I-Lysinotone esefomini yethebhulethi isetshenziselwa ukwengeza umfutho wegazi uma kwenzeka kuqubuka umunyu osesimweni, ukuvikela inkinga yehypertgency ngendlela engalapheki ye-hypertension.
Igama Lezwe elingafanele
ILisinopril igama lento esebenzayo.
I-Lysinotone esefomini yethebhulethi isetshenziselwa ukwengeza umfutho wegazi.
I-ATX
I-C09AA03 - ikhodi yokuhlukaniswa kwamakhemikhali-okwelapha-amakhemikhali.
Khipha amafomu nokwakheka
Amacwecwe azungezayo ayatholakala emabhulini angama-10 ama-pcs. lilinye. Ukuqanjwa kwethebhulethi eyi-1 kufaka i-5 mg, 10 mg noma 20 mg ye-lisinopril dihydrate.
Isenzo se-Pharmacological
Umuthi ungowezidakamizwa ze-antihypertensive (ACE inhibitor).
Idivaysi yezokwelapha inezakhiwo eziningi eziwusizo:
- Yehlisa ingcindezi emithanjeni yegazi emincane yamaphaphu.
- Kuthuthukisa ukuhamba kwegazi, okunomthelela ekuthuthukisweni kwenhliziyo.
- Ukuguquguquka okuhle kwezimpawu zomtholampilo ku-hypertension kuyabonakala ezinsukwini zokuqala zokwelashwa kwezidakamizwa. Futhi ngokuyeka okubukhali kokuthatha amaphilisi, akukho ukwanda kwengcindezi yegazi, okungabhekwa njengokuphimisiwe.
I-Pharmacokinetics
Ungaphuza lo muthi noma kungakanani isikhathi sokudla, njengoba le nto ayithinti ukusebenza nokusebenza kwe-lysinotone.
Ukuqunjelwa okuphezulu kwento esebenzayo kubonwa ngeplasma yegazi emahoreni angama-5 ngemuva kokuthatha umuthi.
ILisinopril idonswa kusuka ku-rectum iye ekujikelezeni kwe-systemic.
Imikhiqizo yokubola yento esebenzayo emzimbeni ayakhiwa, ngenxa yalokho, isitho esisebenzayo sidalulwa izinso sihlangana nomchamo ngendlela engashintshiwe.
Izinkomba zokusetshenziswa
Umuthi unqunyelwe lokhu kutholwa okulandelayo:
- umfutho wegazi ophakeme (ezimweni eziningi usetshenziswa njengezindlela zokwelapha eziyinkimbinkimbi);
- ukungasebenzi kahle kwe-myocardial;
- i-acute myocardial infarction (sikhuluma ngesikhathi sokuqala).
Contraindication
Awukwazi ukuthatha lesi sidakamizwa phambi kwe-edema kaQuincke emlandweni wezokwelapha, futhi uma kwenzeka ungabekezelelwa into ethile esebenzayo.
Nge-stenosis yangaphakathi kwezwe, ukuthatha lo muthi nakho kuphambene.
Ungayithatha kanjani i-lisinotone
Umuthi usetshenziselwa ukusetshenziswa komlomo.
Kubalulekile ukucabanga ngezinto eziningi ezinjalo:
- Ngomfutho wegazi ophakeme, iziguli zithatha u-0.005 g ngosuku. Uma ungekho umphumela wokwelapha, umthamo wokuqala ukhuphuka njalo ezinsukwini ezi-3 ngu-0.005 g, kepha ungabi ngaphezu kwama-20 mg ngosuku.
- Uma kungekho kuthuthukisa ngemuva kwezinsuku eziyi-14-20, khona-ke ukwelashwa kuyangezelelwa ngokuthatha ezinye izidakamizwa ze-antihypertensive.
- Ngomfutho ophikelelayo we-arterial hypertension, ukwelashwa isikhathi eside ngomuthi ku-10 mg ngosuku kuyadingeka.
- Kwi-infutction ebabayo ye-myocardial, amaphilisi athathwa izinyanga ezimbili.
Umuthi usetshenziselwa ukusetshenziswa komlomo.
Ngoshukela
Umuthi awuthinti ukuhlangana kwe-glucose egazini, ngakho-ke ukuthatha amaphilisi akuvimbi ukuthuthukiswa kwe-hypoglycemia. Kepha kungenzeka ukuthi igazi liqukethe imikhiqizo ye-nitrogenous metabolic excreated yizinso (azotemia).
Imiphumela emibi
Umuthi ubangela imiphumela eminingi engathandeki yomzimba.
Amapheshana wesisu
Ezimweni ezingavamile, iziguli zinenkinga yesitulo. Izindebe zomlomo ezomile nezinguquko zokunambitha zivamile. IHepatitis kanye ne-jaundice kukhula kwesinye isikhathi.
Izitho zeHematopoietic
Kunokwehla kwezinga lama-leukocytes namaplatelet egazini.
Umuthi ungadala ukuncipha kwamaseli egazi amhlophe namaplatelethi egazini.
Isistimu yezinzwa ephakathi
Ubuhlungu obukhulu bekhanda nesiyezi kungenzeka. Inothi leziguli likhuphuka ukukhathala, isifiso sokulala njalo, kanye nokwehla kwemizwa. Amadoda ajwayele ukuthola ukungasebenzi kahle kwe-erectile futhi anciphise isifiso sobulili.
Kusuka ohlelweni lwezinhliziyo
Iziguli azivami ukuzwa izinhlungu ezinzima endaweni yesifuba, umfutho wegazi wazo uyancipha, futhi nenhliziyo yazo iyanda.
Kwesinye isikhathi i-cerebrovascular stroke iba kubantu abane-hypertension engamahlalakhona.
Kusuka ezicutshini zemisipha
Imvamisa kuba nezikhwebu emisipha nobuhlungu emuva.
Kusuka ohlelweni lokuphefumula
Kunezimo ezivame kakhulu zokukhwehlela komile.
Ngemuva kokuthatha umuthi, amacala okukhwehlela owomile akujwayelekile.
Kusuka ohlelweni lwezitho zofuzo
Ukungasebenzi kahle kwe-renal akuvamile ukubonwa.
Kusuka emasosheni omzimba
Ukuvuvukala kobuso, nekhala, ne-larynx akuvamile ukubonwa.
Allergies
Mhlawumbe ukujuluka okwandayo nokubonakala kokuqhuma kwesikhumba esikhumbeni (urticaria).
Umthelela ekhonweni lokulawula izindlela
Phakathi kwemiphumela emibi, isiyezi kuyabonakala, ngakho-ke kunobungozi obukhulu bokulahlekelwa ukulawula ukushayela.
Imiyalo ekhethekile
Kubalulekile ukubonana nodokotela ngaphambi kokuqala ukwelashwa nge-lisinotone.
Sebenzisa ebudaleni
Kukhona ukubambezeleka kokuqothulwa kwento esebenzayo, okuholela ekunciphiseni komfutho wegazi.
Kubalulekile ukubonana nodokotela ngaphambi kokuqala ukwelashwa nge-lisinotone.
Isabelo sezingane
Kuze kube iminyaka engu-18, ukuthatha amaphilisi kubekwe ku-contraindified.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Into esebenzayo iwela isithiyo se-placental, ngakho-ke awukwazi ukusebenzisa umuthi kunoma iyiphi i-trimester. Kwabasanda kuzalwa ababevezwe ama-inhibitors e-ACE esiteji sokuthuthukiswa kwe-intrauterine, kunconywa ukusungula ukuqapha ukuze kutholakale ngesikhathi esifanele i-oliguria (kunciphisa inani lomchamo ochithiwe).
Ngesikhathi sokuncelisa, futhi akunconywa ukwenza ukwelashwa nge-lisinotone.
Isicelo sokusebenza kokulimala kwezinso
Ukwehluleka kwezinso okubangelwa ukuncipha kwe-lumen ye-artery ehambisa izinso, kuyadingeka ukulawula ukuhlangana kwe-potassium egazini.
Sebenzisa umsebenzi wesibindi okhubazekile
Ukulungiswa komthamo wokuqala kuyadingeka kwiziguli ezinokuqina kwesibindi.
Ukweqisa
Uma umthamo onconyiwe udluliwe, kuboniswa izimpawu ezilandelayo zokubonisa:
- ukugcinwa komchamo;
- izinga eliphakeme lokungabekezeleleki;
- ukuqunjelwa.
Uma umthamo onconywe udokotela udluliwe, ukugcinwa komchamo kuyabonakala.
Kunconywa ukubuyisa ibhalansi yama-electrolyte, bese kusetshenziswa ukudayela ukukhipha i-lisinopril emzimbeni.
Ukuxhumana nezinye izidakamizwa
Kubalulekile ukucubungula okulandelayo:
- Ngokuphathwa kanyekanye kwama-diuretics, ukumbiwa kwe-potassium kuyancipha.
- Ngokusetshenziswa okuhlangene kwe-lisinotone ne-indomethacin, ukusebenza kwe-lisinopril kuyancishiswa.
- Endabeni yokusetshenziswa kanyekanye kwama-antacid, ukumunzwa kwengxenye esebenzayo yeLysinotone kusuka emgodini we-gastrointestinal worsensens.
Ukuhambisana notshwala
I-Ethanol ithuthukisa isenzo sento esebenzayo.
Ama-Analog
Ukusetshenziswa kwe-lisinotone N. kuyanconywa. Umuthi uyinhlanganisela ye-lisinopril (10 mg noma 20 mg) ne-hydrochlorothiazide (12.5 mg).
I-Lysinotone H inomphumela wokugaya nokuqina ngasikhathi sinye.
Leli thuluzi linomphumela wokugaya nokuqina ngasikhathi sinye.
Izimo zeholide zeLysinotone kusuka ekhemisi
Ezimweni eziningi, umuthi kadokotela uyadingeka.
Ngingakwazi ukuthenga ngaphandle kadokotela
Kumakhemisi amaningi eRussia, lesi sidakamizwa siyathengiswa.
Intengo yeLysinotone
Izindleko zomuthi ziyehluka kusuka kuma-ruble ayi-120 kuya kwangama-200.
Izimo zokugcina zomuthi
Kubalulekile ukugcina umkhiqizo endaweni emnyama futhi epholile.
Isikhathi sokuphelelwa yisikhathi
Sebenzisa amaphilisi weminyaka engu-3 kusukela ngosuku lokukhiqizwa.
Into esebenzayo iwela isithiyo se-placental, ngakho-ke awukwazi ukusebenzisa umuthi kunoma iyiphi i-trimester.
Umenzi weLysinotone
Umuthi ukhiqizwa e-Iceland yinkampani yemithi i-Actavis.
Ukubuyekezwa kodokotela mayelana neLysinotone
UNikolay, oneminyaka engama-38, eMoscow
Ukwelashwa kwe-Inhibitor kukuvumela ukuthi uzuze umphumela omuhle ngesikhathi esifushane. Kepha waphawula imiphumela eminingi emibi evela ohlelweni lwe-urinal (ukugcinwa komchamo).
UMikhail, oneminyaka engama-47, eSt
Njengezici zokwelapha zalo muthi. Ingxenye esebenzayo isekela umsebenzi wenhliziyo ngokumelene nesizinda somfutho wegazi ophakeme, kepha inkambo ende yokwelashwa iyadingeka.
Ukubuyekezwa kweziguli
UMarina, oneminyaka engama-50, u-Omsk
Ingcindezi ibuyele kwesejwayelekile emuva kweviki lokuphuza amaphilisi, kepha isimo somngane wakhe saba sibi. Ayikho imiphumela emibi. Umlomo owomile wawusukhona ngosuku lwe-2 lokusetshenziswa kwe-lysinotone. Ngincoma ukuthi ngiqale ngibonisane nodokotela.
U-Elena, oneminyaka engama-43, u-Ufa
Ubhekene nesiyezi ezinsukwini zokuqala zokuphuza umuthi. Udokotela ukhansele umuthi. Kepha ngezwa ukuthi kubantu abaningi, amaphilisi asiza ukubhekana nenkinga yomfutho wegazi ophezulu ekuhlulekeni kwenhliziyo okungapheli.
