Ungasisebenzisa kanjani isidakamizwa i-Amaryl M?

I-Amaryl M - indlela yokwehlisa ushukela wegazi. Umuthi unomsebenzi we-extrapancreatic, uthuthukisa ukugcinwa kwe-insulin. Yabela iziguli ezinesifo sikashukela sohlobo 2 esihambisana nokudla nendlela yokuphila esebenzayo.

Igama Lezwe elingafanele

I-Glimepiride + Metformin.

I-ATX

A10BD02.

Khipha amafomu nokwakheka

Ukukhishwa ifomu - amaphilisi. Izakhi ezisebenzayo ekwakhiweni kwazo ziyi-gliperide ne-metformin kumthamo we-1 mg + 250 mg noma we-2 mg + 500 mg.

I-Amaryl M - indlela yokwehlisa ushukela wegazi.

Isenzo se-Pharmacological

Ithuluzi linomphumela we-hypoglycemic. Ngaphansi kwesenzo sezinto ezisebenzayo, i-insulin ephuma kumaseli we-beta iyakhululwa bese ingena egazini. Izicubu zomzimba ziba buthakathaka kakhulu ku-insulin, inqubo yokwakheka koshukela emikhiqizweni engeyona eye-carbohydrate imisiwe, izinga le-LDL ne-triglycerides liyancipha.

I-Pharmacokinetics

Izifundo ze-Pharmacokinetic zibika 100% ukubopha kwe-glimepiride kumaprotheni e-plasma. Ngokufakwa kanyekanye, ukumunca kwayo kuncipha kancane. Akuqongeleli izicubu, kuthunyelwa esikhunjeni ngokwakhiwa kwama-metabolites ayi-2, okukhishwe ngokusebenzisa amathumbu nomchamo (ngendlela yama-metabolites angasebenzi).

IMetformin isheshe futhi igxile ngokuphelele. Akuhlanganisiwe Ezigulini ezinokwehluleka kwe-renal, zingaqongelela izicubu. Kuyakhishwa emchameni.

Izinkomba zokusetshenziswa

Umuthi unqunyelwe isifo sikashukela sohlobo 2, uma izinga le-glucose lingakwazi ukunakekelwa ezingeni ngosizo lokudla nokuzivocavoca umzimba.

Ifomu lokukhulula lingamathebulethi, izakhi ezisebenzayo ekwakhiweni kwazo ziyi-gliperide ne-metformin kumthamo we-1 mg + 250 mg noma 2 mg + 500 mg.

Contraindication

Ukwemukelwa kwalesi sidakamizwa kuphambene nezimo ezithile kanye nezifo:

• ukwehluleka kwe-renal kanye nokunye ukusebenza kwengqondo okuphazamisekile;
• Isimo esibi sokulimala kwesibindi somsebenzi;
• uphuzo oludakayo;
• isimo ngaphambi kokukhohlisa;
• thayipha i-1 isifo sikashukela;
• i-allergy to sulfonylureas, izingxenye zomuthi noma i-Biguanides, ama-sulfonamides;
• ukwehluleka ukuphefumula;
• isifo sikashukela sikashukela, kanye nesigaba esibuhlungu nesingamahlalakhona se-metabolic acidosis;
• ukwehluleka kwenhliziyo;
• infarction myocardial;
• i-lactic acidosis;
• umkhuhlane
• ukuba khona kwesifo esikhulu;
• ubuthi begazi;
• ukukhubazeka kwemisipha yamathumbu;
• ukucindezelwa ngemuva kokulimala, ukusha, ukusebenza okuyinkimbinkimbi, ukubulawa yindlala;
• ukuvinjwa kwamathumbu;
• isifo sohudo
• ubuthi umzimba ngotshwala;
• ukwephulwa kokuwohloka koshukela obisini;
• iminyaka efinyelela eminyakeni eyi-18;
• galactosemia;
• ukucaphuna nokukhulelwa.

Ukwehluleka kwangempela kanye nokunye ukusebenza kwengqondo okuphazamisekile kungukuphikisana nokuthatha i-Amaril M.

Ukuthatha i-Amaril M kufakwe kubusela obudakayo obungapheli.

Uma kutholwa ukuhluleka kwenhliziyo, ukuthathwa kwe-Amaril M kuyenqatshelwe.

Ngoshevu wegazi, kwenqatshelwe ukuthatha umuthi i-Amaril M.

Thatha amaphilisi ngokuqapha uma kwenzeka umsebenzi we-thyroid uphazamisekile.

Ngesikhathi sokusebenza kanzima, Amaryl M uthathwa ngokuqapha.

Akuphephile ukuthatha i-Amaril M ngokudla okungenamafutha.

Ukwelapha akufanele kuqale ngesikhathi se-hemodialysis.

Ngokunakekela

Kwezinye izimo, ukuthatha amaphilisi ngokuqapha:

• ukudla okungenampilo;
• ukuntuleka kokuzivocavoca umzimba;
• ukungasebenzi kwe-yegilo;
• ukusweleka kwe-glucose-6-phosphate dehydrogenase;
• ukuba khona kwesifo okuxaka inkambo yesifo sikashukela sohlobo 2;
• ukusebenza kanzima.

Ebudaleni, udinga ukuyithatha ngaphansi kokuqondisa udokotela.

Ungamthatha kanjani u-Amaryl M

Umuthi wokulawulwa ngomlomo kufanele uthathwe ngokudla. Ukweqa umthamo akufanele kuholele ekwenyukeni komthamo.

Ngoshukela

Umthamo unqunywa udokotela ngokuya nge-glucose egazini. Thatha isidakamizwa izikhathi ezi-1-2 ngosuku. Umthamo omkhulu ngamaphilisi ama-4 ngosuku.

Imiphumela emibi Amarila M

Umuthi ubekezelelwa kahle, kepha ezimweni ezingandile ungadala imiphumela emibi ezinhlotsheni nasezinhlotsheni ezahlukahlukene.

Ku-mellitus yesifo sikashukela, umthamo unqunywa udokotela ngokuya nge-glucose egazini.

Engxenyeni yezitho zombono

Kukhona ukuwohloka komqondo obonakalayo ngenxa yokushintshashintsha kokugcotshwa kweglucose egazini.

Amapheshana wesisu

Izimpawu ezivela emgudwini wokugaya ukudla: ukulahlekelwa isifiso sokudla, isisu okuxekethile, isicanucanu, ukugabha, izinhlungu esiswini, ukwanda kwerhasi.

Izitho zeHematopoietic

Ukuphuza amaphilisi kungaholela ekukhuleni kwe-pancytopenia (ukwehla kwezakhi ezidingekayo ekugxambeni kwegazi), kanye ne-thrombocytopenia, i-aplastic anemia ne-leukopenia.

Ngasohlangothini lwe-metabolism

Izimpawu zingahle zivele zikhombisa ukwehla kokuxineka kweglucose yegazi: i-migraine, isiyezi, ukujuluka, umfutho wegazi ophakeme, i-tachycardia, ukungavikeleki kwemisipha, ukwethuka, ukunganaki, ukozela.

Kukhona ukuwohloka komqondo obonakalayo ngenxa yokushintshashintsha kokugcotshwa kweglucose egazini.

Izimpawu ezingezinhle ezingaba khona emgudwini wokugaya ukudla: ukulahleka kwesifiso sokudla, izihlalo ezikhululekile, isicanucanu, ukuhlanza.

Ukuphuza amaphilisi kungaholela ekuthuthukisweni kwe-pancytopenia, kanye ne-thrombocytopenia, i-aplastic anemia ne-leukopenia.

Izimpawu zingavela ezikhombisa ukwehla kokuxineka kwegazi glucose: migraine, isiyezi.

Ukujuluka okunamandla kubonisa imiphumela emibi yesidakamizwa i-Amaril M.

Umphumela ongemuhle ongemuhle ungavela ngesimo se-urticaria, rash.

Umuthi ungaholela ekuthuthukisweni kwe-hypoglycemia, ngakho-ke akunconywa ukuphatha izindlela eziyinkimbinkimbi ngesikhathi sokwelapha.

Allergies

Kukhona i-urticaria, ukuqubuka. Ezimweni ezingavamile, lesi simo sihlanganiswa nezinkinga ze-anaphylactic.

Umthelela ekhonweni lokulawula izindlela

Umuthi ungaholela ekuthuthukisweni kwe-hypoglycemia, ngakho-ke akunconywa ukuphatha izindlela eziyinkimbinkimbi ngesikhathi sokwelapha.

Imiyalo ekhethekile

Ngokuhluleka kwe-renal kanye nezifo zesibindi, i-lactic acid inganqwabelana egazini nezicubu (lactic acidosis). Ngokuncipha kwezinga lokushisa lomzimba, ubuhlungu besisu nokufushane komoya, udinga ukuyeka ukuthatha lo muthi. Misa okwesikhashana ukwelashwa ngaphambi kokuhlinzwa.

Ngesikhathi sokwelashwa, kunconywa ukuthi kuqashwe i-glucose egazini ukuvimba ukuthuthukiswa kwe-hypoglycemia. Okubaluleke ngokulinganayo ukulawula kokuhlushwa kwe-hemoglobin, i-creatinine ne-Vitamin B12. Sekela i-glycemia ngokuzivocavoca, ngokudla.

Sebenzisa ebudaleni

Kumele kuqashelwe ukuqapha ukusebenza kwezinso.

Ukunquma i-Amaril M ezinganeni

Ezinganeni ezingaphansi kweminyaka eyi-18 akuvunyelwe.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

It is contraindicated ukuqala ukwelashwa ngesikhathi sokukhulelwa kanye ne-lactation. Ukuncelisa amabele kufanele kumiswe.

Isicelo sokusebenza kokulimala kwezinso

Ekulimazeni okukhulu kwezinso namazinga e-creatinine aphezulu akacacisiwe.

Sebenzisa umsebenzi wesibindi okhubazekile

Kwephulwa okukhulu, ukusebenza kwesibindi akunqunyelwe.

Ebudaleni, u-Amaryl M kufanele athathwe ngaphansi kokuhlolwa udokotela.

Ezinganeni ezingaphansi kweminyaka engu-18 ubudala, ukuthatha i-Amaril M akuvunyelwe.

Kuphikisiwe ukuqala ukwelashwa nomuthi i-Amaril M ngesikhathi sokukhulelwa.

Lapho uthatha i-Amaril M, ukuncelisa amabele kufanele kumiswe.

Ukwephulwa okukhulu kwesibindi, i-Amaryl M ayinqunyelwe.

Ukweqiwa kwe-Amaril M

I-overdose iholela ekuphenduleni okwandayo kanye nokuthuthukiswa kwe-hypoglycemia. Izimpawu ze-hypoglycemia zimiswa ushukela. Ukwelashwa okubonakalayo kuyenziwa.

Ukuxhumana nezinye izidakamizwa

Umuthi uxhumana nezinye izidakamizwa kanjena:

• ukusetshenziswa kanyekanye kwama-inducers noma ama-inhibitors we-CYP2C9, ama-tetracyclines, ama-azapropazone, ama-antimicrobial agents weqembu le-quinolone, i-tritokvalin, ama-inhibitors we-MAO kanye ne-ACE inhibitors, i-fluconazole, i-coumarin anticoagulants, i-phenenecid, i-anabolic steroid, fenfanulinan, isenfululaminene, ianabolulin, fenfaminulin, ianfidulin. i-tritokvalina, i-beta-blockers, i-aminosalicylic acid iholela ekuthuthukisweni kwe-hypoglycemia;
• akunqweneleki ukuhlanganisa ukuphatha nama-x-ray kanye nokusetshenziswa kwezinto eziqukethe iodine;
• i-nifedipine ne-furosemide yandisa ukuqina kwe-Metformin egazini;
• ukuthatha i-histamine H2 receptor blockers, i-clonidine ne-reserpine kungaholela ku-hyperglycemia noma hypoglycemia;
• i-ibuprofen ayithinti imingcele ye-pharmacokinetic;
• ukwehla komphumela we-hypoglycemic kungavela ngaphansi kwethonya le-diuretics, epinephrine, nicotinic acid, acetazolamide, diazoxide, estrogens, rifampicin, barbiturates, sympathomimetics, corticosteroids, laxatives, phenytoin, ama-hormone egilo.

Ngaphezu kwalokho, ukuphathwa kanyekanye nge-glamicin kufanele kugwenywe.

Ukusetshenziswa kanyekanye kwama-inducers noma ama-inhibitors we-CYP2C9, ama-tetracyclines, i-azapropazone kuholela ekwakhiweni kwe-hypoglycemia.

I-Ibuprofen ayithinti imingcele ye-pharmacokinetic.

Kuyinto engathandeki ukuhlanganisa ukuphathwa kwama-x-ray kanye nokusetshenziswa kwezinto eziqukethe iodine.

Ngenxa yengozi ye-hypoglycemia, ukusetshenziswa okufana nakho notshwala kuyaphikiswa.

Ukuhambisana notshwala

U-Ethanol uyakwazi ukuqinisa noma enze buthaka umphumela wesidakamizwa. Ngenxa yengozi ye-hypoglycemia, ukusetshenziswa okufana nakho notshwala kuyaphikiswa.

Ama-Analog

Ekhemisi ungathenga ezinye izidakamizwa ze-hypoglycemic ngesakhiwo esihlanganisiwe:

• Ama-Glucovans.
• I-Glimecomb.
• UGalvus Met.

Ngaphambi kokusebenzisa, udinga ukubonana nodokotela ukuvimbela ukwenzeka kwemiphumela emibi.

Imibandela yekhefu lekhemisi

Ikhishwe ngumbhalo.

Ngingakwazi ukuthenga ngaphandle kadokotela

Ungayithenga ngemuva kokwethula incwadi kadokotela evela kudokotela.

Ekhemisi ungathenga ezinye izidakamizwa ze-hypoglycemic ngesakhiwo esihlanganisiwe, isibonelo, amaGlucovans.

Amaryl M Intengo

Izindleko zokufaka zivela kuma-ruble angama-800 kuye kwangama-900.

Izimo zokugcina zomuthi

Gcina amaphilisi asendaweni emnyama emazingeni okushisa aze afike ku- + 25 ° C.

Isikhathi sokuphelelwa yisikhathi

Impilo yeshelf iyiminyaka emithathu.

Umkhiqizi

Handok Pharmaceuticals Co, Ltd., Korea.

Ukubuyekezwa mayelana ne-Amarila M

U-Anna Kazantseva, udokotela wezokwelapha

Umshini wesidakamizwa ukuvala iziteshi ze-potassium futhi uvule iziteshi ze-calcium. Ngasikhathi sinye, i-insulin ikhishwa ngenani elincane kunaphansi kokunye okwenziwe nge-sulfonylurea. Ngakho-ke, ubungozi bokukhula kwe-hypoglycemia buncishisiwe.

Anatoly Romanov, endocrinologist

Izakhi zomuthi zihlangana ngokuphelele nomunye. Impahla ye-hypoglycemic ye-metformin iziveza ngesikhathi sokukhishwa kwe-insulin kumaseli we-beta. I-Metformin ithuthukisa umphumela we-glimepiride futhi iholele ekunciphiseni kwe-cholesterol "embi" egazini kanye ne-triglycerides. Kuyadingeka ukuthatha umuthi ngokuqapha uma kwenzeka ukungasebenzi kahle kwe-yegilo kanye nokuqina kwesibindi.

U-Eugene, oneminyaka engama-38

Ithuluzi lisiza ukulawula amazinga kashukela. Ngiphuza ithebhulethi engu-1 esiswini esingenalutho ekuseni futhi angikwazi ukukhathazeka usuku lonke. Ngashintsha umuthi wokuhlanganisa njengoba kuchazwe ngudokotela. Ngenxa yemiphumela emibi, ngenxa yokushintshashintsha kwe-glucose esegazini, umbono wehla, kwesinye isikhathi ukugabha. Ngokuhamba kwesikhathi, izimpawu zanyamalala. Ngenelisekile ngomphumela futhi ngizoqhubeka nokwelapha.