Umuthi onokwakheka okuhlanganisiwe wenza kube njalo izinga le-glycemia. Ithuluzi linciphisa ukumelana ne-insulin, linomphumela we-antioxidant, othinta ukukhishwa kwe-insulin. Kusetshenziswa ekwelapheni isifo sikashukela sohlobo 2.
Igama Lezwe elingafanele
I-Glimepiride + Metformin.
I-Amaryl 500 - umuthi onokwakheka okuhlanganisiwe wenza ngokwejwayelekile izinga le-glycemia.
I-ATX
A10BD02.
Khipha amafomu nokwakheka
Umenzi ukhiqiza umuthi ngendlela yamathebulethi. Izithako ezisebenzayo ziyi-glimepiride ne-metformin ngenani le-2 mg + 500 mg. Ekhemisi ungathenga amaphilisi ngomthamo we-1 mg + 250 mg.
Isenzo se-Pharmacological
Ithuluzi linciphisa ushukela wegazi ukuba amazinga ajwayelekile. Izinto ezisebenzayo zinomthelela ekukhulisweni nasekukhulisweni kwe-insulin ngamaseli e-beta. Ithuluzi linciphisa ukumelana ne-insulin, kwehlisa i-cholesterol yegazi.
I-Pharmacokinetics
Kukhishwe emgodini wokugaya ngokuphelele futhi ngokushesha. I-98% iboshelwe kumaprotheni. Ukudla akukuthinti ukumunwa. Kunqunywa kubisi lwebele futhi lunqamule i-placenta. I-Metabolism yenzeka esibindini ngokwakhiwa kwezinto ezingasebenzi. Uma ukusebenza kwezinso kulimale, into ibopha buthakathaka kumaprotheni egazi futhi isheshe ikhishwe kumchamo. Akuhlanganisiwe emathanjeni. Kukhishwa amathumbu nezinso.
Ukufakwa kwe-Metformin kuyashesha. Ayibophele amaprotheni. Ingozi yokuqongelelwa kwento emzimbeni ezigulini ezinomsebenzi wezinso ezingasebenzi. Kuyakhishwa emchameni.
Uma ukusebenza kwezinso kulimale, into ibopha buthakathaka kumaprotheni egazi futhi isheshe ikhishwe kumchamo.
Izinkomba zokusetshenziswa
Umuthi ukhonjiswa ezigulini ezinesifo sikashukela sohlobo 2. Ukwelashwa kufanele kuxhaswe ngokudla nangokomzimba.
Contraindication
Kuyenqatshelwa ukuqala ukwelashwa phambi kwezifo noma izimo ezithile, ezifana:
- ukwephulwa kwezinso nezinso;
- uphuzo oludakayo;
- ukuba khona kokungezwani komzimba ezicini zomuthi noma nge-Biguanides, ama-sulfonylamides;
- thayipha i-1 isifo sikashukela;
- hyperproduction ye-glucose kanye nemizimba ye-ketone esibindini;
- ukwephulwa kwebhalansi ye-acid emzimbeni (i-metabolic acidosis);
- ama-pathologies angaholela ku-tishu hypoxia;
- i-lactacidemia;
- izifo ezithathelwanayo ezinzima ezinomkhuhlane;
- i-septicemia;
- izimo ezicindezelayo ngenxa yokushiswa, ukulimala, ukuhlinzwa;
- ukukhathala;
- i-intestinal paresis noma ukuvinjwa;
- izihlalo ezikhululekile;
- ukuzila ukudla;
- ukuhlanza
- ukudakwa kakhulu komzimba;
- ukungabekezeleli i-galactose ne-lactose;
- ukukhulelwa kanye nokuncelisa;
- iminyaka engu-18.
Ukuhlanganisa ukusetshenziswa kwesidakamizwa ne-hemodialysis kuyaphulwa.
Ngokunakekela
Ukuqapha kufanele kusetshenziswe lapho usebenzisa amaphilisi ezimweni ezinjalo:
- ukungondleki okungajwayelekile;
- indlela yokuphila;
- isifo se-thyroid esingavuthiwe;
- ubudala
- ukusebenza kanzima ngokomzimba;
- ushukela we-glucose-6-phosphate dehydrogenase.
Lapho kukhona izifo ezithinta inkambo yesifo sikashukela, kubalulekile ukulungisa umthamo futhi uqaphe isilinganiso se-glycemia.
Ungayithatha kanjani i-Amaryl 500
Umuthi uphuzwa izikhathi ezi-1-2 ngosuku ngokudla. Uma ukwamukela okuphuthelwe, kufanele uqhubeke nokuthatha umuthi ngokuya ngemiyalo.
Ngoshukela
Umthamo ophansi kakhulu odingekayo ukwehlisa ushukela wegazi unqunywe. Umthamo omkhulu ngosuku ngamathebulethi ayi-4. Ukwanda okuzimele komthamo kuzoholela ku-hypoglycemia.
Imiphumela emibi ye-Amaril 500
I-Amaryl 500 ingadala imiphumela emibi ehlukahlukene kusuka ohlelweni lwezinzwa - ukozela, ukunganaki, nokuqwasha.
Umuthi ubonakala ngemiphumela emibi evela ohlelweni oluphambili lwezinzwa ngendlela yokuqwasha.
Engxenyeni yesitho sombono
Ukushintshashintsha kwamazinga kashukela kungaholela ekunciphiseni okubonakalayo.
Amapheshana wesisu
Indlala iyanyamalala, kuqhume ukuhlanza. Imvamisa ukukhathazeka nge-nausea, Ubuhlungu be-epigastric nokuqhakaza. Isitulo singadedelwa.
Izitho zeHematopoietic
I-anemia, i-thrombocytopenia yenzeka.
Ngasohlangothini lwe-metabolism
Izimpawu ezivela ohlangothini lwe-metabolism - ikhanda, isiyezi, ukungakwazi ukugxilisa ingqondo, ukubabaza, ukuthuthumela, ukuzwakala, ukuqina, ukunyuka kwengcindezi, ukujuluka. Izimpawu zibonisa ukukhula kwe-hypoglycemia.
Allergies
I-Urticaria, ukulunywa kwesikhumba, ukuqubuka, ukushaqeka kwe-anaphylactic.
Imiphumela yokungezwani komzimba eyenzeka ngemuva kokuphuza umuthi ifaka phakathi: ukulunywa nokuqhuma.
Umthelela ekhonweni lokulawula izindlela
Ngesikhathi sokwelashwa, udinga ukwenqaba ukuphatha izindlela ezinzima nezimoto. Umuthi unciphisa ukugxilisa ingqondo.
Imiyalo ekhethekile
Ukuphuza umuthi wokusebenza kahle kwezinso nesibindi kungaholela ekuqongeleleni i-lactic acid ezithanjeni nasegazini. Uma ukuphefumula kancane, ubuhlungu besisu kwenzeka, futhi izinga lokushisa lomzimba lehla kakhulu, kufanele uthintane nodokotela. Umuthi uyanqatshwa okwesikhashana ngaphambi kokuhlinzwa.
Ngesikhathi sokwelashwa, kuyadingeka ukulawula izinga le-glucose, hemoglobin ne-creatinine egazini. Ukuze ulondoloze i-glycemia ejwayelekile, isiguli kufanele ngaphezu kwalokho sivivinye umzimba futhi sidle ngendlela efanele.
Lapho kukhona ukwehluleka okukhulu kwenhliziyo, ukuwa, ukushaqeka, kanye ne-infyoction ye-myocardial eshubile, ukwelashwa kufanele kuyekwe.
Sebenzisa ebudaleni
Iziguli esezikhulile kufanele zithathwe ngokuqapha. Kunconywa ukubheka isimo sezinso noshukela wegazi.
Ukunquma i-Amaril ezinganeni ezingama-500
Abantu abangaphansi kweminyaka engu-18 ubudala ababekiwe.
Abantu abangaphansi kweminyaka engu-18 ubudala ababekiwe.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ungasebenzisi ngesikhathi sokukhulelwa. Ngaphambi kokuqala ukwelashwa, ukuncelisa kuyamiswa.
Isicelo sokusebenza kokulimala kwezinso
Uma umsebenzi wezinso ukhubazekile futhi imvume ye-creatinine iyanda, ukuphuza amaphilisi kuyaphikiswa.
Sebenzisa umsebenzi wesibindi okhubazekile
Kuphikisiwe uma kwenzeka kwephulwa kakhulu kwesibindi.
I-overdose ye-Amaril 500
Uma kwenzeka kweqa ngokweqile, imiphumela emibi evela ohlangothini lokukhula kwe-metabolism inyuka. Uma isiguli sazi, kubalulekile ukudla ukudla okuqukethe ushukela bese ushayela i-ambulensi.
Ukuxhumana nezinye izidakamizwa
Ukugwema ukusabela okungafuneki, cabanga ngokuhlangana komuthi nezinye izidakamizwa:
- ushukela wegazi wehla ngokunamandla lapho uhlanganiswa nama-inducers noma ama-inhibitors we-CYP2C9, ama-anabolic steroid, i-Allopurinol, izidakamizwa ze-hypoglycemic, i-insulin, ama-inhibitors e-ACE, i-Ifosfamide, i-Fibrate, i-probenitsid, amanxusa wokuzwela, ama-beta-adrenergic blocking agents, i-Chloramfenicolomolomolomolomolomolomolomolomolomolomolomolomolomolomolom I-Oxyphenbutazone, iGuanethidine, i-MAO inhibitors, i-aminosalicylic acid, iSalicylates, iTetracyclines, i-Azapropazone, ethanol, Tritokvalin;
- ukuphathwa kanyekanye nge-glamicin akunconywa;
- kwenqatshelwe ukuhlanganisa ukuphatha nokuphathwa kwe-iodine ye-iodine equkethe i-iodine;
- Kuba nzima ukulawula i-glycemia uma kwenzeka ukusebenzisa kanyekanye izidakamizwa ukwandisa i-potency, ama-estrogens, ama-sympathomimetics, i-phenytoin, i-epinephrine, i-diazoxide, ama-hormone egilo, i-glucocorticosteroids, ama-laxatives kanye ne-diuretics, i-nicotinic acid, rifampicin, acetazolamide, barbit.
Ukusetshenziswa okufanayo kwesidakwa notshwala kukhulisa ubungozi bokulimala kwesibindi kanye nezinso.
Kuyadingeka ukuthatha i-histamine H2-receptor blockers, i-clonidine ne-reserpine ngemuva kokubonana nodokotela.
Ukuhambisana notshwala
Ukusetshenziswa kotshwala kuholela ekwakhiweni kwemiphumela engathandeki. Ngaphansi kwethonya le-ethanol, ushukela ungehla uye emazingeni abucayi. Ukusetshenziswa okufanayo kwesidakwa notshwala kukhulisa ubungozi bokulimala kwesibindi kanye nezinso.
Ama-Analog
Kunezikhalo zesenzo se-pharmacological:
- UGalvus Met;
- I-Bagomet Plus;
- I-Glimecomb.
Imiyalo ikhombisa contraindication kanye nemiphumela emibi. Ngaphambi kokushintsha ikhambi elifanayo, kungcono ukuvakashela udokotela wakho.
Imibandela yekhefu lekhemisi
Ikhemisi lingathengwa ngesibhedlela.
Intengo ye-Amaryl 500
Intengo yokufaka ngama-ruble angama-850.
Izimo zokugcina zomuthi
Amacwecwe kufanele abekwe emaphaketheni asekuqaleni futhi agcinwe endaweni emnyama. Izimo lokushisa - kufinyelela ku- + 30 ° C.
Isikhathi sokuphelelwa yisikhathi
Impilo yeshelf iyiminyaka emithathu.
Umkhiqizi
Handok Pharmaceuticals Co, Ltd., Korea.
Umuthi ungathengwa ekhemisi ngemithi.
Amaril 500 Ukubuyekezwa
UMarina Sukhanova, udokotela wezempilo, i-Irkutsk
Umuthi ngezinga elincane kunamanye ama-hypoglycemic agents abangela ukwehla kwe-insulin. Futhi, umuthi ubekezelelwa kahle yiziguli (kufaka phakathi ingozi encishisiwe ye-hypoglycemia). Umuthi unciphisa kancane isifiso sokudla. Ilungele iziguli ezinesifo sikashukela esinga-insulin.
UMaxim Sazonov, udokotela we-endocrinologist, uKazan
Izakhi ezisebenzayo zisekelana isenzo somunye nomunye. I-Metformin ithuthukisa imiphumela ye-glimepiride. Egazini kukhona ukwehla kwenani le-glucose, LDL ne-triglycerides. Ithuluzi elihle kakhulu lokugcina ushukela ojwayelekile. Imiphumela emibi ingenzeka ngendlela yokwaliwa, i-hypoglycemia, ukuphazamiseka kokulala.
UMarina, oneminyaka engama-43, uSamara
Ngohlobo 2 sikashukela, isidakamizwa esisebenzayo esinegama elihlanganisiwe sanqunywa. Kuvimbela ukukhula kwe-hyperglycemia futhi akuholeli ku-hypoglycemia, uma umthamo odingekayo unamathelwa. Emavikini ambalwa okuqala, wezwa ukuthi unesiphukuphuku, kwavela nohudo. Izimpawu zanyamalala ngokuhamba kwesikhathi, futhi manje angizizwa ngiphazamiseka.
