I-Protafan NM yindlela yeziguli ezikwazi ngayo ukuqeda ushukela, okungukuthi, ingeyoqembu lezidakamizwa ze-hypoglycemic.
Igama Lezwe elingafanele
I-Isulin insulin (ubunjiniyela bofuzo). Igama lesi Latin: Protaphane.
I-ATX
A10AC01.
Khipha amafomu nokwakheka
Umuthi uyatholakala ngegama elicacisiwe negama elithi Penfill. Umehluko ukuthi izinhlobonhlobo zesibili zibekwa kumakhadibhodi, kanti ezokuqala ebhodleleni, okungukuthi, zinokufakwa okuhlukile. Ibhodlela eli-1 liqukethe umuthi ongu-10 ml wesidakamizwa, esifana ne-1000 IU. Ebhokisini elilodwa, i-3 ml yesidakamizwa (300 IU). Ku-1 ml yokumiswa kokuphathwa kwe-subcutaneous kuqukethe i-100 IU ye-insulin-isophan, okuyiwona osebenzayo.
Ku-1 ml yokumiswa kokuphathwa kwe-subcutaneous kuqukethe i-100 IU ye-insulin-isophan, okuyiwona osebenzayo.
Isenzo se-Pharmacological
Umuthi osebenzayo wakhiqizwa kusetshenziswa kabusha i-biotechnology ye-DNA. Ngenxa yokuxhumana ne-receptor ethile yolwelwesi lwangaphandle lweseli nokwakheka kwenkimbinkimbi, iba namandla okuvuselela izinqubo ezithile ngaphakathi kweseli, okubandakanya nokukhiqizwa kwama-enzyme abaluleke kakhulu.
Izinga le-glucose egazini liyancipha ngenxa yokuthi isibindi siqala ukulikhiqiza ngamanani amancane futhi iqiniso lokuthi lifakwa yizicubu ngezinga elikhulu. Izici ezithonya izinga lokuthathwa kwe-insulin ngumzimba womuntu zihlukile futhi zifaka indawo yomjovo, iminyaka yesiguli nezinye izinkomba.
Umuthi ungathinta umzimba emini. Iqala ukusebenza amahora angama-1.5 ngemuva kokuphathwa, ukugxilisa okuphezulu kakhulu egazini kutholakele emahoreni angama-4 ukuya kwengu-12 emva kokuba into esebenzayo ingene emzimbeni.
I-Pharmacokinetics
Ukuthi i-insulin ifakwa ngokuphelele kanjani kuya endaweni lapho kwathathwa khona isinqumo sokuyisebenzisa, kudokotela ophuculwe umuthi. Imijovo ivunyelwe ethangeni, amabhuzu noma isisu.
I-Protafan NM - isiza ukuqeda ushukela, ungoweqembu lezidakamizwa ze-hypoglycemic.
Empeleni akubophele amaprotheni egazi e-plasma. Onke ama-metabolites akhiwa ngenxa yokusabela kokubola awasebenzi. Ingxenye-yokuphila isebangeni kusuka emahoreni amahlanu kuya kwayi-10.
Izinkomba zokusetshenziswa
Isifo sikashukela i-mellitus ukuphela kwesifo esingalashwa ngalo muthi. Kungaba isifo sikashukela 1 noma uhlobo 2 sikashukela.
Contraindication
Musa ukuphatha isiguli ngomuthi lapho kukhona i-hypersensitivity ku-insulin noma i-hypoglycemia.
Ngokunakekela
Uma kwenzeka ukungasebenzi kahle kwe-adrenal gland dysfunction, izifo zesikhumba se-pituitary, gland yegland, ukulungiswa kwamthamo kuyadingeka.
Ungayithatha kanjani i-Protafan NM
Ngoshukela
Isiguli ngasinye kufanele sisebenzise imiyalo ngaphambi kokusebenzisa umkhiqizo. Umuthi wenzelwe ukusetshenziswa komuntu ngamunye. Umthamo kufanele ukhethwe ngokuhlukile esigulini ngasinye ngokususelwa kudatha yelabhorethri.
Umthamo kufanele ukhethwe ngokuhlukile esigulini ngasinye ngokususelwa kudatha yelabhorethri.
Imvamisa, umthamo ubanga kusuka ku-0.3 kuya ku-1 IU nge-1 kg yesisindo seziguli ngosuku. Isidingo se-insulin singase siphakeme ezigulini eziphikiswa ne-insulin. Ngokuvamile kwenzeka ngesikhathi sokuthomba nakubantu abakhuluphele.
Umuthi ungasetshenziswa njenge-monotherapy, kepha kwesinye isikhathi uhlanganiswa ne-insulin esheshayo noma emfushane futhi ngenxa yalokho uyingxenye yokwelashwa okuphelele.
Isingeniso senziwa ikakhulukazi ngokwenziwa esifundeni sowesifazane. Uma isiguli sikhululeke ngokwengeziwe ngemijovo ehlombe, esinqeni noma odongeni lwesisu sangasemva, angakwenza lokho. Kubalulekile ukukhumbula ukuthi umuthi uzodonswa kancane kancane ukusuka ethangeni.
Ungahlali ubeka imijovo endaweni efanayo, ngoba lokhu kungaholela ekubukekeni kwe-lipodystrophies. Musa ukuphatha ukumiswa ngamandla.
Imiphumela emibi yeProtafan NM
Konke ukusabela okungekuhle lapho usebenzisa lo muthi kubhekwa njengokuya ngomthamo. Umphumela omubi ovame kakhulu yi-hypoglycemia. Uma kunzima, ukwehluleka, ukulahlekelwa ukwazi, futhi nokufa kungenzeka.
Ngaphezu kwalokhu kwephula umthetho, ukwephulwa kungahle kwenzeke ekusebenzeni kwezinhlaka zezitho zesiguli. Uma amasosha omzimba ehlupheka, kuqhuma imithambo kanye nezinqe, ukuphefumula okushodayo nokulahlekelwa ukwazi, futhi kungaqhamuka nemizwa yokungajwayelekile.
I-Refractory pathologies, i-neuropathy yangaphakathi, kanye nokuphendula endaweni yomjovo kuba yimiphumela emibi kakhulu. Okuningi kwalokhu kwephulwa kuguqulwa kabusha.
Imiyalo ekhethekile
Sebenzisa ebudaleni
Kubalulekile ukubonisana nochwepheshe ngokuphepha kwezidakamizwa.
Ukuyalela izingane i-Protafan NM ezinganeni
Izingane zingabekwa umuthi, kepha ukuqapha okukhethekile kwesimo sazo ngesikhathi sokwelashwa kufanele kwenziwe.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Uma owesifazane enesifo sikashukela ngaphambi kokuba akhulelwe, futhi ngesikhathi sokuzala kwesibeletho, kufanelekile ukuqhubeka nokwelashwa nomuthi. Lokhu kuyadingeka ngoba iqiniso lokuthi uma kungekho ukwelashwa, impilo ye-fetus ingaba yingozi.
Ngesikhathi sokuqunjelwa, umuthi awubi yingozi enganeni.
Ukweqisa kweProtafan NM
Uma iziguli zinikezwa imithamo ephezulu ye-insulin, lokhu kungadala ukubonakala kwe-hypoglycemia. Uma izinga lokuphazamiseka okunjalo lithambile, isiguli sidinga ukudla ushukela noma yikuphi ukudla okugcwele ama-carbohydrate. Kepha uma isimo sikwazile ukukhula saba sibucayi, kuyadingeka ukwethula isisombululo se-glucagon noma i-dextrose futhi senze ejwayelekile ekudleni.
Ukuxhumana nezinye izidakamizwa
Ama-Reserpine nama-salicylates angakhulisa futhi enze buthaka umphumela wesidakamizwa.
I-cyclophosphamide, i-anabolic steroid, amalungiselelo we-lithium, bromocriptine, i-monoamine oxidase inhibitors ingathuthukisa isenzo sento esebenzayo. I-Clonidine, i-morphine, i-danazole, i-heparin nezindlela zokuvimbela inzalo ngomlomo, i-phenytoin yenza buthaka umsebenzi wesidakamizwa.
Ukuhambisana notshwala
Kungcono ukwenqaba utshwala ngenkathi ukwelashwa kusaqhubeka, ngoba kungandisa umphumela we-insulin.
Ama-Analog
Biosulin N, Insuman Bazal GT.
Imibandela yekhefu lekhemisi
Ngingakwazi ukuthenga ngaphandle kadokotela
Akunakwenzeka lokho, incwadi kadokotela evela kudokotela iyadingeka.
Intengo yeProtafan NM
Kusuka kuma-ruble angama-400.
Izimo zokugcina zomuthi
Emazingeni okushisa ukusuka ku-2 ° C kuya ku-8 ° C
Isikhathi sokuphelelwa yisikhathi
Izinyanga ezingama-30
Umkhiqizi
UNovo Nordisk A / S, uNovo Alla. I-DK-2880 Bugswerd, eDenmark.
I-analogue yesidakamizwa i-Protafan NM ingaba yi-ejenti Biosulin N.
Ukubuyekezwa mayelana ne-Protafan NM
UKarina, oneminyaka engama-38, uRostov-on-Don: "Ngiphathwe ngalesi sidakamizwa kudala kakhulu. Ngincoma kulabo abanesifo sikashukela ngokuzethemba okugcwele. Kucace bha ukuthi awungeke usebenzise umuthi ngaphandle kwemiyalo yezokwelapha, futhi kusatshalaliswa emakhemisi kuphela uma umuthi ovela kudokotela. Kepha kungenzeka futhi kufanelekile ukusebenzisa umkhiqizo ekhaya, ngoba imiyalo enemininingwane inamathiselwe kuyo. "
U-Anton, oneminyaka engama-50, eMoscow: "Ukusetshenziswa kwalesi sidakamizwa kukuvumela ukugcina umzimba usesimweni esizinzile. Akunakwenzeka ukuba ususe ngokuphelele i-pathology okwamanje, kepha kusenethemba lakho. Ukujova kwe-insulin kukuvumela ukugcina ukuhlushwa kwe-glucose kusezingeni elifanele. Ngijwayelwa ngezikhathi ezithile ngudokotela futhi ngiyaneliseka ukuthi "Ngingasebenza ngokuphepha futhi ngiphile. Ngaphandle kwalo muthi, bekungeke kusebenze. Ngakho-ke ngiyakwazi ukumeluleka kuwo wonke umuntu."
UCyril, oneminyaka engama-30 ubudala, uZheleznogorsk: "Banginikeza lo muthi emasontweni ambalwa edlule. Kwakufanele ngibone udokotela ngoba ngaqala ukuba nezimpawu ezifana nesifo sikashukela kudala. Ngacabanga ukuthi nginalesi sifo. Ngemuva kokubonisana nodokotela onguchwepheshe futhi ngaphumelela ekuhlolweni okudingekayo, lokhu kwaqinisekiswa. Udokotela waqinisekisa futhi wathi kungenzeka ukwelapha i-pathology.
Lesi sidakamizwa sinqunyelwe. Ngifaka imijovo ekhaya ngedwa. Lokhu kulula ukukwenza, ngoba ukulungiselela kuhambisana nemiyalo eningilizayo echaza ukulandelana kwezenzo. Ngibona sengathi izimpawu ezingezinhle zihamba. ”
