I-Tegretol CR - umuthi olwa negciwane elidala ovusa umngcele wokulungela ukukholisa, ngaleyo ndlela uvimbele ukwenzeka kokuhlaselwa.
Igama Lezwe elingafanele
Carbamazepine.
I-Tegretol CR - umuthi olwa nama-antiepileptic ovusa umngcele wokulungela ukukhohlisa.
I-ATX
Ikhodi ye-ATX yi-N03AF01.
Khipha amafomu nokwakheka
Umuthi uyatholakala ngesimo samathebhulethi efakiwe. Izibhebhe zine-biconvex oval ukuma.
Okuqukethwe kwezithako okusebenzayo kumathebulethi kungaba ngama-200 mg noma ama-400 mg. Into esebenzayo yi-carbamazepine.
Amaphilisi we-200 mg ayatholakala emaphaketheni ebhokisi wezingcezu ezingama-50. Ngaphakathi kwephakethe lezinhlamvu ezi-5 zezingcezu eziyi-10.
I-400 mg amaphilisi atholakala emaphaketheni wezingcezu ezingama-30. Ngaphakathi kwepaketi 3 amanxeba ezingcezu eziyi-10.
Isenzo se-Pharmacological
I-Carbamazepine iboniswa ukukhululeka kokuquleka okukhohlisayo. Isithako esikhulu esisebenzayo somuthi i-dibenzoazepine derivative. Inomphumela we-antiepileptic kanye ne-neurotropic kanye ne-psychotropic.
Umsebenzi we-pharmacological wesidakamizwa awucwaningwanga ngokuphelele. Kukhona imininingwane yokuthi isakhi esisebenzayo sithinta ulwelwesi lweseli lwama-neurons, sizenze sizingene futhi sivimbele ukwanda ngokweqile. Lokhu kuyenzeka futhi ngenxa yokucindezelwa okusheshayo kwe-neural, ngenxa yokuthi lapho kukhona khona i-hyperactivation of the nerveakhiwo.
Ukusetshenziswa kweTegretol ezigulini ezinesithuthwane kuhambisana nokucindezelwa kwezimpawu zengqondo ezikhiqizayo.
Isakhi esiyinhloko somsebenzi womuthi uvimba ukuvuselelwa kabusha kwama-neurons ngemuva kokudilizwa. Lokhu kungenxa yokuqalwa kokusetshenziswa kweziteshi ze-ion ezihlinzeka ngezithuthi zesodium.
Ucwaningo luye lwabonisa ukuthi ukusetshenziswa kweTegretol ezigulini ezinesithuthwane kuhambisana nokucindezelwa kwezimpawu zengqondo ezikhiqizayo: ukuphazamiseka kwengcindezelo, ulaka nokukhathazeka okukhulayo.
Akunabufakazi obucacile bokuthi i-carbamazepine iyalithinta yini inani lokushintshwa kwama-psychomotor kanye namakhono okuqonda eziguli. Ngenkathi ezinye izifundo, idatha yokuphikisana yatholakala, abanye bakhombisa ukuthi isidakamizwa sithuthukisa amakhono okuqonda.
Umphumela we-neurotropic we-Tegretol ukuvumela ukuthi uyisebenzise ekwelapheni ama-pathologies wezinzwa. Kubekelwe iziguli ezine-neuralgia n. I-trigeminus yokukhululeka kokuhlaselwa kobuhlungu obuvele buvele.
Iziguli ezihoxiswa ngotshwala zinqunyelwe ukunciphisa ubungozi bokubanjwa.
Iziguli ezihoxiswa ngotshwala zinqunyelwe ukunciphisa ubungozi bokubanjwa. Iphinde yehlise ubulukhuni bokubonakaliswa kwe-pathological ye-convulsive syndrome.
Kubantu abanesifo sikashukela i-insipidus, ukusetshenziswa kwalesi sidakamizwa kuyinto ejwayelekile.
Umphumela we-psychotropic we-tegretol usetshenziselwa ukwelapha ukuphazamiseka kwengqondo okuhlobene. Ingasetshenziswa ngokuhlukile futhi ngokuhlanganiswa namanye ama-antipsychotic, ama-antidepressants. Ukucindezela kwezimpawu ze-manic kuchazwa yi-inhibition engenzeka yomsebenzi we-dopamine ne-norepinephrine.
I-Pharmacokinetics
Ukuqunjelwa kwengxenye esebenzayo kwenzeka nge-mucosa yamathumbu. Ukukhishwa kwaso ezibhebheni kuhamba kancane, okuvumela ukusebenza isikhathi eside. Inani eliphakeme lezinto ezisegazini lifinyelelwa cishe amahora angama-24. Iphansi kune-concentration uma uthatha uhlobo olujwayelekile lomuthi.
Ngenxa yokukhishwa okuhamba kancane kwento esebenzayo, ukushintshashintsha kokuhlushwa kwayo ku-plasma akubalulekile. I-bioavailability ye-carbamazepine lapho uthatha amaphilisi akhululiwe wokukhishwa ancishiswa ngo-15%.
Uma ingena egazini, ingxenye esebenzayo ibopha ukuthutha ama-peptide ngo-70-80%. Inqamula kwi-placenta iye kubisi lwebele. Ukuqunjelwa umuthi ekugcineni kungaba ngaphezu kwe-50% yesikhombi esifanayo egazini.
I-bioavailability ye-carbamazepine lapho uthatha amaphilisi akhululiwe wokukhishwa ancishiswa ngo-15%.
I-metabolism yento esebenzayo yenzeka ngaphansi kwethonya lama-enzyme wesibindi. Njengomphumela wokuguqulwa kwamakhemikhali, i-metabolite esebenzayo ye-carbamazepine nesakhiwo sayo esine-glucuronic acid siyakhiwa. Ngaphezu kwalokho, kwakheka inani elincane le-metabolite engasebenzi.
Kukhona indlela ye-metabolic engahlobene ne-cytochrome P450. Ngakho-ke kwenziwa amakhompiyutha e-monohydroxylated we-carbamazepine.
Ukuphila kwesigamu kwengxenye esebenzayo kungamahora ayi-16-36. Kuya ngesikhathi sokwelashwa. Ngokusebenza kwama-enzyme wesibindi ngeminye imithi, ingxenye yempilo ingancishiswa.
I-2/3 yomuthi ikhishwa ezinso, 1/3 - ngamathumbu. Umuthi ucishe uqedwe ngokuphelele ngesimo sama-metabolites.
Izinkomba zokusetshenziswa
Izinkomba zokusetshenziswa kwaleli thuluzi yilezi:
- isithuthwane (sinqunyelwe ukubanjwa okulula nokuxubile nokuhlanganisiwe);
- ukuphazamiseka kwengqondo okuguquguqukayo;
- i-psychic acute manic;
- i-trigeminal neuralgia;
- isifo sikashukela se-neuropathy, sihambisana nobuhlungu;
- isifo sikashukela i-insipidus esine-diuresis ne-polydipsia.
Contraindication
Ukusetshenziswa kweTegretol kufakwe emacaleni alandelayo:
- hypersensitivity yomuntu ngamunye kulokho okusebenzayo noma ezinye izinto zomuthi;
- i-atrioventricular block;
- i-syndrome yokuhoxiswa kotshwala;
- ukwephulwa komsebenzi we-hematopoietic womongo wamathambo;
- i-porphyria eyenzeka njalo;
- inhlanganisela yomuthi ne-monoamine oxidase inhibitors.
Ungayithatha kanjani i-Tegretol CR
Ukudla akukuphazamisi ukusebenza komuthi. Ithebhulethi lithathwa ligcwele futhi ligezwe ngenani lamanzi elidingakalayo.
I-Monotherapy ene-Tegretol kungenzeka, kanye nokuhlanganiswa kwayo namanye ama-ejenti.
Uhlobo olusetshenziselwa umuthi luhlinzeka ngokuphathwa kwezikhathi ezibhebheni zamathebulethi. Ngenxa yemithelela yemithi yesidakamizwa ngomphumela wesikhathi eside, kungakhuphuka umthamo wansuku zonke.
Ithebhulethi lithathwa ligcwele futhi ligezwe ngenani lamanzi elidingakalayo.
Abantu abanesifo sokuwa banconywa i-tegretol monotherapy. Okokuqala, kunqunywa imithamo ephansi, okuthi kancane kancane ikhuphuke ibejwayelekile. Umthamo wokuqala ophakanyisiwe wezidakamizwa ngu-100 mg 1 noma izikhathi ezi-2 ngosuku. Umthamo owodwa ofanele ungama-400 mg izikhathi ezingama-2-3 ngosuku. Kwezinye izimo, ungadinga ukwandisa umthamo wansuku zonke ukuya ku-2000 mg.
Nge-neuralgia n. I-trigeminus umthamo wokuqala wansuku zonke ufike ku-400 mg. Ukunyuka okwengeziwe kuya ku-600-800 mg. Iziguli esezikhulile zithola u-200 mg wesidakamizwa ngosuku.
Abantu abahoxisa utshwala banqunywe ukusuka ku-600 kuye ku-1200 mg / ngosuku. Ezibonakalweni zokuhoxa kanzima, umuthi uhlanganiswa nemithi yokwelapha.
Iziguli ezine-psychic manic psychosis zinqunywe kusuka ku-400 kuye ku-1600 mg weTegretol ngosuku. Ukwelapha kuqala ngemithamo ephansi, ekhula kancane kancane.
Ngoshukela
I-Carbamazepine iboniswa kwiziguli ezinesifo sikashukela se-neuropathy. Umuthi uvimba izinhlungu ezenzeka ngenxa yokushintshwa kwe-metabolic izicubu zezinzwa. Umthamo wansuku zonke onconywayo we-neuropathy yesifo sikashukela ngu-400 kuya ku-800 mg.
I-Carbamazepine iboniswa kwiziguli ezinesifo sikashukela se-neuropathy.
Imiphumela emibi yeTegretol CR
Engxenyeni yesitho sombono
Kungenzeka:
- ukuphazamiseka kokubona ukunambitheka;
- ukuvuvukala kwe-conjunctival;
- tinnitus;
- hypo-hyperacusia;
- ukugcwala kwamalensi.
Kusuka ezicutshini zemisipha
Ukuphendula okulandelayo okungenzekayo kungenzeka:
- Ubuhlungu bemisipha
- izinhlungu ezihlangene.
Amapheshana wesisu
Ukuvela kokuvela okungathandeki okunokwenzeka kungenzeka:
- isicanucanu
- ukuhlanza
- ukuvuvukala kolwelwesi lwe-mucous lomlomo;
- ushintsho esimweni sesihlalo;
- ukuvuvukala kwamanyikwe;
- ushintsho kuzinga lomsebenzi wama-enzyme wesibindi.
Izitho zeHematopoietic
Bangaphendula ekwelashweni ngokubonakala kokuthi:
- i-leukopenia;
- i-thrombocytopenia;
- i-agranulocytosis;
- i-anemia
- ukunciphisa amazinga we-folic acid.
Izitho zeHematopoietic zingase ziphendule ekwelashweni nge-thrombocytopenia.
Isistimu yezinzwa ephakathi
Kwangathi kungaphendulwa ekwelashweni ngokuphendula okulandelayo okulandelayo:
- Isiyezi
- ikhanda
- i-peripheral neuropathy;
- paresis;
- ukukhubazeka kwenkulumo;
- ubuthakathaka bemisipha;
- ukozela
- i-hallucinatory syndrome;
- ukukhuphuka kokukhathazeka;
- ukuphazamiseka komoya okucindezelayo;
- umbono ophindwe kabili
- ukuphazamiseka kokunyakaza;
- ukuphazamiseka kwemizwa;
- ukukhathala.
Isistimu yezinzwa ephakathi nendawo ingaphendula ekwelashweni ngokubona okuphindwe kabili.
Kusuka ohlelweni lomchamo
Kungabonakala:
- i-jade;
- i-polakiuria;
- ukugcinwa komchamo.
Kusuka ohlelweni lokuphefumula
Ukuvela okungenzeka:
- ukuphefumula
- inyumoniya.
Engxenyeni yesikhumba
Kungabonakala:
- i-photosensitivity;
- dermatitis;
- ukulunywa
- i-erythema;
- i-hirsutism;
- i-pigmentation;
- imishayo;
- hyperhidrosis.
Kusuka ohlelweni lwezitho zofuzo
Ukungabi namandla okwesikhashana kungenzeka.
Ukusuka ohlelweni lwezitho zofuzo, ukuvela kwesikhashana kungenzeka.
Kusuka ohlelweni lwezinhliziyo
Kungenzeka:
- i-atrioventricular block;
- arrhythmia;
- ukwehla kwenhliziyo;
- ukwanda kwezimpawu zesifo senhliziyo ezi-coronary.
Uhlelo lwe-Endocrine
Ukubonakala okungenzeka:
- ukudumba;
- gynecomastia;
- i-hyperprolactinemia;
- i-hypothyroidism.
Ngasohlangothini lwe-metabolism
Kungenzeka:
- i-hyponatremia;
- triglycerides ephakeme;
- ukwanda kokuhlushwa kwe-cholesterol.
Allergies
Ukubonakala okungenzeka:
- ukusabela kwe-hypersensitivity;
- i-lymphadenopathy;
- umkhuhlane
- i-angioedema;
- i-aseptic meningitis.
Ngokuthatha i-Tegretol CR njengemphumela wecala, isiguli singakwazi ukubona umkhuhlane.
Umthelela ekhonweni lokulawula izindlela
Imisebenzi engaba yingozi ehlobene nokugxila okwengeziwe kokunakwa kufanele igwenywe ngenkathi kuthathwa i-carbamazepine. Lokhu kungenxa yokwenzeka kwemiphumela emibi evela ohlelweni lwezinzwa.
Imiyalo ekhethekile
Sebenzisa ebudaleni
Kwezinye izimo, ukulungiswa komthamo wansuku zonke kungadingeka.
Isabelo sezingane
Umuthi ungabekelwa izingane. Imithamo yansuku zonke isukela ku-200-1000 mg, kuya ngeminyaka nangesisindo sesiguli. Lapho unquma umuthi, izingane ezineminyaka engaphansi kwemithathu zinconywa ukuba zikhethe umuthi ngendlela yesiraphu.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukwelapha nge-carbamazepine ngesikhathi sokukhulelwa kufanele kwenziwe ngokuqapha ngokweqile. Khumbula ukuthi i-tegretol ingakhulisa ukushoda kwe-Vitamin B12 kwabesifazane abakhulelwe.
Lapho uphatha umama ongumhlengikazi nge-carbamazepine, kufanele ukwedlulisele ingane ekudla okungenamsoco. Ukondla okuqhubekayo kungenzeka ngokuqapha njalo udokotela wezingane. Uma ingane iba nemiphumela emibi, ukondla kufanele kuyekwe.
Isicelo sokusebenza kokulimala kwezinso
Yabela i-Tagretol ngemuva kokuhlola umsebenzi wezinso. Akunconyelwe ukusebenzisa umuthi ezigulini ezine-dnessfunction ezinzima.
Yabela i-Tagretol ngemuva kokuhlola umsebenzi wezinso.
Sebenzisa umsebenzi wesibindi okhubazekile
Umlando wesifo sesibindi uyisizathu sokuqapha lapho uphuza umuthi. Ukuqashwa ngezikhathi ezithile kokusebenza kwesibindi kuyadingeka ukuvikela ukuqhubeka kwezifo zipheshana le-hepatobiliary.
Ukweqisa kweTegretol CR
Ngenxa yokwanda ngokweqile kwe-carbamazepine, izimpawu ze-pathological zenzeka engxenyeni yesistimu yezinzwa, ukucindezelwa kokuphefumula kanye nokusebenza kwenhliziyo. I-Vomiting, i-anuria, ukuvimbela okujwayelekile nakho kuvela.
Izimpawu ze-overdose zimiswa ngokugeza isisu nokusebenzisa izangoma. Ukwelashwa kufanele kwenziwe esibhedlela. Ukwelashwa okubonakalayo, ukuqapha umsebenzi wezinhliziyo kukhonjisiwe.
Ukuxhumana nezinye izidakamizwa
Lapho i-Tegretol ihlanganiswa namanye ama-ejenti aguqula izinga lomsebenzi we-CYP3A4 isoenzyme, ukugcwala kwe-carbamazepine ekushintsheni kwegazi. Lokhu kungadala ukwehla kokusebenza kahle kokwelashwa. Ukuhlanganiswa okunjalo kwemithi kungadinga ukulungiswa komthamo.
Yehlisa ukuhlangana kwento esebenzayo ngokuhlanganiswa ne-phenobarbital.
Ama-Macrolides, ama-azoles, ama-histamine receptor blockers, izidakamizwa zokwelashwa kwe-retroviral zingakhulisa ukugcwala kwento esebenzayo egazini.
Inhlanganisela ene-phenobarbital, i-valproic acid, i-rifampicin, i-felbamate, i-clonazepam, i-theophylline, njll., Inciphisa ukuqoqwa kwento esebenzayo.
Ukuphathwa kanyekanye kwezidakamizwa ezithile kudinga ukulungiswa kwemithamo yazo: ama-anticepressants ama-tricyclic, ama-corticosteroids, ama-proteinase inhibitors, ama-calcium blockers, ama-estrogens, ama-antiviral agents, izidakamizwa ze-antifungal.
Ukuhlanganiswa namanye ama-diuretics kuholela ekunciphiseni kokuhlushwa kwe-plasma ye-sodium. I-Carbamazepine inganciphisa ukusebenza kwezokwelapha ngokuvuselela izicubu kwemisipha engacwasi.
Ukusetshenziswa okuvumelanayo nezindlela zokuvimbela inzalo ngomlomo kungadala ukopha kowesifazane.
Ukuhambisana notshwala
Akunconyelwe ukuthi kudle noma yiluphi uhlobo lotshwala ngesikhathi sokusetshenziswa kweTegretol.
Ama-Analog
Ama-analoggs aleli thuluzi yilawa:
- IFinlepsin Buyisela;
- I-Finlepsin;
- Carbamazepine.
Enye yezimpawu zesidakamizwa nguFinlepsin Retard.
Umehluko phakathi kweTegretol neTegretol CR
Lesi sidakamizwa sehluke ku-Tegretol ejwayelekile ngesikhathi sokukhishwa kwe-carbamazepine. Amathebulethi abe nomphumela wesikhathi eside.
Imibandela yekhefu lekhemisi
Umuthi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela
Cha.
Intengo
Kuya ngendawo yokuthenga.
Izimo zokugcina zomuthi
Kufanele igcinwe endaweni eyomile emazingeni okushisa angadluli + 25 ° C.
Isikhathi sokuphelelwa yisikhathi
Ngokuya ngezimo zesitoreji, impilo yeshelufu yiminyaka emi-3 ukusuka ngosuku lokukhipha.
Umkhiqizi
Umuthi wenziwa nguNovartis Pharma.
Ukubuyekezwa
U-Artem, oneminyaka engama-32, Kislovodsk
I-Tegretol isidakamizwa esihle esisiza ukubhekana nokuquleka. Ukuqala ukuthatha leli khambi, ngithole nethuba lokuphila impilo ejwayelekile. Amathebulethi abhekana nokubanjwa okuncane nokukhulu. Angibonanga imiphumela emibi ngesikhathi sokufaka isicelo. Ngeluleka wonke umuntu onesifo sokuwa.
UNina, oneminyaka engama-45, eMoscow
Usebenzise leli thuluzi ngonyaka owedlule. Izidakamizwa ezindala ze-antiepileptic zaba umlutha, udokotela wanquma iTegretol njengeyona esikhundleni sayo. Ngiphuze amaphilisi cishe amasonto amabili. Ngemuva kwalokho kwavela izinkinga. Isicanucanu nokuhlanza kwavela. Impilo yami yayisiba mibi, ngikhathazekile ngesiyezi. Kwakufanele ngiphinde ngiye kudokotela. Wenza lokho kuhlaziya. Umuthi wabangela ukusabela kwe-hematological: i-anemia ne-thrombocytopenia ithuthukisiwe. Kwadingeka ngishintshe umuthi ngokushesha.
UCyril, oneminyaka engama-28 ubudala, uKursk
Udokotela wanquma lesi sidakamizwa ngokuhlanganiswa namanye ekwelapheni i-negegia ye-trigeminal. Angazi ukuthi iTegretol noma ezinye izidakamizwa zisizile, kodwa izimpawu zanyamalala. Ukuhlaselwa kobuhlungu kwaqala ukukhathazeka kancane. Nakulokhu futhi ngangikwazi ukulala nokudla okujwayelekile. Ngingasincoma lesi sidakamizwa kunoma ngubani oye wahlangabezana nezinkinga ezifanayo.
