Umuthi Clopidogrel C3: imiyalo esetshenzisiwe

I-Clopidogrel C3 iyisidakamizwa sesenzo se-antitrobocytic. Kusetshenziswa ekwelapheni izifo zohlelo lwezinhliziyo, olubonakala ngokwakhiwa kweziqalo zegazi.

Igama Lezwe elingafanele

Clopidrogel.

IClopidogrel C3 - isetshenziswa ekwelapheni izifo zezifo zenhliziyo, ezibonakala ngokwakhiwa kweziqalo zegazi.

I-ATX

B01AC04.

Khipha amafomu nokwakheka

Amathebulethi amhlophe apende, apende. Isithako esikhulu esisebenzayo yi-clopidrogel bisulfate. Ithebhulethi elilodwa liqukethe i-75 mg yento esemqoka. Izinto ezengeziwe: isitashi sommbila, i-lactose monohydrate, i-calcium stearate, i-titanium dioxide, i-microcrystalline cellulose.

I-1 carton pack iqukethe ama-1 noma ama-2 amaphakethe we-10.

Isenzo se-Pharmacological

I-metabolite esebenzayo ye-clopidogrel iyi-inhibitor ye-platelet aggregation (ihlanganisa ndawonye amaseli amaningana epuleti, okuholela ekwakhekeni kwe-thrombus), imise. Inomphumela we-coronary dilating effect, okusho ukwanda kwemithambo yegazi ye-coronary, ngaleyo ndlela kwenziwe ngcono ukuhamba kwegazi.

IClopidogrel C3 ine-coronary dilating effect, okusho ukwanda kwemithambo yegazi e-coronary, ethuthukisa ukuhamba kwegazi.

I-Pharmacokinetics

Umuthi udonswa ngokushesha yi-mucous membranes yesistimu yokugaya ukudla. I-metabolism yezakhi zomuthi yenzeka ezicutshini zesibindi. Ukuhoxiswa kwenziwa ngama-50% ngokusebenzisa izinso ngomchamo, cishe ama-46% ashiya umzimba ungene emathunjini unama-ndun.

Izinkomba zokusetshenziswa

Njenge-prophylactic ukuvimbela izinkinga ezimeni ezilandelayo:

• infarction myocardial;
• ischemic stroke;
• i-peripheral artery occlusion;
• i-coronary syndrome;
• angina pectoris.

Umuthi ubekelwe iziguli ezine-fibrillation ye-atrial, lapho kukhona ingozi yokushayeka kwegazi. Ngokuya kobunzima becala lomtholampilo, lisetshenziswa njengesidakamizwa esizimele noma ndawonye ne-acetylsalicylic acid.

Ischemic stroke - isibonakaliso sokusetshenziswa kwomuthi i-Clopidogrel C3.

I-Coronary syndrome - isibonakaliso sokusetshenziswa kwe-clopidogrel C3.

Umuthi ubekelwe ukuvikela izinkinga zokuqalwa kwe-myocardial infarction.

IClopidogrel C3 inconyelwe i-angina pectoris.

Umuthi wenqatshelwe ukuthatha nge-intracranial hemorrhage.

I-Clopidogrel C3 yezidakamizwa ayivunyelwe ukusetshenziswa ekuhlulekeni kwesibindi okunzima.

Umuthi wenqatshelwe ukuthatha nesilonda esihambisana nokutholakala kokopha kwangaphakathi.

Contraindication

Akuvunyelwe ukuthatha ezimeni ezinjalo:

• ukungabekezelelani ngakunye ezingxenyeni ezithile zomuthi;
• ukwehluleka kwesibindi okunzima;
• isilonda, esihambisana nokutholakala kokopha kwangaphakathi;
• intracranial hemorrhage.

Umkhawulo wobudala ungaphansi kweminyaka eyi-18. Umuthi uqukethe i-lactose. Uma isiguli sinokubandakanyeka kokuzala kwe-lactose, kuyenqatshelwe ngokuphelele ukuphuza umuthi (ngenxa yengozi ephezulu kakhulu yokuba nezimpawu eziseceleni).

Ngokunakekela

Kudingeka ukuqapha njalo kwesimo sempilo (ukwenza izivivinyo njalo nokuhlola imingcele yeelebhu) ngesikhathi sokwelashwa nge-clopidogrel C3 ezigulini ezinokuhlonza okulandelayo:

• ubulukhuni obumnene nobulinganiselayo bokuhluleka kwesibindi;
• imisebenzi edlulisiwe;
• ukulimala kwemishini, ukulimala kwezitho zangaphakathi;
• Izifo lapho kunobungozi obukhulu bokuphuma kwegazi.

Ungayithatha kanjani i-clopidogrel C3?

Umyalo unikeza izincomo ezijwayelekile mayelana nemithamo yomuthi. Ezigulini zabantu abadala - 75 mg 1 isikhathi ngosuku. Umuthi ungaphuzwa kungakhathalekile ukuthi udla ini.

Umuthi ungaphuzwa kungakhathalekile ukuthi udla ini.

Ukwelashwa kwe-coronary syndrome, i-angina engazinzile kanye nokuhlaselwa yisifo senhliziyo kufanele kuqalwe ngomthamo owodwa ophakeme wama-300 mg we-clopidogrel. Ngosuku lwesibili nolandelayo lokwelashwa, umthamo ngu-75 mg.

Ngokuphathwa kanyekanye ne-Aspirin, umthamo we-acetylsalicylic acid ngu-100 mg. Imithamo ephezulu ye-Aspirin ingaholela ekopha.

I-infutate ye-myocardial esebenzayo: umthamo wokuqala - ukulayisha okungama-300 mg, bese kuba ngu-75 mg. Inkambo yokwelashwa okungenani inyanga eyi-1.

Ngoshukela

Ukulungiswa kwedosi akudingeki. Umthamo ungama-75 mg ngosuku, inkambo yokwelashwa iyaqhubeka nengozi ephezulu ye-thrombophlebitis.

Imiphumela emibi ye-clopidogrel C3

Imiphumela emibi ejwayelekile ifaka phakathi: izinhlungu esifubeni, izimpawu ezifana nomkhuhlane. Akuvamile: i-bronchospasm, ukuthuthukiswa kokuphazamiseka kwe-anaphylactic.

Engxenyeni yesitho sombono

Akuvamile: hemorrhage ocular, ukuthuthukiswa kwe-conjunctivitis.

Imiphumela emibi ye-clopidogrel C3 ifaka izinhlungu endaweni yesifuba.

Umuthi ungadala i-conjunctivitis.

Ngemuva kokusetshenziswa kwe-clopidogrel C3, kuzovela izimpawu ezifana nesimo somkhuhlane.

Ngokuphikisana nesizinda sokusebenzisa umuthi, i-bronchospasm kungenzeka.

Kwesinye isikhathi, ngemuva kokuthatha amaphilisi, isicanucanu nokuhlanza kungenzeka.

Ukungaphenduki okwanele kulo muthi kungavela njenge-arthritis.

Ukusetshenziswa kwesidakamizwa kungahambisana nokuqhakaza.

Kusuka ezicutshini zemisipha

I-Myalgia, isifo samathambo, i-hemorrhage yemisipha, i-arthralgia.

Amapheshana wesisu

Ukopha okungaphakathi ohlelweni lokugaya ukudla, ukuphazamiseka kwesisu - isisu, izinhlungu esiswini. Okuncane kakhulu: ukukhula kwesilonda esidala kanye ne-gastritis, isicanucanu esivamile nokuhlanza, ukuqhakaza. Akuvamile kakhulu: ukopha kakhulu onobungozi obukhulu bokufa, ukubonakala kwe-pancreatitis, ulcerative noma i-lymphocytic colitis.

Izitho zeHematopoietic

I-Leukopenia, i-thrombocytopenia enzima, isigaba esibi kakhulu se-neutropenia.

Isistimu yezinzwa ephakathi

Akuvamile: ukopha kwe-intracranial, okungaholela ekufeni. Ukulimala kwekhanda ngezikhathi ezithile, isiyezi, ushintsho lokunambitheka.

Uma usebenzisa umuthi, ungahlangabezana nesiyezi.

Ngemuva kokusebenzisa umuthi, kuvame ukuvela ikhanda, okuwuphawu lomthelela omubi.

Engxenyeni yohlelo lokuphefumula, ngemuva kokusebenzisa umuthi, ukopha kwamakhala kuvame ukuvela.

Ngemuva kokuthatha umuthi, i-hematuria ingavela.

Umuthi ungadala ukukhula kwe-leukopenia.

I-Glomerulonephritis imiphumela emibi ye-clopidogrel C3.

Kusuka ohlelweni lomchamo

Ukuthuthukiswa kwe-hematuria, glomerulonephritis, ukwanda kokuhlushwa kwe-creatinine.

Kusuka ohlelweni lokuphefumula

Imvamisa kuba nokopha kwamakhala, ezimweni ezingavamile kakhulu - i-bronchospasm, i-pneumonitis yangaphakathi kwenhliziyo, ukopha emaphashini, ukuvela kwegazi emathebeni.

Engxenyeni yesikhumba

Ukuphendula okuphindaphindiwe okuvela esikhunjeni: ukuphuma kwesikhumba ngaphansi kwesikhumba. Akuvamile: ukuqubuka esikhunjeni, ukulunywa, ukubukeka kwe-purpura. Akuvamile kakhulu: uhlobo lwe-edema ye-angioedema, ukubonakala kwe-urticaria kanye nokuqhuma okungatheni, i-erythema yefomu le-multiform. Amacala angajwayelekile: ukuthuthukiswa kweStevens-Johnson syndrome, i-necrolysis enobuthi, ilayisi elibomvu.

Kusuka ohlelweni lwezitho zofuzo

Akuvamile: hematuria. Akuvamile kakhulu ukubonakala kwe-hypercreatininemia noma i-glomerulonephritis.

Kusuka ohlelweni lwezinhliziyo

Ukuvela kwe-hematomas, kuyaqabukela: ukuphuma kwegazi okuyinkimbinkimbi, ukutholakala kokopha isikhathi eside ngesikhathi sokuhlinzwa, kwehlisa umfutho wegazi.

Lapho usebenzisa i-Clopidogrel C3 yezidakamizwa, ungahlangabezana nokubonakaliswa okubi njengokuncipha komfutho wegazi.

Imiphumela engaphenduki engemihle ngemuva kokusebenzisa umuthi iwukuqhuma esikhunjeni, ukulunywa.

Ukusabela kokungezwani nomuthi kukhonjiswa edema likaQuincke.

Ukuphuza umuthi akusona isithiyo ekushayeleni.

Allergies

Ukuqubuka esikhunjeni, i-edema kaQuincke, ukusabela kohlobo lwe-hematological, ngokwesibonelo, ukubonakala kwe-neutropenia ne-thrombocytopenia.

Umthelela ekhonweni lokulawula izindlela

Umuthi awuthinti ukuhanjiswa kokunakwa kanye nesivinini sokuphendula, noma lo mphumela awubalulekile. Ngakho-ke, ukuthatha umuthi akusona isithiyo sokushayela izimoto nokusebenza ngamasu ayinkimbinkimbi.

Imiyalo ekhethekile

Uma kunesidingo, yenza ukuhlinzwa okuhleliwe, ukuthatha uClopidogrel C3 kufanele kukhanseliwe ngeviki elilodwa ngaphambi kokuhlinzwa okuhleliwe. Uma isiguli sinikezwa noma yimuphi umuthi, kufanele sazise udokotela ukuthi uthatha i-clopidogrel.

Udokotela, lapho enquma umuthi, kufanele achazele isiguli ukuthi noma yikuphi ukopha kuzoyeka isikhathi eside, ngenxa yalokho, noma yikuphi ukubonakaliswa kokuphuma kwe-atypical, isiguli kufanele sithinte isikhungo sezokwelapha ngokushesha.

Ngesikhathi sonke sokwelashwa nge-clopidogrel C3, kuyadingeka ukulawula izinga lamaplatelet.

Ezigulini ezine-pathologies yesibindi ezisebenzisa isikhathi eside i-clopidogrel C3, kunengozi enkulu yokuhlakulela uhlobo lwe-hemorrhagic hlobo diathesis.

Umuthi awukhuthazwanga ukuthi usetshenziswe yiziguli osekudlule izinsuku ezingaphezu kwezingu-7 kuqale i-ischemic stroke. Ezimweni ezingavamile kakhulu, kodwa i-thrombocytopenic purpura iyavela. Isibonakaliso esiseceleni singenzeka ngokusetshenziswa isikhathi eside komuthi, nangemva kokulashwa kwesikhashana.

Ngenxa yezizathu zokuphepha, umuthi awubekelwe abantu abangaphansi kweminyaka eyi-18.

IClopidogrel C3 ayinqunyelwe abesifazane ngesikhathi sokukhulelwa nangesikhathi ukuncelisa.

Lapho usebenzisa umuthi ekwaluphaleni, ukulungiswa komthamo akudingeki.

Uma isiguli siphuthelwe umthamo olandelayo, futhi sekudlule amahora angama-12 seluthathiwe imithamo, imithamo elahlekile ithathwa, umthamo olandelayo uthathwa ngesikhathi esijwayelekile. Uma sekudlule amahora angaphezu kwayi-12, umuthi uthathwa ngesikhathi esijwayelekile, umthamo awuphindwe kabili.

Sebenzisa ebudaleni

Ukulungiswa komthamo akudingeki. Kwi-infutction ye-myocardial ebabayo, kufanelekile ukulahla umthamo wokulayisha wokuqala we-300 mg futhi uthathe umuthi ngokushesha umthamo we-75 mg ngosuku.

Ukunquma uClopidogrel C3 ezinganeni

Izifundo zemitholampilo maqondana nokuphepha kwemithi ezinganeni azenziwanga. Ngenxa yezizathu zokuphepha, uma kucatshangelwa ukuthi kungenzeka kube nezimpawu ezimbi, lo muthi awubekelwe abantu abaneminyaka engaphansi kwengu-18.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Idatha yemitholampilo yokudla kwe-clopidogrel C3 ngabesifazane ngesikhathi sokukhulelwa nangesikhathi sokuncelisa ibele ayitholakali. Kulokhu, umuthi awubekelwe le mikhakha yeziguli.

Sebenzisa umsebenzi wesibindi okhubazekile

Ukulungiswa komthamo ngamunye akudingeki.

Lapho i-aspirin ihlanganiswa ne-clopidogrel C3, kunengozi enkulu yokopha.

Ukuphathwa kanyekanye kwe-clopidogrel C ene-warfarin kukhulisa isikhathi sokuphuma kwegazi namandla alo.

IHeparin ene-clopidogrel ingathathwa, kepha ngokucophelela ngenxa yengozi yokuvula ukopha okuningi.

Ukweqisa kwe-clopidogrel C3

Izimpawu: Ukopha okuhlala isikhathi eside ngokuthuthukiswa kwezinkinga. Lo muthi awunawo i-antidote ethize. Ukwelashwa kuqukethe izindlela zokwelapha zokuyeka ukopha. Ukumisa izibonakaliso zokweqisa futhi yenze isimo sibe singejwayelekile kwesiguli, kuthululelwa inqwaba yeplatelet.

Ukuxhumana nezinye izidakamizwa

Ezinye izinhlanganisela zidinga ukunakekelwa okwengeziwe:

1. Ukusetshenziswa okubonisana neWarfarin kukhulisa isikhathi sokuphuma kwegazi namandla alo.
2. I-Aspirin: Kunengozi enkulu yokopha uma i-acetylsalicylic acid ithathwa ngemithamo ephezulu njenge-antipyretic.
3. IHeparin ene-clopidogrel ingathathwa, kepha ngokucophelela ngenxa yengozi yokuvula ukopha okuningi.
4. Ukulungiselela okuvela eqenjini le-thrombolytics: imvamisa yokuvulwa kwegazi kufana naleyo ebonwa ezigulini ngethamo elilodwa le-clopidogrel.
5. Izidakamizwa ezingezona ezokwehlisa ukuvuvukala: ucwaningo lwezempilo selukhombisile ukuthi ukusetshenziswa kanyekanye kwe-clopidogrel kanye ne-NSAIDs kukhulisa ubungozi bokulahleka kwegazi kwezitho zomzimba ezithweni zamapheshana emathunjini. Akukwaziwa ukuthi ngabe ukuphuma kwegazi ohlelweni lokugaya kungenzeka. Izidakamizwa ezingezona ezokwehlisa ukuvuvukala ezihlanganiswa ne-clopidogrel zithathwa ngokucophelela okukhulu.

Inhlanganisela ephephile ne-clopidogrel Nifedipine, Atenolol, Cimetidine, Phenobarbital, Digoxin, Phenytoin, iqembu lama-calcium blockers.

Ukuhambisana notshwala

Kwenqatshelwe ukuphuza utshwala ngenkathi ulashwa nge-clopidogrel.

Ama-Analog

Izidakamizwa ezingaphansi kwalezi: Plavix, Zilt, Trombo ACC, Atherocard, Float, Lopigrol, Klopilet.

Ungasifaka isidakamizwa umuthi onjenge-Thrombo ACC.

Lowo obambele esikhundleni kungenzeka abe uZake.

Enye indlela, ungakhetha iPlavix.

IKlopilet iyi-analogue ye-clopidogrel C3.

Uma kunesidingo, umuthi ungathathelwa indawo nge-Aterocard.

Ukwakheka okufanayo iLopigrol.

Uyini umehluko phakathi kwe-clopidogrel C3 ne-clopidogrel?

Akukho mehluko phakathi kwezidakamizwa. Lezi izidakamizwa ezimbili ezinokwakheka okufanayo nokufana kwesenzo, ezikhiqizwa yizinkampani ezahlukene zemithi.

Imibandela yekhefu lekhemisi

Umuthi.

Ngingakwazi ukuthenga ngaphandle kadokotela?

Cha.

Intengo ye-clopidogrel C3

Izindleko (iRussia) zivela kuma-ruble angama-400.

Izimo zokugcina zomuthi

Umbuso wokushisa awuphakeme kuno-25 ° C. Endaweni lapho kungekho ukukhanya kwelanga.

Isikhathi sokuphelelwa yisikhathi

Iminyaka emi-2

Umkhiqizi

IRussia, i-Northern Star, i-CJSC.

Ukubuyekezwa mayelana ne-clopidogrel C3

UKsenia, oneminyaka engama-32, uTyumen: "Lesi sidakamizwa esihle. Isifundo seClopidogrel C3 sanikezwa udokotela kugogo wami ngemuva kokuhlaselwa yisifo sokuwa ischemic. Umuthi ubukeka ufana ne-Aspirin ngokwesimo sokwenza kwawo lokho - wenza igazi libe mncane, okunciphisa ingozi yokuqhekeka kwegazi."

U-Andrey, oneminyaka engama-42, u-Astana: "Sekuphele iminyaka engu-3 ngiphatha i-C3 nge-clopidogrel. Nginesifo sikashukela, ngakho-ke amathuba okuba ne-thrombosis asephezulu. Ikhambi elihle. Ngingasho ukuthi liwuthinta kahle wonke umzimba, lithuthukisa ukugeleza kwegazi. Ngiliphuza ngezifundo ezinde eziningana. izinyanga, ngibe sengiphumula bese ngiqala ukuthatha futhi. Iminyaka emibili edlule selokhu ngiqale ukuphuza umuthi wedlulile kalula ngokuya ngempilo kanye nenhlala-kahle jikelele. "

U-Angela, oneminyaka engama-48, uKerch: "Sayibeka uClopidogrel C3 ngemuva kokutholakala kwegazi emzimbeni emlenzeni wesobunxele emthanjeni ophelile. Umlenze wami wangihlukumeza njalo futhi kubi. Lo muthi usanda kungisindisa .Akungekhona ukuthi lobuhlungu buhamba ngokushesha, kepha futhi ngemuva kwesikhashana i-beg yegazi Ixazululwe ngokuphelele, futhi ngacabanga ukuthi ukuhlinzwa kuphela okuzosiza ukuyiqeda. Ikhambi elisebenzayo, okuwukuphela kwento yokuthi ngeke ukwazi ukuyithenga ngaphandle kadokotela, futhi lokhu akuhlale kulula, ngakho-ke bekufanele ngiyithenge ngekusasa. "