Umuthi unqunyelwe ngaphezu komzimba nokudla. Ithuluzi linciphisa ushukela wegazi. Kusetshenziswa ekwelapheni i-mellitus yesifo sikashukela esinga-insulin. Ngohlobo 1 lwesifo sikashukela alunqunywa.
Igama Lezwe elingafanele
I-Repaglinide.
Ukuxilonga kwehlisa ushukela wegazi.
I-ATX
A10BX02.
Khipha amafomu nokwakheka
Umenzi ukhipha umuthi ngendlela yamathebulethi okuphatha ngomlomo. Isithako esisebenzayo siyi-repaglinide enanini le-0.5 mg, 1 mg ne-2 mg. Ukupakisha kuphethe amaphilisi angama-20 noma angama-60.
Isenzo se-Pharmacological
Inomphumela we-hypoglycemic. Ithinta amaseli e-beta esebenzayo esebenzayo. Ivimbela iziteshi ze-potassium futhi ibangele ukuvulwa kweziteshi ze-calcium. Ishukumisa ukukhishwa kwe-insulin.
I-Pharmacokinetics
I-100% ethathwe emgodini wokugaya ukudla. Ibopha amaprotheni ngo-98% futhi isetshenziswa kwisibindi ngokwakhiwa kwama-metabolites angasebenzi. Ngemuva kwemizuzu engama-60, inani eliphakeme kakhulu le-repaglinide eplasma yegazi lifinyelelwa. Kuyakhishwa ku-bile nomchamo ngemuva kwamahora angama-5-6.
Umuthi udonswa 100% emgodini wokugaya ukudla.
Izinkomba zokusetshenziswa
Umuthi we-hypoglycemic unqunyelwe uhlobo 2 lwesifo sikashukela (uma kungenakwenzeka ukulawula izinga likashukela usebenzisa indlela yokuphila esebenzayo kanye nokudla okunempilo).
Contraindication
Akuvunyelwe ukuqala ukwelashwa ngalo muthi ezimweni ezinjalo:
- Uhlobo 1 sikashukela;
- ukukhulelwa
- ukuncelisa;
- ukungezwani komzimba ezakhiweni zomuthi;
- ukwephulwa kwe-carbohydrate metabolism ngenxa yokushoda kwe-insulin (ketoacidosis);
- ikhefana ne-precoma;
- ukuba khona kokutheleleka, ukuhlinzwa kanye nezinye izimo ezidinga ukwelashwa kwe-insulin.
Ezimweni ezimbi kakhulu, ngokusebenza kokuphazamiseka kwesibindi nezinso, i-Diagnlinide ayinqunyelwe.
Ngokunakekela
Ukuqapha ngesikhathi sokwelashwa kuyadingeka ekusebenzeni kahle kwesibindi nezinso (kumnene ukuya kokulinganiselayo), ukwehluleka kwezinso okungamahlalakhona, ukudakwa kanye ne-febrile syndrome.
Ukuhlola uhlobo lomthamo
Thatha umuthi imizuzu engu-15-30 ngaphambi kokudla. Umthamo wokuqala ngu-0.5 mg. A.
Ukwehla kwesisindo
Esikhathini sikashukela, umuthi uboniswa ukunciphisa umzimba kanye nokujwayelekile kwe-metabolism.
Ukwelashwa kwesifo sikashukela
Umthamo ukhethwa ngamunye ngokuya ngezinga loshukela egazini. Uma ngaphambilini belashwa ngemithi ye-hyperglycemia, ungaqala ukuthatha i-1 mg ngosuku. Ukulungiswa kwedose kwenziwa isikhathi esingu-1 ngezinsuku eziyi-7-14. Umthamo omkhulu ngosuku ngu-16 mg.
Thatha umuthi imizuzu engu-15-30 ngaphambi kokudla.
Imiphumela emibi ye-Diagninide
Umuthi uyakwazi ukubanga imiphumela emibi ezinhlotsheni ezahlukahlukene zezinhlelo.
Engxenyeni yesitho sombono
Ukulimazeka okubukwayo kungenzeka.
Kusuka ezicutshini zemisipha
Ayikho idatha enikeziwe.
Amapheshana wesisu
Ukuqunjelwa, inqubo yokugaya edabukisayo, isifo sohudo, nenausea. Ubuhlungu esiswini kungenzeka.
Izitho zeHematopoietic
Umsebenzi wama-enzyme wesibindi awuvamile ukwanda.
Ngenxa yokuthatha umuthi, ukuqunjelwa kwesinye isikhathi kwenzeka.
Isistimu yezinzwa ephakathi
Ukukhathala, ukujuluka, ukuthuthumela kuyabonakala.
Kusuka ohlelweni lomchamo
Ayikho idatha enikeziwe.
Kusuka ohlelweni lokuphefumula
Ayikho idatha enikeziwe.
Kusuka ohlelweni lwezinhliziyo
Umuthi ungadala ukuthuthukiswa kwe-acute coronary syndrome.
Engxenyeni yesibindi ne-biliary
Ukusebenza kwesibindi kukhubazekile.
Ngemuva kokuthatha umuthi, ukusebenza kwesibindi kwesinye isikhathi kuyaphazamiseka.
Ngasohlangothini lwe-metabolism
Ezimweni eziningi, i-hypoglycemia iyakhula (amazinga weglucose ayancipha). Kulokhu, isimo sesiguli sincike kumthamo, ukungena okwengeziwe kwamanye ama-hypoglycemic agents kanye nokudla.
Allergies
Amasosha omzimba abangela i-hypersensitivity (ukulunywa, isikhumba, ukuqubuka).
Umthelela ekhonweni lokulawula izindlela
Umuthi uthinta amandla okugxilisa nokulawula izindlela.
Imiyalo ekhethekile
Ingozi yokukhula kwe-hypoglycemia inyuka ngokungahambisani nokudla, ukuzila ukudla, ukuphuza utshwala kanye nokweqa umthamo ovumelekile. Kuyadingeka ukulawula izinga le-glucose ku-plasma yegazi ngesikhathi sokwelashwa. Ukuqala ngomthamo omncane kuyadingeka ngokweqile ngokomzimba nangokomzwelo.
Ingozi yokuhlakulela i-hypoglycemia inyuka uma ukudla kungalandelwa.
Sebenzisa ebudaleni
Akunalo ulwazi ngokusebenza nokuphepha kwasebekhulile. Iziguli esezikhulile esezineminyaka yobudala engama-75 ziyagqunywa.
Isabelo sezingane
Kuze kube yiminyaka engu-18 ubudala, lo muthi awunqunyelwe.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Abesifazane abakhulelwe kufanele bangaphuzi umuthi. Isikhathi sokwelashwa, kuyadingeka ukuyeka ukuncelisa ibele.
Isicelo sokusebenza kokulimala kwezinso
Iziguli ezinenkinga yezinso ukusebenza kufanele ziqaphele lapho zikhetha umthamo.
Sebenzisa umsebenzi wesibindi okhubazekile
Ezimweni zokulimala okulinganiselayo okulinganiselwe, umuthi kufanele unqunywe ngudokotela. Ezimweni ezinzima, umuthi uvunyelwe.
Iziguli ezinenkinga yezinso ukusebenza kufanele ziqaphele lapho zikhetha umthamo.
Ukweqiwa Kweqile kweDiagninid
Nge-overdose, amadoda nabesifazane bahlakulela i-hypoglycemia. Kulokhu, kuvela izimpawu ezilandelayo:
- ukwanda kwesifiso sokudla;
- i-migraine
- uvalo
- Ukukhathazeka
- umjuluko obandayo;
- isicanucanu
- i-tachycardia;
- ukudideka kokwazi;
- coma.
Uma isimo sinelisekile, thatha ama-carbohydrate. Ezimweni ezimbi kakhulu, isixazululo sikashukela esingu-50% sisebenza ngokuphathwa ngaphakathi.
Ukuxhumana nezinye izidakamizwa
Umuthi uxhumana neminye imithi kanjena:
- umphumela wokuthatha uyathuthukiswa ngenkathi uthatha ama-inhibitors e-ATP, ama-beta-blockers, ama-anticoagulants engaqondile, ama-NSAIDs, i-probenecid, utshwala, ama-anabolic steroid, ama-salicylates, ama-inhibitors we-MAO, ama-sulfonamides;
- Ama-blockers wesiteshi se-calcium, ama-diuretics, ama-corticosteroids, ama-hormone we-thyroid, ama-sympathomimetics, isoniazid, ama-phenothiazines, ama-estrogens ne-phenytoin angawenza buthaka umphumela.
Ukusetshenziswa okubonakalayo kwe-gemfibrozil kuchazwe ngemithetho.
Ungahlanganisa ukwelashwa ne-thiazolidinediones ne-Metformin. Ukusetshenziswa okubonakalayo kwe-gemfibrozil kuchazwe ngemithetho.
Ukuhambisana notshwala
Kuyahlukaniswa ukuphuza utshwala ngesikhathi sokwelashwa.
Ama-Analog
Iziguli zesifo sikashukela sohlobo 2 zingakhetha enye i-ejenti ye-hypoglycemic. Izidakamizwa ezilandelayo ziyafana ukusebenza:
- UGlidiab;
- I-Amaryl;
- I-Attokana;
- IGlucophage;
- Diabetesalong;
- I-Novonorm.
Ngaphambi kokushintsha lo mkhiqizo nge-analogue, kufanele uvakashele udokotela. Uzocacisa umthamo odingekayo, kucatshangelwa isimo sesiguli nezinye izici. Izidakamizwa ziyafakazelwa kwezinye iziguli futhi zingadala ukusabela okungekuhle.
Ngaphambi kokushintsha lo mkhiqizo nge-analogue, kufanele uvakashele udokotela.
Imibandela yekhefu lekhemisi
Uyakhishwa umuthi onikezwa umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ungayithenga kuphela ngomuthi kadokotela wakho.
Intengo ye-Diaglinide
Izindleko ezijwayelekile ngama-ruble angama-300.
Izimo zokugcina zomuthi
Gcina umuthi ephaketheni. Qinisekisa ukuthi amazinga okushisa afinyelela ku- + 25 ° C.
Isikhathi sokuphelelwa yisikhathi
Impilo yeshelf iyiminyaka emi-2.
Umkhiqizi
Isitshalo samakhemikhali nezemithi i-Akrikhin, OJSC (Russia).
Ukubuyekezwa kodokotela
U-Egor Konstantinovich, udokotela wezokwelapha, eMoscow
Ithuluzi lisetshenziselwa uhlobo 2 sikashukela. Kungakapheli imizuzu engama-30 ngemuva kokuthatha iphilisi, kukhona ukwehla ushukela wegazi. Umphumela uhlala isikhathi eside. Umuthi uvimbela ukukhula kwe-hyperglycemia phakathi kokudla.
UMarina Stanislavovna, i-endocrinologist, uZelenograd
Ngokwengeziwe, ungathatha iMetformin nezinye izidakamizwa ze-hyperglycemia. Udinga ukuqala ukuthatha umuthi ngomthamo omncane futhi ubheke njalo ushukela wakho wegazi. Umuthi omuhle, kepha ngaphandle kokuthola udokotela, ungalimaza umzimba.
Ukubuyekezwa kwesifo sikashukela
U-Ana, oneminyaka engama-36, uTuapse
Umuthi obizwa ngokuthi yi-hypoglycemic ngomlomo ubekelwe udokotela ngokungezelela ukwelashwa kokudla. Isimo sempilo sithuthuke imizuzu engama-30 ukuya kwengama-40 ngemuva kokuphathwa. Ngiqale ukuya endlini yangasese kaningi futhi ngome kancane. Ngijabule ngokuthenga.
U-Eugene, oneminyaka engama-45, uTver
Umuthi ongabizi uvimbela ushukela wegazi ophezulu. Uma kuthathwe ngokwemiyalo akubangeli zimpendulo ezingezinhle.
Ukubuyekezwa kokuncipha kwesisindo mayelana ne-Diaglinide
UJulia, oneminyaka engama-28 ubudala, uSmolensk
Wawuthatha lo muthi amasonto ambalwa, kepha wenqaba ukuwusebenzisa ngenxa yokuphendula kabi. Kwakunokwenzeka ukuguqula imetabolism ngokwejwayelekile, ukususa i-2-3 kg. Kusebenza kangcono ukuya kwezemidlalo nokunamathela ekudleni.
