Amathebulethi e-Metformin 1000 mg angama-oval ne-convex nhlangothi zombili.
Into yamakhemikhali eyingxenye yesidakamizwa inombala omhlophe.
Njengengxenye yesidakamizwa Metformin 1000, ikhemikhali esebenzayo esebenzayo yi-metformin hydrochloride. Le khompiyutha iqukethe ama-milligram angama-1000 ngethebhulethi.
Ngaphezu komthamo we-1000 mg, umuthi onomthamo ongu-850 no-500 mg ukhiqizwa imboni yezemithi.
Ngaphezu kwenhlanganisela esemqoka yamakhemikhali, ithebhulethi ngayinye iqukethe izinto eziyinkimbinkimbi zamakhemikhali enza imisebenzi yokusiza.
Izakhi zamakhemikhali ezenza imisebenzi yokusiza yilezi ezilandelayo:
- i-microcrystalline cellulose;
- i-croscarmellose sodium;
- amanzi ahlanziwe;
- i-povidone;
- i-magnesium stearate.
Umuthi ungowesiqhema sezidakamizwa ezinciphisa ushukela futhi sisetshenziswa ekwelapheni isifo sikashukela. Umuthi uhloselwe ukulawula ushukela wegazi, usetshenziswa ngomlomo. Amakhemikhali asebenzayo asebenzayo abhekisela kuma-Biguanides.
Umuthi ungathengwa kunoma yisiphi isikhungo sokhemisi onikezwe umuthi. Iningi leziguli lishiya ukubuyekezwa okuhle ngomuthi, okukhombisa ukusebenza kahle kwezokwelapha okuphezulu kwomuthi.
I-Metformin ozone inentengo engu-1000 mg eRussia, eyehluka esifundeni esithengiswayo eRussia Federation futhi isukela ku-193 iye kuma-ruble angama-220 iphakethe ngalinye.
Izici ze-pharmacological zomuthi
Ngemuva kokusebenzisa umthamo odingekayo wesidakamizwa, i-metformin igxiliswa emgodini wesisu. Umuthi ovela ku-lumen wepheshana lesisu udonswa ngokuphelele. I-bioavailability yesidakamizwa cishe i-50-60%. Okuqukethwe okuphezulu emzimbeni kutholakala ngemuva kwamahora ama-2-2,5 ngemuva kokuthatha umuthi.
Ngokufakwa ngasikhathi sinye kokudla nomuthi, ukumuncwa kwengxenye esebenzayo kwehlisa izinga lokulimala futhi kuthambe nesikhathi.
Lapho ungena kwi-plasma yegazi, i-metformin hydrochloride empeleni ayihlangani namaprotheni e-plasma futhi ayakhi izakhi eziyinkimbinkimbi.
I-Metformin isetshenziswe kancane futhi yatshelwa yizinso.
Ukuphila kwesidakamizwa kwenzeka ngaphakathi kwamahora ayi-6.5.
Lapho kukhona ukwehluleka kwezinso esigulini esinesifo sikashukela, isikhathi sempilo siyakhuphuka futhi kukhona nengozi yokuqalwa kokuqalwa komuthi emzimbeni.
Ukusebenzisa umuthi ukuvumela ukuthi wehlise i-hyperglycemia emzimbeni wesiguli, ngaphandle kokuvusa ukubonakala kwezimpawu ze-hypoglycemia. Umuthi awuthinti ukwakheka kwe-insulin ngamaseli we-beta wezicubu ze-pancreatic. Umuthi awucasuli ukuthuthukiswa kwesimo se-hypoglycemic kubantu abaphilile
Ukusetshenziswa kwe-Metformin ozone kwenza ukwanda kokuzwela kwezingqimba zamaseli kuncike kuma-insulin, okufaka isandla ekwandeni kwesibalo se glucose esetshenziswa ngamangqamuzana.
I-Metformin hydrochloride iyakwazi ukuvimbela izinqubo ze-gluconeogeneis ezenzeka kumaseli wezicubu zesibindi futhi zibambezele ukumuncwa kwe-glucose kusuka ku-lumen ye-gastrointestinal tract.
Umphumela wesakhi esisebenzayo somuthi ku-glycogen synthetase kuholela ekwandeni kwenqubo yokwenziwa kwe-glycogen. Ngesenzo sayo kulolwelwesi lweseli, i-metformin inyusa umthamo wazo zonke izinhlobo zezithwali ze-carbohydrate kulo lonke ulwelwesi lweseli.
Ukungena kwengxenye esebenzayo emzimbeni kuholela emiphumeleni enenzuzo ku-lipid metabolism, okuholela ekuncipheni kwe-cholesterol ephelele emzimbeni.
Ukwemukelwa kweMetformin kunomthelela ekujuleni kwesisindo somzimba, kungahle kube okuzinzile noma kunciphe kancane kancane kube ngamazinga amukelekayo.
Imiyalo yokusebenzisa umuthi
Isisekelo sokusetshenziselwa umuthi ubukhona be-Type 2 sikashukela kumuntu, uma kungekho zinguquko ezinhle ekushintsheni kwezinguquko emazingeni kashukela ngokuchayeka kwesiguli ekwelashweni kokudla kanye nokuzivocavoca okwenziwe emzimbeni. Lokhu kuyiqiniso ikakhulukazi kubantu abakhuluphele.
Amathebulethi asetshenziswa ekwelapheni abantu abadala ngendlela ye-monotherapy noma ngokuhlanganiswa nezinye izidakamizwa zomlomo ze-hypoglycemic noma i-insulin esebenza njalo.
I-Metformin 1000 ingasetshenziswa ekwelapheni isifo sikashukela ezinganeni ezineminyaka engaphezu kwe-10, njenge-ejenti ye-monotherapeutic noma ngokuhlanganiswa nemijovo ye-insulin.
Lapho uthatha umuthi, amaphilisi kufanele agwinywe wonke ngaphandle kokuhlafuna, ngenkathi ukuphuza umuthi kufanele kuhambisane nokuphuza amanzi amaningi. Ukusetshenziswa kwomuthi kufanele kwenziwe ngokushesha ngaphambi noma ngesikhathi sokudla.
Lapho usebenzisa umuthi kubantu abadala ngesikhathi sokwelashwa kwe-mono noma eyinkimbinkimbi, kufanele kulandelwe izincomo ezilandelayo:
- Umthamo wokuqala womuthi othathwe kufanele ungabi ngaphezu kwama-500 mg izikhathi ezingama-2-3 ngosuku. Ngokuzayo, uma kunesidingo, isilinganiso somuthi singalungiswa sibheke phezulu. Umthamo womuthi othathwe kuncike kuzinga lama-carbohydrate asemapulazini egazi lomuntu ophethwe yisifo sikashukela.
- Umthamo wokulungisa umuthi ungama-1500-2000 mg ngosuku. Ukunciphisa ukubakhona kwemiphumela emibi emzimbeni, umthamo wansuku zonke uyanconywa ukuba uhlukaniswe ngemithamo engu-2-3. Umthamo ophelele wansuku zonke ngu-3000 mg ngosuku. Umthamo ophelele kufanele uhlukaniswe ngemithamo engu-2-3 ngosuku.
- I-Metformin 1000 iyanconywa kwiziguli ezinomthamo wansuku zonke wezokwelapha osukela ku-2000-3000 mg ngosuku.
Lapho ushintsha ukuthatha iMetformin 1000, kufanele wenqabe ukuthatha eminye imithi ye-hypoglycemic.
Contraindication kanye nemiphumela emibi
Njenganoma yimuphi omunye umuthi, iMetformin inezimpawu ezithile zokuzisebenzisa.
Ngaphezu kwalokho, lapho unquma umuthi, umuntu kufanele acabangele ukuthi umuntu ovela emiphuzweni emibi angaba khona.
Ngaphambi kokuthi uqale ukusebenzisa umuthi njenge-ejenti yokwelapha, kufanele uthintane nodokotela we-endocrinologist.
I-contraindication ejwayelekile kakhulu yokusebenzisa imi kanje:
- ukuba khona kwe-hypersensitivity ku-metformin hydrochloride noma ezintweni ezisizayo;
- ukuba khona kwezimpawu zokuthuthuka kwe-ketoacidosis yesifo sikashukela;
- ukugula okuthinta ukusebenza kwezinso, ukuba khona kwezifo ezinzima ezithathelanayo;
- izinhlobo ezahlukahlukene zezifo ezikhuthaza ukuba khona kwendlala ye-izicubu zomzimba emzimbeni wesiguli;
- ukwenza ukungenelela kokuhlinzwa lapho kunconywa ukusetshenziswa kwe-insulin therapy;
- ukuphazamiseka ekusebenzeni okujwayelekile kwesibindi;
- ukuba khona kwezidakwa ezingalapheki noma ubuthi obudakayo obukhulu;
- i-lactic acidosis;
- isikhathi sokukhulelwa kwe-intrauterine nesikhathi sokuqunjelwa;
- iminyaka yesineke kuze kufike eminyakeni eyi-10.
Imiphumela emibi eyinhloko lapho usebenzisa iMetformin ukubonakala kokuphazamiseka emgodini wokugaya ukudla, okubonakaliswa ngokuhlanza, isicanucanu nesifo sikashukela, kanye nokwehla kokudla. Esikhunjeni, kuqhamuke ukulunywa. Uma kunezinkinga esibindini, ukukhula kwe-hepatitis kunyamalale emva kokuyekiswa komuthi kungenzeka.
Imininingwane engaphezulu mayelana nesidakamizwa iMetformin ichazwe kuvidiyo kule ndatshana.
