I-Amoxiclav 500 mg ngenye yezindawo eziholayo phakathi kwama-ejenti ahlanganisiwe we-antimicrobial. Lokhu kungenxa yokusebenza kwayo, ukubekezelela okuhle kweziguli eziningi kanye nokuba khona kwezinhlobo eziningana zokukhishwa.
I-ATX
Umuthi unekhodi ye-ATX J01CR02.
I-Amoxiclav 500 mg ngenye yezindawo eziholayo phakathi kwama-ejenti ahlanganisiwe we-antimicrobial.
Khipha amafomu nokwakheka
Umuthi uyatholakala ngesimo se:
- amaphilisi we-gastroprotective camera;
- i-powder yokulungiselela ukumiswa komlomo;
- impuphu eyenzelwe umjovo.
Okunye okuthengiswayo yizinhlobo ezahlukene zamathebulethi (i-Amoxiclav Quicktab).
Ukwakheka kwalesi sidakamizwa kufaka izingxenye ezi-2 ezisebenzayo: i-antibiotic amooticillin ne-β-lactamase inhibitor clavulanic acid. Inketho yokumiswa kumthamo we-500 mg ayikhiqizwa. I-Amoxicillin trihydrate isetshenziselwa izinhlobo zomlomo zesidakamizwa, futhi usawoti wayo we-sodium usetshenziselwa ukugxilisa umjovo.
Amathebulethi we-enteric-soluble aqukethe i-125 mg ye-bacterial enzyme inhibitor ngendlela ye-potasium clavulanate. I-Amoxicillin ingahle ibe khona ngesilinganiso sama-250, 500 mg noma ama-875 mg.
Ukuqanjwa kwengqangi eyengeziwe
- i-talc;
- i-croscarmellose sodium;
- i-anhydrous silicon dioxide colloid;
- i-magnesium stearate;
- i-povidone;
- i-microcellulose.
Igobolondo lenziwe nge-hypromellose, talc ne-titanium oxide ngokufakwa kwe-polysorbate 80, triethyl citrate ne-ethyl cellulose ether. Le mipako inezinto ezilwa ne-ulcerogenic futhi inyibilika amathumbu. Iithebhulethi zithengiswa ngohlobo lwamaqhubu noma ezibilinini. Iphakethe le-carton engaphandle.
Amathebulethi angafinyeleleki angaba nomthamo ohlukile we-clavulanate ne-antibiotic, kufaka phakathi u-125 mg + 500 mg. Ukugcwaliswa okusizayo kufaka:
- i-microcrystalline cellulose;
- isilika;
- i-talc yemithi;
- i-polyethylene glycol;
- i-ferric oxide (E172);
- i-sweetener;
- ukunambitha.
Imikhiqizo ifakwa emabhulashini ama-10 noma ayi-14 ama-pcs. Iphakethe lekhadibhodi liqukethe amapuleti ama-2 blister kanye nepheshana elinemiyalo yokusebenzisa.
Uhlobo lomjovo lomuthi i-powder emhlophe noma ephuzi kancane equkethe ingxube ye-sodium amoxicillin ene-inhibitor ngokwesilinganiso esingu-5: 1. Kunemithamo ye-0,5 g + 0,1 g noma 1 g + 0,2 g. Umuthi ubekwa ezilwaneni. Ibhokisi liqukethe amabhodlela ama-5 anjalo kanye nepheshana lemiyalo.
Isenzo se-Pharmacological
I-Amoxiclav yigciwane elwa namagciwane. Umphumela wokwelapha umuthi unikezwa i-antibacterial component amoxicillin. I-Clavulanate inweba ububanzi besenzo sayo, kepha ayinayo impahla yokuqhathanisa nazo.
Ngaphansi kwethonya lomuthi, amandla odonga lweseli ayancipha, okuholela ekufeni komzimba.
I-Amoxicillin iyi-blocker ye-bacterial transpeptidase enzymes, ngaphandle kwayo i-biosynthesis yesakhi esiyinhloko se-membreane se-murein kumabhaktheriya ayinakwenzeka. Ngaphansi kwethonya lomuthi, amandla odonga lweseli ayancipha, okuholela ekufeni komzimba. Amanye ama-pathogen angenwe yisenzo se-antibiotic, ngoba afunde ukukhiqiza ama-β-lactamases, abhubhisa isakhiwo sawo. Ukwenza i-inactivate lezi zingxube ze-enzymatic ekwakhiweni kwe-Amoxiclav ne-clavulanate kwethulwa.
Ngenxa yomsebenzi ohlanganyelwe wezinto ezisebenzayo, isidakamizwa siyakwazi ukuqeda ngempumelelo izifo ezahlukahlukene ezithathelwanayo ezibangelwa ama-microorganisms we-pathogenic anjenge:
- staphylococci;
- ISalmonella
- i-hemophilic bacillus;
- chlamydia
- streptococci;
- clostridia;
- i-enterobacteria;
- i-gono- ne-meningococci;
- UShigella
- I-Proteus
- i-legionella;
- E. coli;
- cholera vibrio;
- treponema ophuzi;
- i-brucella;
- Helicobacter pylori;
- Ama-preotellas nabanye
I-Pharmacokinetics
Lapho uthatha umuthi ngomlomo, izakhi zawo ezisebenzayo zimunwa zivela emathunjini ngokugcwele ngemizuzu engama-60-90. Isilinganiso sabo se-bioavailability sifinyelela ku-70%, futhi ubukhulu be-plasma okuhlushwa buthembele kumthamo osetshenzisiwe.
Lapho uthatha umuthi ngomlomo, izakhi zawo ezisebenzayo zimunwa zivela emathunjini ngokugcwele ngemizuzu engama-60-90.
Umuthi usatshalaliswa kahle kumanzi we-biological kanye nezicubu ezahlukahlukene. Ingasinqoba isithiyo esiyimbaza, sitholakala ngamanani amancane ekubunjweni kobisi lwebele, kepha ayinqobi i-BBB lapho kungekho ukuvuvukala kwasendaweni. Ukuxhumana nezinhlaka zamaprotheni egazi kuyinto elinganiselayo (cishe ama-20%), ngakho-ke umuthi owedlulele ungasuswa nge-hemodialysis.
Iningi lomuthi (kufika ku-65-70%) likhishwa izinso ngendlela yazo yasekuqaleni emahoreni ayi-6, kuyilapho i-clavulanic acid ichithiwe futhi ikhululwe kuqala emahoreni angama-2-3 ngemuva kokuphathwa. I-Amoxicillin, ngokungafani nayo, itholakala kalula emgudwini we-metabolism. Imikhiqizo yokubola ayisebenzi, ichazwa ikakhulu ekwakhekeni komchamo, ngokwengxenye ngamalondolo.
Isilinganiso sempilo-yezingxenye zezinto ezisebenzayo ihora eli-1. Ezigulini ezinokwehluleka okungapheli kwe-renal, le ejenti yemithi idedelwa kaninginingi isikhathi eside, ngenxa yalokho, kuncishiswa imithamo kanye / noma imvamisa yokuphatha kwayo kuyadingeka.
Izinkomba zokusetshenziswa
I-Amoxiclav imiselwe ukuqeda izifo ezibangelwa amagciwane azwela zona.
I-Amoxiclav 500 isetshenziselwa ukwelapha umphimbo obuhlungu.
Kuyasetshenziswa:
- kumazinyo;
- ngezifo zokuphefumula kanye nezifo zezingxenye ezingezansi zohlelo lokuphefumula, kufaka phakathi i-pneumonia;
- ekwelapheni i-tonsillitis, imidiya ye-otitis, i-sinusitis nezinye izilonda ze-otolaryngological;
- nge-peritonitis, ukutheleleka komgudu wokugaya kanye ne-biliary tract;
- ku-urology kanye ne-gynecology;
- ukulwa ne-gonorrhea ne-chancroid;
- ngezikhumba nezikhumba zemisipha;
- ngokutheleleka kwezinto ezicacile kanye nezicubu zamathambo;
- ngezifo ezijwayelekile nezixubile.
Umuthi futhi ungasetshenziselwa ukuvikela, ngokwesibonelo, esikhathini sokusebenza.
Contraindication
Imikhawulo eqinile yokunquma umuthi ifaka phakathi:
- ukungabekezelelani ngakunye, kufaka phakathi noma yiziphi ezinye izinto ezingezekile;
- i-allergy etholakele ku-penicillin, ama-analogues ayo, ama-carbapenems noma amalungiselelo e-cephalosporin;
- umlando we-hepatitis kanye ne-jaundice, othuthukiswe njengomphumela wokwelashwa ngama-antibiotic;
- i-lymphocytic leukemia;
- i-acute lymphoblastosis.
Abesifazane abakhulelwe nabambekile, iziguli ezinokulimala kwezinso kanye / noma umsebenzi wesibindi, kanye ne-pseudomembranous colitis zidinga ukukhethwa ngokucophelela kwemithamo nokuqapha okukhethekile kwezokwelapha.
Amathebulethi we-Quicktab nawo angabekelwa i-phenylketonuria.
Abesifazane abakhulelwe badinga ukukhetha ngokucophelela imithamo ye-Amoxiclav 500 nokuqashwa okukhethekile kwezokwelapha.
Ungayithatha kanjani i-Amoxiclav 500
Uhlobo lokwelashwa, umthamo kanye nesikhathi semithi kunqunywa udokotela, kucatshangelwa iminyaka yobudala besiguli, ubukhulu besifo, amandla abonwayo, ukuhlangana kwezidakamizwa. Ngakho-ke, akunakwenzeka ukusebenzisa isidakamizwa ukuzelapha.
Amatafula ane-gastroprotating coating kumele agwenywe aphelele, agezwe ngamanzi, futhi amaphilisi ahlakazekile kufanele amunwe aze ancibilike ngokuphelele. Kunconywa ukusebenzisa umuthi ngokudla ukuvikela mucosa wesisu emiphumeleni yaso ecasulayo.
I-500 mg + 100 mg yokugxilisa ukujula iyachithwa ku-10 ml wamanzi wokujova. Isixazululo sifakwa emthanjeni kancane. Ukulungiswa okwengeziwe kuyadingeka ukuthola uketshezi lokufakwa. Ngemuva kokususa isimo esibucayi sesiguli, zidluliselwa ekuphathweni komlomo kwe-Amoxiclav.
Okwezingane
Kuze kube yiminyaka eyi-6, kunconywa ukunikeza iziguli umuthi ngendlela yokumiswa komlomo. Imithamo ibalwa ngawodwana. Umkhawulo weminyaka wamathebulezi ahlakazekile yiminyaka eyi-12. Izingane ezingaphezu kweminyaka engu-12 ubudala, uma isisindo sazo singekho ngaphansi kwama-40 kg, thatha imithamo efanayo neyabantu abadala.
Kwabadala
Amaphilisi we-500 mg + 125 mg angasetshenziswa ngabantu abadala nentsha eneminyaka eyi-12 ubudala nangaphezulu. Imvamisa badakwa ngezikhathi ezithile ezingamahora ayi-12. Kwezifo ezinzima kanye nezifo zokuphefumula, athathwa njalo amahora angama-8.
Zingaki izinsuku okufanele uthathe
Ngemuva kokuqeda izimpawu ezibonakalayo, ukwelashwa akufanele kuyekwe ezinsukwini ezingama-2-3 ezizayo. Isikhathi esilinganiswayo sokwelashwa sisukela ezinsukwini ezi-5 kuya kumaviki ama-2. Ngemuva kokuhambela kwesibili kudokotela, inkambo yokwelashwa inganwetshwa.
Ukuthatha umuthi wesifo sikashukela
Akukho okubangisana ngokuthatha umuthi wesifo sikashukela. Kusetshenziswa imithamo ejwayelekile, kepha inkambo ende yokwelashwa ngama-antibiotic ingadingeka.
Ku-mellitus yesifo sikashukela, kusetshenziswa imithamo ejwayelekile ye-Amoxiclav, kepha inkambo ende yokwelashwa ngamakhambi ingadingeka.
Imiphumela emibi
Imvamisa, ukubonakaliswa okungafuneki akubalulekanga futhi akudingi ukuyekiswa kokwelashwa.
Amapheshana wesisu
Ukuhlaselwa isicanucanu, ukulahleka kwesifiso, i-dyspepsia, ubuhlungu besisu, ukugabha, i-stomatitis, i-enterocolitis, isifo sohudo, i-gastritis, umsebenzi wesibindi ongasebenzi kahle, umsebenzi owandayo wama-enzyme wesibindi. Amazinyo angafiphala, ukuvela okumnyama kulimi kungavela.
Izitho zeHematopoietic
Ukucindezelwa kokusebenza kwamathambo, izinguquko ekwakhekeni kwegazi, kufaka phakathi i-thrombocytosis kanye ne-hemolytic anemia, hemophilia ephindayo.
Isistimu yezinzwa ephakathi
I-Migraines, ubuthakathaka, isiyezi, ukukhathazeka, ukuzwela, ukuthambekisa okungokomzwelo, ukuphazamiseka kokulala. Ukushintshana kungenzeka, kungenzeka kwabo kuphakama ikakhulukazi ngokusebenza kwezinso noma ukwethulwa kwemithamo emikhulu yomuthi.
Kusuka ohlelweni lomchamo
I-nephropathy enokwenzeka, i-hematuria, i-crystallization kasawoti emchameni.
Allergies
Ukuqubuka komzimba, i-hyperemia, ukulunywa, i-urticaria, ukuvuvukala, i-erythema multiforme noma i-malignant, i-dermatitis exfoliative, i-Lyell syndrome, i-exanthema, vasculitis, ukusabela kwe-anaphylactoid, nobuhlungu endaweni yomjovo.
Imiyalo ekhethekile
Leli thuluzi alisetshenziselwa ukwelapha iziguli nge-mononucleosis, ngoba ingadala imivimbo efana nesimungumungwane.
Lapho usebenzisa imithamo ephezulu ye-Amoxiclav ukuvimbela i-crystalluria, irejimeni yokuphuza ethuthukisiwe kufanele ibonwe.
Ngesikhathi sokwelashwa ngamakhambi, ukuqapha kwesimo sezinhlaka ze-renal-hepatic kanye nokwakheka kwamangqamuzana egazi kuyadingeka.
Umuthi ungavusa ukubonakala kokukhulu, c. kufaka phakathi i-vaginitis yangempela, i-stomatitis, i-mycoses yesikhumba. Uma kukhona ukuzwela okuphezulu kwama-penicillin ama-antibiotic, i-cross-allergy ene-cephalosporins kungenzeka.
Lapho usebenzisa imithamo ephezulu ye-Amoxiclav ukuvimbela i-crystalluria, irejimeni yokuphuza ethuthukisiwe kufanele ibonwe. Ukugwema imiphumela emihle ye-pseudo lapho kuhlaziywa umchamo ushukela, kufanele kusetshenziswe ukuhlolwa kwe-glucosidase.
Nge-colitis yezidakamizwa, ukuphatha ama-antibiotic kufanele kuphele. Susa ukwahlukaniswa kwezidakamizwa okuvimbela ukuhamba kwamathumbu, kubekiwe.
Umthelela ekhonweni lokulawula izindlela
Ngenxa yamandla okusabela kwe-psychomotor, ukunakekelwa kufanele kuthathwe lapho ushayela noma uhlanganyela ezintweni ezingaba yingozi.
Isicelo sokusebenza kokulimala kwezinso
Uma izinga le-creatinine likububanzi be-10-30 ml / min, khona-ke umthamo we-500 mg + 125 mg uthathwa ngokungadluli amahlandla ama-2 ngosuku. Ngamazinga we-creatinine angaphansi kwe-10 ml / min, isikhathi esiphakathi komthamo sikhushulwa saba amahora angama-24.
Sebenzisa umsebenzi wesibindi okhubazekile
Ngokuhluleka kwesibindi, udinga ukukhetha ngokucophelela umthamo, ukuqapha isimo sesiguli.
Ngokuhluleka kwesibindi, udinga ukukhetha ngokucophelela umthamo we-Amoxiclav.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Abesifazane abakhulelwe nabomama abancelayo bangasebenzisa lesi sidakamizwa kuphela ngokubonisana nodokotela. Ngesikhathi sokuphathwa kwe-Amoxiclav, okondlayo ngokwemvelo kufanele kulahlwe.
Ukweqisa
Uma imithamo idlulile, kungavela okulandelayo:
- ikhanda
- dyspepsia
- isicanucanu
- amathumbu aphatheke kabi;
- ukuhlanza
- iminyakazo
- ukweqile;
- ukuphazamiseka kokulala;
- ukudideka.
Kunconywa ukuhlanza i-patity yesisu futhi uthathe i-enterosorbent. Ukwelashwa okubonakalayo kunqunyelwe. Kwi-overdose enzima, i-hemodialysis iyenziwa.
Kwi-overdose enkulu ene-Amoxiclav, i-hemodialysis iyenziwa.
Ukuxhumana nezinye izidakamizwa
Lapho kukhona i-ascorbic acid, ukufakwa kwezakhi ezisebenzayo zomuthi kuyathuthukiswa. Ama-antacid, ama-laxatives, ama-aminoglycoside agents kanye ne-glucosamine anciphisa inqubo yokumuncwa kwawo. Ukuhlushwa kwe-Amoxicillin ku-plasma kuyanda ngokusetshenziswa kanyekanye kwezidakamizwa ngama-NSAIDs, ama-diuretics, i-probenecid, i-Phenylbutazone, i-Allopurinol.
Ngokuhlanganiswa ne-Amoxiclav, imiphumela emibi ye-Methotrexate, iDisulfiram, i-Allopurinol iyathuthukiswa, kungenzeka ukwandisa umphumela we-anticoagulants engaqondile futhi yenze buthaka ukuthembeka kwezindlela zokuvimbela inzalo ze-estrogen. Ama-Sulfanilamides nama-bacteriostatic antibiotic angabaphikisi bawo, futhi ukubambisana ngokubambisana ne-rifampicin kunciphisa ukusebenza kwalezi zidakamizwa zombili.
Analogs of Amoxiclav 500
Njengokuthi indawo yaleli thuluzi, ungasebenzisa lezi zidakamizwa:
- Flemoklav Solutab;
- Amoxicillin + Clavulanic acid;
- Augmentin;
- I-Verklav;
- I-Clamosar;
- I-Amoxivan;
- I-Rapiclav;
- Isikhundla
- I-Arlet nezinye izifaniso.
Imibandela Yeholide ye-Amoxiclav 500
Umuthi okukhulunywa ngawo awutholakali ngokukhululekile.
Ngingakwazi ukuthenga ngaphandle kadokotela
Umuthi uyadingeka ukuthenga noma yiluphi uhlobo lomuthi.
Intengo
Izindleko zamacwecwe ekuhlanganiseni ifilimu zisuka kuma-ruble angama-326. ama-pcs ayi-15. 500 mg + 125 mg. Intengo yomjovo ka-500 mg + 100 mg ugxilisa isilinganiso sama-ruble angama-485. imithamo emi-5.
Izimo zokugcina zomuthi
Ukuvezwa kwimisebe yelanga eqondile, umswakama ophakeme namazinga okushisa angaphezu kuka-25 ° C akumele avunyelwe. Imithi akufanele itholakale ezinganeni.
Isikhathi sokuphelelwa yisikhathi
Amathebhulethi anokuhlakazeka agcinwa iminyaka emi-3 kusukela ngosuku lokukhiqizwa. Impilo yeshalofu yazo zonke ezinye izinhlobo ze-Amoxiclav yiminyaka emi-2. Imithi ephelelwe yisikhathi ayikwazi ukusetshenziswa.
Ukubuyekezwa kwe-Amoxiclav 500
Lo muthi uthola izimpendulo eziningi ezinhle. Ukubuyekezwa okungalungile kuhlangene nokuphendula komzimba ngamunye noma ukuzwela okwanele kwezinto ezithile zamagciwane.
Odokotela
I-Kornilin A.A., udokotela wezinhlungu, uVolgograd
Umuthi omuhle we-penicillin onobubanzi obude bokuvezwa. Iphumelela i-cystitis, nephritis, urethral syndrome. Ngincoma ukuyithatha ngokuhambisana nabaphatheli be-probiotic.
I-Piskarchuk E. G., udokotela ojwayelekile, uSmolensk
Umuthi osebenzayo wokulwa nezifo eziningi ezithathelwanayo nezifo. Ayikho imiphumela emibi ngemuva kokuyisebenzisa mkhuba wami, ngakho-ke ngiyithatha njengeyigciwane elaphephile elilondekile.
Umuthi uyadingeka ukuthenga noma yiluphi uhlobo lomuthi.
Iziguli
UTamara, oneminyaka engama-59, uVyazma
Amaphilisi angabizi akusiza ungene ngezinyawo zakho ngokushesha. Ngibathatha ngine-exacerbations ye-bronchitis engapheli. Umuthi ubekezelelwa kahle uma uthathwa ngokudla. Ngaphandle kwalokho, kukhona ukungakhululeki esiswini.
U-Alexandra, oneminyaka engama-27, uPenza
Ngathatha amaphilisi lapho, ngenxa yomkhuhlane, ukuvuvukala kudluliselwa endlebeni ephakathi. Ngemuva kwezinsuku ezimbili zokwelashwa, izinga lokushisa lehla, izinhlungu zahamba futhi nokuzwa sekujwayelekile. Kwakukhona isifo sohudo esincane, kodwa singabangelwa yisifo, hhayi ikhambi.
