I-Rinsulin P isetshenziselwa ukwelapha zonke izinhlobo zesifo sikashukela. Lolu hlobo lwe-insulin lufanelekile ngisho nasekwelapheni abesifazane abakhulelwe. Kuyadingeka ukulandela ngokucophelela yonke imithetho yokuphuza umuthi ukuze uvikele ukuvela kokuphazamiseka okungaba khona.
Igama Lezwe elingafanele
I-soluble insulin imake "ubunjiniyela bozalo lomuntu."
I-Rinsulin P isetshenziselwa ukwelapha zonke izinhlobo zesifo sikashukela.
I-ATX
A10AB01.
Khipha amafomu nokwakheka
Umuthi uyatholakala ngesimo sesisombululo somjovo esicacile. Into esemqoka insulin yabantu. I-1 ml yesisombululo esimsulwa iqukethe i-100 IU. Izithako ezingeziwe ezifakiwe: i-methacrizol, glycerin namanzi omjovo.
Umuthi uthengiswa emaphaketheni amakhulu ama-3:
- Ama-cartridge ama-5 wengilazi eqinile enenthamo ye-3 ml abekwe kwiphakeji yeseli;
- Ama-cartridge ama-5 3 ml afakwe kumapeni akhethekile wokufaka inaliti owenzelwe imijovo engenziwa kabusha (Rinastra);
- Ibhodlela lengilazi le-1 elinomthamo we-10 ml.
Onke lamakhabethe amabhodlela namabhodlela afakwa kwiphakethe lamakhadibhodi.
Isenzo se-Pharmacological
I-Rinsulin yi-ejenti ye-hypoglycemic, i-insulin yabantu, etholakala ngokuhlanganiswa kwamaketanga e-RNA. Ngenxa yokusebenzisana kwento esebenzayo nama-receptors angaphandle ama-membrane angamaseli, kwakheka isakhi esikhethekile se-insulin-receptor. Iyasiza ukukhuthaza cishe kwazo zonke izinqubo ezenzeka ngaphakathi kwamangqamuzana. Ithatha iqhaza ekwakhekeni kwama-enzyme. Izinga le-glucose egazini liyancishiswa ngokwandisa ukuthuthwa kwalo okuyi-intracellular, ukumuncwa kangcono koshukela yizicubu. Ngasikhathi sinye, izinga lokukhiqizwa koshukela esibindini lehliswa kakhulu.
I-Rinsulin yi-ejenti ye-hypoglycemic, i-insulin yabantu, etholakala ngokuhlanganiswa kwamaketanga e-RNA.
I-Pharmacokinetics
Umphumela wesidakamizwa uqala kungakapheli isigamu sehora ngemuva kokuphathwa kobuhlakani. Okuqukethwe okuphezulu egazini kubonwa ngemuva kwamahora ama-3. Umphumela wokwelapha uthatha amahora angama-8.
Ukufakwa kanye nokusatshalaliswa kwalo muthi kuncike kwindlela yokuphatha, isiza somjovo, umthamo, kanye nokuxineka kwe-insulin emgqonyeni kadokotela olungiselelwe. Ukubhujiswa kwalo kwenzeka ngaphansi kwethonya le-insulinase. Kukhululwa ngokuhlunga kwe-renal.
Amafushane noma amade
I-insulin yomuntu enjalo ibizwa ngokuthi yimithi ebamba amafushane. Lokhu kungenxa yezinga lokumunca, ngokuya ngethamo nendlela yokuphatha yikhambi yezidakamizwa.
Izinkomba zokusetshenziswa
Kunezinkomba ezimbalwa eziqondile zokusetshenziswa kwe-insulin yabantu. Phakathi kwazo kukhona:
- isifo sikashukela i-mellitus ohlotsheni lokuqala nolwesibili;
- thayipha 2 ushukela kwabesifazane ngesikhathi sokukhulelwa;
- izimo eziphuthumayo kuma-diabetes, ezihambisana nokubola kwe-carbohydrate metabolism.
Abesifazane abakhulelwe kufanele balandele ngokucacile imiyalo ye-gynecologist.
IRinsulin P imiselwe isifo sikashukela sohlobo lokuqala nesesibili.
Contraindication
Izimpawu ezihlobene ngqo nokusetshenziswa kwe-insulin yabantu yilezi:
- i-hypoglycemia;
- hypersensitivity ezingxenyeni ngazinye zesidakamizwa.
Ngokuqapha, i-Rinsulin kufanele ithathwe abesifazane abakhulelwe nezingane, abantu bevezwe izinhlobo ezahlukahlukene zokubonakaliswa kwe-allergic.
Ungayithatha kanjani i-Rinsulin P
Umuthi wenzelwe imijovo yokufakelwa, engaphakathi emzimbeni, ne-intravenous. Kwethulwa uhhafu wehora ngaphambi kwesidlo se-carbohydrate. Izinga lokushisa le-insulin elungiselelwe kufanele lihlale lingukushisa kwegumbi. Imvamisa, umuthi ufakwa esifundeni sodonga olungaphandle lwethambo lesisu. Kwesinye isikhathi imijovo yenziwa ehlombe, ethangeni noma emaqhingeni.
Ukuze uvimbele ukuthuthukiswa kwe-lipodystrophy, isayithi lomjovo liguqulwa, kodwa kuphela esifundeni esifanayo se-anatomical. Ngokuphathwa kwe-subcutaneous, ukunakekelwa kufanele kuthathwe ukuze kungalimazi imithambo yegazi. Ngemuva komjovo, isayithi lomjovo ngokwalo akufanele lithintwe, lihlafunwe noma lihlikihlwe. Izindondo zilungele ukusetshenziswa kuphela uma isisombululo kuzo zicacile futhi singenawo umdlandla.
Ngomphumela wesikhathi eside, kanye ne-Rinsulin P emele ukubamba iqhaza, i-Rinsulin NPH yesikhathi esisezingeni eliphakathi komphumela wokwelapha uyasetshenziswa.
Ngomphumela wesikhathi eside, i-Rinsulin NPH isetshenziswa ndawonye no-Rinsulin P. osebenza okwesikhashana.
Ngoshukela
Umthamo wansuku zonke wezinto zokwelapha usukela ku-0,5 uye ku-1 IU nge-1 kg yesisindo somzimba wesiguli. Umuthi uphathwa kathathu ngosuku. Uma kunesidingo esinjalo, imvamisa yokuphatha iyakhuphuka ibe ngu-5 ngosuku. Uma umthamo wansuku zonke ungaphezu kwe-0.6 IU, khona-ke imijovo emi-2 iyadingeka, efakwa ezindaweni ezihlukile. Yonke imijovo yenziwa nge-insulin ekhethekile enenalithi elincanyana kodwa ende enamathiselwe kwisibambo esincanyana se-syringe. Lokhu akuvumeli uketshezi ukuba luqoqane ngokuqinile endaweni eyodwa, futhi umuthi ungena ujule ezingxenyeni ezingaphansi komhlaba.
Imiphumela emibi yeRinsulin P
Uma ungaphuza umuthi ngokungalungile, imiphumela emibi elandelayo ingahle ivele:
- i-hypoglycemia;
- pallor
- ukuthuthumela
- ukuzindla kwenhliziyo;
- ukujuluka ngokweqile;
- Isiyezi
- imivimbo yesikhumba;
- I-edema kaQuincke;
- ukuvuvukala ebusweni nasemilenzeni.
I-hypoglycemia enkulu ingaholela ekwandeni kwe-hypoglycemic coma. Uma kwenzeka ulahlekelwe ukwazi noma ukuvela kwezinye izimpawu, kufanele uthintane nodokotela.
Umthelela ekhonweni lokulawula izindlela
Udinga ukuthi uqaphele lapho ushayela nezinye izindlela eziyinkimbinkimbi esimweni sokuqokwa kokuqala kwe-insulin, ushintsho kwezokwelapha noma ushintsho kwindlela yokuphila, ngoba konke lokhu kuthinta ijubane lokuphendula kanye nokuhlushwa.
Imiyalo ekhethekile
Usebenzisa ithuluzi, kubalulekile ukubheka ushukela wegazi njalo. I-Hypoglycemia ivame ukuholela ekweqisweni ngokweqile, esikhundleni somuthi noma endaweni yokwethulwa, ukusebenza kwesibindi kanye nezinso. Ukuqunjelwa okufanayo, ikakhulukazi ezigulini zohlobo lokuqala lwesifo sikashukela, kungaholela kumthamo ongalungile noma imijovo ephuthelwe njalo. Kulesi simo, isiguli sinokuphazamiseka kwe-dyspeptic, umlomo owomile nephunga le-acetone.
Umthamo kufanele ulawulwe ngokucacile ezigulini esezikhulile ezinokulimala kwe-renal kanye ne-hepatic function. Iyashintsha ngokushintshwa komsebenzi nomsebenzi womzimba.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Lolu hlobo lwe-insulin lungasetshenziswa ngesikhathi sokukhulelwa nokuncelisa ibele. Kepha udinga ukubheka njalo izinga le-glucose. Ukwehla kokuhlolwa kudinga ukulungiswa okuthe xaxa komthamo.
I-Rinsulin IR ingathathwa ngesikhathi sokukhulelwa.
Ukuhambisana notshwala
Ungahlanganisi imijovo nokuphuza utshwala. Ngamanani amancane, utshwala abukwazi ukuthinta ukumuncwa kanye nomphumela, kepha ukusetshenziswa kabi kotshwala kungaholela emiphumeleni emibi.
Ukweqisa kwe-Rinsulin P
Akunakuchazwa ngqo kwe-overdose, ngoba izici ezahlukahlukene zingathonya izinga likashukela wegazi. Imbangela ye-hypoglycemia ingaba i-insulin ngokweqile egazini ngenxa yezondlamzimba noma isimo sokuzivocavoca umzimba. Kubangela ukuphathwa ikhanda, ukudideka, isicanucanu, ngisho nokuhlanza.
Isiguli singasusa izinga elithile le-hypoglycemia ngokudla ucezu kashukela noma ama-carbohydrate. Uma umuntu elahlekelwa ingqondo, ufakwa ngaphakathi nge-40% dextrose solution ne-glucagon ngaphakathi noma emsipha.
Ukuxhumana nezinye izidakamizwa
Kwisirinji esisodwa, umuthi unganikezwa kuphela kanye neRinsulin NPH. Ungawuhlanganisi umuthi nezinsizi zabanye abakhiqizi.
Ama-inhibitors e-ACE nama-ejenti we-hypoglycemic womlomo, ama-beta-blockers, bromocriptine, amanye ama-sulfonamides, ama-steroid, ama-tetracyclines, i-ketoconazole, i-pyridoxine, i-theophylline ne-lithium ukulungiselela kungandisa umphumela we-hypoglycemic.
Umphumela we-hypoglycemic wenza buthaka yi-glucagon, i-estrogen, izindlela zokuvimbela inzalo ngomlomo, ama-glucocorticosteroids, eminye imishanguzo yama-hormonal, kanye nama-diuretics, uHeparin, Morphine, Nicotine kanye ne-calcium blockers.
Ama-Analog
Kukhiqizwa ama-analogues amaningana afana nawo ngokuya ngezinto ezisebenzayo kanye nomphumela wokwelapha. Okuvame kakhulu phakathi kwabo yilezi:
- I-Actrapid;
- I-Actrapid NM;
- I-Insuman Rapid;
- I-Humodar R;
- I-Farmasulin;
- I-Insugen-R;
- I-Farmasulin N;
- I-Rinsulin NPH;
- Ifa le-Insulin.
Ezinye zazo zingabizi kakhulu futhi zingabizi kakhulu, kepha kukhona futhi ezibizayo.
Imibandela yekhefu lekhemisi
Ungathenga ezitolo zezidakamizwa noma uthathe uhlangothi olukhethekile emtholampilo.
Ngingakwazi ukuthenga ngaphandle kadokotela
Lesi sidakamizwa sitshelwa kuphela ngemithi ekhethekile evela kudokotela wakho.
Intengo yeRinsulin R
Ukuthola umuthi kunzima. Izindleko zezichazi zayo ziyahlukahluka ngokuya ngesifunda nangamamaki ekhemisi futhi yi: eRussia - kusuka kuma-ruble angama-250 kuye kwangama-2750., E-Ukraine - kusuka ku-95 kuye ku-1400 UAH. ukupakisha.
Izimo zokugcina zomuthi
Gcina endaweni eyomile futhi emnyama, ubheka umbuso wokushisa + 2 ... + 8ºC. Awukwazi ukuyiqola. Gwema kude nezingane ezincane nezilwane ezifuywayo.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emi-2 kusukela ngosuku lokukhishwa, olukhonjisiwe kwiphakheji. Ukusetshenziswa komkhiqizo ngemuva kwalesi sikhathi kwenqatshelwe ngokuphelele.
Umkhiqizi
Inkampani yokukhiqiza: OJSC "GEROPHARM-Bio", isifunda saseMoscow, Obolensk.
Ukubuyekezwa mayelana neRinsulin R
Odokotela
U-Elizaveta, 39, ongumqondisi we-endocrinologist, eSt.
USergey, oneminyaka engama-44 ubudala, udokotela wezokuqina kwemvelo: "Namuhla ngingasho ukuthi umuthi ungaba muhle uma ungakhipha kalula. Ngibeka kakhulu iRinsulin NPH noma ezinye izifaniso ezikhona."
Iziguli
U-Anna, oneminyaka engama-28 ubudala, uVoronezh: "Ngigculisekile ngomuthi, ngawusebenzisa ngokwemiyalo. Unganikezwa kalula ngaphandle kosizo, izinaliti zincanyana, isingeniso asibangeli ukungezwani. Ungasithola emakhemisi abakhethekile anikezwe umuthi wokuthola abanesifo sikashukela."
UMikhail, oneminyaka engama-46, eMoscow: "Kunzima ukuthola ikhambi. Ngisebenzise iRinsulin NPH inyanga eyodwa futhi angibonanga mphumela. Bekumele ngishintshele kwenye i-insulin."
UKarina, oneminyaka engama-21 ubudala, eKiev: "URinsulin NPH wasondela. Umuthi uphathwa kalula, akukho kusabela okuhlukile okuye kwabonwa. Into kuphela ukuthi, ungacasuki uma umuthi ungasizi evikini lokuqala lokwelashwa, izinga likashukela selilijwayelekile kusukela ngeviki lesibili lokuphathwa futhi ngisaligcina ke. "
