Umuthi i-Thrombomag: imiyalo yokusebenzisa

I-Thrombomag - isidakamizwa seqembu le-NSAID, sibonisa umphumela we-antiplatelet. Ngenxa yalokhu, ubungozi bokuthola izinkinga obangelwa ukwakheka kwezihibe zegazi buncishisiwe. Ngaphezu kwalokho, umuthi ukhombisa ezinye izakhiwo, ikakhulukazi, zisiza ukuqeda ukuvuvukala.

Igama Lezwe elingafanele

Acetylsalicylic acid + Magnesium hydroxide

I-Thrombomag - isidakamizwa seqembu le-NSAID, sibonisa umphumela we-antiplatelet.

I-ATX

B01AC30

Khipha amafomu nokwakheka

Umuthi ungathengwa kuphela ngefomu lepilisi. Umelela iqembu lamathuluzi wezinto ezimbili. Umsebenzi wokubonisa amakhompiyutha uboniswa ngezakhiwo ezahlukahlukene. Njengoba izinto ezisebenzayo yilezi:

• i-acetylsalicylic acid;
• i-magnesium hydroxide.

Amathebulethi aqukethe inani elihlukile lalezi zinto. Isibonelo, umthamo we-ASA ngu-0.75 no-0.15 g. Magnesium chloride itholakala kwithebhulethi elingu-15.2 no-30.39 mg. Amacwecwe ahlanganiswa, kepha ngokungafani nama-analogues, avunyelwe ukuwagaya ngaphambi kokuthatha. Ngaphezu kwalokho, izakhi ze-Thrombomag zifaka phakathi izinto ezingakhombisi umsebenzi wokulwa nokuhlangana nokuhlukumeza:

• isitashi sommbila;
• isitashi samazambane;
• i-microcrystalline cellulose;
• i-citric acid;
• i-magnesium stearate.

Umuthi unikezwa emaphaketheni (ama-3 nama-10 ama-pcs.), Ngalinye liqukethe amaphilisi ayi-10.

Umuthi ungathengwa kuphela ngefomu lepilisi.

Isenzo se-Pharmacological

Injongo eyinhloko yesidakamizwa ukuvimbela ukukhiqizwa kwe-thromboxane A2. Lo mphumela utholakala ngokuvimbela ukuhlanganiswa kwe-COX-1 isoenzymes. Kodwa-ke, kukhona ukwehla kwezinga lokukhiqizwa kwama-reag prostaglandins. Ngenxa yalokhu, ukubonakaliswa okungekuhle kokuvuvukala kuhamba kancane kancane noma ubukhulu bawo buncipha kakhulu.

I-ASA isatshalaliswa kuwo wonke umzimba, inganikezi kuphela i-antithrombotic, imiphumela yokulwa nokuvuvukala, kodwa futhi inikeze umphumela we-antipyretic. Okokugcina kwezakhiwo kungenxa yethonya elikhulayo ku-hypothalamus kanye nendawo ephakathi nendawo ye-thermoregulation. Ngemuva kokuthatha umuthi, i-acetylsalicylic acid iyasikwa, ngenxa yalokho, kukhishwa ama-salicylates. Lezi zinto zisiza ukunciphisa umphumela we-algogenic we-bradykinin, ngenxa yokuthi kukhona ukwehla kobunzima bezinhlungu.

Ngenxa yenani elikhulu lezinto ezibonakalisa i-ASA, into ingeniswa ekwakhekeni kwezidakamizwa eziningi. Umphumela wayo we-antiplatelet kungenxa yekhono hhayi kuphela lokuvimbela ukuhlanganiswa kweplatelet, kodwa futhi nokunciphisa inani lokuzibopha kwabo komunye nomunye. I-ASA ithinta ulwelwesi lwamaseli abomvu egazi, ngenkathi ukungezwani kwabo kuncipha. Njengomphumela, inqubo yokudlula kwamangqamuzana egazi abomvu ngokusebenzisa ama-capillaries iyenziwa lula, ngenxa yokuthi ukuqondisisa kwezezakhiwo zegazi kuphawulwe, ukuphuma kwayo kuyancipha.

Umphumela womuthi ukhulisa ukopha. Enye impahla yeqoqo le-ASA ukususwa kweziqalo zegazi. Yonke imiphumela enikezwe yile nto ixhumekile. Ngakho-ke, impahla yokulwa nokuhlanganiswa iqinisekiswa ngokukhishwa kwama-prostaglandins, kepha ngohlobo oluhlukile lomsebenzi. Lokhu kunciphisa izinga le-ionized calcium, esiza ukunciphisa ikhono lokuhlanganiswa kwamapuleti.

Impahla ye-ASA aggregate ingukuqedwa kweziqeshana zegazi.

Ububi besidakamizwa ukucindezela kokuhlanganiswa kwama-antithrombotic prostaglandins. Lo mphumela unikezwa lapho umuthi uthathwa ngomuthi omkhulu. Umphumela uba okuphambene nomphumela ofunwayo. Ngenxa yalesi sizathu, umthamo wansuku zonke ophakanyiselwe umenzi (hhayi ngaphezulu kwama-325 mg) kufanele ulandelwe.

Enye into esebenzayo ekwakhiweni kukhombisa izakhiwo ze-antacid ne-laxative. Ngenxa yalokho, ubungozi bezinkinga ngesikhathi sokwelashwa buncishisiwe, ngoba le nto ithambisa umphumela onolaka we-ASA kulwelwesi lwama-mucous lomgudu wesisu. Ngemuva kokuthatha umuthi, i-magnesium hydrochloride ixhumana nejusi esiswini, okuholela ekwakhiweni kwe-magnesium chloride.

Lapho le nto ifinyelela emathunjini, umphumela wayo we-laxative uyabonakala. Lokhu kungenxa yamandla amancane wokuqothula endaweni enje. I-Magnesium chloride ivuselela i-peristalsis yesitho. Enye impahla yikhono lokubopha ngama-bile acid. Le nto idliwa umzimba kancane kancane, okunomthelela esenzweni sayo eside.

Ngemuva kokuthatha umuthi, i-magnesium hydrochloride ixhumana nejusi esiswini, okuholela ekwakhiweni kwe-magnesium chloride.

I-Pharmacokinetics

Kunconywa ukuthatha umuthi ngokwehlukana nokudla, ngoba ukumuncwa kwezinto ezisebenzayo kungahle kwehle, okuzothinta isilinganiso sokukhululwa kwawo. Izakhi zomuthi zidonswa ngaso leso sikhathi, futhi zigcwele. Inqubo yokuguqulwa kwe-acetylsalicylic acid isiteji esiningi. Okokuqala, kukhishwa i-salicylic acid, esebenza ngemuva kwalokho ibangelwe ngamakhompiyutha amaningi: i-phenyl salicylate, glucuronide salicylate, salicyluric acid.

Ukusebenza kwesiqongo somuthi kwenzeka imizuzu eyi-10-20 ngemuva kokuthatha iphilisi. Ukusatshalaliswa okwandisiwe emzimbeni wonke kungenxa yokubopha kwayo kakhulu amaprotheni egazi. Kodwa-ke, le nqubo incike kumthamo we-ASA: inani elikhulu lomuthi othathwe, kokubi kakhulu amangqamuzana ento abopha amaprotheni e-plasma.

Izakhi ezisebenzayo zisuswa egazini ngokushesha - kungakapheli imizuzu engama-20, ama-metabolites abambezeleka isikhathi eside. I-ASA ishiya umzimba ngokuphelele ngemuva kwezinsuku ezingama-1-3. Izinso zinesibopho senqubo yokususa izakhi eziyinhloko. Ingxenye yesibili esebenzayo (i-magnesium hydrochloride) ayithinti i-bioavailability ye-acetylsalicylic acid.

Kunconywa ukuthatha umuthi ngokwehlukana nokudla.

Izinkomba zokusetshenziswa

Leli khambi linqunyelwe kulezo zimo ze-pathological:

• ukuvikela okuyinhloko kwezifo ezahlukahlukene ze-CVD: i-embolism ne-thrombosis yama-veins kanye nemithambo yegazi, ukwehluleka kwenhliziyo, uma kunezici zobungozi: isifo sikashukela, umfutho wegazi ophakeme, imikhuba emibi, njengokubhema noma ukusebenzisa kabi utshwala;
• i-angina pectoris yesimo esingazinzi;
• ukuvimbela kwesibili kwe-myocardial infarction;
• ukuvimbela izinkinga ngemuva kokuhlinzwa, ubungozi balokhu bukhuphuka ngemuva kokuxhunyelelwa kwe-coronary artery by gassting, coronary angioplasty.

Ngabe kuzosiza ngomfutho wegazi ophakeme?

Umuthi okukhulunywa ngawo ufaka ukwehla komfutho wegazi, kepha ngezinga elikhulu ngalo mphumela uzibonakala ngemuva kokuthatha iphilisi ngaphambi kokulala. Kumele kukhunjulwe ukuthi ngaphansi kwethonya le-Thrombomag, ingcindezi inokwehlela ku-esibucayi. Ngalesi sizathu, akufanele isetshenziswe ngenkathi uthatha izidakamizwa ze-antihypertensive.

Contraindication

Umuthi unemikhawulo eminingi ngokuqokwa:

• ukonakala kohlelo lokuphefumula ngesikhathi sokwelashwa nge-acetylsalicylic acid;
• ukusabela okungekuhle komlingiswa ngamunye ekutholeni i-ASA nezinye izakhi ekwakhekeni;
• iqoqo le-pathologies: i-asthma ye-bronchial, ukucinana kwamakhala, i-hypersensitivity ku-acetylsalicylic acid, kulokhu, ingozi yokwehluleka ukuphefumula inyuka;
• ukopha emgodini wokugaya ukudla;
• i-corrhea hemorrhage;
• ukuthuthukiswa kokuguguleka kwesakhiwo sezindonga zendlela yokugaya ukudla;
• ingozi enkulu yokuphuma kwegazi (ngokumelene nesizinda se-thrombocytopenia, ukusweleka kwe-Vitamin K, njll.);
• ushukela we-glucose-6-phosphate dehydrogenase.

I-Thrombomagum ayinqunyelwe ukukhinyabeza kohlelo lokuphefumula.

E-asthma ye-bronchial, ukuthatha umuthi kuyaphulwa.

Ithuluzi limunca izindonga zendlela yokugaya ukudla cishe ngokuphelele.

Ukwephula umthetho wokusebenzisa umuthi i-hemorrhage e-cerebral.

Ngokunakekela

Kunenombolo enkulu yokuphikisana okuhlobene lapho kuvunyelwe ukusebenzisa umuthi, kepha kufanele kuqashelwe:

• i-hyperuricemia
• gout
• sepsis
• kulapho kwatholakala khona izilonda zesisu kanye ne-duodenal ulcer;
• uhlobo olungejwayelekile lwesibindi nokusebenza kwezinso ukwehluleka;
• isifuba somoya;
• i-pathology yohlelo lokuphefumula;
• isikhathi sokusebenza;
• ukuthambekela komzimba.

Ungayithatha kanjani i-thrombomag?

Ezimweni eziningi, kuthathwa umthamo ongaphezu kwe-amaphilisi ayi-1-2 ngosuku. Umuthi uthathwa kanye. Izinhlobo zokwelashwa zingahluka. Isibonelo, ukuze kuvikeleke ama-pathologies we-CCC, i-150 mg ngosuku inqunywa kuqala, bese le mali incishiswa amahlandla ama-2. Kwezinye izimo, kuthathwa njengokwanele ukuthatha ithebhulethi e-1 nganoma imuphi umthamo we-ASA (75 noma i-150 mg), okuya ngobucayi besifo.

Ngefomu emnene yokuhluleka kwezinso nezinso, umuthi kufanele uthathwe ngokuqapha.

Ngoshukela

Umuthi uvunyelwe ukusetshenziswa, ukuguqulwa kwamthamo akwenziwanga, kepha isiguli kufanele sibhekwe.

Imiphumela emibi ye-Thrombomagus

Ukuphendula okungalungile ngesikhathi sokwelashwa nalesi sikhungo akuvamile kakhulu kune-Acetylsalicylic acid, ngoba inani lezithako ezisebenzayo lincane, futhi umphumela wamathebulethi uyaqhubeka nokuthanjiswa. Imiphumela emibi eyenzeka kaningi:

• ikhanda
• ukopha
• i-bronchospasm;
• isicanucanu nokuhlanza
• ukushaya kwenhliziyo.

Ukuvela kwezibonakaliso ezinjalo kuvame kakhulu:

• ubuthakathaka obujwayelekile;
• Isiyezi
• ukulahleka kwezindlebe, kuhambisana ne-tinnitus engapheli;
• i-corrhea hemorrhage;
• ukuphazamiseka kohlelo lwe-hematopoietic, olukhonjiswa yi-anemia, thrombocytopenia, njll.
• ukukhuphula isilonda esiswini, okuthi ezimeni eziningi kwandulelwe yizinhlungu esiswini;
• izihlakala;
• ukubonakaliswa okuhlukahlukene kokungezwani komzimba: ukuvuvukala kwepheji lokuphefumula, ukulunywa, ukuqubuka, i-hyperemia, i-rhinitis;
• umsebenzi wezinso ongonakalisiwe.

Ngenkathi uthatha umuthi, ukuvela kobuthakathaka obujwayelekile kungenzeka.

I-Thrombomagus ibanga ukushisa kwenhliziyo.

Ngenkathi uthatha i-thrombomag, isicanucanu nokuhlanza kungenzeka.

Ukuba nesiyezi okuqhubekayo kungumphumela wokuthatha i-Aspirin.

Ubuhlungu esiswini bungumphumela ongemuhle wesidakamizwa uStrombomag.

Umuthi ungadala ukungasebenzi kahle kwezinso.

Umthelela ekhonweni lokulawula izindlela

Ukushayela imoto akuyona into ephula umthetho. Kodwa-ke, uma kucatshangelwa ukuthi kungenzeka kube nezinkinga ezinkulu lapho uselashwa, kufanele kusetshenziswe ukuqaphela.

Imiyalo ekhethekile

Lapho unquma umuthi okukhulunywa ngawo ngaphambi kokuhlinzwa, kufanele ukhunjulwe ukuthi impahla yokulwa nomuthi yomuthi kungenzeka ngaphakathi kwezinsuku ezintathu kusukela kwithebhulethi yokugcina.

Ngesikhathi sokwelashwa kweziguli ezinenkinga yezinso ezitholakele, kubalulekile ukubheka njalo izinkomba eziphambili zesimo salesi sitho.

Ezingeni lokugcina nelokugcina lokwelashwa, kufanele kwenziwe ukuhlolwa kokwakhiwa kwegazi.

Sebenzisa ebudaleni

Ezigulini zaleli qembu, ingozi yokuphuma kwegazi ikhuphuka uma kuthathwa umthamo omncane weTrobomag. Ukugwema ubunzima, izinkomba zokwakheka kwegazi nesibindi ziqashwa njalo.

Ezigulini esezikhulile, ingozi yokuphuma kwegazi ikhuphuka uma kuthathwa umthamo omncane weTrobomag.

Isabelo sezingane

Ayisetshenziswa.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Umuthi awuchaziwe ngesikhathi sokukhulelwa, imikhawulo isebenza kuphela kuma-trimesters we-I ne-III. Ukuphambana okunjalo kungenxa yengozi yokuqalwa kwama-pathologies. Amathuba okuvalwa kwangaphambi kwesikhathi kwe-ductus arteriosus esibelethweni kuyaphawulwa. Kungaba nokukhubazeka kwenhliziyo enganeni. Kwi-trimester yesi-II, kuvunyelwe ukusebenzisa umuthi ngenani elingadluli ku-150 mg ngosuku.

Ngesikhathi sokuncelisa, umuthi okukhulunywa ngawo nawo awuchaziwe.

Isicelo sokusebenza kokulimala kwezinso

Ukuqapha kufanele kuvikelwe, ngoba i-magnesium hydrochloride ingangena ku-plasma yegazi. Kulokhu, umphumela onobuthi wento uyakhuphuka. Le nqubo ibonakaliswa ukucindezelwa kohlelo lwezinzwa oluphakathi.

Ukwehluleka okukhulu kwezinso, umuthi awusetshenziswa. Kulokhu, kufanele ugxile kusinkomba sokucaciswa kwe-creatinine (ngaphansi kwama-30 ml ngomzuzu).

Ukulimala kwesibindi okukhulu kungukuphambana kokuthatha lo muthi.

Sebenzisa umsebenzi wesibindi okhubazekile

Ukulimala okukhulu kwalesi sitho kuwukuphikisana nokuphuza umuthi.

I-Thrombomag overdose

Umphumela wemiphumela emibi eminingana echazwe ngenhla uyathuthukiswa. Uma kuthathwe imithamo emikhulu, izimpawu zefomu elinamandla lesimo se-pathological zenzeka. Izimpawu

• umkhuhlane
• hyperventilation yamaphaphu;
• i-hypoglycemia;
• i-alkalosis;
• ketoacidosis;
• ukulimala okukhulu ezinhlelweni zenhliziyo nokuphefumula.

Kulokhu, ukwelashwa kufaka isidingo sokuhlinzwa esiswini. Isiguli sinconywa ukuthi sithathe i-sorbent ngamanani amakhulu, i-hemodialysis, i-alkaline diuresis sinqunyelwe ngokungeziwe. Kuthathwa izinyathelo zokubuyisa ibhalansi yama-electrolyte. Uma kwenzeka okweqa umuthi, isiguli silaliswa esibhedlela.

Uma kwenzeka kweqisa ngokweqile, ukwelashwa kufaka ukuqubuka kwesisu.

Ukuxhumana nezinye izidakamizwa

Umphumela we-methotrexate, i-valproic acid uyathuthukiswa.

Izidakamizwa nezinto eziningi ziyaphawulwa, ngokuphathwa kanyekanye lapho ukuvela okungekuhle kube khona:

• ama-analcics we-narcotic;
• Ama-NSAIDs;
• Insulin
• izidakamizwa ze-hypoglycemic;
• ama-antiplatelet, ama-anticoagulant kanye nama-thrombolytic agents;
• ama-sulfonamides;
• I-Digoxin;
• i-lithium;
• ethanol.

Izinga lokusebenziseka kwe-ASA liyancishiswa ngaphansi kwethonya lezidakamizwa nezinto ezithile: i-GCS yokusetshenziswa okuhleliwe, i-Ibuprofen, amanye ama-antacid, aqukethe i-magnesium noma i-aluminium hydroxide.

Umphumela we-Methotrexate uyathuthuka lapho uthathwa nge-Thrombomag.

Ukuhambisana notshwala

Ukuqapha kufanele kwenziwe ngesikhathi sokwelapha nge-Thrombomagum, ngenkathi kuphuzwa iziphuzo eziqukethe utshwala.

Ama-Analog

Izinto ezingezansi ezingasetshenziswa esikhundleni somuthi okukhulunywa ngawo:

• I-Cardiomagnyl;
• Phasostable;
• I-Thrombital;
• I-Clopidogrel Plus.

Imibandela yekhefu lekhemisi

Umuthi yiqembu lezidakamizwa zemithi esezingeni eliphakeme.

Ngingakwazi ukuthenga ngaphandle kadokotela?

Kukhona ithuba elinjalo.

I-Cardiomagnyl iyi-analogue ephelele yesidakamizwa i-Thrombomag.

I-Cardiomagnyl ithathwa njenge-analogue yesidakamizwa i-Phazostabil.

Esikhundleni somuthi i-Thrombomag, ungathatha i-thrombital.

I-Clopidogrel Plus kwesinye isikhathi inqunyelwa esikhundleni sesidakamizwa i-Thrombomag.

Intengo

Izindleko ziyahlukahluka kusuka kuma-ruble ayi-100 kuye kwangama-200.

Izimo zokugcina zomuthi

Ukushisa okunconyelwayo - akukho ngaphezu kwe- + 25 ° С.

Isikhathi sokuphelelwa yisikhathi

Kuvunyelwe ukusebenzisa umkhiqizo iminyaka emi-2 kusukela ngosuku lokukhishwa.

Umkhiqizi

IHemofarm, eRussia.

Ukubuyekezwa

UVeronika, oneminyaka engama-33, eSt.

Umuthi omuhle. Thatha ngemuva kokuhlinzwa. Imiphumela emibi, ngaphandle kokusabela kwesikhumba esiteji sokuqala, bekungenjalo. Ngenxa ye-Thrombomag, bekungekho zinkinga, okubalulekile, ngoba igazi lami likhulu impela.

U-Elena, oneminyaka engama-42, u-Alupka.

Ngomfutho wegazi ophakeme, kuyadingeka ukulawula umthamo womuthi. Uma uyithatha ngokungalawulwa, umfutho wegazi ungokwehla kakhulu.Benginecala: Ngikhohliwe ukuphuza umuthi ngesikhathi, bese ngiwukhumbula futhi ngiwuphuza ngaso leso sikhathi, kodwa ngokushesha isikhathi somuthi olandelayo kufanele sifike. Angikukhathaleli lokhu futhi ngiphinda kabili ukwamukela. Ngenxa yalokhu, babephela ngaphandle, kwengcindezi enkulu yawa.