ngomlomo nsuku zonke ngaphandle kwekhefu. Amathebulethi akufanele achotshozwe noma ahlafunwe. Ukuze ugweme imiphumela emibi engathandeki noma unciphise ubulukhuni bokubonakaliswa kwayo, kuyadingeka ukuqala ukwelashwa ngalo muthi kusuka kumthamo ophansi kakhulu (500 mg ngosuku) bese uwukhulisa ngokunensa kulowo obekwe yi-endocrinologist. Umuthi ungathathwa zombili inqubo yokudla nangemva kwayo.
Isikhathi sokulutha emzimbeni sithatha izinsuku eziyi-10-15. Ngalesi sikhathi, kubalulekile ukukala ushukela wegazi njalo nge-glucometer futhi ugcine idayari yokubonwa. Lolu lwazi luzosiza udokotela ukuthi akhethe kahle umthamo kanye nohlobo lokwelashwa. Isikhathi sokwelashwa sibekwa ngawodwana.
Okwezingane
Ucwaningo lukhombisa ukuthi ukusetshenziswa kwe-Glucophage ekwelapheni isifo sikashukela sohlobo 2 ezinganeni ngonyaka 1 akubangeli ukuphambuka ekukhuleni nasekuthuthukeni. Kodwa-ke, izifundo ezinde azange zenziwe, ngakho-ke, nangaphambi kokuqala kokwelashwa, kuyadingeka ukuqinisekisa ukutholakala kwesi sifo futhi uqiniseke ukuthi umuthi uyasetshenziswa. Futhi-ke kukho konke ukwelashwa, qapha isimo somntwana ngokucophelela, ikakhulukazi uma eseminyakeni yokuthomba.
Ucwaningo lukhombisa ukuthi ukusetshenziswa kwe-Glucophage ekwelapheni isifo sikashukela sohlobo 2 ezinganeni ngonyaka 1 akubangeli ukuphambuka ekukhuleni nasekuthuthukeni.
IGlucophage inqunyelwe ezinganeni zombili ngesimo se-monotherapy, futhi ngokuhlanganiswa neminye imithi. Emavikini amabili okuqala, umthamo wansuku zonke ungama-500 mg. Iphilisi lithathwa isikhathi esingu-1 ngosuku. Umthamo owodwa omkhulu kakhulu akufanele udlule ku-1000 mg, umthamo omkhulu wezinsuku zonke - 2000 mg (kufanele uhlukaniswe ngemithamo eminingana). Umthamo wokulungisa usethwa ngokuya ngobufakazi.
Kwabadala
Abantu abadala bathatha i-Glucophage ukwelapha i-prediabetes, isigaba sokuqala sikashukela nokunciphisa isisindo somzimba.
Nge-monotherapy yesimo sangaphambi kwesifo sikashukela, umthamo wokulondolozwa ngu-1000-1700 mg. Umuthi uphuzwa kabili ngosuku. Uma isiguli sinezinkinga ezihluleka ukuqina kwezinso, khona-ke umthamo omkhulu kakhulu akufanele ube ngaphezulu kuka-1000 mg. Thatha umuthi kabili ngosuku ku-500 mg.
Ukwelashwa kufanele kwenziwe ngokuhambisana nesizinda sokubheka njalo ukufundwa kashukela, futhi, uma kunesidingo, imvume ye-creatinine.
Ukwehla kwesisindo
IGlucophage yisidakamizwa okuhloswe ngaso ukulungisa ushukela wegazi, futhi asihloselwe ukwehlisa isisindo. Kodwa-ke, abesifazane abaningi basebenzisa izakhiwo zayo zokwelapha kanye nemiphumela emibi eyenzeka njalo yokulahleka kokudla ukuze banciphise isisindo.
I-Metformin, ngakolunye uhlangothi, ivimbela ukukhiqizwa kwe-glucose esibindini, ngakolunye uhlangothi, kuvuselela ukusetshenziswa kwento ngemisipha. Zombili lezi zenzo ziholela ekwehleni kweshukela. Ngaphezu kwalokho, i-metformin, ebamba iqhaza ekuthini i-lipid metabolism ivimbe ukuguqulwa kwama-carbohydrate ibe ngamafutha futhi inciphise iphango ngokufanele.
Ochwepheshe batusa ukuthatha lo muthi ukuze ulungise isisindo futhi belulekwa ukuba banamathele kule mithetho elandelayo:
- umthamo wansuku zonke wezidakamizwa ezisetshenziselwa ukunciphisa umzimba akufanele udlule i-500 mg;
- thatha iphilisi ebusuku;
- inkambo enkulu yokwelashwa okusebenzayo akufanele yeqe izinsuku ezingama-22;
- umuthi wokunciphisa umzimba wenqatshelwe ngokuphelele ukuthatha kubantu abanezifo zegazi, inhliziyo, ipheshana lokuphefumula, thayipha isifo sikashukela 1.
Yize iqiniso lokuthi odokotela bengavumeli ukuthatha i-Glucofage yokulungiswa kwesisindo, bagcizelela ukuthi akunakuba nesiqinisekiso sokufeza inhloso (ukwehla kwesisindo okungcono kakhulu kungama-2-3 kg), futhi kubangele imiphumela emibi kakhulu, futhi kwezinye izimo kungaphenduki izinqubo zivunyelwe.
Ukwelashwa kwesifo sikashukela Glucofage 1000
Ekwelapheni uhlobo lwesifo sikashukela sohlobo 2, umthamo wokwelapha ungama-1500-2000 mg ngosuku, okumele uhlukaniswe ngemithamo eminingana. Umthamo omkhulu kakhulu akumele wedlule kuma-3000 mg ngosuku, futhi kufanele uphuzwe ngo-1000 mg (i-1 ithebhulethi) izikhathi ezi-3 ngosuku.
Ngokwelashwa okuhlanganisiwe kwalesi sifo (ukuze kufinyelele umphumela ongcono wokulawula amazinga kashukela), i-glucophage ithathwa kanye nemijovo ye-insulin. Umthamo wokuqala we-Glucofage ungama-500 noma ama-850 mg ngosuku (ama-dragees athathwa ngesikhathi sasekuseni noma ngemuva kwawo). Umthamo we-insulin ukhethwa ngamunye futhi kuya izinkomba zikashukela. Ngenkathi yokwelashwa, imithamo kanye nenombolo yemithamo kuyalungiswa.
Ukuze uzuze umphumela ongcono wokulawula amazinga kashukela, i-glucophage ithathwa ngomjovo we-insulin.
Imiphumela emibi
Imvamisa, i-metmorphine ibanga imiphumela emibi evela emgudwini wesisu kanye nohlelo lwezinzwa, kuyaqabukela kakhulu kwezinye izinhlelo - isikhumba, isibindi kanye nephephabhuku lokuphamba, uhlelo lwe-metabolic. Ngokusho kokuhlolwa komtholampilo, ukuboniswa kwemiphumela emibi kubantu abadala nasezinganeni kuyafana.
Amapheshana wesisu
Esigabeni sokuqala sokwelashwa nge-Glucofage, ukuphazamiseka okunjalo emgodini wesisu kuvame ukuvela njengokucanuzelelwa kwenhliziyo, ubuhlungu besisu, i-dyspepsia, ukugabha, uhudo. Ezimweni eziningi, le miphumela emibi ihamba yodwa. Ukunciphisa ubungozi bokuvela kwabo, kunconywa ukwandisa kancane umthamo futhi emavikini okuqala thatha umuthi amahlandla ama-2-3 ngosuku ngokudla noma ngemuva kokudla.
Isistimu yezinzwa ephakathi
Imvamisa kukhona ukwephulwa kwemizwa yokunambitha.
Kusuka ohlelweni lomchamo
Ukuphambuka ekusebenzeni kohlelo lwe-urinary ngesikhathi sokwelashwa nge-metformin akulona irekhodiwe.
Engxenyeni yesibindi ne-biliary
Ukusetshenziswa kwe-metamorphine kungavusa ukwephulwa kokusebenza kwesibindi futhi kubangele i-hepatitis. Kepha ngemuva kokumisa umuthi, konke ukubonakalisa okungalungile kuyanyamalala.
Imiyalo ekhethekile
Umphumela oyingozi oyingozi kakhulu wokuthatha i-metamorphine ukuthuthukiswa kwe-lactic acidosis. Lokhu kuyivelakancane ezimweni lapho isiguli sinezinkinga zokuphazamiseka kwembobo, ngenxa yalokho into iqala ukuqwabelana emzimbeni. Ingozi ile hhayi kuphela ebubini besifo uqobo, kepha futhi nasezigabeni ukuthi ingaziveza ngezimpawu ezingekho emthethweni, ngenxa yalokho isiguli singalutholi usizo ngesikhathi futhi singafa. Izimpawu ezifanayo ezingenangqondo zifaka:
- izicubu zomsipha;
- dyspepsia
- Ubuhlungu besisu
- ukuphefumula
- kwehlisa izinga lokushisa.
Uma kwenzeka lezi zimpawu ezingenhla, kufanele ukhansele ukuphathwa kwe-Glucofage bese uthintana nesikhungo sezokwelapha esingalapheki ngokushesha.
Umphumela oyingozi oyingozi kakhulu wokuthatha i-metamorphine ukuthuthukiswa kwe-lactic acidosis.
I-Metamorphine akumele iyekwe kungaphelanga izinsuku ezi-2 ngaphambi kokuqala kokungenelela okuhleliwe kokuhlinzwa, futhi ungaqali ngaphambi kwezinsuku ezimbili emva kwayo.
Ukuhambisana notshwala
Utshwala buhlukaniswa kubantu abanesifo sikashukela nezinkinga zesibindi.Iziguli ezinjengalezi kufanele zinamathele ekudleni okuphansi kwekhalori, ukuze zingavumeli ukwanda kwamazinga kashukela. IGlucophage yehlisa ushukela. Ngakho-ke, inhlanganisela yokwelashwa kweGlucofage nokusetshenziswa kotshwala noma izidakamizwa eziqukethe utshwala ekudleni kungadala ukwehla okubukhali koshukela wegazi kuze kufike ku-hypoglycemic coma noma kuvuse ukukhula kwe-lactic acidosis.
Umthelela ekhonweni lokulawula izindlela
Ukwelashwa kwe-Glucofage akubangeli isimo sokwehla ushukela okubukhali, okusho ukuthi akubeki engcupheni yokushayela izimoto noma kumishini eyinkimbinkimbi yemishini. Kodwa-ke, izinga le-glucose lingehla kakhulu uma i-Glucofage ihlanganiswa nezinye izidakamizwa ezinciphisa ushukela, isibonelo, i-Insulin, i-Repaglinide, njll.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Uma ngesikhathi sokukhulelwa owesifazane ophethwe i-hyperglycemia engathathi izinyathelo zokunciphisa ushukela, khona-ke lo mbungu uvusa amathuba okuba nokukhubazeka kokuzala. Kuyadingeka ukulondolozela ushukela we-plasma eduze nokujwayelekile ngangokunokwenzeka. Ukusetshenziswa kwe-metmorphine kukuvumela ukufeza lo mphumela futhi uwulondoloze. Kodwa idatha emiphumeleni yayo ekuthuthukisweni kwesibeletho akwanele ukuqiniseka ngokuphepha okuphelele kwengane.
Isiphetho yilesi: uma owesifazane esesimweni sikashukela noma esetholakale ukuthi unesifo sikashukela sohlobo 2, usebenzisa i-metmorphine futhi ngasikhathi sinye uhlela ukukhulelwa noma usuqalile, umuthi kufanele uyekwe bese ushintshela ekwelashweni kwe-insulin.
I-Metmorphine idlulela kubisi lwebele. Kepha njengasesimweni sokukhulelwa, imininingwane ngethonya lalesi sici ekuthuthukiseni ingane ayanele. Ngakho-ke, kunconywa ukuthi noma wenqabe umuthi noma uyeke ukondla.
Sebenzisa ebudaleni
Iningi labantu asebekhulile bathinteka kakhulu noma kancane ngenxa yokusebenza kwe-renal engasebenzi kahle kanye nomfutho wegazi ophakeme. Lezi yizinkinga eziphambili zokwelashwa kwe-metmorphine.
Uma isifo sezinso sithambile sikhona, khona-ke ukwelashwa kweGlucofage kuvunyelwe ngesimo sokuqashwa njalo kwe-creatinine clearance (okungenani izikhathi ezingama-3-4 ngonyaka). Uma izinga layo lehla laya ku-45 ml ngosuku, isidakamizwa sikhanseliwe.
Ukuqapha okwandayo kufanele kusetshenziswe uma isiguli sithatha ama-diuretics, izidakamizwa ezingezona ze-steroidal anti-inflammatory kanye ne-antihypertensive.
Ukweqisa
Noma ngine-overdose ephezulu (amahlandla angaphezu kwama-40) ene-metformin, umphumela we-hypoglycemic awuzange utholakale, kepha izimpawu zokuthuthuka kwe-lactic acidosis zabonwa. Lesi isibonakaliso esiyinhloko sokweqisa kwemithi. Ezimpawu zokuqala zokudakwa kwezidakamizwa, kuyadingeka ukuthi uyeke ukuphuza i-Glucofage ngokushesha, kanti ohlukunyeziwe kufanele ayiswe esibhedlela lapho kuzothathelwa izinyathelo zokususa i-metmorphine ne-lactate egazini. Umuthi omuhle kakhulu wale nqubo yi-hemodialysis. Ngemuva kwalokho yenza inkambo yokwelashwa okubonakalayo.
Ezimpawu zokuqala zokudakwa kwezidakamizwa, kuyadingeka ukuthi uyeke ukuphuza i-Glucofage ngokushesha, kanti ohlukunyeziwe kufanele uyiswe esibhedlela.
Ukuxhumana nezinye izidakamizwa
I-Glucophage ivame ukusetshenziswa ekwelapheni okuyinkimbinkimbi, kepha kunemithi eminingana ethi, ngokuhlangana ne-metformin, idale ukuhlanganiswa okuyingozi, okusho ukuthi ukusetshenziswa kwayo okuhlangene akuvunyelwe. Kwezinye izimo, ukuhlangana kuvumelekile, kepha kungadala imiphumela emibi uma kuhlanganiswa izimo, ngakho-ke ukuqokwa kwabo kufanele kuphathwe ngokucophelela okukhulu.
Inhlanganisela ehlanganisiwe
Ukubethelwa okuphelele ukuhlanganiswa kwe-metmorphine nezidakamizwa eziqukethe iodine.
Akuhlanganisiwe ukuhlanganisa
Ukuhlanganiswa kweGlucophage nezidakamizwa eziqukethe notshwala akunconywa.
Inhlanganisela edinga ukuqashelwa
Ukusetshenziswa ngokucophelela kudinga ukuhlanganiswa kwe-Glucophage nezidakamizwa ezifana:
- UDanazole Ukuphathwa kanyekanye kunganikeza umphumela we-hyperglycemic onamandla. Uma ukusetshenziswa kweDanazole kuyisinyathelo esidingekayo, khona-ke ukwelashwa nge-Glucophage kuyaphazamiseka. Ngemuva kokumisa ukusetshenziswa kweDanazol, umthamo we-metmorphine ulungiswa ngokuya ngezinkomba zoshukela.
- I-Chlorpromazine. Kungenzeka futhi ukugxuma kumazinga kashukela kanye nokwehla kanyekanye kwenani le-insulin (ikakhulukazi lapho uthatha umthamo omkhulu womuthi).
- I-Glucocorticosteroids. Ukusetshenziswa okuhlanganisiwe kwezidakamizwa kungadala ukuncipha koshukela noma kuvuse ukuthuthukiswa kwe-ketosis, okuzovela kokubekezelelwa kwe-glucose.
- Ukufakwa kwe-beta2-adrenergic agonists. Umuthi uvusa ama-beta2-adrenergic receptors, ngaleyo ndlela andise ushukela wegazi. Ukusetshenziswa okufanayo kwe-insulin kunconyiwe.
Kuzo zonke izimo ezingenhla (ngesikhathi sokuphathwa kanye kanye nangesikhathi esithile ngemuva kokuhoxiswa kwezidakamizwa), ukulungiswa komthamo we-metmorphine kuyadingeka ngokuya ngezinkomba zeglucose.
Ngokuqapha okwandayo, i-glucophage inqunywa ngokuhambisana nezidakamizwa ezibangela i-hypoglycemia, okubandakanya:
- ingcindezi yokunciphisa izingcindezi;
- ama-salicylates;
- I-Acarbose;
- Insulin
- derivatives sulfonylurea.
Ukusetshenziswa okufanayo kweGlucofage ene-diuretics kungaholela ekwakhiweni kwe-lactic acidosis. Kulokhu, imvume ye-creatinine kufanele ihlolwe.
Ukusetshenziswa okufanayo kweGlucofage ene-diuretics kungaholela ekwakhiweni kwe-lactic acidosis.
Izidakamizwa ze-Cationic zingakhuphula inani eliphezulu le-metmorphine. Lokhu kufaka phakathi:
- IVancomycin;
- I-Trimethoprim;
- I-Triamteren;
- I-Ranitidine;
- I-Quinine;
- I-Quinidine;
- Morphine.
I-Nifedipine inyusa izinga lokuhlangana kwe-metformin futhi ithuthukise ukumuncwa kwayo.
I-Glucophage analogues 1000
Izifanekiso zomuthi yilezi:
- U-Formentin noForinin Long (Russia);
- I-Metformin neMetformin-Teva (Israel);
- IGlucophage Long (Norway);
- IGlatini (iRussia);
- Metformin Long Canon (Russia);
- Metformin Zentiva (Czech Republic);
- IMetfogamma 1000 (Germany);
- Siofor (Germany).
Imibandela yekhefu lekhemisi
Ngokusho kwemiyalo esetshenzisiwe, umuthi udluliswa kuphela ngomuthi obhaliwe.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Umuthi uthathwa njengomuthi ongenabungozi, futhi ungathengwa ngokukhululekile ekhemisi ngaphandle kwencwadi kadokotela.
Intengo
Intengo ejwayelekile yamathebulethi angama-30 eGlucofage emakhemisi aseMosike ahluka kusuka kuma-ruble angama-200 kuye kwangama-400., Amaphilisi angama-60 - kusuka kuma-ruble angama-300 kuye kwangama-725.
Izimo zesitoreji Glucofage 1000
Umuthi kumele ugcinwe endaweni engafinyeleleki ezinganeni, emazingeni okushisa angeqi ku-25 ° C.
Isikhathi sokuphelelwa yisikhathi
Umuthi ulungele ukusetshenziswa iminyaka engu-3 kusukela ngosuku lokukhululwa oluboniswe kuphakethe.
Ukubuyekezwa kwe-Glucofage 1000
IGlucophage ingeyolesigaba sezidakamizwa esinomphumela ofakazelwe. Kusetshenziswa ngenkuthalo ekwelashweni kwesifo sikashukela, kuyilapho kutholwa imiphumela egculisayo, njengoba kufakazelwa izibuyekezo eziningi zabodokotela neziguli.
Odokotela
U-Boris, oneminyaka engama-48, uchwepheshe we-urologist, oneminyaka engama-22 yesipiliyoni, eMoscow: "Kade ngisebenzisa i-Glucophage iminyaka engaphezu kwe-10 ekwelapheni izinhlobo ezithile zokuzala okuncishisiwe kwabesilisa abakhuluphele kakhulu kanye ne-hyperglycemia. Umphumela uphezulu impela. Kubalulekile ukuthi i-hypoglycemia ingakhuli ukwelashwa okuhlala isikhathi eside. Umuthi unikeza umphumela omuhle ekuqothulweni okuphelele kokuzala kwabesilisa. "
UMaria, oneminyaka engama-45 ubudala, i-endocrinologist, iminyaka engama-20 yesipiliyoni, eSt. Petersburg: "Ngisisebenzisa kakhulu lesi sidakamizwa ekwelapheni isifo sikashukela sohlobo 2 kanye nokukhuluphala. Umphumela uyenelisa: iziguli zehlisa isisindo kahle ngaphandle kokulimaza impilo futhi zizuze ushukela wegazi ozinzile. Ukudla nokuzivocavoca umzimba kumele kube yingxenye ebalulekile yokwelashwa. Ukufakazelwa ngempumelelo okuhlanganiswe nentengo engabizi yizona zinzuzo eziphambili zomuthi. "
Ngokuqapha okwandayo, iGlucophage inqunywe ngokuhlanganiswa nezidakamizwa ezibangela i-hypoglycemia, okubandakanya, ngokwesibonelo, i-Acarbose.
Iziguli
U-Ana, oneminyaka engama-38, uKemerovo: "Umama wami ubephethwe yisifo sikashukela iminyaka eminingi, athole isisindo esiningi kule minyaka engu-2 eyedlule, ukuphefumula okuvela ngokushesha. Udokotela wathi izimbangela zokuphazamiseka kwengqondo kulele ekuphazamisweni kwe-metabolic kanye nokwenyuka kwe-cholesterol kanye ne-Glucofage.
Ngemuva kwezinyanga eziyisithupha, isimo sathuthuka kakhulu: izivivinyo zacishe zabuya zabajwayelekile, isimo esejwayelekile sathuthuka, isikhumba esithendeni sayeka ukuphuka, umama waqala ukuhamba yedwa ngezitebhisi. Manje uyaqhubeka nokuthatha lesi sidakamizwa futhi ngasikhathi sinye aqaphe umsoco - lesi simo ukuze kwelashwe ngempumelelo kumele. ”
UMaria, oneminyaka engama-52, uNizhny Novgorod: "Ezinyangeni eziyisithupha ezedlule ngiqale ukuthatha i-Glucophage ekwelapheni isifo sikashukela sohlobo 2. Ngakhathazeka kakhulu ngoshukela omningi, kodwa ngavele ngathola amaphawundi awengeziwe. Kodwa-ke, ngemuva kwezinyanga eziyisithupha ngisebenzisa lo muthi nokudla okukhethekile, ushukela wami awuzange wehle futhi uzinze , kodwa futhi "bashiye" ama-9 kg wesisindo ngokweqile. Ngizizwa ngingcono kakhulu. "
